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The role of graft reperfusion sequence in the development of non-anastomotic biliary strictures following orthotopic liver transplantation: A meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 4-11页

作者： Mohamed Bekheit Matteo Catanzano Stuart Shand irfan Ahmed ELSaid ELKayal Gihan Mohamed Shehata Adel Zaki Center of Liver Surgery and Transplantation Paul Brousse Hospital University of Paris-Sud Medical Research Institute University of Alexandria HPB Surgery Unit Department of Surgery Aberdeen Royal Infirmary Department of Surgery Elkabbary General Hospital University of Aberdeen Department of Surgery Alexandria Main University Hospital Faculty of Medicine

Background: Liver transplant is a potential cure for liver failure and hepatic malignancy but there are many techniques which have been described for vascular reconstruction. This study was to compare the prevalence of non-anastomotic biliary stricture and other surgical complications based on Clavien-Dindo scoring system, in initial portal reperfusion(sequential) versus simultaneous or initial artery reperfusion. Data sources: Meta-analysis of published studies comparing the outcomes of both techniques was carried out. Data search was conducted across the major databases and studies were selected under the guidance of the Cochrane guidelines for systematic reviews and meta-analysis. Results: Seven studies were included to address the primary and the secondary outcomes. No statistical difference was found in the incidence of non-anastomotic biliary strictures(OR = 0.40; P = 0.14), regardless of reperfusion technique. The pooled estimate of the Clavien-Dindo grading of complications was not significantly different between the techniques, though Clavien-Dindo II complications were higher in the simultaneous or initial artery reperfusion group than the initial portal reperfusion group(OR = 2.73; P = 0.01). Similarly, there was no difference in the operative time, hospital stay and other outcomes addressed in this report. Conclusions: The available evidence suggests that there is no significant difference demonstrated in the rate of non-anastomotic biliary strictures or other complications, between the two techniques, except for Clavien-Dindo II complications.

关键词： Liver transplantation Organ transplantation Liver surgery Rejection

Transcription regulators differentiate mesenchymal stem cells into chondroprogenitors,and their in vivo implantation regenerated the intervertebral disc degeneration

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World Journal of Stem Cells 2022年第2期14卷 163-182页

作者： Shumaila Khalid Sobia Ekram Asmat Salim G.Rasul Chaudhry irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Department of Biological Sciences Oakland UniversityRochesterMI 48309United States

BACKGROUND Intervertebral disc degeneration(IVDD)is the leading cause of lower back *** degeneration is characterized by reduced cellularity and decreased production of extracellular matrix(ECM).Mesenchymal stem cells(MSCs)have been envisioned as a promising treatment for degenerative ***-based therapy using ECM-producing chondrogenic derivatives of MSCs has the potential to restore the functionality of the intervertebral disc(IVD).AIM To investigate the potential of chondrogenic transcription factors to promote differentiation of human umbilical cord MSCs into chondrocytes,and to assess their therapeutic potential in IVD *** MSCs were isolated and characterized morphologically and immunologically by the expression of specific *** were then transfected with Sox-9 and Six-1 transcription factors to direct differentiation and were assessed for chondrogenic lineage based on the expression of specific *** differentiated MSCs were implanted in the rat model of *** regenerative potential of transplanted cells was investigated using histochemical and molecular analyses of *** Isolated cells showed fibroblast-like morphology and expressed CD105,CD90,CD73,CD29,and Vimentin but not CD45 *** of Sox-9 and Six-1 greatly enhanced the gene expression of transforming growth factor beta-1 gene,BMP,Sox-9,Six-1,and Aggrecan,and protein expression of Sox-9 and *** implanted cells integrated,survived,and homed in the degenerated intervertebral *** grading showed that the transfected MSCs regenerated the IVD and restored normal *** Genetically modified MSCs accelerate cartilage regeneration,providing a unique opportunity and impetus for stem cell-based therapeutic approach for degenerative disc diseases.

关键词： Intervertebral disc degeneration Human umbilical cord Transcription factors Mesenchymal stem cells Gene expression Regeneration

Enhanced room temperature ferromagnetism in Cr-doped ZnO nanoparticles prepared by auto-combustion method

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Journal of Semiconductors 2018年第4期39卷 20-27页

作者： Khizar-ul Haq M.irfan Muhammad Masood Murtaza Saleem Tahir Iqbal Ishaq Ahmad M.A.Khan M.Zaffar Muhammad irfan Department of Physics Mirpur University of Science and Technology (MUST) Department of Physics SBASST Lahore University of Management Sciences Experimental Physics Labs National Centre for Physics Quaid-e-Azam University Department of Physics University of Azad Jammu and Kashmir Muzaffarabad

Zn1-xCrxO （x = 0.00, 0.01, 0.03, 0.05, 0.07, and 0.09） nanoparticles were synthesized, by an auto-com- bustion method. Structural, optical, and magnetic characteristics of Cr-doped ZnO samples calcined at 600 ℃ have been analyzed by using X-ray diffraction （XRD）, field emission scanning electron microscope （FESEM）, UV-Vis spectroscopy and vibrating sample magnetometer （VSM）. The XRD data confirmed the hexagonal wurtzite structure of pure and Cr-doped ZnO nanoparticles. The calculated values of grain size using Scherrer＇s formula are in the range of 30.7-9.2 nm. The morphology of nanopowders has been observed by FESEM, and EDS results con- firmed a systematic increase of Cr content in the samples and clearly indicate with no impurity element. The band gaps, computed by UV-Vis spectroscopy, are in the range of 2.83-2.35 eV for different doping concentrations. By analyzing VSM data, significantly enhanced room temperature ferromagnetism is identified in Cr-doped ZnO samples. The value of magnetization is a 12 times increased of the value reported by Daun et al. （2010）. Room temperature ferromagnetism of the nanoparticles is of vital prominence for spintronics applications.

关键词： Cr-doped ZnO auto-combustion DMS ferromagnetism

Impact of Artificial Compressibility on the Numerical Solution of Incompressible Nanofluid Flow

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Computers, Materials & Continua 2023年第3期74卷 5123-5139页

作者： Tohid Adibi Shams Forruque Ahmed Seyed Esmail Razavi Omid Adibi irfan Anjum Badruddin Syed Javed Department of Mechanical Engineering University of BonabBonabIran Science and Math Program Asian University for WomenChattogram4000Bangladesh School of Mechanical Engineering University of TabrizTabrizIran Energy Management Group Energy and Environment Research CenterNiroo Research InstituteTehranIran Mechanical Engineering Department College of EngineeringKing Khalid UniversityAbha61421Saudi Arabia

The numerical solution of compressible flows has become more prevalent than that of incompressible *** the help of the artificial compressibility approach,incompressible flows can be solved numerically using the same methods as compressible *** artificial compressibility scheme is thus widely used to numerically solve incompressible Navier-Stokes *** numerical method highly depends on its accuracy and speed of *** the artificial compressibility approach is utilized in several numerical simulations,the effect of the compressibility factor on the accuracy of results and convergence speed has not been investigated for nanofluid flows in previous ***,this paper assesses the effect of this factor on the convergence speed and accuracy of results for various types of *** improve the stability and convergence speed of time discretizations,the fifth-order Runge-Kutta method is applied.A computer program has been written in FORTRAN to solve the discretized equations in different Reynolds and Grashof numbers for various *** results demonstrate that the artificial compressibility factor has a noticeable effect on the accuracy and convergence rate of the *** optimum artificial compressibility is found to be between 1 and *** findings can be utilized to enhance the performance of commercial numerical simulation tools,including ANSYS and COMSOL.

关键词： Navier-Stokes equations incompressible flow artificial compressibility convergence rate convection flow

A Hybrid Feature Selection Framework for Predicting Students Performance

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Computers, Materials & Continua 2022年第1期70卷 1893-1920页

作者： Maryam Zaffar Manzoor Ahmed Hashmani Raja Habib KS Quraishi Muhammad irfan Samar Alqhtani Mohammed Hamdi High Performance Cloud Computing(HPC3) Department of Computer and Information SciencesUniversiti Teknologi PETRONAS32610SeriIskandarMalaysia Department of Computer Science and Information Technology University of LahorePakistan Department of Process Engineering Pakistan Institute of Engineering&Applied SciencesNiloreIslamabadPakistan Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Saudi Arabia College of Computer Science and Information Systems Najran University61441NajranSaudi Arabia

Student performance prediction helps the educational stakeholders to take proactive decisions and make interventions,for the improvement of quality of education and to meet the dynamic needs of *** selection of features for student’s performance prediction not only plays significant role in increasing prediction accuracy,but also helps in building the strategic plans for the improvement of students’academic *** are different feature selection algorithms for predicting the performance of students,however the studies reported in the literature claim that there are different pros and cons of existing feature selection algorithms in selection of optimal *** this paper,a hybrid feature selection framework(using feature-fusion)is designed to identify the significant features and associated features with target class,to predict the performance of *** main goal of the proposed hybrid feature selection is not only to improve the prediction accuracy,but also to identify optimal features for building productive strategies for the improvement in students’academic *** key difference between proposed hybrid feature selection framework and existing hybrid feature selection framework,is two level feature fusion technique,with the utilization of cosine-based ***,according to the results reported in existing literature,cosine similarity is considered as the best similarity measure among existing similarity *** proposed hybrid feature selection is validated on four benchmark datasets with variations in number of features and number of *** validated results confirm that the proposed hybrid feature selection framework performs better than the existing hybrid feature selection framework,existing feature selection algorithms in terms of accuracy,f-measure,recall,and *** reported in presented paper show that the proposed approach gives more than 90%accuracy on benchmark dataset that is better tha

关键词： Educational data mining feature selection hybrid feature selection

Overexpression of GATA binding protein 4 and myocyte enhancer factor 2C induces differentiation of mesenchymal stem cells into cardiac-like cells

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World Journal of Stem Cells 2022年第9期14卷 700-713页

作者： Syeda Saima Razzaq irfan Khan Nadia Naeem Asmat Salim Sumreen Begum Kanwal Haneef University of Karachi Karachi 75270Pakistan Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270Pakistan Dow Research Institute of Biotechnology&Biomedical Sciences(DRIBBS) Dow University of Health Sciences(DUHS)Ojha CampusKarachi 75200Pakistan Stem Cells Research Laboratory(SCRL) Sindh Institute of Urology and Transplantation(SIUT)Karachi 74200Pakistan

BACKGROUND Heart diseases are the primary cause of death all over the *** myocardial infarction,billions of cells die,resulting in a huge loss of cardiac *** cell-based therapies have appeared as a new area to support heart *** transcription factors GATA binding protein 4(GATA-4)and myocyte enhancer factor 2C(MEF2C)are considered prominent factors in the development of the cardiovascular *** To explore the potential of GATA-4 and MEF2C for the cardiac differentiation of human umbilical cord mesenchymal stem cells(hUC-MSCs).METHODS hUC-MSCs were characterized morphologically and immunologically by the presence of specific markers of MSCs via immunocytochemistry and flow cytometry,and by their potential to differentiate into osteocytes and ***-MSCs were transfected with GATA-4,MEF2C,and their combination to direct the *** differentiation was confirmed by semiquant itative real-time polymerase chain reaction and *** hUC-MSCs expressed specific cell surface markers CD105,CD90,CD44,and vimentin but lack the expression of *** transcription factors GATA-4 and MEF2C,and their combination induced differentiation in hUC-MSCs with significant expression of cardiac genes i.e.,GATA-4,MEF2C,NK2 homeobox 5(NKX2.5),MHC,and connexin-43,and cardiac proteins GATA-4,NKX2.5,cardiac troponin T,and *** Transfection with GATA-4,MEF2C,and their combination effectively induces cardiac differentiation in *** genetically modified MSCs could be a promising treatment option for heart diseases in the future.

关键词： Heart disease GATA binding protein 4 Myocyte enhancer factor 2C Transcription factors Differentiation Human umbilical cord-mesenchymal stem cells

Exploring Placer Gold Deposits through Integrated Geophysical and Geochemical Techniques at the Confluence of the Indus and Kabul Rivers,NW Pakistan

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Acta Geologica Sinica(English Edition) 2020年第5期94卷 1440-1450页

作者： Asghar ALI Khaista REHMAN Owais TAYYAB Tahir ZAMAN Mahad JAMEEL Azeem KHAN Rafique AHMAD Muhammad irfan Department of Geology University of PeshawarKhyber Pakhtunkhwa 25120Pakistan National Centre of Excellence in Geology University of PeshawarKhyber Pakhtunkhwa 25120Pakistan Department of Geology The Bacha Khan UniversityCharsadda24420Pakistan

Analysis of the anomalous magnetic mineral intensities and geochemistry for placer gold deposits are presented for those of the Attock area at the confluence of the Indus and Kabul rivers in northwestern *** grids covering an area of 10 x18 m2 and 8 x10 m2 were analyzed using a G-858 Cesium Vapor *** anomalous zones obtained were plotted on contour maps,2 D and 3 D magnetic intensity *** on the magnetic anomalies,grid-1 of the study area was sampled at three different anomalous zones for geochemical *** zones contain gold concentrations,ranging from 2.11 ppm to 6.109 ppm with an average of 4.01 *** in gold concentration in the subsurface within the anomalous zones indicates that magnetometer survey followed by a geochemical analysis can potentially narrow down the gold-bearing anomalous zones.

关键词： geochemistry geophysics placer gold deposits magnetometer survey anomalous zones Pakistan

Zinc enhances the cell adhesion,migration,and self-renewal potential of human umbilical cord derived mesenchymal stem cells

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World Journal of Stem Cells 2023年第7期15卷 751-767页

作者： Iqra Sahibdad Shumaila Khalid G Rasul Chaudhry Asmat Salim Sumreen Begum irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Department of Biological Sciences Oakland UniversityRochesterMI 48309United States Stem Cell Research Laboratory(SCRL) Sindh Institute of Urology and Transplantation(SIUT)Karachi 74200SindhPakistan

BACKGROUND Zinc(Zn)is the second most abundant trace element after Fe,present in the human *** is frequently reported in association with cell growth and proliferation,and its deficiency is considered to be a major disease contributing *** To determine the effect of Zn on in vitro growth and proliferation of human umbilical cord(hUC)-derived mesenchymal stem cells(MSCs).METHODS hUC-MSCs were isolated from human umbilical cord tissue and characterized based on immunocytochemistry,immunophenotyping,and tri-lineage *** impact of Zn on cytotoxicity and proliferation was determined by MTT and Alamar blue *** determine the effect of Zn on population doubling time(PDT),hUC-MSCs were cultured in media with and without Zn for several *** in vitro scratch assay was performed to analyze the effect of Zn on the wound healing and migration capability of hUC-MSCs.A cell adhesion assay was used to test the surface adhesiveness of *** analysis of genes involved in the cell cycle,proliferation,migration,and selfrenewal of hUC-MSCs was performed by quantitative real-time polymerase chain *** protein expression of Lin28,a pluripotency marker,was analyzed by *** Zn at lower concentrations enhanced the rate of proliferation but at higher concentrations(>100μM),showed concentration dependent cytotoxicity in ***-MSCs treated with Zn exhibited a significantly greater healing and migration rate compared to untreated *** also increased the cell adhesion rate,and colony forming efficiency(CFE).In addition,Zn upregulated the expression of genes involved in the cell cycle(CDC20,CDK1,CCNA2,CDCA2),proliferation(transforming growth factorβ1,GDF5,hypoxia-inducible factor 1α),migration(CXCR4,VCAM1,VEGF-A),and self-renewal(OCT4,SOX2,NANOG)of *** of Lin28 protein was significantly increased in cells treated with *** Our findings suggest that zinc enhances the proliferat

关键词： Human umbilical cord Mesenchymal stem cells Zinc Cell proliferation In vitro expansion

Click through Rate Effectiveness Prediction on Mobile Ads Using Extreme Gradient Boosting

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Computers, Materials & Continua 2021年第2期66卷 1681-1696页

作者： AlAli Moneera AlQahtani Maram AlJuried Azizah Taghareed AlOnizan Dalia Alboqaytah Nida Aslam irfan Ullah Khan College of Computer Science and Information Technology Imam Abdulrahman bin Faisal UniversityDammam34221Saudi Arabia

Online advertisements have a significant influence over the success or failure of your ***,it is important to somehow measure the impact of your advertisement before uploading it online,and this is can be done by calculating the Click Through Rate(CTR).Unfortunately,this method is not eco-friendly,since you have to gather the clicks from users then compute the *** is where CTR prediction come in *** CTR prediction relies on the users’log regarding click information *** prediction of CTR is a challenging and critical process for e-advertising platforms these *** prediction uses machine learning techniques to determine how much the online advertisement has been clicked by a potential client:The more clicks,the more successful the ad *** this study we develop a machine learning based click through rate prediction *** proposed study defines a model that generates accurate results with low computational power *** used four classification techniques,namely K Nearest Neighbor(KNN),Logistic Regression,Random Forest,and Extreme Gradient Boosting(XGBoost).The study was performed on the Click-Through Rate Prediction Competition *** is a click-through data that is ordered chronologically and was collected over 10 *** results reveal that XGBoost produced ROC-AUC of 0.76 with reduced number of features.

关键词： Advertisement XGBoost random forest K-nearest-neighbor logistic regression click through rate