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Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears

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Bioactive Materials 2023年第10期28卷 61-73页

作者： Solaiman tarafder Jaskirti Ghataure David Langford Rachel Brooke Ryunhyung Kim Samantha Lewis Eyen Julian Bensadoun Jeffrey t.Felix James L.Cook chang h.Lee Regenerative Engineering Laboratory Columbia University Medical Center630 W.168 St.-VC12-212New YorkNY10032USA thompson Laboratory for Regenerative Orthopaedics Missouri Orthopedic InstituteUniversity of Missouri1100 Virginia AvenueColumbi1MO65212USA

Meniscus injuries are extremely common with approximately one million patients undergoing surgical treatment annually in the U.S. alone, but no regenerative therapy exist. Previously, we showed that controlled applications of connective tissue growth factor (CtGF) and transforming growth factor beta 3 (tGFβ3) via fibrin-based bio-glue facilitate meniscus healing by inducing recruitment and stepwise differentiation of synovial mesenchymal stem/progenitor cells. here, we first explored the potential of genipin, a natural crosslinker, to enhance fibrin-based glue’s mechanical and degradation properties. In parallel, we identified the harmful effects of lubricin on meniscus healing and investigated the mechanism of lubricin deposition on the injured meniscus surface. We found that the pre-deposition of hyaluronic acid (hA) on the torn meniscus surface mediates lubricin deposition. then we implemented chemical modifications with heparin conjugation and CD44 on our bioactive glue to achieve strong initial bonding and integration of lubricin pre-coated meniscal tissues. Our data suggested that heparin conjugation significantly enhances lubricin-coated meniscal tissues. Similarly, CD44, exhibiting a strong binding affinity to lubricin and hyaluronic acid (hA), further improved the integrated healing of hA/lubricin pre-coated meniscus injuries. these findings may represent an important foundation for developing a translational bio-active glue guiding the regenerative healing of meniscus injuries.

关键词： Knee meniscus Bioactive glue Stem cell recruitment Lubricin

Multimodal separation for ultrasonic Lamb wave using independent component analysis in the time-frequency domain

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Chinese Journal of Acoustics 2021年第4期40卷 583-596页

作者： LOU Sijia LIU Zhenli XU Kailiang tRAN tho N.h.t. ZhOU chang LE Lawrence h. tA De'an Center for Biomedical Engineering Fudan UniversityShanghai 200433 Academy for Engineering and technology Fudan UniversityShanghai 200433 Ningbo Marvoto Intelligent technology Ningbo 315300 Department of Radiology and Diagnostic Imaging University of Alberta EdmontonCanada T6G2R3

Aiming at facilitating Lamb wave signal analysis and mode characterization,an ultrasonic-Lamb wave niultimodal separation method combining short-time Fourier transform(StFt)and independent component analysis(ICA)was *** signals were projected into the time-frequency domain through *** that the energy trajectory of each Lamb mode is indepenclent in the time-frequency domain,ICA method was then applied to separate tlie superposed *** group velocity curve of each mode was extracted according to its time-frequency energy trajectory,based on which the plate thickness can be further *** finite-difference time-domain(FDtD)simulated signals and experimental signals for a 1 nmi-thick steel plate were used to validate the performance of the proposed *** three fundainental Lamb modes,A0,SO and A1 modes were *** average errors of group velocity estimation in the simulation and experiment were about 1.5%and 2.0%,with that of plate thickness estimation being 0.3%and 2.0%*** simulated results indicate that,when the signal-to-noise ratio(SNR)is larger than 0 dB,the ICA method in the time-frequency domain can be used for ultrasonic Lamb wave multimodal separation,group velocity extraction and plate thickness estimation.

关键词： separation wave analysis

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焦化行业碳氢资源利用潜力与低碳路径评价

化工进展 2024年第5期43卷 2862-2871页

作者：狄子琛雷飞霞常成功陈文慧程芳琴山西大学资源与环境工程研究所山西太原030006

中国焦炭产量达4.73×10^(8)t,副产焦炉气约2×10^(11)m^(3)。焦炉气富含h_(2)、Ch_(4)和CO等碳氢资源,对其有效利用并衔接上下游产业的氢能需求,有望产生显著的产业链减碳效益。本研究构建全国焦化企业的空间地理坐标和产能数据库,针... 详细信息

中国焦炭产量达4.73×10^(8)t,副产焦炉气约2×10^(11)m^(3)。焦炉气富含h_(2)、Ch_(4)和CO等碳氢资源,对其有效利用并衔接上下游产业的氢能需求,有望产生显著的产业链减碳效益。本研究构建全国焦化企业的空间地理坐标和产能数据库,针对典型焦化企业开展物质流、碳流分析,系统比较焦炉气不同利用路径的环境影响、碳减排效益及碳氢资源利用率,提出优化的焦炉气利用策略。结果表明,我国焦化企业集中度较低,山西省是独立焦化企业最多的省份,企业规模在2×10^(6)t以下;河北、辽宁、吉林、江苏等地则主要以钢焦联合企业为主,主要为大型焦化企业。焦化行业副产大量焦炉气,可产氢气达1×10^(11)m^(3)。生命周期评价结果表明,焦炉气用于化工转化和还原剂高炉喷吹相比作燃料直接发电均可有效降低碳排放,尤其制氢路径和高炉喷吹路径的全球变暖潜值减少量分别是制甲醇路径的5倍和67倍。此外,在各种焦炉气利用路径中,总环境影响从高到低依次为制甲醇、发电、制LNG、制合成氨、制氢、高炉喷吹。结合各焦炉气利用路径分析与钢、焦企业空间分布,山西省等地独立焦化企业较多,可优先考虑向焦炉气制氢方向转型。而有条件发展钢焦联合发展区域,如河北、辽宁、吉林、江苏等地,向高炉喷吹焦炉气工艺改造转型,更有利于产生行业间协同效益,有效推动减污降碳发展。

关键词：焦炉气碳氢资源生命周期分析碳减排潜力焦钢耦合

Glass Formability and Soft Magnetic Properties of Bulk Y-Fe-B-ti Metals

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材料科学与工程学报 2007年第6期25卷 871-874,829页

作者： h. W. chang Y. C. huang C. W. chang C. h. Chiu W. C. chang Physics Department National Chung Cheng University Ming-Hsiung Chia-Yi Taiwan China Institute of Physics Academia Sinica Nankang Taipei China

the ti effects on the glass forming ability and the magnetic properties of Y-Fe-B-ti bulk metallic glasses have been *** 2 and 4 at% ti for Fe or B in Y_6Fe_ 70B_ 22 alloys decrease the saturation magnetization(σ_s)and deteriorate the glass forming ability,***,substitution of 2 at% ti for Y in Y_6Fe_ 72B_ 22 alloy induces larger supercooled region of 72.7℃,which not only makes the bulk glassy rod as large as 3mm in diameter,but also results in the superior soft magnetic properties of σ_s=126emu/g,coercivity(h_c)=0.2 Oe and Curie temperature(t_C)=268℃.Among all Y-Fe-B-ti bulk amorphous rods,Y_4Fe_ 72B_ 22ti_2 displays the best glass forming ability and also the proper soft magnetic properties.

关键词：软磁性质钇铁硼钛合金玻璃成形性温度

基于Na_(3)Y(VO_(4))_(2):Yb^(3+)/Er^(3+)实现高灵敏度的双模式光学测温

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发光学报 2024年第6期45卷 952-958页

作者：相国涛易园园张羽熊明徐秦玉陈红豆常瑛姚璐重庆邮电大学理学院重庆400065

基于高温固相法合成了Na_(3)Y(VO_(4))_(2):Yb^(3+)/Er^(3+)上转换发光材料,该材料在绿光区和近红外二区均表现出较强的发光强度。在绿光区,基于Er^(3+)的~2h_(11/2)→^(4)I_(15/2)和^(4)S_(3/2)→^(4)I_(15/2)跃迁进行荧光强度比光学测温,其最佳的绝对灵敏度、相对灵敏度和温度分辨率可分别达到1.7%·K^(-1)、1.2%·K^(-1)和0.027 K;在近红外二区,基于Er^(3+):^(4)I_(13/2)→^(4)I_(15/2)跃迁的Stark劈裂所进行的光学测温,其最佳的绝对灵敏度、相对灵敏度和温度分辨率分别为3.01%·K^(-1)、0.59%·K^(-1)和0.06 K。更为重要的是,在生理温度范围内,以上两种光学温度计均表现出较高的测温准确性。所有数据均表明,Na_(3)Y(VO_(4))_(2):Yb^(3+)/Er^(3+)是一种优异的光学测温材料,可在可见区和近红外二区实现高灵敏度的双模式光学测温。

关键词：稀土离子上转换发光光学测温荧光强度比

the ALMA-QUARKS Survey.Ⅱ.the ACA 1.3 mm Continuum Source Catalog and the Assembly of Dense Gas in Massive Star-Forming Clumps

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Research in Astronomy and Astrophysics 2024年第6期24卷 119-139页

作者：许峰玮 Ke Wang tie Liu Lei Zhu Guido Garay Xunchuan Liu Paul Goldsmith Qizhou Zhang Patricio Sanhueza Shengli Qin Jinhua he Mika Juvela Anandmayee tej hongli Liu Shanghuo Li Kaho Morii Siju Zhang Jianwen Zhou Amelia Stutz Neal JEvans Kee-tae Kim Shengyuan Liu Diego Mardones Guangxing Li Leonardo Bronfman Ken’ichi tatematsu chang Won Lee Xing Lu Xiaofeng Mai Sihan Jiao James O.Chibueze Keyun Su Viktor L.tóth Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Center for Astrophysics|harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan School of Physics and Astronomy Yunnan UniversityKunming 650091China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Department of Physics University of HelsinkiPO Box 64FI-00014 HelsinkiFinland Indian Institute of Space Science and technology Thiruvananthapuram 695547KeralaIndia Max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Department of Astronomy Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Max-Planck-Institut für Radioastronomie Auf dem Hügel 6953121 BonnGermany Departamento de AstronomÂıa Universidad de ConcepcionCasilla 160-CConcepci onChile Department of Astronomy The University of Texas at AustinTexas 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617TaiwanChina South-Western Institute for Astronomy Research Yunnan UniversityKunming 650091China Korea Astronomy and Space Science Institute 776 Daedeok-daeroYuseong-guDaejeon 34055Republic of

Leveraging the high resolution,sensitivity,and wide frequency coverage of the Atacama Large Millimeter/submillimeter Array(ALMA),the QUARKS survey,standing for“Querying Underlying mechanisms of massive star formation with ALMA-Resolved gas Kinematics and Structures”,is observing 139 massive starforming clumps at ALMA Band 6(λ~1.3 mm).this paper introduces the Atacama Compact Array(ACA)7 m data of the QUARKS survey,describing the ACA observations and data *** multiwavelength data,we provide the first edition of QUARKS atlas,offering insights into the multiscale and multiphase interstellar medium in high-mass star *** ACA 1.3 mm catalog includes 207 continuum sources that are called ACA *** gas kinetic temperatures are estimated using three formaldehyde transitions with a non-LtE radiation transfer model,and the mass and density are derived from a dust emission *** ACA sources are massive(16–84 percentile values of 6–160 M_(⊙)),gravity-dominated(M∝R^(1.1))fragments within massive clumps,with supersonic turbulence(M>1)and embedded star-forming *** find a linear correlation between the masses of the fragments and the massive clumps,with a ratio of 6%between the *** considering fragments as representative of dense gas,the ratio indicates a dense gas fraction(DGF)of 6%,although with a wide scatter ranging from 1%to 10%.If we consider the QUARKS massive clumps to be what is observed at various scales,then the size-independent DGF indicates a self-similar fragmentation or collapsing mode in protocluster *** the ACA data over four orders of magnitude of luminosity-to-mass ratio(L/M),we find that the DGF increases significantly with L/M,which indicates clump evolutionary *** observed a limited fragmentation at the subclump scale,which can be explained by a dynamic global collapse process.

关键词： stars:formation ISM:kinematics and dynamics ISM:clouds stars:protostars

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IAPP在全身系统中的作用机制研究

中华内分泌代谢杂志 2024年第4期40卷 359-364页

作者：徐畅王鑫尹智坚牛宥莹赵薇大理大学临床医学院大理617000 大理大学第一附属医院眼科大理617000 兴义市人民医院眼科 562400

胰岛淀粉样多肽(islet amyloid polypeptide,IAPP)与胰岛素由β细胞共同分泌,当胰岛素抵抗时2种蛋白均会增多,β细胞因加工超载积累错误折叠的IAPP,损伤胰岛正常分泌功能。然而,IAPP还可产生活性氧、激活多种信号通路、干扰细胞代谢、... 详细信息

胰岛淀粉样多肽(islet amyloid polypeptide,IAPP)与胰岛素由β细胞共同分泌,当胰岛素抵抗时2种蛋白均会增多,β细胞因加工超载积累错误折叠的IAPP,损伤胰岛正常分泌功能。然而,IAPP还可产生活性氧、激活多种信号通路、干扰细胞代谢、在细胞内形成沉淀物、与其他淀粉样蛋白交叉折叠等方式,导致不同程度的细胞或组织损伤,最终引起全身多系统疾病。然而,IAPP在其他系统疾病发生发展过程中发挥的作用尚未形成广泛共识,有关研究结果也未被有效整合。本文将系统、全面地阐述不同结构形态的IAPP对神经、循环、运动、免疫等系统疾病的作用机制,有助于探索IAPP相关系统疾病的病理机制,为制定治疗和预防策略提供新思路。

关键词：胰岛淀粉样多肽神经系统循环系统运动系统免疫系统综述

2型糖尿病患者认知功能障碍与糖尿病自主神经病变的相关性研究

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智慧健康 2024年第6期10卷 93-96页

作者：沈可常震英常熟市第二人民医院老年医学科江苏常熟215500

目的探讨2型糖尿病患者认知功能障碍与糖尿病自主神经病变的相关性。方法选取2022年1—12月本院治疗的120例2型糖尿病(t2MD)患者作为研究对象。根据有无心血管自主神经病变(CAN)进行分组,对照组(n=70)无CAN,观察组(n=50)有CAN,对比两... 详细信息

目的探讨2型糖尿病患者认知功能障碍与糖尿病自主神经病变的相关性。方法选取2022年1—12月本院治疗的120例2型糖尿病(t2MD)患者作为研究对象。根据有无心血管自主神经病变(CAN)进行分组,对照组(n=70)无CAN,观察组(n=50)有CAN,对比两组MMSE和MoCA量表检查结果、COMPASS-31量表检查结果;根据是否存在认知功能障碍进行分组,A组(n=82)无认知功能障碍,B组(n=38)有认知功能障碍,对比各项生化指标。结果观察组MMSE评分、MoCA评分均低于对照组(PhbA1c、tC、tG、LDL-C、hDL-C、空腹C肽与A组相当(P>0.05),但餐后2h C肽低于A组,CAN比例高于A组(Pt2MD患者认知功能障碍与CAN存在显著关联,CAN可增加认知功能障碍发生风险。

关键词： 2型糖尿病认知功能障碍自主神经病变相关性

黄芪提取物调控Nrf2/ARE信号通路对糖尿病肾病大鼠氧化应激的影响

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中国临床药理学杂志 2024年第15期40卷 2217-2221页

作者：吴乙偲谭菲易露露宋长军赣州市人民医院肾内科江西赣州341000 赣州市人民医院风湿科江西赣州341000 赣州市人民医院急诊科江西赣州341000

目的探讨黄芪提取物调控核因子E2相关因子2(Nrf2)/抗氧化反应元件(ARE)信号通路对糖尿病肾病大鼠氧化应激的影响。方法用高脂饮食联合腹腔注射链脲佐菌素法构建糖尿病大鼠模型,并随机分为模型组、高剂量+ML385组和低、高剂量实验组,每... 详细信息

目的探讨黄芪提取物调控核因子E2相关因子2(Nrf2)/抗氧化反应元件(ARE)信号通路对糖尿病肾病大鼠氧化应激的影响。方法用高脂饮食联合腹腔注射链脲佐菌素法构建糖尿病大鼠模型,并随机分为模型组、高剂量+ML385组和低、高剂量实验组,每组12只;另选12只大鼠作为空白组。空白组和模型组大鼠均灌胃等体积的0.9%NaCl,低、高剂量实验组大鼠分别灌胃50、100 mg·kg^(-1)黄芪提取物,高剂量+ML385组大鼠在灌胃100 mg·kg^(-1)黄芪提取物的同时腹腔注射20 mg·kg^(-1)ML385,qd,连续8周。检测大鼠肾组织中氧化应激相关指标含量,用二氢乙啶染色法检测活性氧表达水平,用蛋白质印迹法检测大鼠肾组织中醌氧化还原酶1(NQO1)、血红素加氧酶1(hO-1)及细胞核Nrf2的蛋白相对表达水平。结果空白组、模型组、高剂量实验组和高剂量+ML385组的超氧化物歧化酶分别为(163.89±20.28)、(71.35±12.72)、(132.11±19.29)和(73.04±13.28)U·mg^(-1),谷胱甘肽过氧化物酶分别为(12.82±1.57)、(4.91±1.18)、(8.54±1.09)和(5.10±1.43)U·mg^(-1),活性氧分别为0.02±0.01、0.09±0.01、0.05±0.01和0.08±0.01,细胞核Nrf2蛋白相对表达水平分别为0.63±0.09、0.28±0.06、0.60±0.08和0.32±0.05,NQO1蛋白相对表达水平分别为0.58±0.11、0.27±0.07、0.63±0.12和0.31±0.08,hO-1蛋白相对表达水平分别为0.53±0.08、0.23±0.06、0.59±0.09和0.28±0.05。高剂量实验组的上述指标与模型组比较,在统计学上差异均有统计学意义(均P<0.05);高剂量+ML385组的上述指标与高剂量实验组比较,在统计学上差异均有统计学意义(均P<0.05)。结论黄芪提取物可以减轻糖尿病肾病大鼠氧化应激损伤,其机制可能是通过调控Nrf2/ARE信号通路实现的。

关键词：黄芪提取物糖尿病肾病核因子E2相关因子2 抗氧化反应元件氧化应激