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Relation of COVID-19 with liver diseases and their impact on healthcare systems:The Portuguese case

World Journal of Gastroenterology 2023年第6期29卷 1109-1122页

作者： Sara Fernandes Milaydis Sosa-Napolskij Graça Lobo isabel silva Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP) Porto 4050-313Portugal CINTESIS@RISE Center for Health Technology and Services Research at The Associate Laboratory RISE–Health Research NetworkFaculty of Medicine of The University of PortoPorto 4200-219Portugal Laboratory of Pharmacology and Neurobiology–Department of Immuno-physiology and Pharmacology Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal Center for Drug Discovery and Innovative Medicines(MedInUP) Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal

BACKGROUND The impact caused by the coronavirus disease 2019(COVID-19)on the Portuguese population has been addressed in areas such as clinical manifestations,frequent comorbidities,and alterations in consumption ***,comorbidities like liver conditions and changes concerning the Portuguese population's access to healthcare-related services have received less *** To(1)Review the impact of COVID-19 on the healthcare system;(2)examine the relationship between liver diseases and COVID-19 in infected individuals;and(3)investigate the situation in the Portuguese population concerning these *** For our purposes,we conducted a literature review using specific *** COVID-19 is frequently associated with liver ***,liver injury in COVID-19 individuals is a multifactor-mediated ***,it remains unclear whether changes in liver laboratory tests are associated with a worse prognosis in Portuguese individuals with *** COVID-19 has impacted healthcare systems in Portugal and other countries;the combination of COVID-19 with liver injury is *** liver damage may represent a risk factor that worsens the prognosis in individuals with COVID-19.

关键词： COVID-19 Healthcare systems Liver Portuguese individuals Comorbidities Clinical outcomes

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Predictive models for the assessment of bodily harm

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Forensic Sciences Research 2017年第4期2卷 185-191页

作者： Lucia Ordonez Mayan isabel Martinez silva Carlos Represas Vazquez Jose Ignacio Munoz Barus Institute of Forensic Science University of Santiago de CompostelaLa CorunaSpain SiDOR Statistical InferenceDecision and Operations ResearchUniversity of VigoPontevedraSpain Department of Forensic Science PathologyGynecology and ObstetricsPediatricsUniversity of Santiago de CompostelaLa CorunaSpain

The Spanish scale to quantify or qualify bodily harm resulting from any unintentional traffic accident prior to 1 January 2016 is established by Royal Legislative Decree(RDL)8/*** scale assigns points to the sequelae,which are converted into Euros using a table that is updated *** objective of this study is to develop a predictive model of sequelae points that will enable the estimation of compensation a short time after the *** will facilitate the calculation of the money reserve and rapid access to compensation for the injured *** conduct this study,we developed a database with information from 999 individuals who had suffered car crash injuries which were evaluated according to the scale contained in RDL 8/2004 for medical *** models based on logistic regression models were designed on this *** choose the best model,we calculated Mallow’s *** use of hurdle models made it possible to predict the points received by an injured party within a relatively short period of time after the *** these points are known,it is a simple matter to calculate the corresponding *** prediction models developed provide an easy way to predict the compensation to be awarded to the injured *** models use days of hospitalization,sex,age and the results of international scales based on the Abbreviated Injury *** variables can be used soon after the occurrence of the crash.

关键词： Forensic science assessment of bodily harm AIS ISS default interest Royal Legislative Decree(RDL)

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Biochemical mechanisms implemented by human acute myeloid leukemia cells to suppress host immune surveillance

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Cellular & Molecular Immunology 2018年第11期15卷 989-991页

作者： Inna M.Yasinska isabel Gonçalves silva Svetlana Sakhnevych Bernhard F.Gibbs Ulrike Raap Elizaveta Fasler-Kan Vadim V.Sumbayev Medway School of Pharmacy Universities of Kent and GreenwichChatham MaritimeUK Department of Dermatology and Allergy University of OldenburgOldenburgGermany Department of Pediatric Surgery and Department of Biomedical Research Children’s HospitalInselspitalUniversity of BernBernSwitzerland Department of Biomedicine University Hospital Basel and University of Basel BaselSwitzerland

Acute myeloid leukaemia(AML)is a blood/bone marrow cancer originating from myeloid cell precusors capable of *** cells implement biochemical mechanisms which allow them not only to survive,but also to successfully escape immune *** this work,we discuss crucial molecular mechanisms used by human AML cells in order to evade immune attack.

关键词： Acute myeloid leukaemia Immune surveillance Tim-3 galectin-9

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Risk factors associated with the development of ischemic colitis

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World Journal of Gastroenterology 2010年第36期16卷 4564-4569页

作者： Joaquín Cubiella Fernández Luisa Núez Calvo Elvira González Vázquez Maria Jesús García García Maria Teresa Alves Pérez isabel Martínez silva Javier Fernández Seara Department of Gastroenterology Complexo Hospitalario de Ourense32005 OurenseSpain Department of Internal Medicine Complexo Hospitalario de Ourense32005 OurenseSpain Department of Internal Medicine Fundación Pública Hospitalaria de Verín32600 VerinSpain Research Support Unit Complexo Hospitalario de Orense32005 OurenseSpain Biostatistic Unit University of Santiago de Compostela15703 Santiago de CompostelaSpain

AIM:To ascertain the role of cardiovascular risk factors,cardiovascular diseases,standard treatments and other diseases in the development of ischemic colitis(IC).METHODS:A retrospective,case-control study was designed,using matched data and covering 161 incident cases of IC who required admission to our hospital from 1998 through *** was diagnosed on the basis of endoscopic findings and diagnostic or compatible *** were randomly chosen from a cohort of patients who were admitted in the same period and required a colonoscopy,excluding those with diagnosis of *** were matched with controls(ratio 1:2),by age and sex.A conditional logistic regression was ***:A total of 483 patients(161 cases,322 con-trols)were included;mean age 75.67±10.03 years,55.9%*** principal indications for colonos-copy in the control group were lower gastrointestinal hemorrhage(35.4%),anemia(33.9%),abdominal pain(19.9%)and diarrhea(9.6%).The endoscopic findings in this group were hemorrhoids(25.5%),diverticular disease(30.4%),polyps(19.9%)and colorectal cancer(10.2%).The following variables were associated with IC in the univariate analysis:arterial hypertension(P= 0.033);dyslipidemia(P<0.001);diabetes mellitus(P =0.025);peripheral arterial disease(P=0.004);heart failure(P=0.026);treatment with hypotensive drugs(P=0.023);angiotensin-converting enzyme inhibitors;(P=0.018);calcium channel antagonists(P=0.028);and acetylsalicylic acid(ASA)(P<0.001).Finally,the following variables were independently associated with the development of IC:diabetes mellitus[odds ratio(OR)1.76,95%confidence interval(CI):1.001-3.077,P=0.046];dyslipidemia(OR 2.12,95%CI:1.26-3.57,P=0.004);heart failure(OR 3.17,95%CI:1.31-7.68,P=0.01);peripheral arterial disease(OR 4.1,95%CI:1.32-12.72,P=0.015);treatment with digoxin(digitalis)(OR 0.27,95%CI:0.084-0.857,P=0.026);and ASA(OR 1.97,95%CI:1.16-3.36,P=0.012).CONCLUSION:The development of an episode of IC was independently associat

关键词： Ischemic colitis Diabetes mellitus Dyslipidemia Acetylsalicylic acid Peripheral arterial disease Digoxin

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Strategic Environmental Assessment to Improve Infrastructure Impact Assessments in Brazil

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Journal of Environmental Protection 2013年第10期4卷 1189-1196页

作者： isabel silva Dutra de Oliveira Marcelo Montano Marcelo Pereira de Souza Research Cluster for Studies of Environmental Sciences and Policies Ribeirao Preto Faculty of Philosophy Sciences and LettersUniversity of Sao PauloRibeirao PretoBrazil Research Cluster for Studies of Environmental Policy Sao Carlos School of EngineeringUniversity of Sao PauloSao CarlosBrazil

The wider consideration of environmental effects and alternatives in early stages of decision-making has been pointed as one of the major benefits of Strategic Environmental Assessment (SEA). Adopted by virtually all of developed countries and sprawling around emergent and developing ones, it is recognized that SEA effectiveness is attached to its systematic application in development plans and programmes. Brazil and many developing countries have different experiences with this instrument and lacks of definition of a procedural framework to promote the use of SEA in strategic levels of decision. As a consequence development projects are frequently “threatened” by impact assessment outcomes, especially when a mandatory project-EIA has to inform decisions. In order to contribute to the implementation of SEA in developing countries, the present paper discusses the potential benefits of using SEA in transport infrastructure plans and programmes, through a case study applied to transport plans in the state of Sao Paulo (south-eastern Brazil). The outcomes indicate that SEA could contribute to improve infrastructure impact assessments, minimizing social and environmental conflicts, augmenting the acceptability of projects and decisions, reinforcing the need for SEA to be systematically implemented in Brazil.

关键词： SEA EIA Environmental Licensing Environmental Policy Brazil

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Motivations for and barriers to innovation in non-profit organizations: The case of nursing homes in Northern Portugal

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International Journal of Innovation Studies 2024年第1期8卷 25-44页

作者： Ana Rita Gonçalves Lopes Aldina isabel de Azevedo Correia Alexandra Maria da silva Braga Center for Research and Innovation in Business Sciences and Information Systems School of Management and TechnologyPolitecnico do PortoRua do Curral-Margaride4610-156 FelgueirasPortugal

To contribute to the empirical literature on innovation in non-profit organizations,this study examines innovation in Private Social Solidarity Institutions with social responses for the elderly in Northern *** enriches the literature by clarifying the concept of innovation applied to non-profit organizations,which represents a perspective different from the business ***,it is important to support the innovation decisionmaking process in similar non-profit *** this study,the population was surveyed through questionnaires based on the PUBLIN research project,which has already been applied in different countries,and the targets were employees of organizations with social responses for the *** sample is small,with 28 respondent institutions and 51 employees,but it is representative,as it includes institutions from all districts in Northern *** study employed a quantitative approach,particularly factor analysis,multiple linear regression,and correlation analyses,using scales already applied in other dimensions of the social sector,to understand the effect of each innovation dimension/determinant on creativity and innovation in nonprofit *** results show that in these organizations with social responses for the elderly,learning orientation,risk-taking,and job satisfaction have a positive impact on innovation.

关键词： Determinants of innovation non-profit organizations social responses for the elderly Northern Portugal

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Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression

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Cellular & Molecular Immunology 2018年第11期15卷 994-997页

作者： Svetlana S.Sakhnevych Inna M.Yasinska Alison M.Bratt Ouafa Benlaouer isabel Gonçalves silva Rohanah Hussain Giuliano Siligardi Walter Fiedler Jasmin Wellbrock Bernhard F.Gibbs Yuri A.Ushkaryov Vadim V.Sumbayev Medway School of Pharmacy Universities of Kent and GreenwichChatham MaritimeUK Beamline B23 Diamond Light SourceDidcotUK Department of Oncology Hematology and Bone Marrow Transplantation with Section PneumologyHubertus Wald University Cancer CenterUniversity Medical Center Hamburg-EppendorfHamburgGermany Department of Medicine Dermatology and AllergologyUniversity of OldenburgOldenburgGermany

The progression of acute myeloid leukemia(AML)—the most severe blood/bone marrow cancer—is determined by the ability of malignant cells to escape host immune ***,the systemic regulatory mechanisms underlying this phenomenon remain largely *** this study,we discovered a fundamental systemic biochemical strategy that allows AML cells to employ physiological systems within the body to survive and escape immune *** found that AML cells use a crucial human adrenal cortex hormone(cortisol)to induce the expression of neuronal receptor latrophilin 1(LPHN1),which facilitates *** receptor interacts with the blood plasma protein fibronectin leucine rich transmembrane protein 3(FLRT3)to cause secretion of the immune suppressor galectin-9,which impairs the anticancer activities of cytotoxic lymphoid cells.

关键词： acute myeloid cortex

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Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China:A nested case-control study

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Chinese Journal of Cancer Research 2020年第6期32卷 742-754页

作者： Fangfang Liu Mengfei Liu Ying Liu Chuanhai Guo Yunlai Zhou Fenglei Li Ruiping Xu Zhen Liu Qiuju Deng Xiang Li Chaoting Zhang Yaqi Pan Tao Ning Xiao Dong Zhe Hu Huanyu Bao Hong Cai isabel Dos Santos silva Zhonghu He Yang Ke Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of GeneticsPeking University Cancer Hospital&InstituteBeijing 100142China Novogene Co. LtdBeijing 100080China Hua County People's Hospital Anyang 456400China Anyang Cancer Hospital Anyang 455000China Department of Non-communicable Disease Epidemiology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK

Objective:We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of ***:We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in *** oral microbiome was evaluated with 16 S ribosomal RNA(rRNA)gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with esophageal lesions of severe squamous dysplasia and above(SDA)and 168 matched healthy *** analysis was performed to identify taxa of differential *** oral species together with subject characteristics were evaluated for their potential in predicting SDA risk by constructing conditional logistic regression ***:A total of 125 taxa including 37 named species showed significantly different abundance between SDA cases and controls(all P***:The oral microbiome may play an etiological and predictive role in esophageal cancer,and it holds promise as a non-invasive early warning biomarker for risk stratification for esophageal cancer screening programs.

关键词： Early warning biomarker esophageal squamous cell carcinoma oral microbiome risk prediction

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Differences in age modulates neutrophils function

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Advances in Biological Chemistry 2014年第1期4卷 51-58页

作者： Claudia J. Lagranha Tatiana C. Alba-Loureiro Aline isabel da silva Danuta Duarte Bezerra de Lima Anderson Apolonio Pedroza Diorginis Ferreira Tania Pithon-Curi Department of Nutrition Federal University of Pernambuco Recife Brazil Department of Physical Education and Sports Science Federal University of Pernambuco Vitoria de Santo Ant&atilde o Brazil Department of Physiology and Biophysics Institute of Biomedical Sciences University of S&atilde o Paulo S&atilde o Paulo Brazil Post-Graduate Program in Human Movement Science Biological Sciences and Health Center Cruzeiro do Sul University Sao Paulo Brazil

The sexual maturation in all mammals is the period in which the quiescent gonads are activated by gonadotropins from anterior pituitary, increasing the secretion of sexual hormones. Sexual maturation it is also related with the development of several other body features such as body mass and maturation of the circulatory, skeletal and hematopoietic systems. The aim of the present study was to evaluate the function of neutrophils submitted to in vivo lower and higher concentration of testosterone (sexually immature: 60 days and sexually mature: 90 days). Using different approaches we evaluated cell viability and function and gene expression in rat neutrophils from 60 and 90 days-old animals. Neutrophils from 90 days-old rats showed a decrease in phagocytic and fungicidal capacity, without change in cellular viability. Additionally, we verified that sexual maturation induced increase in production of reactive oxygen and nitrogen species (RONS) and also in TNF-α, IL-6 and IL-10 cytokines. In conclusion, our data suggest that increase in testosterone levels induced significant alteration in neutrophil function, impairing phagocytic capacity.

关键词： Testosterone Neutrophils Function NADPH-Oxidase Components Sexual Maturation

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Alpha-1 antitrypsin deficiency and Pi^(*)Z allele as important co-factors in the development of liver fibrosis

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World Journal of Hepatology 2024年第8期16卷 1099-1110页

作者： Ana isabel Ferreira Catarina Guimarães Vitor Macedo silva Sofia Xavier Joana Magalhães JoséCotter Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal Life and Health Sciences Research Institute/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Pulmonology Hospital Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal

BACKGROUND Alpha-1 antitrypsin deficiency(AATD)is a codominant autosomal hereditary condition that predisposes patients to the development of lung and/or liver disease,and Pi*Z allele is the most clinically relevant *** To evaluate the impact of clinical parameters and AATD phenotypes,particularly the Pi*Z allele,in liver *** Cross-sectional cohort study including consecutive patients with AATD followed in Pulmonology or Hepatology *** Included 69 patients,49.3%had Pi*MZ phenotype and 10.1%Pi**** age≥55 years,age at diagnosis≥41 years and AAT at diagnosis<77 mg/dL predicted a nonalcoholic fatty liver disease fibrosis score(NFS)not excluding advanced fibrosis[area under the curve(AUC)=0.840,P<0.001;AUC=0.836,P<0.001;AUC=0.681,P=0.025].An age≥50 years and age at diagnosis≥41 years predicted a fibrosis-4 index of moderate to advanced fibrosis(AUC=0.831,P<0.001;AUC=0.795,P<0.001).Patients with hypertension,type 2 diabetes mellitus(DM),dyslipidaemia,metabolic syndrome,and regular alcohol consumption were more likely to have a NFS not excluding advanced fibrosis(P<0.001,P=0.002,P=0.008,P<0.001,P=0.033).Patients with at least one Pi*Z allele and type 2 DM were 8 times more likely to have liver stiffness measurement≥7.1 kPa(P=0.040).CONCLUSION Risk factors for liver disease in AATD included an age≥50 years,age at diagnosis≥41 years,metabolic risk factors,regular alcohol consumption,at least one Pi*Z allele,and AAT value at diagnosis<77 mg/*** created an algorithm for liver disease screening in AATD patients to use in primary care,selecting those to be referred to Hepatology consultation.

关键词： Alpha-1 antitrypsin deficiency Liver fibrosis Nonalcoholic fatty liver disease fibrosis score Fibrosis-4 index Liver stiffness measurement

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