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Brentuximab Vedotin Monotherapy and Combined with Low Dose Donor Lymphocyte Infusion to Control Minimal Residual Disease and Sustain Clinical Remission in a Child with Relapsed Anaplastic Large Cell Lymphoma

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Journal of Cancer Therapy 2017年第8期8卷 683-690页

作者： Alina S.fedorova Maria V.Stegantseva Nina V.Minakovskaya Olga V.Aleinikova Clinical Research Department Belarusian Research Center for Pediatric OncologyHematology and ImmunologyMinsk RegionBelarus Laboratory of Genetic Biotechnology Belarusian Research Center for Pediatric OncologyHematology and ImmunologyMinsk RegionBelarus Department of Bone Marrow Transplantation Belarusian Research Center for Pediatric OncologyHematology and ImmunologyMinsk RegionBelarus

Minimal residual disease (MRD) appears to have a strong negative predictive value for disease recurrence in children with anaplastic large cell lymphoma (ALCL). Brentuximab vedotin (BV) can be a therapeutic option for MRD-positive patients to achieve molecular remission and to decrease risk of subsequent relapse. We here report a 4-year-old child with ALCL progression during relapse treatment who received BV as a bridging therapy before haploidentical hematopoietic stem-cell transplantation, and as a maintenance therapy post-transplant alone or combined with simultaneous low dose donor-lymphocyte infusions. MRD monitoring showed a complete molecular response and reflected both BV efficiency and graft-versus-lymphoma effect.

关键词： Anaplastic Large Cell Lymphoma Relapse Brentuximab Vedotin Donor Lymphocyte Infusion Minimal Residual Disease

Peculiarities of Calculating Bridges with Seismic Isolation Including Spherical Bearings and Hydraulic Dampers in Russia

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Journal of Civil Engineering and Architecture 2015年第4期9卷 401-409页

作者： Natalia V. Durseneva Andrey V. Indeykin Inna O. Kuznetsova Alexander M. Uzdin Maria fedorova Theoretical Mechanics Department St-Petersburg State Railway Transport University St-Petersburg 190031 Russia Faculty of Mathematics and Mechanics St-Petersburg State University St-Petersburg 191119 Russia

The peculiarities of calculating isolated structures with spherical bearings are analyzed in this paper. Some of peculiarities are caused by the lack of data at the moment when engineering solutions had to be made, Other peculiarities are connected with physical peculiarities of the device behaviour. To provide the analysis of structure hehaviour under the condition of the lack of input information, two types of design models of seismic protection devices were considered. They are the dampers linearization and the modelling of real dampers by dry friction ones. The dampers linearization makes it possible to use the existing software for calculating linear strongly-damped systems. To calculate structures with dry friction dampers, a new software was worked out. In this case, the structure is described as a piecewise-linear system of a relay-type. The investigations of the structure oscillations take into account both horizontal and vertical components of earthquake input. Under this condition, horizontal oscillation equations of structures are the MaRie-Hill ones. The input and structure parameters which caused the structure instability are estimated. To exclude the structure instability, high damping devices should be used. These methods were used for seismic resistant analysis of bridges with spherical bearings and hydraulic dampers applied in Sochi.

关键词： Seismic isolation spherical bearings hydraulic dampers calculations.

Microbiota of Fossil Animals Preserved in Yakut Permafrost

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Journal of Earth Science and Engineering 2014年第8期4卷 484-489页

作者： Neustroev Mikhail Petrovich Tarabukina Nadezhda Petrovna Neustroev Mikhail Mikhailovich fedorova Marfa Pavlovna Stepanova Anna Mikhailovna Parnikova Svetlana Ivanovna Baishev AlekseyAntonovich Laboratory of Veterinary Biotechnology SSI YSRIA (Yakut Scientific Research Institute of Agriculture) Yakutsk 677001 Russia Laboratory of Microbial Preparations Development SSI YSRIA (Yakut Scientific Research Institute of Agricluture) Yakutsk677001 Russia Institute of Natural Sciences NEFU (North-Eastern Federal University) Yakutsk 677001 Russia

Microbiological investigation of the fossil animals preserved in permafrost represents obvious interest for science. Lack of data in this sphere gives even greater importance to any findings giving us opportunity to learn more about remote past of microorganisms. In this respect, preserved remains of fossil are considered as unique biological materials for scientific investigations. Bacillus bacteria strains isolated from the paleomicrobiota of mammoth fauna are not only have high durability （20-30 thousand of years） in permafrost, but are still able to produce biologically active substances. Strains of bacteria of the genus Bacillus, isolated from the tissues of the representatives of the mammoth fauna have strong antagonistic properties to hemolytic streptococci--Streptococcus equi, pathogenic for animals--Salmonella abortus equi, also toxigenic micromycetes genera Aspergillus, Alternuria, Penicillum and fungal pathogens of plant diseases--Botrytis cimeria and Fuzarium oxysporium. The strains of bacteria of the genus Bacillus are not pathogenic to plants and animals, but initially resistant to wide range of antibiotics. Dominance strains of Bacillus bacteria, producing strong bacteriocins in the soft tissues of fossil animals, contributing to their long cryo bio conservation. In addition, bacterial strains of Bacillus subtilis, isolated from paleo microbiota have strong oxidizing properties. Microbiota of fossils preserved in permafrost of Yakutia is of particular interest for microbiology and modem biotechnology.

关键词： Permafrost mammoth fauna microflora Bacillus modem biotechnology.

Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound

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Chinese Optics Letters 2017年第9期15卷 2-6页

作者： O.Semyachkina-Glushkovskaya A.Abdurashitov A.Pavlov A.Shirokov N.Navolokin O.Pavlova A.Gekalyuk M.Ulanova N.Shushunova A.Bodrova E.Saranceva A.Khorovodov I.Agranovich V.fedorova M.Sagatova A.E.Shareef C.Zhang D.Zhu V.Tuchin Saratov National Research State University Saratov 410012Russia Yuri Gagarin State Technical University of Saratov Saratov 410054Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of SciencesSaratov 410049Russia Saratov State Medical University Saratov 410012Russia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and Technology(HUST)Wuhan 430074China Key Laboratory for Biomedical Photonics HUSTMinistry of EducationWuhan 430074China National Research Tomsk State University Tomsk 634050Russia Institute of Precision Mechanics and Control Russian Academy of SciencesSaratov 410028Russia

The cerebral blood flow（CBF） alterations related to sound-induced opening of the blood–brain barrier（BBB） in adult mice are studied using laser speckle contrast imaging（LSCI） and wavelet analysis of vascular *** results clearly show that the opening of the BBB is accompanied by the changes of venous but not microvessel circulation in the brain. The elevation of the BBB permeability is associated with the decrease of venous CBF and the increase of its complexity. These data suggest that the cerebral veins rather than microvessels are sensitive components of the CBF related to the opening BBB.

关键词： BBB Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood brain barrier by sound

Novel materials for solid oxide fuel cells cathodes and oxygen separation membranes:Fundamentals of oxygen transport and performance

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Carbon Resources Conversion 2020年第1期3卷 112-121页

作者： Vladislav A.Sadykov Ekaterina M.Sadovskaya Nikita F.Eremeev Elena Yu.Pikalova Nina M.Bogdanovich Elena A.Filonova Tamara A.Krieger Yulia E.fedorova Alexey V.Krasnov Pavel I.Skriabin Anton I.Lukashevich Robert Steinberger-Wilckens Izaak C.Vinke Federal Research Center Boreskov Institute of Catalysis SB RAS 630090 NovosibirskRussia Novosibirsk State University 630090 NovosibirskRussia Institute of High Temperature Electrochemistry UB RAS 620137 YekaterinburgRussia Ural Federal University 620002 YekaterinburgRussia University of Birmingham EdgbastonBirmingham B152TTUK Forschungszentrum Jülich GmbH 52425 JülichGermany

In the field of modern hydrogen energy,obtaining pure hydrogen and syngas and then being able to use them for green energy production are significant *** solid oxide fuel cells(SOFC)and catalytic membranes for oxygen separation as well as materials for these devices is one of the most likely ways to solve these *** this work,the authors’recent studies in this field are reviewed;the fundamentals of developing materials for SOFC cathodes and oxygen separation membranes’permselective layers based on research of their oxygen mobility and surface reactivity are ***-Popper phases Ln_(2-x)Ca_(x)NiO_(4+δ)(LnCNO)and perovskite-fluorite nanocomposites PrNi_(0.5)Co_(0.5)O_(3-δ)-Ce_(0.9)Y_(0.1)O_(2-δ)(PNC-YDC)were studied by isotope exchange of oxygen with C_(18)O_(2)and^(18)O_(2)in flow and closed *** LnCNO a high oxygen mobility was shown(D*~10^(-7)cm^(2)/s at 700℃),being provided by the cooperative mechanism of oxygen migration involving both regular and highly-mobile interstitial *** PNC-YDC dominated a wide fast diffusion channel via fluorite phase and interphases due to features of the redistribution of cations resulting in superior oxygen mobility(D*~10^(-8)cm^(2)/s at 700℃).After optimization of composition and nanodomain structure of these materials,as cathodes of SOFC they provided a high power density,while for asymmetric supported oxygen separation membranes-a high oxygen permeability.

关键词： Solid oxide fuel cells Oxygen separation membranes Oxygen mobility Perovskites Nanocomposites Ruddlesden-Popper phases

Agonist-directed sorting of β2-adrenergic receptor signaling and its therapeutic implication in heart

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郑州大学学报(医学版) 2000年第1期35卷 37-45页

作者： ZHANG Shengjun,XIAO Ruiping,ZHOU Yingying,Meike Kuschel,XIA Xianmin,Richard A.Bond ,Olga V.fedorova,Alex Y.Bagrov,C.Wiuiam Balke,Edward G.Lakatta,CHEN Heping Laboratory of Cardiovascular Science ,Gerontology Research Center,NIA,NIH,Baltimore,MD 21224

Cardiac β 2 adrenergic receptor (AR) dually couples to G s and to pertussis toxin(PTX) sensitive G i proteins ,resulting in opposing effects on cell *** we show that the coupling preference of β 2AR to the bifurcated signaling pathways,tested over wide ranges of agonist concentrations and receptor densities,is determined by agonist *** β 2AR agonists including zinterol,procaterol or salbutamol activate concurrent G s and G i signaling in both rat and mouse ventricular myocytes,as evidenced by a marked potentiating effect of PTX on contractile ***,however ,sorts the β 2AR primarily to G s signaling,as evidenced by the lack of effect of *** results were observed in transgenic mice overexpressing human β *** cells from failing rat hearts where the contractile response to zinterol was severely depressed due to an up regulation of G i,fenoterol,which activates G s bypassing the G i signaling pathway,rescued the diminished β 2AR ***,agonist directed sorting of receptor stimulus affords a novel therapeutic strategy to enhance desired “signaling specific”effects while avoiding adverse side effects of therapeutic agents.

关键词： adrenergic beta receptor agonists G protein toxins cell contra-ctihty

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亚马尔北极和亚北极地区考古研究

北冰洋研究 2019年第1期 34-44页

作者： [俄]Н.В.费奥多洛娃齐山德(译) 俄罗斯亚马尔-涅涅茨自治区萨列哈尔德市北极研究中心聊城大学历史文化与旅游学院北冰洋研究中心

西西伯利亚北极和亚北极地区考古研究始于20世纪20年代初,21世纪以前,仅莫斯科和列宁格勒的考古小组进行了初步考察。关于新世纪以来考古研究的进展情况,本文从以下三个方面阐述:①该区域人类居住史,包括鄂毕河谷、亚马尔半岛及吉丹半... 详细信息

西西伯利亚北极和亚北极地区考古研究始于20世纪20年代初,21世纪以前,仅莫斯科和列宁格勒的考古小组进行了初步考察。关于新世纪以来考古研究的进展情况,本文从以下三个方面阐述:①该区域人类居住史,包括鄂毕河谷、亚马尔半岛及吉丹半岛。②极地适应性的形成,包括经济、社会文化特征及生物适应性。③该区域与邻近地区古典和中世纪文明的联系。大体而言,2000年至今,得益于俄罗斯国家对极地考古研究的支持,西西伯利亚北极和亚北极地区发现大量遗迹,与此同时有相当数量的学术著作问世,涌现出相当数量综合性的、跨学科的、学术价值较高的考古科研成果。

关键词：西西伯利亚北极和亚北极石器时代和青铜时代早期铁器时代中世纪跨学科研究