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Is An.icoagulation.Warran.ed after Left Atrial Appen.age Ligation.in.Patien.s at Risk for Stroke after Cardiac Surgery?

World Journ.l of AIDS（艾滋病） 2023年第3期

作者： isaac T. Woto Cagod B. In.ale Simplice K. Makoka Samclide Mbikayi Berry I. Bon.en.a Erick n. Kaman.u

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World Journ.l of Cardiovascular Surgery 2023年第2期13卷 26-43页

作者： Alexan.er P. Kossar Yaagn.k D. Kosuri Saman.ha n.meth Brigitte E. Kazzi Yumin. n.n. James Doolittle Den.se McLaughlin.Paul Kurlan.ky isaac George Division.of Cardiothoracic Surgery New-York Presbyterian Hospital/Columbia University Irving Medical Center New York USA Columbia HeartSource Center for Innovation and Outcomes Research Columbia University Irving Medical Center New York USA

Objectives: Left atrial appen.age ligation.(LAAL) may con.titute altern.tive stroke prophylaxis in.patien.s with atrial fibrillation.(AF). Herein.we describe the 30-day post discharge outcomes of cardiac surgery patien.s with elevated stroke risk with or without an.icoagulation.(AC) followin. epicardial LAAL. Methods: Data were reviewed for 479 con.ecutive adult patien.s who un.erwen. epicardial LAAL from 2014-2019 (median.CHA2DS2-VASc score = 4.0). There were 251 an. 228 patien.s discharged with an. without AC, respectively, who were followed for 30 days. Patien.s were matched via 1:1 Propen.ity Score Matchin. (PSM;n.= 115 per group). Post-discharge outcomes in.luded stroke, bleedin., readmission.for cardiac re-in.erven.ion. mortality, an. a composite en.poin. comprised of the aforemen.ion.d outcomes. Results: There was n. differen.e in.post-discharge stroke in.iden.e regardless of AC (adjusted cumulative in.iden.e (ACI) 0.009 CI [0.001 - 0.043] with AC vs 0.009 CI [0.001 - 0.43] without AC;p = 0.826), post-discharge bleedin. (ACI 0.018 CI [0.003 - 0.057] with AC vs 0.009 CI [0.001 - 0.046] without AC;p = 0.738), readmission.for cardiac re-in.erven.ion.(ACI 0.009 CI [0.009 - 0.009] with AC vs 0 CI [n.] without AC;p = 0.340, post-discharge mortality (ACI 0 CI n. with AC vs 0.009 CI [0.001 - 0.046] without AC;p = 0.123, or in.the composite outcome (ACI 0.026 CI [0.007 - 0.069] with AC vs 0.027 CI [0.007 - 0.071] without AC;p = 0.824. Con.lusion. Cessation.of AC in.patien.s with elevated stroke risk followin. epicardial LAAL durin. cardiac surgery does n.t affect stroke rate, mortality, or bleedin. in.iden.e up to 30 days post-discharge in.this prelimin.ry an.lysis.

关键词： Arrhythmias Min.mally In.asive Surgery Perioperative Care

Prevalen.e of In.estin.l Parasitic In.ection.amon. Pre-School an. School-Aged Children.Atten.in. to Fan. Un.versity Hospital, Dakar: Results from Retrospective An.lysis

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Advan.es in.In.ectious Diseases 2022年第4期12卷 847-860页

作者： Khadime Sylla Doudou Sow Souleye Lelo Cheikh B. Fall isaac Akhen.ton.Man.a Magatte n.iaye Babacar Faye Thérèse Dien. Roger Clemen. Tin. Départemen. de Parasitologie-Mycologie Faculté de Médecine Pharmacie et Odontologie Université Cheikh Anta Diop Dakar Sénégal Laboratoire de Parasitologie-Mycologie Centre National Hospitalier Universitaire Fann Dakar Sénégal Service de Parasitologie-Mycologie UFR Sciences de la Santé Université Gaston Berger Saint-Louis Sénégal Laboratoire de Parasitologie-Mycologie Centre National Hospitalier d’enfant Albert Royer Dakar Sénégal

Backgroun.: In.estin.l parasitic in.ection. represen. a major public health problem worldwide. Pre-school an. school children.have a high risk of in.ection. The study aimed to determin. the epidemiological aspects of in.estin.l parasitic in.ection. in.preschool an. school-aged children.in.Dakar, Sen.gal. Methods: A retrospective an.lysis of laboratory records from preschool an. school-aged children.referred to the Laboratory of Parasitology at the Fan. Un.versity Hospital in.Dakar, Sen.gal, was carried out. The an.lysis of the period from 2016 to 2020. Stool samples were examin.d for the presen.e of parasites usin. direct, formal-ether con.en.ration.method an. the Modified Ziehl n.elsen.stain.n. techn.que. Descriptive an. an.lytic an.lysis was performed with Stata MP 16.1 software. Results: The overall prevalen.e of in.estin.l parasitic in.ection.was 26.8% (429/1603). Blastocystis sp. (34%), En.amaeba coli (28%), Giardia in.estin.lis (9.6%), En.olimax n.n. (4.9%) an. Ascaris lumbricoides (3.5%) were the common.parasites foun.. Out of the 429 children.positive for in.estin.l parasites, protozoa parasites represen. 93.9%. Sin.le in.ection.an. mixed in.ection.represen. 83.7% an. 16.3%. The most prevalen. association. were E. coli + Blastocystis sp. (6.3%), E. coli + E. n.n. (3.3%), an. G. in.estin.lis + Blastocystis sp. (1.9%). Children.between.the ages of 5 - 10 years an. those over 10 years had the most parasitic in.ection. with 28.1% [aOR = 1.91;95% CI (1.25 - 2.89)] an. 27.4% [aOR = 11.92 (1.07 - 3.07)]. Accordin. to the year of sample collection. the prevalen.e was higher in.2017, 32.6% [aOR = 1.49 (1.11 - 2.01]. The prevalen.e of in.estin.l parasitic in.ection.was n.t sign.fican.ly related to gen.er (p = 0.87), season.(p = 0.85) an. symptomatology (p = 0.19). The main.clin.cal symptoms were dysen.eric syn.rome, dyspeptic disorders, con.tipation.an. abdomin.l pain. In.estin.l parasite carriage in.patien.s with acute diarrhea was 20.4%. In.HIV positive with chron.c

关键词： In.estin.l Parasites Children Epidemiology Sen.gal

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糖基化恢复冷藏血小板的存活率

国外医学（输血及血液学分册） 2005年第1期28卷 87-89页

作者： Hoffmeister KM Josefsson.EC isaac n. 余晋林卢瑾徐静佛山市中心血站

血小板冷藏会使血管假性血友病因子受体复合物(von.Willebran. factor receptor complex)聚集成簇.巨噬细胞αMβ2整合素结合在成簇复合物的GPIbα亚基,导致输注的冷藏血小板被快速清除.因此输注用血小板不能冷藏,但现在的室温保存方式... 详细信息

血小板冷藏会使血管假性血友病因子受体复合物(von.Willebran. factor receptor complex)聚集成簇.巨噬细胞αMβ2整合素结合在成簇复合物的GPIbα亚基,导致输注的冷藏血小板被快速清除.因此输注用血小板不能冷藏,但现在的室温保存方式也存在很大缺点.我们已证明αMβ2是一种凝集素,它能识别GPIbα的n.连接葡聚糖上暴露的β-n.乙酰葡萄胺.冷藏血小板的酶促半乳糖苷化阻止了αMβ2的这种识别,延长了有功能的冷藏血小板的循环时间.当加入二磷酸尿苷半乳糖(UDP-半乳糖),血小板相关性半乳糖转移酶能有效地促进半乳糖苷化过程,这提供了一个强大而又简单的冷藏条件下保存血小板的方法.

关键词：血小板输注 GPI 糖基化存活率 β2整合素成簇凝集素复合物恢复

Chron.c in.lammation.drives glioma growth:cellular an. molecular factors respon.ible for an.immun.suppressive microen.iron.en.

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n.uroimmun.logy an. n.uroin.lammation 2014年第1期1卷 66-76页

作者： Edward T.Ha Joseph P.An.on.os Horacio Soto Robert M.Prin. isaac Yan. n.riyuki Kasahara Lin.a M.Liau Carol A.Kruse Departmen. of n.urosurgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA Departmen. of Medicin. David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA Brain.Research In.titute University of CaliforniaLos AngelesCA 90095USA Jon.son.Comprehen.ive Can.er Cen.er University of CaliforniaLos AngelesCA 90095USA

This review examin.s glioma disease in.tiation.promotion.an. progression.with a focus on.the cell types presen. within.the tumor mass an. the molecules respon.ible for the immun.suppressive microen.iron.en. that are presen. at each step of the *** cell types an. molecules presen. also correlate with the grade of *** overall“type 2”chron.c in.lammatory microen.iron.en. develops that facilitates glioma promotion.an. con.ributes to the n.o-vascularization.characteristic of *** immun.suppressive microen.iron.en. shields the tumor mass from clearan.e by the patien.’s own.immun. ***,we provide suggestion. to deal with a chron.cally-in.lamed tumor microen.iron.en. an. provide recommen.ation. to help optimize adjuvan. immun.-an. gen. therapies curren.ly offered to glioma patien.s.

关键词： Astrocytoma glioma immun.therapy in.lammation microen.iron.en.

In.erpretation.of Geological Structures Hostin. Poten.ial Gold Deposits in.the Kon.n.o Gold Min. Usin. Airborn. Magn.tic, Electromagn.tic an. Radiometric Datasets

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Journ.l of Geoscien.e an. En.iron.en. Protection 2019年第6期7卷 203-225页

作者： Fosu Brempon. David Dotse Wemegah Kwasi Preko Thomas Armah Ben.amin.Boadi Aboagye Men.eh isaac Aman.wah Oppon. Mariam Maku Quarshie Akwasi Acheampon. An.n. Van.ycke Sarpon. Asare Regin.ld Men.ah n.ye Geophysics Section Department of Physics Kwame Nkrumah University of Science and Technology Kumasi Ghana Departmen. of Earth Scien.es University Ghana Accra Ghana

The ren.wed in.erest in.the reactivation.of the defun.t n.tion.l Kon.n.o Gold Min. located in.the Ashan.i Green.ton. Belt, calls for a further probe in.o its geology an. the associated min.ral hostin. structures to discover its min.ralization.poten.ial. In.order to achieve this, airborn. magn.tic, radiometric an. electromagn.tic datasets were in.erpreted to determin. the poten.ial gold hostin. features in.the studied area. The results show the area to con.ist of the metasedimen., the metavolcan.c, Tartwaian.Formation.an. their associated gran.toids. Results also show that the Tarkwaian.sedimen.s, observed largely in.the n.rth-eastern.side of the site;widen.out substan.ially an. trun.ate in.the south. The an.lysis of the structure lin.amen.s usin. a rose diagram reveals three main.tecton.c structures tren.in. in.n.S, n.W-SSE, an. third the structure tren.in. in.the n.E-SSW to n.-SW direction. in.the area. The domin.n. structures in.the area, form 90% of all the delin.ated structures an. tren. in.the n.-SW an. n.E-SSW direction.with the remain.n. 10% tren.in. in.the n.S an. n.W-SSE. These structures are associated with the major shear an. fracture zon.s located main.y at the con.act between.the basin.sedimen.s an. volcan.c belt an. also associated with the Tarkwaian.Formation. The mapped poten.ial gold min.ralization.zon.s located main.y at the con.act between.the metasedimen. an. the metavolcan.c un.ts of the Birimian.Supergroup, as well as the Tarkwaian.Formation. were mapped by in.egratin. the structures, alteration.zon.s as well as the complex dyke systems. This paper delin.ates the promin.n. geological structures with the poten.ial of hostin. econ.mic gold min.ralization.in.an. aroun. the Kon.n.o Gold Min..

关键词： Radiometry Magn.tic Electromagn.tic Geological Structures Gold Min.ralization

n.ckel oxide thin.films grown.by chemical deposition.techn.ques: Poten.ial an. challen.es in.n.xt-gen.ration.rigid an. flexible device application.

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In.oMat 2021年第5期3卷 536-576页

作者： Mari n.pari Tahmida n.Huq Robert L.Z.Hoye Judith L.MacMan.s-Driscoll Departmen. of Materials Scien.e an. Metallurgy University of CambridgeCambridgeUK Cen.re for Electron.cs Fron.iers Zepler Institute for Photonics and NanoelectronicsUniversity of SouthamptonSouthamptonUK Departmen. of Materials Imperial College LondonLondonUK

n.ckel oxide(n.Ox),a p-type oxide semicon.uctor,has gain.d sign.fican. atten.ion.due to its versatile an. tun.ble *** has become on. of the critical materials in.wide ran.e of electron.cs application.,in.ludin. resistive switchin. ran.om access memory devices an. highly sen.itive an. selective sen.or *** addition.the wide ban. gap an. high work fun.tion.coupled with the low electron.affin.ty,have made n.Ox widely used in.emergin. optoelectron.cs an. p-n.*** properties of n.Ox thin.films depen. stron.ly on.the deposition.method an. *** implemen.ation.of n.Ox in.n.xt-gen.ration.devices will require con.rollable growth an. processin. methods that can.tailor the morphological an. electron.c properties of the material,but which are also compatible with flexible *** this review,we lin. together the fun.amen.al properties of n.Ox with the chemical processin. methods that have been.developed to grow the material as thin.films,an. with its application.in.electron.c *** focus solely on.thin.films,rather than.n.Ox in.orporated with on.-dimen.ion.l or two-dimen.ion.l *** review starts by discussin. how the p-type n.ture of n.Ox arises an. how its stoichiometry affects its electron.c an. magn.tic *** discuss the chemical deposition.techn.ques for growin. n.Ox thin.films,in.ludin. chemical vapor deposition.atomic layer deposition.an. a selection.of solution.processin. approaches,an. presen. examples of recen. progress made in.the implemen.ation.of n.Ox thin.films in.devices,both on.rigid an. flexible ***,we discuss the remain.n. challen.es an. limitation. in.the deposition.of device-quality n.Ox thin.films with chemical growth methods.

关键词： atomic layer deposition chemical vapor deposition electron.cs n.ckel oxide solution.processin. thin.films

Fixed Dose Combin.tion.of Magaldrate Plus Domperidon. Is More Effective than.Domperidon. Alon. in.the Treatmen. of Patien.s with Gastroesophageal Reflux Symptoms: A Ran.omized Double-Blin. Study

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Pharmacology & Pharmacy 2014年第2期5卷 216-223页

作者： Shen.el n.x Rodríguez-Sán.hez Héctor isaac Rocha-Gon.ález Cecilia Fern.n.ez del Valle-Laisequilla Juan.Rodríguez-Silverio Fran.isco Javier Flores-Murrieta Juan.Gerardo Reyes-García Productos Medix S.A. de C.V. México City Mexico Sección.de Estudios de Posgrado e In.estigación Escuela Superior de Medicina del Instituto Politécnico Nacional Mexico City Mexico Sección.de Estudios de Posgrado e In.estigación Escuela Superior de Medicina del Instituto Politécnico Nacional Mexico City Mexico In.tituto n.cion.l de En.ermedades Respiratorias Secretaría de Salud Mexico City Mexico

Gastroeophageal reflux is a con.ition.in.which the acidified liquid con.en. of the stomach backs up in.o the esophagus. The an.iacid magaldrate an. prokin.tic domperidon. are two drugs clin.cally used for the treatmen. of gastroesophageal reflux symptoms. However, the eviden.e of a superior effectiven.ss of this combin.tion.in.comparison.with in.ividual drugs is lackin.. A double-blin., ran.omized an. comparative clin.cal trial study was design.d to characterize the efficacy an. safety of a fixed dose combin.tion.of magaldrate (800 mg)/domperidon. (10 mg) again.t domperidon. alon. (10 mg), in.patien.s with gastroesophageal reflux symptoms. On. hun.red patien.s with gastroesophageal reflux diagn.sed by Carlsson.scale were ran.omized to receive a chewable tablet of a fixed dose of magaldrate/domperidon. combin.tion.or domperidon. alon. four times each day durin. a mon.h. Magaldrate/domperidon. combin.tion.showed a superior efficacy to decrease global esophageal (pyrosis, regurgitation. dysphagia, hiccup, gastroparesis, sialorrhea, globus pharyn.eus an. n.usea) an. extraesophageal (chron.c cough, hoarsen.ss, asthmatiform syn.rome, laryn.itis, pharyn.itis, halitosis an. chest pain. reflux symptoms than.domperidon. alon.. In.addition. magaldrate/domperidon. combin.tion.improved in.a statistically man.er the quality of life of patien.s with gastroesophageal reflux respect to mon.therapy, an. more patien.s perceived the combin.tion.as a better treatmen.. Both treatmen.s were well tolerated. Data suggest that oral magaldrate/domperidon. mixture could be a better option.in.the treatmen. of gastroesophageal reflux symptoms than.on.y domperidon..

关键词： An.iacid Domperidon. Gastroesophageal Reflux Magaldrate Prokin.tic

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科学术语渊源小词典

Improvin. social media use for disaster resilien.e: challen.es an. strategies

1991年

作者： isaac·阿西莫夫(isaac Asimov)

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In.ern.tion.l Journ.l of Digital Earth 2023年第1期16卷 3023-3044页

作者： n.n. S.n.Lam Michelle Meyer Margaret Reams Seun.won.Yan. Kisun. Lee Lei Zou Volodymyr Mihun.v Kejin.Wan. Ryan.Kirby Hen. Cai Departmen. of En.iron.en.al Scien.es Louisiana State UniversityBaton RougeUSA Lan.scape Architecture an. Urban.Plan.in. Texas A&M UniversityCollege StationUSA School of In.ormation.Studies Center for Computation and TechnologyLouisiana State UniversityBaton RougeUSA Division.of Computer Scien.e an. En.in.erin. Louisiana State UniversityBaton RougeUSA Departmen. of Geography Texas A&M UniversityCollege StationUSA Escambia Coun.y n.tural Resources Man.gemen. PensacolaFloridaUSA

This paper develops a social media-disaster resilien.e an.lysis framework by categorizin. types of social media use an. their challen.es to better un.erstan. an. assess its role in.disaster resilien.e research an. *** framework is derived primarily from several case studies of Twitter use in.three hurrican. even.s in.the Un.ted States-Hurrican.s isaac,San.y,an. *** paper first outlin.s four major con.ribution. of social media data for disaster resilien.e research an. man.gemen.,which in.lude servin. as an.effective commun.cation.platform,providin. groun. truth in.ormation.for emergen.y respon.e an. rescue operation.,providin. in.ormation.on.people's sen.imen.s,an. allowin. predictive ***,there are four_key challen.es to its uses,which in.lude,easy spreadin. of false in.ormation.social an. geographical disparities of Twitter use,techn.cal issues on.processin. an. an.lyzin. big an. n.isy data,especially on.improvin. the location.l accuracy of the tweets,an. algorithm bias in.Al an. other types of ***,the paper proposes twen.y strategies that the four sectors of the social media commun.ty-organ.zation.,in.ividuals,social media compan.es,an. researchers-could take to improve social media use to in.rease disaster resilien.e.

关键词： Twitter use challen.es an. strategies disaster resilien.e social an. geographical disparities emergen.y rescue Hurrican. isaac Hurrican. San.y Hurrican. Harvey