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Gender-specific associations between coronary heart disease and other chronic diseases: cross-sectional evaluation of national survey data from adult residents of Germany

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journal of Geriatric Cardiology 2019年第9期16卷 663-670,I0002-I0005页

作者： Marie-isabel K Murray Kerstin Bode Peter Whittaker Department of Cardiology University Hospital Frankfurt am Main Frankfurt Germany Department of Electrophysiology Heart Center Leipzig Leipzig Germany Cardiovascular Research Institute and Department of Emergency Medicine Wayne State University Detroit MI USA

Background Combinations of coronary heart disease(CHD) and other chronic conditions complicate clinical management and increase healthcare costs. The aim of this study was to evaluate gender-specific relationships between CHD and other comorbidities. Methods We analyzed data from the German Health Interview and Examination Survey(DEGS1), a national survey of 8152 adults aged 18-79 years. Female and male participants with self-reported CHD were compared for 23 chronic medical conditions. Regression models were applied to determine potential associations between CHD and these 23 conditions. Results The prevalence of CHD was 9%(547 participants): 34%(185) were female CHD participants and 66%(362) male. In women, CHD was associated with hypertension(OR = 3.28(1.81-5.9)), lipid disorders(OR = 2.40(1.50-3.83)), diabetes mellitus(OR = 2.08(1.24-3.50)), kidney disease(OR = 2.66(1.101-6.99)), thyroid disease(OR = 1.81(1.18-2.79)), gout/high uric acid levels(OR = 2.08(1.22-3.56)) and osteoporosis(OR = 1.69(1.01-2.84)). In men, CHD patients were more likely to have hypertension(OR = 2.80(1.94-4.04)), diabetes mellitus(OR = 1.87(1.29-2.71)), lipid disorder(OR = 1.82(1.34-2.47)), and chronic kidney disease(OR = 3.28(1.81-5.9)). Conclusion Our analysis revealed two sets of chronic conditions associated with CHD. The first set occurred in both women and men, and comprised known risk factors: hypertension, lipid disorders, kidney disease, and diabetes mellitus. The second set appeared unique to women: thyroid disease, osteoporosis, and gout/high uric acid. Identification of shared and unique gender-related associations between CHD and other conditions provides potential to tailor screening, preventive, and therapeutic options.

关键词： Chronic diseases Comorbidities Gender Heart disease Risk factors Survey data

Developments and characteristics of craft beer production processes

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Food Bioscience 2022年第1期45卷 232-248页

作者： Salvador Villacreces Carlos A.Blanco isabel Caballero Dpto de Ingeniería Agrícola Forestal ETS de Ingenierías AgrariasUniversidad de Valladolid34004Palencia.Spain

Beer is a popular drink and represents the most widely consumed alcoholic beverage in the *** recent years,there has been a significant growth of independent craft breweries,even in countries without a brewing tradition.A craft brewery is usually defined as a small,independent and traditional ***,consumers are looking for genuine,singular,different and high-quality *** beer manufacturers have responded to this with the introduction of a novel combination of raw or malted cereals and have modified the beer flavours and taste with the addition of fruit,spices,*** work presents an analysis of the different aspects related to craft *** characteristics and brewing singularities are *** quality and safety standards used are examined and future trends of craft beer are also discussed.

关键词： Craft beer Ingredients Craft beer quality By-products Microbiological safety

Intraspecific competition in Zabrotes subfasciatus： Physiological and behavioral adaptations to different amounts of host

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Insect Science 2012年第1期19卷 102-111页

作者： isabel R.V.Teixeira Fernando S.Zucoloto Insect Nutrition and Feeding Behavior Laboratory Department of BiologyFaculdade de Filosofia Ciencias e Letras de Ribeirao Preto Universidade de Sao PauloSao Paulo epartment of Biology Federal Institute of Sul de Minas-Campus MuzambinhoIFSULDEMINAS MuzambinhoMinas GeraisBrazil

The effects of competition on populations of the bean weevil Zabrotes sub- fasciatus were analyzed during 41 generations under different competition levels. Three competition environments were established by maintaining the number of couples （6） and varying the amount of available host seeds： HC, high （limited availability of host： 1.35 g）; IC, intermediate （intermediate availability of host： 6 g）; and LC, low competition （abun- dance of host： 36 g）. It was found that the distribution of the eggs laid on grains was different among treatments： in LC, for example, although females showed high fecundity （35.4 ± 5.6 eggs/female） the number of eggs laid on each grain was small （1.2 ± 0.4 eggs on each seed）, thus avoiding larval competition of their offspring; whereas in HC treatment, females showed low fecundity （27.04 ± 4.5 eggs/female） but laid many eggs on each grain （15.03 ± 4.3 eggs）. There were no changes in the ability to respond to different amounts of host via oviposition behavior （egg distribution） during 41 generations. How- ever, HC females had more offspring than LC females under HC conditions. This suggests that HC insects evolved toward higher fitness in crowded conditions. In addition, after inverting the competition level, insects behaved independently of the treatment conditions they experienced through generations, thus showing that oviposition behavior is flexible. Taken together, our results show that Z. subfasciatus presents a broad range of behavioral and physiological responses which allows for quick and reversible adjustments to sudden changes in the amount of resources.

关键词： bean weevil Coleoptera egg distribution oviposition Phaseolus vulgaris phenotypic plasticity

Strain-induced band gap engineering in layered TiS3

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Nano Research 2018年第1期11卷 225-232页

作者： Robert Biele Eduardo Flores jose Ramon Ares Carlos Sanchez isabel j. Ferrer Gabino Rubio-Bollinger Andres Castellanos-Gomezs Roberto D'Agosta Nano-Bio Spectroscopy Group and European Theoretical Spectroscopy Facility (EFSF) Universidad del Pals Vasco 20018 San Sebastidn Spain Materials of Interest in Renewable Energies Group (MIRE Group) Dpto. de Fisica de Materiales Universidad Aut6noma de Madrid 28049 Madrid Spain Instituto de Ciencia de Materiales "Nicolds Cabrera" Campus de Cantoblanco 28049 Madrid Spain Dpto. de Ffsica de la Materia Condensada Condensed Matter Physics Center (IFIMAC) Universidad Aut6noma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto de Ciencia de los Materiales de Madrid (ICMM-CSIC) Cantoblanco 28049 Madrid Spain IKERBASQUE Basque Foundation for Science 48013 Bilbao Spain

By combining ab initio calculations and experiments, we demonstrate how the band gap of the transition metal trichalcogenide TiS3 can be modified by inducing tensile or compressive strain. In addition, using our calculations, we predicted that the material would exhibit a transition from a direct to an indirect band gap upon application of a compressive strain in the direction of easy electrical transport. The ability to control the band gap and its nature could have a significant impact on the use of TiS3 for optical applications. We go on to verify our prediction via optical absorption experiments that demonstrate a band gap increase of up to 9% （from 0.99 to 1.08 eV） upon application of tensile stress along the easy transport direction.

关键词： band gap engineering titanium trisulfide 2-D materials strain

A qualitative study on the pulsatile flow phenomenon in a dense fly ash pneumatic conveyor

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Particuology 2014年第6期12卷 81-91页

作者： Wei Chen Kenneth C.Williams isabel jabs Mark G.jones Centre for Bulk Solids and Particulate Technologies Newcastle Institute for Energy and ResourcesThe University of Newcastle Faculty of Mechanical Engineering Leibniz University of Hanover

Understanding of the dynamic particulate flow structures within a dense gas-fly ash pneumatic conveyor must be improved in order to better aid its design *** complex pulsatile movement of the gas-fly ash mixture dominates the flow performance within the pipeline,and historically,non-invasive measurement devices such as the electrical capacitance tomography（ECT） were often used to sufficiently capture the flow ***,inadequate studies have been conducted on the pulsatile flow phenomenon,which directly relate to the gas-fly ash two-phase flow *** paper aims to investigate the pulsatile flows using an ECT ***,pulsatile flow patterns under various experimental conditions were obtained through *** within a flow were then characterised into pulse growth and decay segments,which represent the superficial fluidisation and deaeration processes during ***,structural and statistical analyses were performed on the pulse growth and decay *** suggested that the increasing air mass flow rate led to the decrease of the superficial fluidisation/deaeration magnitude,however,the increase of the superficial fluidisation/deaeration ***,the air mass flow rate was indicated as the dominant factor in determining the pulsing statistical *** research provides fundamental insights for further modelling the dense fly ash pneumatic flows.

关键词： Pneumatic conveying Electrical capacitance tomography Fly ash Pulsatile flows Flow pattern analysis

Evolution of radical hysterectomy for cervical cancer along the last two decades: single institution experience

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Chinese journal of Cancer Research 2016年第2期28卷 215-220页

作者： Claudia Arispe Ana isabel Pomares javier De Santiago Ignacio Zapardiel Gynecologic Oncology Department La Paz University Hospital

Background： The radical hysterectomy （RH） surgical technique has improved along the years. It is used for the treatment of cervical cancer, endometrial cancer when affecting the cervix, and upper vaginal carcinomas. Our aim was to describe the historical evolution of the technique after the introduction of laparoseopy at our institution. Methods： We performed a retrospective review of medical records of patients who underwent RH, grouped in three periods according to the year of surgery： 1990-1999, 2000-2009 and 2010-2013. Patients＇ characteristics, pathologic details, intraoperative and postoperative complications were analyzed and comoared throughout the time periods. Results： A total of 102 cases of RH were performed at our center during the study period. Among all data collected, the presence of necrosis, age, number of lymph nodes, surgery route, operating time, hospital stay, blood loss and transfusion requirement were statistically significant different among groups. Conversion to laparotomy rate was 19% for the second period compared to the absence of cases in the last one. No significant differences （P=0.124） were observed in the adjuvant treatment received among the three different groups. At the time of the last contact the patients free of disease were 12 （85.7%）, 53 （91.3%） and 26 （86.6%） respectively （P=0.406）. Regarding the disease-free interval, we found significant better outcomes in the group of laparotomy compared to laparoscopy （P=0.015）.Conclusions： Laparoscopic RH is an acceptable surgery with advantages like magnified vision of the operation＇s field, lower surgical complications, shorter hospital stay and earlier resumption to daily activities.

关键词： Gynaecological cancer radical hysterectomy (RH) laparoscopy cervical cancer

Origin and evolution of the genera Lonsdaleia and Actinocyathus:Insights for the Mississippian palaeogeography from the western Palaeotethys

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journal of Palaeogeography 2023年第2期12卷 296-310页

作者： isabel Rodríguez-Castro Ian D.Somerville Sergio Rodríguez Departamento de Geodinamica Estratigrafía y PaleontologíaUniversidad Complutense de Madrid28040MadridSpain UCD School of Earth Sciences University College DublinBelfieldDublin 4Ireland Instituto de Geociencias(CSIC UCM)Ciudad Universitaria28040MadridSpain

Representatives of the subfamily Lonsdaleiinae Chapman,1893 are common in the Mississippian of the western Palaeotethys.A general analysis of the origin,distribution and evolution of that subfamily has been *** most probable hypothesis for the origin of the genus Lonsdaleia McCoy,1849 is to acquire colonialism via the genus Axophyllum Milne Edwards and Haime,*** d'Orbigny,1849 would be a descendant of Lonsdaleia by increasing integration in the *** first occurrences of Lonsdaleia have been recorded in the lower Visean from northern Britain and northern Tianshan Mountains of northwestern China,but the diversification and migration to the whole Palaeotethys only happened in the late *** hypotheses are proposed on that *** Serpukhovian was also a period of migrations and diversification for these *** Lonsdaleia and Actinocyathus have been recorded in Bashkirian refuges,the Sverdrup Basin in northern Laurasia and the Tindouf Basin in northern Africa,*** division of the western Palaeotethys into six subprovinces based on the distribution of corals is proposed.

关键词： Carboniferous Palaeotethys Biogeography Evolution Rugosa

Host preference of the bean weevil Zabrotes subfasciatus

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Insect Science 2008年第4期15卷 335-341页

作者： isabel Ribeiro do Valle Teixeira Angel Roberto Barchuk Fernando Sergio Zucoloto Department of Biology Centro Universitario da Fundacao Educacional de Guaxupe Minas Gerais Department of Biology Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto Universidade de Sao Paulo Sao Paulo Department of Biological Sciences Universidade Federal de Alfenas UnifaI-MG Alfenas Minas Gerais Brazil

It is largely known that the range of an insect diet is mostly determined by oviposition behavior, mainly in species with endophytic larvae such as Zabrotes subfasciatus. However, the proximate factors determining host choice and the subsequent steps leading to the expansion or reduction of the host number and occasional host shifts are largely unknown. We analyzed various factors determining host preference of Z. subfasciatus through the evaluation of：（i） oviposition preference of a wild population of Z. subfasciatus on the usual host （bean） and unusual hosts （lentil, chickpea and soy）, and the performance of the offspring; （ii） artificial selection for increasing preference for hosts initially less frequently chosen; （iii） comparison of oviposition behavior between two different populations （reared for -30 generations in beans or chickpeas, respectively）; （iv） oviposition timing on usual and unusual hosts; and （v） identification of preference hierarchies. We found that when using unusual hosts, there is no correlation between performance and preference and that the preference hierarchy changes only slightly when the population passes through several generations on the less frequently accepted host. We also found a positive response to artificial selection for increasing oviposition on the less preferred host; however, when the host-choice experiment involved two varieties of the usual host, the response was faster than when the choice involved usual and unusual hosts. Finally, beetles reared on an unusual host （chickpea） for 26 generations showed similar good fitness on both usual and unusual hosts, indicating that the use of a new host does not necessarily result in the loss of performance on the original host. Nevertheless, this population showed lower fitness on the usual host than that of the original population, suggesting an underlying partial trade-off phenomenon which may contribute to a broadening of diet of this insect species.

关键词： artificial selection evolution Phaseolus Cicer plant-insect interaction

Impact of socioeconomic and health-related factors on consumption of homeopathic and natural remedies in Spain in 2006, 2011 and 2017

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journal of Integrative Medicine 2022年第1期20卷 52-56页

作者： jose Antonio Castilla-jimena isabel Ruiz-Perez jesus Henares-Montiel Andalusian School of Public Health 1801J GranadaSpain Unit of Clinical Management of Preventive Medicine and Public Health and Occupational Medicine Puerto del Mar University Hospital11009 CadizSpain Consortium for Networked Biomedical Research in Epidemiology and Public Health 28029 MadridSpain Institute for Biosanitary Research(ibs.GRANADA) 18012 GranadaSpain

Objective: Complementary and alternative medicine use and type of use may be influenced by sociodemographic and economic determinants through which we could identify characteristics of patients with greater trend to use it. This paper aims to describe the changes in the consumption of homeopathic and natural remedies in Spain for three time points in order to discern changes in rate of consumption, associated factors and whether their use has been affected by a period of economic ***: This study utilized 2006, 2011 and 2017 cross-sectional data from the Spanish National Health Survey, a nationally representative survey of the population aged more than 15 years old and resident in Spain. Independent bivariate and multivariate descriptive analyses for each of the 3 years studied were ***: The rate of consumption of both homeopathic and natural remedies has decreased over the periods studied. In spite of this decrease, the consumer profile appears to remain stable over the three periods. The sociodemographic factors associated with their consumption were being female, being 30–64 years old, being separated/divorced, having higher education qualifications, being employed and belonging to a higher social class. Psychiatric morbidity, chronic health problems such as pain, mental health problems or malignant tumors, and absence of major cardiovascular events were the clinical factors ***: It can be concluded that beyond the economic situation, the use of homeopathic and natural remedies obeys to the needs of the patients related to their state of health and the response they receive from the health system. It may be that women have different needs and expectations of the healthcare system and, given this breach of expectations, seek remedy to alleviate their needs outside the system and conventional medicine.

关键词： Complementary and alternative medicine Homeopathic remedies Natural remedies Economic recession Gender differences