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αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma Martinez-Redondo isabel guillen-guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol isabel guillen-vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta guillen-vicente George Church Pradeep Reddy Pedro guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain Department of Traumatology and Research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

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Role of robotic-assisted pancreatic surgery:lessons learned from our initial experience

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 652-658页

作者： Emilio vicente Yolanda Quijano Benedetto Ielpo Hipolito Duran Eduardo Diaz isabel Fabra Luis Malave Riccardo Caruso General Surgery Department Sanchinarro University Hospital San Pablo University CEU Madrid Spain

BACKGROUND:Minimally invasive surgery has achieved worldwide acceptance in various fields, however, pancreatic surgery remains one of the most challenging abdominal procedures. In fact, the indication for robotic surgery in pancreatic disease has been controversial. The present study aimed to assess the safety and feasibility of robotic pancreatic ***:We retrospectively reviewed our experience of robotic pancreatic resection done in Sanchinarro University Hospital. Clinicopathologic characteristics, and perioperative and postoperative outcomes were recorded and ***:From October 2010 to April 2016, 50 patients underwent robotic-assisted surgery for different pancreatic pathologies. All procedures were performed using the da Vinci robotic system. Of the 50 patients, 26 were male and 24 female. The average age of all patients was 62 years. Operative time was 370 minutes. Among the procedures performed were 16 pancreaticoduodenectomies(PD), 23 distal pancreatectomies(DP), 11 tumor enucleations(TE). The mean hospital stay was 17.6 days in PD group, 9.0 days in DP group and 8.4 days in TE group. Pancreatic fistula occurred in 10 cases(20%), 2 after PD, 3 after DP, and 5 after TE. Four patients had postoperative transfusion in PD group and one in DP group. Conversion to open laparotomy occurred in four patients(8%). No serious intraoperative complications were observed. CONCLUSIONS:From our early experience, robotic pancreatic surgery is a safe and feasible procedure. Further experience and follow-up are required to confirm the role of robotic approach in pancreatic surgery.

关键词： robotic surgery pancreatic cancer minimal invasive surgery

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In vitro toxicity of particulate matter emissions from residential pellet combustion

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Journal of Environmental Sciences 2022年第5期34卷 215-226页

作者： Estela D.vicente Daniela Figueiredo Catia Goncalves isabel Lopes Helena Oliveira Nora Kovats Teresa Pinheiro Celia A.Alves Department of Environment and Planning and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Department of Biology and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Centre of Natural Environmental Sciences University of PannoniaEgyetem str.108200 VeszpremHungary Instituto de Bioengenharia e Biociencias Departamento de Engenharia e Ciencias NuclearesInstituto Superior TecnicoUniversidade de LisboaAv.Rovisco Pais 11049-001 LisboaPortugal

Particulate matter emissions(PM10)from the combustion,in a residential stove,of two com-mercial brands of certified(ENplus A1)pellets,a non-certified brand and laboratory made pellets of acacia were tested for their ability to induce ecotoxic,cytotoxic,and mutagenic re-sponses in unicellular organisms and a human cell *** was evaluated through the Vibrio fischeri bioluminescence inhibition ***,cytotoxicity was assessed at two time points(24-and 48-hr)through two complementary techniques in order to evaluate the cellular metabolic activity and membrane integrity of human lung epithelial cells *** Ames test using two Salmonella typhimurium strains(TA100 and TA98)was employed to assess the mutagenic potential of the polycyclic aromatic hydrocarbon fraction extracted from the PM10 *** obtained with the bioluminescent bacteria indicated that only particles from the combustion of acacia pellets were *** samples induced im-pairment on the A549 cells metabolic activity,while no significant release of lactate dehy-drogenase was ***10 emissions from acacia pellets were the most cytotoxic,while samples from both certified pellets evoked significant cytotoxicity at lower ***-icity time-dependency was only observed for PM10 from the combustion of acacia pellets and one of the brands of certified *** activity was not detected in both *** murium *** study emphasises the role of the raw material for pellet manu-facturing on the toxicological profile of PM *** raw materials should be deeply investigated before their use in pelletisation and combustion in residential appli-ances.

关键词： Ecotoxicity Cytotoxicity Mutagenicity Fuel quality Pellet combustion PM10 emissions

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Diagnosis and treatment of pancreas divisum: A literature review

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 332-336页

作者： Valentina Ferri Emilio vicente Yolanda Quijano Benedetto Ielpo Hipolito Duran Eduardo Diaz isabel Fabra Riccardo Caruso Division of General Surgery Sanchinarro Hospital San Pablo University

Background:Pancreas divisum is a congenital embryological disease caused by a lack of fusion between the ventral and dorsal pancreatic ducts in the early stages of *** acute pancreatitis,chronic pancreatitis or chronic abdominal pain are the main clinical syndromes at presentation and occur in only 5%of the patients with pancreas *** review aimed to discuss diagnosis and treatment strategies in patients with symptomatic pancreas *** sources:We report a literature review from 1990 up to January 2018 to explore the various diagnostic modalities and surgical techniques and results reported in the surgical treatment of pancreas ***:There are limited reports available on this topic in the *** analyzed and described the main indications in the treatment of pancreas divisum,focusing on surgical treatment and a discussion of the different ***,we report the results from our experience in two cases of pancreas divisum treated by pancreatic head resection with segmental duodenectomy(the Nakao procedure).Conclusions:Pancreas divisum is a common pancreatic malformation in which only a few patients develop a symptomatic *** treatment is needed in case of endoscopic drainage failure and in cases complicated with chronic pancreatitis and local *** techniques,of greater or lesser complexity,have been proposed.

关键词： Pancreas divisum Duodenal-preserving pancreatectomy Chronic pancreatitis Recurrent acute pancreatitis

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Immediate effect of high-intensity exercise on brain-derived neurotrophic factor in healthy young adults:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第3期11卷 367-375页

作者： Rubén Fernández-Rodríguez CeliaÁlvarez-Bueno isabel A.Martínez-Ortega vicente Martínez-Vizcaíno Arthur Eumann Mesas Blanca Notario-Pacheco Health and Social Research Center Universidad de Castilla-La ManchaCuenca 16071Spain Universidad Politécnica y Artística del Paraguay Asunción 2024Paraguay Faculty of Medicine Universidad Autónoma de ChileTalca 3460000Chile Postgraduate Program in Public Health Universidad Estadual de LondrinaLondrina 86051-990Brazil

Background Although brain-derived neurotrophic factor(BDNF)has been identified as a molecular biomarker of the neurophysiological effects induced by exercise,the acute effects of high-intensity exercise(HIE)on BDNF levels are *** study aims to estimate the immediate effects of HIE on BDNF levels in healthy young *** A systematic search was conducted in the MEDLINE,Scopus,Cochrane CENTRAL,and SPORTDiscuss databases up to December *** controlled trials(RCTs)and non-RCTs reporting pre-post changes in serum or plasma BDNF after an acute intervention of HIE compared to a control condition were *** effect sizes(p-ESs)and 95%confidence intervals(95%CIs)were calculated for RCTs using a random effects model with Stata/SE(Version 15.0;StataCorp.,College Station,TX,USA).The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were *** registration number:*** A total of 22 studies with 552 individuals(age range:20-31 years;59.1%male)were *** meta-analysis included 10 RCTs that reported valid outcome *** BDNF levels were observed when HIE interventions were compared with non-exercise(p-ES=0.55,95%CI:0.12-0.98;I^(2)=25.7%;n=4 studies)and light-intensity exercise(p-ES=0.78,95%CI:0.15-1.40;I^(2)=52.4%;n=3 studies)but not moderate-intensity exercise(p-ES=0.93,95%CI:-0.16 to 2.02;I^(2)=88.5%;n=4 studies)*** In comparison to non-exercise or light-intensity exercises,an immediate increase in BDNF levels may occur when young adults perform *** the benefits obtained maximizing circulating BDNF when performing HIE and its potential effects on brain health,our findings suggest that HIE could be recommended by clinicians as a useful exercise strategy to healthy adults.

关键词： Cognition Exercise Neurogenesis Neuroplasticity

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Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy

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World Journal of Gastroenterology 2006年第45期12卷 7271-7277页

作者： José Eymard Medeiros-Filho isabel Maria vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho Hepatology Branch Department of Gastroenterology University of So Paulo School of Medicine So Paulo Brazil Viral Immu-nology Laboratory Instituto Butantan So Paulo Brazil Hepatology Branch Department of Gastroenterology University of S?o Paulo School of Medicine So Paulo Brazil Faculty of Life Sciences Bar-Ilan Univer-sity Ramat-Gan Israel Virology Branch Instituto Adolfo Lutz So Paulo Brazil

AIM： TO evaluate the impact of hepatitis C virus （HCV） infection with genotype 1 or 3 and the presence or absence of liver cirrhosis （LC） in the early viral kinetics response to treatment. METHODS： Naive patients （n = 46） treated with interferon-α （IFN-α） and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 （n = 28, 7 with LC） or 3 （n = 18, 5 with LC）. RESULTS： The first phase decline was larger in genotype 3 patients than in genotype 1 patients （1.72 vs 0.95 log IU/mL, P 〈 0.001）. The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients （0.87 vs 0.15 log/wk, P 〈 0.001）. Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2^nd phase slope than non-cirrhotic patients （0.06 vs 0.18 log/wk, P 〈 0,02）. None of genotype 1 cirrhotic patients had a 1^st phase decline larger than 1 log （non-cirrhotic patients： 55%, P 〈 0.02）. A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic patients but the 1^st phase slope decline was not different. Sustained viral response was higher in genotype 3 patients than in genotype 1 patients ,（72% vs 14%, P 〈 0.001） and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients （19% vs 0%）. A second phase decline slower than 0.3 log per week was predictive of non-response in all groups. CONCLUSION： Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1^st phase slope decline in genotype 1 patients.

关键词： Hepatitis C virus Treatment Early kinetics Cirrhosis Genotypes

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Cantharellus(Cantharellales,Basidiomycota)revisited in Europe through a multigene phylogeny

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Fungal Diversity 2017年第2期83卷 263-292页

作者： Ibai Olariaga Gabriel Moreno Jose Luis Manjon isabel Salcedo Valerie Hofstetter Diego Rodrıguez Bart Buyck Department of Life Sciences(Botany) University of Alcala28805 Alcalade HenaresMadridSpain Department of Plant Biology and Ecology(Botany) University of the Basque Country(UPV/EHU)Apdo 64448080 BilbaoSpain Department of Plant Protection Agroscope ChanginsWadenswil Research StationACWRte de Duiller1260 NyonSwitzerland Kherdzmari St.Microdistrict 11.Block 58 Flat 69TemkaTbilisiGeorgia Departement Systematique et Evolution CP 39ISYEBUMR 7205 CNRS MNHN UPMC EPHEMuseum National d’Histoire Naturelle12 Rue Buffon75005 ParisFrance

Resolving species delimitation issues of European Cantharellus is crucial to correctly name chanterelles around the *** names referring to Cantharellus *** been described in Europe,some of which are used in other *** on combined analyses of ITS2,LSU,RPB2 and TEF-1,merely eight species are here recognized in Europe applying the genealogical concordance phylogenetic species recognition criteria,one of which,***,is described as ***logical characters used in species delimitation are mapped and their variability *** colour of the hymenophore in young specimens is found to be a rather constant morphological character of taxonomic *** species of Cantharellus are morphologically distinguished by unique combinations of characters,such as the presence of a pink pileal coating,pileus and hymenophore colour when young,and in some cases,the mean spore length and *** type specimens from Europe are *** on revised species concepts sixteen novel taxonomic synonyms are here proposed for European chanterelles:***(=***,***,***),***(=*** ***,*** ***,***),***(=*** ***,***),***(=*** ***),***(=***),***(=*** ***,*** ***,***),and ***sianus(=***,***,***nesianus ***).The type of Cantharellus,***,is ***,colour illustrations and a key to all European species are provided.

关键词： Cantharelloid clade Cantharellaceae Epitype Edible fungi Genealogical concordance Species delimitation

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Consensus Delphi study on guidelines for the assessment of anterior cruciate ligament injuries in children

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World Journal of Orthopedics 2022年第9期13卷 777-790页

作者： Angélica Campón Chekroun Jorge Velázquez-Saornil isabel Guillén vicente Zacarías Sánchez Milá David Rodríguez-Sanz Carlos Romero-Morales Tomas Fernandez-Jaén JoséIgnacio Garrido González MiguelÁngel Sánchez-Garrido Pedro Guillén García Campus San Jerónimo Guadalupe Universidad Católica de MurciaMurcia 30107MurciaSpain Department of Physiotherapy Universidad Católica deÁvilaÁvila 05005ÁvilaSpain Department of Orthopaedic and Trauma Surgery Clínica CemtroMadrid 28035MadridSpain Nursing Physiotherapy and PodiatryUniversidad Complutense de MadridMadrid 28040MadridSpain Department of Physical Therapy Universidad Europea de MadridMadrid 28023MadridSpain Department of Orthopaedic and Trauma Surgery Gabinete Médico GarridoSalamanca 37003SalamancaSpain

Background:Knee examination guidelines in minors are intended to aid decisionmaking in the management of knee *** question:A Delphi study was conducted with a formal consensus process using a validated methodology with sufficient scientific evidence.A group consensus meeting was held to develop recommendations and practical guidelines for use in the assessment of instability injuries in *** findings:there is a lack of evidence to analyse anterior cruciate ligament injuries in children and their subsequent surgical management if *** guidelines and clinical assessment of the patient based on a thorough examination of the knee are performed and a guide to anterior cruciate ligament exploration in children is *** application:In the absence of a strong evidence base,these established guidelines are intended to assist in that decision-making process to help the clinician decide on the most optimal treatment with the aim of benefiting the patient as much as *** this expert consensus,surgical treatment is advised when the patient has a subjective sensation of instability accompanied by a pivot shift test++,and may include an anterior drawer test+and a Lachman test+.If these conditions are not present,the conservative approach should be chosen,as the anatomical and functional development of children,together with a physiotherapy programme,may improve the evolution of the injury.

关键词： Anterior cruciate ligament Diagnoses and examinations Sports injuries Knee Injury to minors

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Starburst amacrine cells,involved in visual motion perception,lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients

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Translational Neurodegeneration 2023年第1期12卷 638-653页

作者： Xavier Sánchez-Sáez isabel Ortuño-Lizarán Carla Sánchez-Castillo Pedro Lax Nicolás Cuenca Department of Physiology Genetics and MicrobiologyUniversity of AlicanteSan Vicente del RaspeigSpain Alicante Institute for Health and Biomedi-cal Research(ISABIAL) AlicanteSpain Ramón Margalef Institute University of AlicanteSan Vicente del RaspeigSpain.

Background The main clinical symptoms characteristic of Parkinson’s disease(PD)are bradykinesia,tremor,and other motor ***,non-motor symptoms,such as visual disturbances,can be identified at early stages of the *** of these symptoms is the impairment of visual motion ***,we sought to determine if the starburst amacrine cells,which are the main cellular type involved in motion direction selectivity,are degenerated in PD and if the dopaminergic system is related to this *** Human eyes from control(n=10)and PD(n=9)donors were available for this *** immunohistochemistry and confocal microscopy,we quantified starburst amacrine cell density(choline acetyltransferase[ChAT]-positive cells)and the relationship between these cells and dopaminergic amacrine cells(tyrosine hydroxylase-positive cells and vesicular monoamine transporter-2-positive presynapses)in cross-sections and wholemount *** First,we found two different ChAT amacrine populations in the human retina that presented different ChAT immunoreactivity intensity and different expression of calcium-binding *** populations are affected in PD and their density is reduced compared to ***,we report,for the first time,synaptic contacts between dopaminergic amacrine cells and ChAT-positive cells in the human *** found that,in PD retinas,there is a reduction of the dopaminergic synaptic contacts into ChAT *** Taken together,this work indicates degeneration of starburst amacrine cells in PD related to dopaminergic degeneration and that dopaminergic amacrine cells could modulate the function of starburst amacrine *** motion perception circuitries are affected in PD,their assessment using visual tests could provide new insights into the diagnosis of PD.

关键词： Parkinson’s disease Retinal neurodegeneration Human retina ChAT amacrine cells Dopaminergic amacrine cells

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Comparison of Interpolation Methods for the Study of Forest Variables Using a Geographic Information System

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Journal of Agricultural Science and Technology(B) 2011年第3期1卷 428-436页

作者： I. Romero-Toro-Gascuena S. Sastre-Merino J. vicente-guillen E. Ayuga-Tellez M. J. Garcia-Garcia C.Gonzalez-Garcia M. A. Grande-Ortiz Technical University of Madrid Madrid 28040 Spain

Interpolation methods in ArcGIS_ESRI Geostatistical Analyst tool allow obtaining unknown values at unsampled points from observed data and generating continuous surfaces. In this paper, forest data variables as tree height and diameter measured in two plots in Central Mountains in Spain. These data were georeferenced to obtain maps that can visualize the spatial variability of these forest variables. In order to evaluate the best interpolation method that could adequately explain the spatial variability of those variables, two interpolation methods were studied： inverse results was made by means of statistical methods to analyze distance weighted （IDW） and Ordinary Kriging （OK）. A comparison of residuals. Results with the kriging method were slightly better.

关键词： GIS tools interpolation methods spatial data models geostatistical techniques.

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