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国际医学放射学杂志 2023年第3期 360-360页

作者： J.C.toro B.Viteri L.Ballester H.A.G.Perdomo A.White M.Pradhan 田诗姣

摘要以往研究探讨的多是对比剂诱导的成人急性肾损伤（AKI），而对儿童和青少年人群的相关研究甚少。目的计算静脉注射碘对比剂后行CT检查的儿童和青少年AKI的

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Generation of high energy laser-driven electron and proton sources with the 200 TW system VEGA 2 at the Centro de Laseres Pulsados

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High Power Laser Science and Engineering 2019年第2期7卷 34-39页

作者： L.Volpe R.Fedosejevs G.Gatti J.A.Pérez-Hernández C.Méndez J.Apinaniz X.Vaisseau C.Salgado M.Huault S.Malko G.Zeraouli V.Ospina A.Longman D.De Luis K.Li O.Varela E.García I.Hernandez J.D.Pisonero J.Garcia Ajates J.M.Alvarez C.García M.Rico D.Arana J.Hernandez-toro L.Roso Centro de Laseres Pulsados(CLPU) Edicio M5.Parque Cientco.C/Adaja&37185VillamayorSalamancaSpain Laser-Plasma Chair at the University of Salamanca SalamancaSpain Department of Electrical and Computer Engineering University of AlbertaEdmontonAlberta T6G2V4Canada University of Salamanca SalamancaSpain

The Centro de Laseres Pulsados in Salamanca,Spain has recently started operation phase and the first user access period on the 6 J 30 fs 200 TW system(VEGA 2)already started at the beginning of *** this paper we report on two commissioning experiments recently performed on the VEGA 2 system in preparation for the user *** 2 system has been tested in different configurations depending on the focusing optics and targets *** configuration(long focal length F=130 cm)is for underdense laser-matter interaction where VEGA 2 is focused onto a low density gas-jet generating electron beams(via laser wake field acceleration mechanism)with maximum energy up to 500 MeV and an X-ray betatron source with a 10 keV critical energy.A second configuration(short focal length F= 40 cm)is for overdense laser-matter interaction where VEGA 2 is focused onto a 5 μm thick Al target generating a proton beam with a maximum energy of 10 MeV and temperature of 2.5 *** this paper we present preliminary experimental results.

关键词： high power laser laser-plasma particle acceleration

一氧化氮合成酶、环氧化酶-2、硝基酪氨酸及血管生成与软骨肉瘤预后的相关性研究

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中华骨科杂志 2010年第12期30卷 I0041-I0049页

作者： Suely Akiko Nakagawa Ademar Lopes Andre Lopes de Carvalho Benedito Mauro Rossi isabela Werneck da Cunha Fernando Augusto Soares Wu Tu Chung Luciola Assuncao 刘沛宜(译) 张伟滨(译) Investigation performed at Departamentos de Cirurgia Petvica-Ortopedia e Anatomia Patologica Hospital A.C. Camargo Sao Paulo Brazil 上海交通大学医学院附属瑞金医院骨科 200025

背景：免疫组织化学标记物有助于肿瘤诊断及预后评估。通过对硝基酪氨酸分析及采用一氧化氮合成酶1（NOS1）、一氧化氮合成酶2（NOS2）、一氧化氮合成酶3（NOS3）检测分析可了解一氧化氮（NO）与肿瘤的相关性。NO与超氧阴离子反应产生... 详细信息

背景：免疫组织化学标记物有助于肿瘤诊断及预后评估。通过对硝基酪氨酸分析及采用一氧化氮合成酶1（NOS1）、一氧化氮合成酶2（NOS2）、一氧化氮合成酶3（NOS3）检测分析可了解一氧化氮（NO）与肿瘤的相关性。NO与超氧阴离子反应产生的过氧亚硝酸对基因有毒性作用，过氧亚硝酸传递一个硝基基团到酪氨酸的苯环上形成硝基酪氨酸。细胞内硝基酪氨酸的积累说明过氧亚硝酸持续生成。NO刺激所生成的环氧化酶-2（COX-2）与肿瘤内新生血管水平相关，研究表明新生血管影响肿瘤预后，免疫组化标记CD34可表示微血管生成，从而被用于预测肿瘤预后。本研究检测上述标记物在软骨肉瘤中的表达并分析与软骨肉瘤分级和预后的相关性。方法：101例软骨肉瘤患者肿瘤组织样本采用甲醛固定，组织样本采用免疫组织化学染色，指标为：NOS1、NOS2、NOS3、COX-2、硝基酪氨酸和CD34。5例正常软骨样本作为对照。研究分析患者特征、手术变量、肿瘤分级与这些指标的相关性。使用Kaplan—Meier多变量统计学方法分析生存曲线及生存率。结果：硝基酪氨酸、COX-2和CD34与组织学分级有明显相关性（p=0．022，p=0．014，p=0．028），但与总体预后无相关性（p=0．064，p=0．143，p=0．581）。NOS2阳性表达常预示较高的局部复发率（p=0．038）。NOS1、NOS2阳性表达预示较低的生存率（p=0．007，p〈0．001）。通过多变量分析处理，NOS2的表达被证实可作为局部复发率的独立预后判断因素；NOS1、NOS2的表达作为因变量，它们单独或复合阳性表达常与较低的总生存率有关（p=0．046，p=0．004）[危险率，3．17（95％置信区间，1．0-9．8）和5．58（95％置信区间，1．7-18．0）]。

关键词：一氧化氮合成酶硝基酪氨酸环氧化酶-2 软骨肉瘤微血管生成预后评估相关性免疫组织化学染色

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全膝置换术后膝前痛采用髌骨置换是否有效?

临床骨科杂志 2016年第2期19卷 143-143页

作者： toro-Ibarguen A N Navarro-Arribas R Pretell-Mazzini J 胡孔足

全膝置换术后部分患者抱怨膝前痛,有时会采用髌骨置换作为处理方案。作者回顾性分析了46例全膝置换术后膝前痛而采用髌骨置换处理的患者。平均随访74个月,发现虽然KSS评分有所提高,但是9%患者疼痛没有改善,65%患者不满意手术效果。4例... 详细信息

全膝置换术后部分患者抱怨膝前痛,有时会采用髌骨置换作为处理方案。作者回顾性分析了46例全膝置换术后膝前痛而采用髌骨置换处理的患者。平均随访74个月,发现虽然KSS评分有所提高,但是9%患者疼痛没有改善,65%患者不满意手术效果。4例出现并发症,其中2例需要再手术。

关键词：全膝置换术

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莫斯托莱斯社区服务中心

世界建筑导报 2021年第3期36卷 70-71页

作者：无伊格纳西奥·博雷戈内斯特·黑山丽娜·托罗 Miguel de Guzmán(摄影) Extudio事务所不详

莫斯托莱斯新社区服务中心的方案初期启动需要面对以下两个重要条件:它需要包含多个布局相同的单人办公室;项目位于市区中,对于交通和建筑朝向有严格限制。同时,该项目必须满足有限的预算并尽可能减少未来的维护负担。

关键词：社区服务中心建筑朝向莱斯斯托办公室项目

高冲击下的保护:清除西墨西哥岛屿外来哺乳动物

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AMBIO－人类环境杂志 2008年第2期37卷 97-103页

作者： Alfonso Aguirre-Muoz Donald A.Croll C.Josh Donlan R.William Henry Ⅲ Miguel Angel Hermosillo Gregg R.Howald Bradford S.Keitt Luciana Luna-Mendoza Marlenne Rodríguez-Malagón Luz María Salas-Flores Araceli Samaniego-Herrera Jose Angel Sanchez-Pacheco Jacob Sheppard Bernie R.Tershy Jorge toro-Benito Shaye Wolf Bill Wood 寒江 Grupo de Ecologíay Conservación de Islas 岛屿保护组织(IC) 高级保护战略(Advanced Conservation Strategies) 加州大学圣克鲁兹分校 IC-Canada IC Grupo de Ecología y Conservación de Islas 墨西哥联邦政府内务部

岛屿蕴含着与其面积不成比例的地球生物多样性,但是,岛屿生物多样性有很大一部分丧失了,这很大程度上是由于外来哺乳动物的冲击。幸运的是,倘若有强有力的手段防止生物灭绝、重建生态系统,那么,可以例行地清除岛屿上的外来哺乳动物。鉴... 详细信息

岛屿蕴含着与其面积不成比例的地球生物多样性,但是,岛屿生物多样性有很大一部分丧失了,这很大程度上是由于外来哺乳动物的冲击。幸运的是,倘若有强有力的手段防止生物灭绝、重建生态系统,那么,可以例行地清除岛屿上的外来哺乳动物。鉴于目前超过80%的世界主要岛群存在外来哺乳动物并且它们构成了对地球生物多样性的首要威胁,推广可重现的、可依比例缩放的行动模式以清除岛屿外来哺乳动物便十分重要了。这里我们报告过去10年来应用于西墨西哥群岛的一种成功的行动模式。非政府组织、理论生物学家、墨西哥政府机构,以及当地个人在3个群岛海进行了通力合作,产生了重大的重建成效。从26个岛屿清除了42个外来哺乳动物种群。对于每一生物群体(colony)花费21 615美元,每一分类(taxon)花费49 370美元,分别有201个海鸟群体、88个陆地特有分类得到了保护。这些保护行动的成功要归功于一种可操作的行动模式,它有3个主要的构成部分:1)将研究、重点设定、资助、公众教育、政策制定、能力建设、保护行动、监测及评估结合在一起的三国通力协作;2)主动的、专门的自然资源管理机构;3)墨西哥和美国学术研究人员的有效参与。现在需要的是:一份将所需的额外资助、能力、技术进步及政策问题综合起来的,本地区其余岛屿清除外来哺乳动物的详细计划。西墨西哥的岛屿保护提供了一种有效的方法,这种方法可以很容易地应用于其它保护努力十分有限的多岛海区域。

关键词：哺乳动物墨西哥岛屿保护清除高冲击生物多样性比例缩放

Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

Glutamine or Glutamine Dipeptide Supplementation Improves Gluconeogenesis and Liver Glycogenosis in Type 1 Diabetic Rats

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 398-407页

作者： Silvia Carla S.F.Azevedo Carlos Vinicius D.da Rosa Ana Luiza M.Wunderlich Laís A.Yamada isabela R.Mariano Camila Bataglini Nayra T.D.Branquinho Scarlett R.Raposo Roberto B.Bazotte Edmara A.Baroni Maria Raquel M.Natali Maria Montserrat D.Pedrosa Vilma A.F.de Godoi Program of Graduate Studies in Cell and Molecular Biology State University of MaringáMaringá87020-900Brazil Program of Graduate Studies in Physiological Sciences State University of MaringáMaringá87020-900Brazil Undergraduation in Biological Sciences University Center of MaringáMaringá87050-390Brazil Department of Pharmacology and Therapeutics State University of MaringáMaringá87020-900Brazil Department of Physiological Sciences State University of MaringáMaringá87020-900Brazil Department of Morphological Sciences State University of MaringáMaringá87020-900Brazil

The effects of the supplementation with L-glutamine(GLN)or L-alanyl-L-glutamine(GDP)on the progression of the systemic and hepatic metabolic status of rats having untreated type 1 diabetes mellitus(T1DM)were *** Wistar diabetic rats(streptozotocin,60 mg/kg)were allotted to four groups supplemented by gavage for thirty days as follows:control and diabetic receiving saline;diabetic receiving GLN(248 mg/kg);and diabetic receiving GDP(400 mg/kg).Body weight,plasmatic parameters and kidney function were *** hepatocytes were used to assess gluconeogenic *** and kidney were used for morphological analyses.T1DM decreased the number and increased the area of the hepatocytes,possibly because of the observed enlargement of glycogen *** weight,glomerular area and proteinuria increased,and glomerular filtration rate decreased,in non-supplemented T1DM *** area and proteinuria were reversed by both *** T1DM hepatocytes released less glucose,which could have been diverted to glycogen synthesis and secondary glycogenosis observed in T1DM;this was partially reversed by the *** results point to a possible beneficial effect of glutamine on the metabolic and hepatic impairments of T1DM.

关键词： Type 1 diabetes mellitus L-glutamine glutamine dipeptide gluconeogenesis glycogenosis

Transcranial direct current electrical stimulation in combination with aerobic exercise:A pilot study in post-COVID-19 systemic autoimmune rheumatic patients

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World Journal of Rheumatology 2023年第1期11卷 1-12页

作者： Rafael Giovani Missé Alexandre Moura dos Santos isabela Bruna Pires Borges Marlise Sítima Mendes Simões Lorenza Rosa Silvério Bruna Lindoso Correia Ana Wook Sook Kim Aline Marques Caetano Sandra Gofinet Pasoto Carla Gonçalves Schahin Saad Diogo Souza Domiciano Clarice Tanaka Julia Maria D’Andrea Greve Abrahão Fontes Baptista Samuel Katsuyuki Shinjo Division of Rheumatology Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Departamento de Fisioterapia Fonoaudiologia e Terapia OcupacionalHospital das Clínicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloNúcleo de Assistência e Pesquisa em NeuromodulaçãoSao PauloBrazil Laboratório de Estudos do Movimento Instituto de Ortopedia e TraumatologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil

BACKGROUND Systemic autoimmune rheumatic diseases(SARDs)are a group of diseases with multiorgan involvement and a high prevalence of chronic pain and *** with SARDs and post-coronavirus disease 2019(COVID-19)syndrome experience aggravation of *** this context,it is essential to establish strategies to reduce chronic pain and fatigue and improve quality of *** To assess the efficacy of transcranial direct current stimulation(tDCS)for the treatment of fatigue and pain-associated post-COVID-19 syndrome in patients with *** This study included nine patients with different types of *** patients had reverse transcription-polymerase chain reaction(RT-PCR)test confirmed COVID-19 as well as significant,persistent fatigue and pain that began to worsen after *** tDCS was administered in five daily sessions(2mA,20 min).Concomitantly,patients were involved in aerobic exercise *** participants were evaluated using specific questionnaires and strength assessment by handgrip and physical function by timed-up-and-go test and sit-to-stand test at baseline(within one week before tDCS protocol),and one week after tDCS *** all procedures,the patients’treatments remained *** The sample comprised eight women and one man with a mean age of 48.7±9.6 *** the tDCS protocol,pain and fatigue significantly improved on the visual analog scale(P<0.05).The physical function also improved 9.5±2.7 vs 6.8±0.8(P=0.001)for timed-up-go-test and 10.3±3.7 vs 15.1±4.0(P=0.037)for sit-to-stand *** of the patients experienced any adverse *** The present study showed that tDCS in combination with aerobic exercise was effective in improving physical function,and reducing fatigue/pain in SARDs patients with post-COVID-19 syndrome.

关键词： Autoimmune diseases COVID-19 Fatigue Neuromodulation Physical function Rheumatic diseases Pain

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING