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Long-term monitoring data reveal effects of age,population density,and environmental aspects on hatching success of Common Cranes(Grus grus)

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Avian Research 2022年第3期13卷 347-355页

作者： isabel Barwisch Wolfgang Mewes Angela Schmitz Ornes AG Vogelwarte Zoological Institute and MuseumUniversity of GreifswaldSoldmannstr.23GreifswaldGermany Grüner Weg 3 19395Plau Am SeeOT KarowGermany

Facing climate and land use change,a species’ability to successfully adapt to changing environments is crucial for its *** drainage and intensification of agriculture and forestry set wetlands and associated species at risk of population *** population of Common Cranes(Grus grus)has experienced considerable fluctuations over the last *** increasing population numbers,hatching success seemed to have decreased over the last *** aim of this study was to identify factors influencing hatching success and nest survival of Common Cranes based on analyses of long-term individual-based monitoring data from northeastern Germany and evaluate the species ability to adapt to changing *** success decreased over the course of the study period from 0.75 to ***,nest survival and hatching success did not vary across different nesting habitats,whereas factors such as female age,timing of nest initiation and breeding pair density were found to have significant effects on hatching *** females showed higher hatching success,even though the proportion of unhatched eggs was highest in females aged 20 years or *** nest initiation had a positive effect on hatching *** levels are more favorable early in the nesting season,whereas increasing evaporation with time causes water levels to decrease,granting easier access for *** of female age,hatching success decreased with increasing numbers of breeding pairs within a 2-km radius around a nesting *** population densities intensify competition for resources and promote intraspecific interactions,affecting reproductive outcome *** study gives first insights into mechanisms behind population regulation in Common Cranes,highlighting the importance of population dynamics and individual *** suggest to further investigate density dependent effects including landscape and habitat features as well as reproduct

关键词： Adaptation Age Cranes Grus grus Habitat Nest survival Population density Reproduction

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Switching to alternative transit:combining bicycle safety improvements with parking regulations

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Chinese Journal of Population,Resources and Environment 2016年第2期16卷 81-87页

作者： isabel Qi Department of Geography University of California

Smart growth policies advocate for economically viable,environmentally conscientious,and socially equitable solutions for urban *** policies were developed largely in response to issues rooted in the automobile-oriented culture:air pollution,high greenhouse gas emissions,traffic congestion,and sedentary *** urban settings,a good transportation alternative is cycling,since it is able to serve the travel needs of nearly half of city dwellers' daily *** European and Canadian cities have successfully increased cycling rates by creating safer bicycle environments and restricting or discouraging automobile *** evaluate the potential effects of the above measures on American urban areas,this paper examines case studies of cycle tracks and bicycle boulevards implemented in American cities,and how these facility improvements have changed how safe cyclists feel on the road and overall bicycle *** show the two methods are indeed effective in increasing bicycle usage ***,increasing cycling rates needs policies to discourage people from driving,the greatest mode share in nearly all urban *** policy has major impacts on people's decision to use the ***,parking is oversupplied and underpriced in many cities,making it irresistible for people to *** the number of parking spaces available and increasing their price will increase pressure on drivers to drive less,especially for short trips,and to bike *** is important for planners and policy makers to realize that solutions from both directions,making biking more enjoyable and making parking,and hence driving,less affordable,should be used in *** complementary nature of the two approaches makes it so the effect of the combination is greater than the sum of the two.

关键词： Transportation transportation policy alternative transit bicycle safety parking regulations

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On the complementarity of DNA barcoding and morphology to distinguish benign endemic insects from possible pests: the case of Dirioxa pornia and the tribe Acanthonevrini (Diptera: lephritidae: Phytalmiinae) in Australia

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Insect Science 2021年第1期28卷 261-270页

作者： Francesco Martoni isabel Valenzuela Mark J.Blacket Agriculture Victoria Research Agri Bio Centre for AgriBioscienceBundooraVictoriaAustralia

Fruit flies are considered economically important insects due to some species being agricultural ***,morphological identification of fruit fly adults and larvae can be difficult requiring a high level of taxonomic expertise,with misidentifications causing problematic false-positiv/negative *** destructive molecular techniques can assist with the identification process,these often cannot be applied where it is mandatory to retain a voucher reference *** this work,we non-destructively(and partialdestructively)processed larvae and adults mostly belonging to the species Dirioxa pornia(Walker,1849),of the poorly studied nonpest fruit fly tribe Acanthonevrini(Tephritidae)from Australia,to enable molecular identifications whilst retaining morphological *** retaining the morphological features of specimens,we confirmed useful characters for genus/species-level identification,contributing to improved accuracy for future diagnostics using both molecular and morphological *** provide DNA barcode information for three species of Acanthonevrini known from Australia,which prior to our study was only available for a single species,*** specimen examinations provide new distribution records for three nonpest species:Acanthonevroides variegatus Permkam and Hancock,1995 in South Australia,Acanthonevroides basalis (Walker,1853)and *** in Victoria,Australia;as well as new host plant records for ***,from kangaroo apple,apricot and loquat.

关键词： biodiversity biosecurity COI fruit flies Agriculture

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Bean yellow disorder virus： Parameters of transmission by Bemisia tabaci and host plant range

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Insect Science 2011年第1期18卷 50-56页

作者： German Martin isabel Maria Cuadrado Dirk Janssen Instituto Andaluz de Investigacion y Formacion Agraria y Pesquera Centro La Mojonera Almeria Spain

Bean yellow disorder virus （BnYDV） was recently identified as the first crinivirus （family Closteroviridae） that infects members of the family Leguminosae. It was first observed during the autumn of 2003, causing heavy losses in French bean （Phaseolus vulgaris L.） grown commercially in Spain. The virus is transmitted by the sweetpotato whitefly, Bemisia tabaci （Hemiptera： Aleyrodidae） Q-biotype, and disease symptoms resemble nutritional disorders consisting of interveinal mottling and yellowing in leaves, combined with stiffness or brittleness, and are typically produced on the middle to lower parts of the plant. Transmission experiments showed that 50% and 100% of B. tabaci adults acquired the virus after a feeding period of 3 and 7 h, respectively. Viruliferous whiteflies infected 66% and 100% ofP. vulgaris plants after a feeding period of 12 and 24 h, respectively. The transmission efficiency of single whiteflies was 37% and persistence of BnYDV in the vector lasted up to 2 weeks with a half-life of 9 days. BnYDV was transmitted to P. vulgaris, Pisum sativum L., Lens culinaris Medik., and Vicia faba L., but not to Vigna unguiculata L., Glycine max （L.） Merr., Cicer arietum L., and to crop species belonging to families of the Solanaceae and Cucurbitaceae. No virus was detected in field samples collected from 30 different species from Boraginaceae, Asteraceae, Geraniaceae, Lamiaceae, Leguminosae, Malvaceae, Scrophulariaceae, Thymelaeaceae and Verbenaceae. The restricted host range and efficient management of crops regarding whitefly infestation may be key elements in the control of BnYDV.

关键词： bean Closteroviridae Crinivirus disease vector whiteflies

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Growth factor-and cytokine-driven pathways governing liver stemness and differentiation

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World Journal of Gastroenterology 2010年第41期16卷 5148-5161页

作者： Aránzazu Sánchez isabel Fabregat School of Pharmacy Complutense University 28040 Madrid Spain Bellvitge Biomedical Research Institute (IDI- BELL) and University of Barcelona Molecular Oncology Laboratory Hospital Duran i Reynals. Gran Via de Hospitalet 199 L' Hospitalet 08907 Barcelona Spain

Liver is unique in its capacity to regenerate in response to injury or tissue loss. Hepatocytes and other liver cells are able to proliferate and repopulate the liver. However, when this response is impaired, the contribution of hepatic progenitors becomes very relevant. Here, we present an update of recent studies on growth factors and cytokine-driven intracellular pathways that govern liver stem/pro-genitor cell expansion and differentiation, and the rel-evance of these signals in liver development, regeneration and carcinogenesis. Tyrosine kinase receptor signaling, in particular, c-Met, epidermal growth factor receptors or fibroblast growth factor receptors, contribute to prolifera-tion, survival and differentiation of liver stem/progenitor cells. Different evidence suggests a dual role for the trans-forming growth factor (TGF)-β signaling pathway in liver stemness and differentiation. On the one hand, TGF-βmediates progression of differentiation from a progenitor stage, but on the other hand, it contributes to the expan-sion of liver stem cells. Hedgehog family ligands are nec-essary to promote hepatoblast proliferation but need to be shut off to permit subsequent hepatoblast differentiation. In the same line, the Wnt family and β-catenin/T-cell fac-tor pathway is clearly involved in the maintenance of liver stemness phenotype, and its repression is necessary for liver differentiation during development. Collectively, data indicate that liver stem/progenitor cells follow their own rules and regulations. The same signals that are essential for their activation, expansion and differentiation are good candidates to contribute, under adequate conditions, to the paradigm of transformation from a pro-regenerative to a pro-tumorigenic role. From a clinical perspective, this is a fundamental issue for liver stem/progenitor cell-based therapies.

关键词： Hepatocyte growth factor Epidermal growth factor Fibroblast growth factor Transforming growth factor-β Hedgehog and β-catenin Liver Stem cell

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Closed loop ileus caused by a defect in the broad ligament:A case report

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World Journal of Clinical Cases 2023年第5期11卷 1182-1187页

作者： isabel Zucal Christian A Nebiker Department of General Surgery Cantonal Hospital of AarauAarau 5001Switzerland

BACKGROUND Closed loop ileus caused by entrapment of bowel in a defect of the broad ligament is a *** a few cases have been reported in the *** SUMMARY We present the case of a 44-year-old,healthy patient with no prior history of abdominal surgery who developed a closed loop ileus due to an internal hernia secondary to a defect in the right broad *** first presented to the emergency department with diarrhea and *** she had had no previous abdominal surgery,she was diagnosed with probable gastroenteritis and *** patient subsequently returned to the emergency department due to a lack of improvement in her *** tests showed an elevated white blood cell count and a closed loop ileus was diagnosed on an abdominal computer tomography *** laparoscopy revealed an internal hernia entrapped in a 2 cm large defect in the right broad *** hernia was reduced and the ligament defect was closed using a running,barbed *** Bowel incarceration through an internal hernia may present with misleading symptoms and laparoscopy may reveal unexpected findings.

关键词： Broad ligament Ileus Internal hernia Laparoscopy Case report

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Gender-specific associations between coronary heart disease and other chronic diseases: cross-sectional evaluation of national survey data from adult residents of Germany

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Journal of Geriatric Cardiology 2019年第9期16卷 663-670,I0002-I0005页

作者： Marie-isabel K Murray Kerstin Bode Peter Whittaker Department of Cardiology University Hospital Frankfurt am Main Frankfurt Germany Department of Electrophysiology Heart Center Leipzig Leipzig Germany Cardiovascular Research Institute and Department of Emergency Medicine Wayne State University Detroit MI USA

Background Combinations of coronary heart disease(CHD) and other chronic conditions complicate clinical management and increase healthcare costs. The aim of this study was to evaluate gender-specific relationships between CHD and other comorbidities. Methods We analyzed data from the German Health Interview and Examination Survey(DEGS1), a national survey of 8152 adults aged 18-79 years. Female and male participants with self-reported CHD were compared for 23 chronic medical conditions. Regression models were applied to determine potential associations between CHD and these 23 conditions. Results The prevalence of CHD was 9%(547 participants): 34%(185) were female CHD participants and 66%(362) male. In women, CHD was associated with hypertension(OR = 3.28(1.81-5.9)), lipid disorders(OR = 2.40(1.50-3.83)), diabetes mellitus(OR = 2.08(1.24-3.50)), kidney disease(OR = 2.66(1.101-6.99)), thyroid disease(OR = 1.81(1.18-2.79)), gout/high uric acid levels(OR = 2.08(1.22-3.56)) and osteoporosis(OR = 1.69(1.01-2.84)). In men, CHD patients were more likely to have hypertension(OR = 2.80(1.94-4.04)), diabetes mellitus(OR = 1.87(1.29-2.71)), lipid disorder(OR = 1.82(1.34-2.47)), and chronic kidney disease(OR = 3.28(1.81-5.9)). Conclusion Our analysis revealed two sets of chronic conditions associated with CHD. The first set occurred in both women and men, and comprised known risk factors: hypertension, lipid disorders, kidney disease, and diabetes mellitus. The second set appeared unique to women: thyroid disease, osteoporosis, and gout/high uric acid. Identification of shared and unique gender-related associations between CHD and other conditions provides potential to tailor screening, preventive, and therapeutic options.

关键词： Chronic diseases Comorbidities Gender Heart disease Risk factors Survey data

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Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas

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World Journal of Gastroenterology 2014年第3期20卷 684-698页

作者： Marta-isabel Pereira José Augusto Medeiros Clinical Hematology Department Coimbra University Hospital Center Institute of Physiology Faculty of MedicineUniversity of CoimbraAzinhaga de Santa Comba

Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent extranodal marginal zone B-cell lymphoma, originating in acquired MALT that is induced in mucosal barriers as part of a normal adaptive immune response to a chronic immunoinflammatory stimulus, most notably chronic infection by Helicobacter pylori (H. pylori). This antigenic stimulation initially leads to lymphoid hyperplasia; the acquisition of additional genetic aberrations culminates in the activation of intracellular survival pathways, with disease progression due to proliferation and resistance to apoptosis, and the emergence of a malignant clone. There are descriptions of MALT lymphomas affecting practically every organ and system, with a marked geographic variability partially attributable to the epidemiology of the underlying risk factors; nevertheless, the digestive system (and predominantly the stomach) is the most frequently involved location, reflecting the gastrointestinal tract’s unique characteristics of contact with foreign antigens, high mucosal permeability, large extension and intrinsic lymphoid system. While early-stage gastric MALT lymphoma can frequently regress after the therapeutic reversal of the chronic immune stimulus through antibiotic eradication of H. pylori infection, the presence of immortalizing genetic abnormalities, of advanced disease or of eradication-refractoriness requires a more aggressive approach which is, presently, not consensual. The fact that MALT lymphomas are rare neoplasms, with a worldwide incidence of 1-1.5 cases per 105 population, per year, limits the ease of accrual of representative series of patients for robust clinical trials that could sustain informed evidence-based therapeutic decisions to optimize the quality of patient care.

关键词： Mucosa-associated lymphoid tissue lymphoma Marginal zone lymphoma Helicobacter pylori Gastric lymphoma Eradication therapy Nuclear factor-kappa B pathway

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Foraging, feeding, and physiological stress responses of wild wood mice to increased illumination and common genet cues

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Current Zoology 2018年第4期64卷 409-417页

作者： Alvaro NAVARRO-CASTILLA isabel BARJA Mario DíAZ Department of Biology Faculty of Sciences Universidad Autónoma de Madrid C/Darwin 2 Campus Universitario de Cantolanco Madrid 28049 Spain Department of Biogeography and Global Change Museo Nacional de Ciencias Naturales CSIC Madrid 28006 Spain

In nature, animals are exposed to a broad range of threats imposed by predators, which may strongly influence the ecology of prey species directly or indirectly by affecting their behavior via fear of predation. Here, we studied wood mice Apodemus sylvaticus behavioral and physiological responses to simulated predation risk. Risk avoidance was analyzed by live trapping with control traps and traps treated with feces of common genet Genetta genetta （direct cue of risk） under new moon nights and following by simulated full moon conditions （indirect cue）. The time devoted to foraging behavior and capture time were analyzed by video recording mice activity around traps. Food intake was calculated based on the amount of bait remaining in each trap. Fecal cortico- sterone metabolites （FCMs） were measured by enzyme-immunoassay as indicators of physio- logical stress responses. Fewer wood mice were captured during full moon, yet only non-breeding adult males clearly avoided common genet odor. Mice were captured sooner at night during the simulated full moon conditions and later in predator-treated traps. Foraging activity was lower when individuals faced predator＇s feces, but neither food intake nor FCM levels were affected by predation risk cues. Direct and indirect cues of predation risk selectively affected wood mice behavior, although behavioral responses seem to be modulated by different costs-benefit balances related to the individual＇s perception of risk. The lack of physiological responses to predation risk cues suggests that wood mice did not perceive them as reliable stressors or the response was too small or transient to be measured by FCM.

关键词： common genet fecal predator cues feeding foraging moonlight predator avoidance

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Immune challenge of mating effort:steroid hormone profile,dark ventral patch and parasite burden in relation to intrasexual competition in male Iberian red deer

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Integrative Zoology 2020年第4期15卷 262-275页

作者： Eva DE LA PEÑA JoséMARTÍN isabel BARJA Raúl PÉREZ-CABALLERO isabel ACOSTA Juan CARRANZA Wildlife Research Unit University of CórdobaCórdobaSpain Department of Evolutionary Ecology National Museum of Natural Sciences(Spanish Research CouncilCSIC)MadridSpain Department of Biology Zoology UnitAutonomous University of MadridMadridSpain Biodiversity and Global Change Research Centre Autonomous University of MadridMadridSpain Parasitology and Parasitic Diseases Unit Animal Health DepartmentUniversity of CórdobaCórdobaSpain Laboratory of Malaria Immunology and Vaccinology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMarylandUSA

Testosterone secretion may regulate the reproductive effort and the development of sexual traits,but it may also involve costs at the immunological and metabolic ***,the evidence for this trade-off in wild populations is *** also plays an important role in mediating the reproductive and immune *** this study,we analyzed whether the endoparasite burden relates to hormonal levels(fecal testosterone and cortisol metabolites)and/or morphological sexual traits(size of the dark ventral patch,a trait that indicates reproductive effort in males)in male Iberian red *** this purpose,we sampled male red deer harvested during hunting actions in 2 types of populations in south western Spain that differed in structure,affecting the level of male–male competition for *** used coprological analyses to estimate the parasite burden mainly of gastrointestinal and bronchopulmonary nematodes and of protozoa,and assessed testosterone and cortisol metabolite levels from fecal *** found a positive relationship of host parasitation with both testosterone levels and the size of the dark ventral patch,but these relationships depended on the intensity of male–male competition in the population,being only found under the high-competition *** results are discussed under the hypothesis of the testosterone immunocompetence handicap,suggesting a cost at the immunological level,and,therefore,higher susceptibility to parasite infection in males that make a greater reproductive ***,this effect seems to be modulated by the social environment(male–male competition)that might lead to different optima in testosterone production and sexual trait development.

关键词： dark ventral patch fecal testosterone metabolites intrasexual competition male Iberian red deer parasite burden

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