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Journal of Environmental Sciences 2011年第3期23卷 372-380页

作者： Xiaohong Guan Haoran Dong Jun Ma irene M. C. Lo State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology Harbin 150090 China Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology Hong Kong 999077 China

Chromium and/or arsenate removal by Fe（Ⅱ） as a function of pH, Fe（Ⅱ） dosage and initial Cr（Ⅵ）/As（Ⅴ） ratio were examined in batch tests. The presence of arsenate reduced the removal efficiency of chromium by Fe（Ⅱ）, while the presence of chromate significantly increased the removal efficiency of arsenate by Fe（Ⅱ） at pH 6-8, In the absence of arsenate, chromium removal by Fe（Ⅱ） increased to a maximum with increasing pH from 4 to 7 and then decreased with a further increase in pH. The increment in Fe（Ⅱ） dosage resulted in an improvement in chromium removal and the improvement was more remarkable under alkaline conditions than that under acidic conditions. Chromium removal by Fe（Ⅱ） was reduced to a larger extent under neutral and alkaline conditions than that under acidic conditions due to the presence of 10 μtmol/L arsenate. The presence of 20 μmol/L arsenate slightly improved chromium removal by Fe（Ⅱ） at pH 3.9-5,8, but had detrimental effects at pH 6.7-9.8. Arsenate removal was improved significantly at pH 4-9 due to the presence of 10μmol/L chromate at Fe（Ⅱ） dosages of 20-60 μmol/L. Elevating the chromate concentration from 10 to 20μmol/L resulted in a further improvement in arsenate removal at pH 4.0-4.6 when Fe（Ⅱ） was dosed at 30-60 μmol/L.

关键词： chromium removal arsenate removal ferrous iron groundwater treatment

Mathematical approach for understanding deagglomeration behaviour of drug powder in formulations with coarse carrier

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Asian Journal of Pharmaceutical Sciences 2015年第6期10卷 501-512页

作者： irene Parisini James L.Collett Darragh Murnane Department of Pharmacy University of HertfordshireHatfieldAL109ABUK Pharmaceutical&Preclinical Development Department Aptuit SrlVeronaItaly Science&Technology Research Institute University of HertfordshireHatfieldAL109ABUK

Deagglomeration of cohesive particles in combination with coarse carrier is a key requirement for inhaled *** aim of the project was to propose a mathematical approach to understand aerosolization behaviour of micronized particles alone and in formulation with *** sulphate and salmeterol xinafoate were blended separately with fine lactose(ratio 1:4)and fine and coarse lactose(1:4:63.5).Laser diffraction was employed to characterize the powder median particle *** deagglomeration of micronized materials followed an asymptotic monoexponential *** the coarse lactose was added,the relationship fitted a bi-exponential equation showing an easily and a poorly dispersed *** model hydrophobic and hydrophilic APIs,this study has demonstrated the utility of an analytical approach that can parameterize deagglomeration behaviour of carrier-free and carrier-based inhalation *** analytical approach provides the ability to systematically study the effect of material,formulation and processing factors on deagglomeration behaviour.

关键词： Ternary agents Deagglomeration Cohesive powders Non-linear regression modelling

An ontological modelling of multi-attribute criticality analysis to guide Prognostics and Health Management program development

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Autonomous Intelligent Systems 2022年第1期2卷 16-31页

作者： Adalberto Polenghi irene Roda Marco Macchi Alessandro Pozzetti Department of Management Economics and Industrial EngineeringPolitecnico di MilanoP.zza Leonardo da Vinci 3320133 MilanItaly

Digital technologies are becoming more pervasive and industrial companies are exploiting them to enhance the potentialities related to Prognostics and Health Management(PHM).Indeed,PHM allows to evaluate the health state of the physical assets as well as to predict their future *** be effective in developing PHM programs,the most critical assets should be identified so to direct modelling *** techniques could be adopted to evaluate asset criticality;in industrial practice,criticality analysis is amongst the most *** the advancement of artificial intelligence for data analysis and predictions,the criticality analysis,which is built upon both quantitative and qualitative data,has not been improved *** is the goal of this work to propose an ontological formalisation of a multi-attribute criticality analysis in order to i)fix the semantics behind the terms involved in the analysis,ii)standardize and uniform the way criticality analysis is performed,and iii)take advantage of the reasoning capabilities to automatically evaluate asset criticality and associate a suitable maintenance *** developed ontology,called MOCA,is tested in a food company featuring a global *** application shows that MOCA can accomplish the prefixed goals;specifically,high priority assets towards which direct PHM programs are *** the long run,ontologies could serve as a unique knowledge base that integrate multiple data and information across facilities in a consistent *** such,they will enable advanced analytics to take place,allowing to move towards cognitive Cyber Physical Systems that enhance business performance for companies spread worldwide.

关键词： Criticality analysis Ontology Artificial intelligence Prognostics and Health Management PHM Maintenance

Structure and Function of TPC1 Vacuole SV Channel Gains Shape

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Molecular Plant 2018年第6期11卷 764-775页

作者： Rainer Hedrich Thomas D. Mueller Dirk Becker irene Marten Institute for Molecular Plant Physiology and Biophysics University of Wurzburg Julius-yon-Sachs Platz 2 97082 Wurzburg Germany

Plants and animals in endosomes operate TPCI/SV-type cation channels. All plants harbor at least one TPC1 gene. Although the encoded SV channel was firstly discovered in the plant vacuole membrane two decades ago, its biological function has remained enigmatic. Recently, the structure of a plant TPC1/SV channel protein was determined. Insights into the 3D topology has now guided site-directed mutation ap- proaches, enabling structure-function analyses of TPC1/SV channels to shed new light on earlier findings. Fou2 plants carrying a hyperactive mutant form of TPC1 develop wounding stress phenotypes. Recent studies with fou2 and mutants that lack functional TPC1 have revealed atypical features in local and long-distance stress signaling, providing new access to the previously mysterious biology of this vacuolar cation channel type in planta.

关键词： Ca^2+ sensors TPC1/SV channel vacuole membrane voltage voltage sensor

Continental accretion and incremental deformation in the thermochronologic evolution of the Lesser Caucasus

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Geoscience Frontiers 2019年第6期10卷 2189-2202页

作者： William Cavazza irene Albino Ghazar Galoyan Massimiliano Zattin Silvia Cattò Department of Biological Geologicaland Environmental SciencesUniversity of BolognaItaly Institute of Geological Sciences National Academy of SciencesYerevanArmenia Department of Geosciences University of PaduaItaly

Apatite fission-track analysis and thermochronologic statistical modeling of Precambrian-Oligocenc plutonic and metamorphic rocks from the Lesser Caucasus resolve two discrete cooling *** occurred during incremental crustal shortening due to obduction and continental accretion along the margins of the northern branch of the Neotethys.(1)The thermochronometric record of a Late Cretaceous(Turonian-Maastrichtian)cooling/exhumation event,coeval to widespread ophiolite obduction,is still present only in a relatively small area of the upper plate of the Amasia-Sevan-Akera(ASA)suture zone,*** suture marking the final closure of the northern Neotethys during the *** area has not been affected by significant later exhumation.(2)Rapid cooling/exhumation occurred in the Early-Middle Miocene in both the lower and upper plates of the ASA suture zone,obscuring previous thermochronologic signatures over most of the study *** contractional reactivation of the ASA suture zone occurred contemporaneously with the main phase of shortening and exhumation along the Bitlis suture zone marking the closure of the southern branch of the Neotethys and the ensuing ArabiaEurasia *** collisional stress from the Bitlis suture zone was transmitted northward across the Anatolian hinterland,which was left relatively undeformed,and focused along preexisting structural discontinuities such as the eastern Pontides and the ASA suture zone.

关键词： Lesser Caucasus Low-temperature thermochronology Apatite fission-track analysis Structural reactivation Far-field tectonics

Liver involvement in inflammatory bowel disease: What should the clinician know?

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World Journal of Hepatology 2021年第11期13卷 1534-1551页

作者： Giuseppe Losurdo irene Vita Brescia Chiara Lillo Martino Mezzapesa Michele Barone mariabeatrice Principi Enzo Ierardi Alfredo Di Leo maria Rendina Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy

Inflammatory bowel disease(IBD)may show a wide range of extraintestinal *** this context,liver involvement is a focal point for both an adequate management of the disease and its prognosis,due to possible serious *** association between IBD and primary sclerosing cholangitis is the most known *** association is relevant because it implies an increased risk of both colorectal cancer and ***,drugs such as thiopurines or biologic agents can cause drug-induced liver damage;therefore,this event should be considered when planning IBD ***,particular consideration should be given to the evidence that IBD patients may have concomitant chronic viral hepatitis,such as hepatitis B and hepatitis *** immunosuppressive regimens may cause a hepatitis flare or reactivation of a healthy carrier state,therefore careful monitoring of these patients is ***,the spread of obesity has involved even IBD patients,thus increasing the risk of non-alcoholic fatty liver disease,which has already proven to be more common in IBD patients than in the non-IBD *** phenomenon is considered an emerging issue,as it will become the leading cause of liver cirrhosis.

关键词： Inflammatory bowel disease Liver Primary sclerosing cholangitis Viral hepatitis Immunosuppression Non-alcoholic fatty liver disease

Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms

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Journal of Environmental Sciences 2017年第12期29卷 133-137页

作者： Renate Kopp irene Ozáez Martínez Jessica Legradi Juliette Legler Institute for Environmental Studies(IVM) VU University Amsterdam1081HVThe Netherlands. Biology and Environmental Toxicology Group Faculty of SciencesNational Distance Education University28015 MadridSpain Institute for Environment Health and SocietiesCollege of Health and Life SciencesBrunel University LondonUxbridgeUB8 3PHUnited Kingdom

A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24 hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds（EDCs）, including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens,can perturb both circadian clocks and lipid metabolism in vertebrates. Exposure of developing zebrafish to EDCs affects core clock activity and leads to a remarkable increase in lipid accumulation that is reminiscent of the effects observed for longdaysin, a known disruptor of circadian rhythms. Our data reveal a novel obesogenic mechanism of action for environmental chemicals, an observation which warrants further research. Because circadian clocks regulate a wide variety of physiological processes, identification of environmental chemicals capable of perturbing these systems may provide important insights into the development of environmentally-induced metabolic disease.

关键词： zebrafish adiposity tributyltin flame retardants clock genes

Laparoscopic appendectomy,stump closure and endoloops:A meta-analysis

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 1060-1071页

作者： Noemi Zorzetti Augusto Lauro maria irene Bellini Samuele Vaccari Barbara Dalla Via Maurizio Cervellera Roberto Cirocchi Salvatore Sorrenti Vito D’Andrea Valeria Tonini Department of General Surgery Ospedale Civile A CostaPorretta Terme 40046Italy Department of Surgical Sciences Sapienza UniversityRome 00161Italy Department of General Surgery Ospedale di BentivoglioBologna 40010Italy Department of Emergency Surgery St Orsola University HospitalBologna 40138Italy Department of General Surgery Ospedale Santissima AnnunziataTaranto 74121Italy Department of General Surgery Ospedale di TerniUniversitàdi PerugiaTerni 05100Italy

BACKGROUND Acute appendicitis(AA)is one of the main indications for urgent *** appendectomy(LA)has shown advantages in terms of clinical results and cost-effectiveness,even if there is still controversy about different devices to utilize,especially with regards to the endoloop(EL)vs endostapler(ES)when it comes to stump *** To compare safety and cost-effectiveness of EL vs *** From a prospectively maintained database,data of 996 consecutive patients treated by LA with a 3 years-follow up in the department of Emergency General Surgery-St Orsola University Hospital,Bologna(Italy)were retrieved.A metaanalysis was performed in terms of surgical complications,in comparison to the international literature published from 1995 to *** The meta-analysis showed no evidence regarding wound infections,abdominal abscesses,and total post-operative complications,in terms of superiority of a surgical technique for the stump closure in *** Even when AA is complicated,the routine use of EL is safe in most patients.

关键词： Acute appendicitis Laparoscopic appendectomy Endoloops Stapler Post-operative complications

Fuel cell performance assessment for closed-loop renewable energy systems

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Journal of Energy Chemistry 2016年第3期25卷 531-538页

作者： Fabio V.Matera irene Gatto Assunta Patti Enza Passalacqua CNR-ITAE Institute for Advanced Energy Technologies "N.Giordano" Via Salita S.Lucia sopra Contesse

Fuel cells and electrolysis are promising candidates for future energy production from renewable energy sources. Usually, polymer electrolyte fuel cell systems run on hydrogen and air, while the most of electrolysis systems vent out oxygen as unused by-product. Replacing air with pure oxygen, fuel cell electrochemical performance, durability and system efficiency can be significantly increased with a further overall system simplification and increased reliability. This work, which represents the initial step for pure H;/O;polymer electrolyte fuel cell operation in closed-loop systems, focuses on performance validation of a single cell operating with pure H;/O;under different relative humidity（RH） levels, reactants stoichiometry conditions and temperature. As a result of this study, the most convenient and appropriate operative conditions for a polymer electrolyte fuel cell stack integrated in a closed loop system were selected.

关键词： Polymer electrolyte fuel cell(PEFC) H_2/O_2 fuel cell Closed-loop fuel cell system

Phosphoinositide and Inositolpolyphosphate Signalling in Defense Responses of Arabidopsis thaliana Challenged by Mechanical Wounding

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Molecular Plant 2008年第2期1卷 249-261页

作者： Alina Mosblech Sabine Konig irene Stenzel Peter Grzeganek Ivo Feussner Ingo Heilmann Department of Plant Biochemistry Albrecht-yon-Hailer-Institute for Plant Sciences Georg-August-University G6ttingen Justus-von-Liebig-Weg 1137077 G6ttingen Germany

Various biochemical signals are implicated in Arabidopsis wound signalling, including jasmonic acid （JA）, salicylic acid, auxin, and Ca^2＋. Here, we report on cross-talk of phytohormones with phosphoinositide signals not previously implicated in plant wound responses. Within 30 min of mechanical wounding of Arabidopsis rosette-leaves, the levels of the lipid-derived soluble inositolpolyphosphate, inositol 1,4,5-trisphosphate （InsP3）, increased four to five-fold. Concom- itantly, the precursor lipids, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate and phosphatidylinositol transiently depleted, followed by re-synthesis after 30-60 min of stimulation. Increased InsP3 levels with wounding coincided with JA increases over the first hours of stimulation. In dde2-2-mutant plants deficient in JA biosynthesis, no InsP3 increase was observed upon wounding, indicating that JA was required for InsP3 formation, and InsP3 levels increased in wild-type plants challenged with sorbitol, increasing endogenous JA levels. In InsP 5-ptase plants with attenuated phosphoinositide signalling, the induction of wounding-inducible genes was diminished compared with wildtype plants, suggesting a role for phosphoinositide signalling in mediating plant wound responses. The gene-expression patterns suggest that phosphoinositides contribute to both JA-dependent and JA-independent aspects of wound signalling. Weight gain of Plutella xylostella caterpillars feeding on InsP 5-ptase plants was increased compared with that of caterpillars feeding on wild-type plants. The ecophysiological relevance of phosphoinositide signals in plant defense responses to herbivory is discussed in light of recent findings of inositolpolyphosphate involvement in phytohormone-receptor function.

关键词： Phosphoinositide and Inositolpolyphosphate Signalling Arabidopsis Mechanical Wounding