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A novel multi-shot target platform for laser-driven laboratory astrophysics experiments

High Power Laser Science and Engineering 2023年第2期11卷 11-19页

作者： Pablo Perez-martin irene Prencipe manfred Sobiella Fabian Donat Ning Kang Zhiyu He Huiya Liu Lei Ren Zhiyong Xie Jun Xiong Yan Zhang Florian-Emanuel Brack michalČervenák Pavel Gajdoš Lenka Hronová Kakolee Kaniz michaela Kozlová Florian Kroll Xiayun Pan Gabriel Schaumann Sushil Singh michalŠmíd Francisco Suzuki-Vidal Panzheng Zhang Jinren Sun Jianqiang Zhu miroslav Krůs Katerina Falk Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiation PhysicsDresdenGermany Technische Universität Dresden DresdenGermany Key Laboratory of High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghaiChina Institute of Plasma Physics Czech Academy of SciencesPragueCzech Republic Czech Technical University Faculty of Nuclear Sciences and Physical EngineeringPragueCzech Republic Department of Physics Jagannath UniversityDhakaBangladesh ELI-Beamlines Institute of PhysicsCzech Academy of SciencesPragueCzech Republic Institute for Nuclear Physics Technical University of DarmstadtDarmstadtGermany Institute of Physics Czech Academy of SciencesPragueCzech Republic Blackett Laboratory Imperial CollegeLondonUnited Kingdom First Light Fusion Oxford Industrial ParkYarntonOxfordUnited Kingdom

A new approach to target development for laboratory astrophysics experiments at high-power laser facilities is *** the dawn of high-power lasers,laboratory astrophysics has emerged as a field,bringing insight into physical processes in astrophysical objects,such as the formation of *** important factor for success in these experiments is *** date,targets have mainly relied on expensive and challenging microfabrication *** design presented incorporates replaceable machined parts that assemble into a structure that defines the experimental *** can make targets cheaper and faster to manufacture,while maintaining robustness and *** platform is intended for experiments on plasma flows,but it is flexible and may be adapted to the constraints of other experimental *** of targets used in experimental campaigns are shown,including a design for insertion in a high magnetic field *** results are included,demonstrating the performance of the targets.

关键词： high magnetic fields laboratory astrophysics laser-plasma interaction magnetized plasmas target design

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现代装饰（家居） 2016年第6期 16-27页

作者： Pitsou Kedem Tamar Berger irene Goldberg Hagar Arad Tsvi Amit Geron 范嘉苑以色列Pitsou Kedem Architects

项目地址以色列特拉维夫项目面积511m^2设计单位Pitsou Kedem Architects工业革命促进的技术进步,使铁及混凝土在建筑方面的运用得到普及,并带来了现代主义的福音。位于以色列特拉维夫的这座住房也是以铁及混凝土作为主要建材,其内部及... 详细信息

项目地址以色列特拉维夫项目面积511m^2设计单位Pitsou Kedem Architects工业革命促进的技术进步,使铁及混凝土在建筑方面的运用得到普及,并带来了现代主义的福音。位于以色列特拉维夫的这座住房也是以铁及混凝土作为主要建材,其内部及外部的关系把控精准,气候条件及隐私需求也被充分考虑在内。

关键词：项目地址设计单位技术进步项目面积气候条件 revolution 儿童房主卧 kitchen 室内外空间

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长时间异丙酚麻醉不伴有血乳酸值的增加

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麻醉与镇痛 2012年第3期8卷 68-75页

作者： irene Rozet, mD Nuj Tontisirin, mD monica S. Vavilala, mD miriam m. Treggiari, mD, PhD Lorri A. Lee, mD Arthur m. Lam, mD, FRCPC 何炯策(译) 喻田(校) Departments of Anesthesiology Surgery Harborview Medical Center University of Washington Seattle Washington Departments of Pediatrics Surgery Harborview Medical Center University of Washington Seattle Washington Departments of Neurological Surgery Harborview Medical Center University of Washington Seattle Washington 不详

背景乳酸酸中毒被认为是异丙酚输注综合征的一种早期信号。本次研究中，我们考察长时间异丙酚麻醉和吸入麻醉下血乳酸和pH的改变。方法选择长达8小时以上择期脊柱手术患者并对麻醉期间记录数据作回顾性分析。在麻醉时间（anesthesia tim... 详细信息

背景乳酸酸中毒被认为是异丙酚输注综合征的一种早期信号。本次研究中，我们考察长时间异丙酚麻醉和吸入麻醉下血乳酸和pH的改变。方法选择长达8小时以上择期脊柱手术患者并对麻醉期间记录数据作回顾性分析。在麻醉时间（anesthesia time，AT）（±30分钟）与失血量（blood loss，BL）（±500m1）的前提下，异丙酚麻醉与吸入麻醉的患者人数匹配比为1：2。结果在合乎条件的246例患者中，50例患者接受异丙酚麻醉[AT=（10±2）小时，BL=（1955±1409）m1]，而匹配100例吸入麻醉患者[AT=（10±1）小时，BL=（1801±1543）ml]。其中分别有40例和72例患者具有完整的基础值和麻醉后8小时乳酸值，包含在主要的分析资料中。异丙酚组接受（8．8±2）mg·kg^-1·h^-1的异丙酚。吸入组患者年龄较异丙酚组大[（58±12）岁vs（51±15）岁，P=0．002]，但两组在性别、ASA分级、术中血流动力学改变和血管升压药物使用方面没有差异。8小时之后，吸入组血乳酸值比异丙酚组相对各自基础值水平上有较大的增加[高于基础值的改变：异丙酚，（0．48±0．72）mmol／L；吸入麻醉，（1．2±1．2）mmol／L。P=0．001]。结论在超过8小时的长时间脊柱手术中，吸入麻醉与异丙酚麻醉相比，更易伴有血乳酸值升高。需要前瞻性的研究以解释该发现的确切机制和临床意义。

关键词：异丙酚麻醉乳酸值血乳酸异丙酚输注综合征患者人数吸入麻醉脊柱手术乳酸酸中毒

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Split Hand/Foot malformation about Two Family Cases

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Open Journal of Pediatrics 2023年第1期13卷 63-68页

作者： Neli Yvette Ngakengni Bredel Djeri Djor mabika Gauthier J. Buambo irene L. P. Ondima Lucie C. Ollandzobo Atipo-Ibara Lynda Gamo Tchidjo Landes C. Togho Abessou Samia m. Oya Angouma Benedicte m. Foueta moukouba Flora Nombo mavoungou Corinne Akouango Gnessou Nuptia C. Obengui Dhalia Y. Ngonya mbongo Rachelle Dusabimana Bowassa Ekouya Gaston Aurore mbika Cardorelle Faculty of Health Sciences Marien Ngouabi University of Brazzaville (Congo) Brazzaville Congo Neonatology Department University Hospital of Brazzaville (Congo) Brazzaville Congo Stomatology Department University Hospital of Brazzaville (Congo) Brazzaville Congo Obstetrics and Gynecology Department University Hospital of Brazzaville (Congo) Brazzaville Congo Surgery Pediatric Department University Hospital of Brazzaville (Congo) Brazzaville Congo Pediatric Departments University Ce Hospital of Brazzaville (Congo) Brazzaville Congo

Split hand/foot malformation (SHFm), formerly known as ectrodactyly is a rare congénital anomaly, its incidence varies from 1/8.500 to 1/25.000 live birth. It mainly affects the development of the limbs, its clinical variability is standard, can present as an isolated feature or as a syndrome associated with other congenital anomalies. Our objective was to present the two cases of SHFm, and to review the literature on the clinical aspects and discuss a probable origin. The father went to school and is a driver because the malformations concerned only the fingers, were less severe, and did not prevent the realization of certain simple gestures of the daily life. On the other hand, the malformations of the fingers of the newborn were severe and the absence of the thumbs compromised the later prehension function. Also the association of a microglossia and a cleft palate contributed to a weight loss that justified hospitalization. The clinical presentation of split hands and feet is variable and the prognosis depends on the type of anomaly. Familial cases suggest a probable genetic origin. Genetic testing is necessary to establish genetic counseling.

关键词： Split Hand/Foot malformation Isolated Form Syndromique Form Family

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危重症患者中谵妄的归因病死率：前瞻性队列研究

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英国医学杂志中文版 2015年第3期18卷 126-127页

作者： Peter m C Klein irene J Zaal Cristian Spitoni David S Y Ong Arendina W van der Kooi marc J m Bonten Arjen J C Slooter Olaf L Cremer 朱玉王玉平 Department ofIntensive Caremedicine UniversityMedical Centre Utrecht 3508 GAUtrecht Netherlands Department ofmathematics UtrechtUniversity UtrechtNetherlands Department of medicalmicrobiology University MedicalCentre UtrechtUtrecht Netherlands 首都医科大学宣武医院

目的明确在危重症患者中因谵妄而导致的病死率。设计前瞻性队列研究。背景2011年1月至2013年7月，荷兰一个有32张混合床位的重症医疗病房（ICU）。研究对象连续收住ICU至少24小时的1112例成人患者。暴露由受过培训的观察人员使用经过验... 详细信息

目的明确在危重症患者中因谵妄而导致的病死率。设计前瞻性队列研究。背景2011年1月至2013年7月，荷兰一个有32张混合床位的重症医疗病房（ICU）。研究对象连续收住ICU至少24小时的1112例成人患者。暴露由受过培训的观察人员使用经过验证的评估工具每天评估患者的谵妄状态。应用Logistic回归分析和竞争风险生存分析校正基线变量，应用边际结构模型分析校正谵妄发作前疾病严重程度进展造成的混杂因素影响。

关键词：队列研究危重病人死亡归因

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Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma

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World Journal of Hepatology 2017年第36期9卷 1322-1331页

作者： Francesca Romana Ponziani irene Spinelli Emanuele Rinninella Lucia Cerrito Antonio Saviano Alfonso Wolfango Avolio michele Basso Luca miele Laura Riccardi maria Assunta Zocco Brigida Eleonora Annicchiarico matteo Garcovich marco Biolato Giuseppe marrone Anna maria De Gaetano Roberto Iezzi Felice Giuliante Fabio maria Vecchio Salvatore Agnes Giovanni Addolorato massimo Siciliano Gian Lodovico Rapaccini Antonio Grieco Antonio Gasbarrini maurizio Pompili Department of Internal medicine Gastroenterology and Hepatology Agostino Gemelli Hospital Department of Liver Transplant Surgery Agostino Gemelli Hospital Department of Oncology Gastroenterology and Hepatology Agostino Gemelli Hospital Department of Bioimaging and Radiological Sciences Agostino Gemelli Hospital Department of Hepatobiliary Surgery Agostino Gemelli Hospital Department of Pathology Agostino Gemelli Hospital

AIm To characterize the survival of cirrhotic patients with Barcelona Clinic Liver Cancer(BCLC) stage C hepatocellular carcinoma(HCC) and to ascertain the factors predicting the achievement of disease control(DC).mETHODS The cirrhotic patients with BCLC stage C HCC evaluated by the Hepatocatt multidisciplinary group were subjected to the investigation. Demographic, clinical and tumor features, along with the best tumor response and overall survival were recorded. RESULTS One hundred and ten BCLC stage C patients were included in the analysis; the median overall survival was 13.4 mo(95%CI: 10.6-17.0). Only alphafetoprotein(AFP) serum level > 200 ng/m L and DC could independently predict survival but in a time dependent manner, the former was significantly associated with increased risk of mortality within the first 6 mo of follow-up(HR = 5.073, 95%CI: 2.159-11.916, P = 0.0002), whereas the latter showed a protective effect against death after one year(HR = 0.110, 95%CI: 0.038-0.314, P microvascular invasion and/or extrahepatic spread recorded lower chances of achieving DC(OR = 0.263, 95%CI: 0.111-0.622, P = 0.002).CONCLUSION The BCLC stage C HCC includes a wide heterogeneous group of cirrhotic patients suitable for potentially curative treatments. The reverse and time dependent effect of AFP serum level and DC on patients' survival confers them as useful predictive tools for treatment management and clinical decisions.

关键词： Hepatocellular carcinoma Cirrhosis Barcelona Clinic Liver Cancer stage C Alphafetoprotein Disease control Performance status Survival

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论小地震的mW与mL之间的关系

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世界地震译丛 2017年第3期48卷 248-256页

作者： irene munafò L.malagnini L.Chiaraluce 杨国栋（译）曾文浩（译）朱玉萍（校）不详甘肃省地震局中国地震局地球物理研究所

估计小地震的矩震级(m_W)是具有挑战性的任务。一个可行的测量办法是计算其地方震级(m_L),再把地方震级转换成具有物理基础的矩震级m_W。不幸的是,正确地进行这样的转换并不容易;而且,虽然很多研究表明小地震的m_L与m_W之间的等值是错误... 详细信息

估计小地震的矩震级(m_W)是具有挑战性的任务。一个可行的测量办法是计算其地方震级(m_L),再把地方震级转换成具有物理基础的矩震级m_W。不幸的是,正确地进行这样的转换并不容易;而且,虽然很多研究表明小地震的m_L与m_W之间的等值是错误的,但不管地震大小,人们时常还是认为这两个参数是严格等值的。我们使用随机振动理论表明,在m_W4以下,小地震的m_L正比于它的地震矩的对数,下列关系式成立:m_(W_(SmALL))=2/3m_(L_(SmALL))+C′我们在台伯河上游流域(意大利亚平宁山脉北部)由0≤m_L≤3.8事件构成的具有m_L和m_W精确估计值的高质量数据集上检验了我们的发现。

关键词：小地震随机振动理论亚平宁山脉矩震级物理基础上游流域估计值挑战性

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DPHL:A DIA Pan-human Protein mass Spectrometry Library for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham Tim Schelfhorst Richard R.G.D.Haas irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang mo Hu Yue Zhou Winan J.Van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic Franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan N.m.Ijzermans John W.m.martens Renske D.m.Steenbergen Nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta mantoo Sze S.Lee Serene J.Y.Yeow Syed m.F.Alkaff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry Lam Ding ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREmEN)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus mC University medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus mC University medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus mC University medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(mS)-based targeted proteomic techniques,including the selected reaction monitoring(SRm),parallel reaction monitoring(PRm),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a mS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source mS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)mS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRm validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-mS and confirmed by *** data demonstrate that the DPHL supports DIA and PRm mS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： Data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma

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An Investigative Immunoassay Targeting Two Osteopontin Epitopes in Boar Semen

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Open Journal of Animal Sciences 2020年第3期10卷 560-571页

作者： C. m. Pilane T. R. Netshirovha m. m. Tshabalala Agricultural Research Council Animal Production Institute Private Bag X2 Irene South Africa Faculty of Health and Environmental Sciences School of Agriculture and Environmental Sciences Central University of Technology Bloemfontein South Africa Department of Animal Science Tshwane University of Technology Pretoria South Africa

The identification of superior sire is largely dependent on the semen quality evaluations, currently through computer-aided sperm class analyser (CASA). Immunoassays present a viable method for analysis of proteins associated with fertility, such as osteopontin. We have targeted osteopontin at an upstream epitope at position 249 - 267 amino acids and a downstream epitope at position 59 - 74 amino acids of full osteopontin protein in raw, BTS, Kobidil, Tris and Citrate liquid preserved Large white and Kolbroek boar semen. The Genetool analysis software was used to quantify the amount of osteopontin detected. Three boars per breed were used and experiments were repeated five times. Our results revealed that the downstream 15 amino acid epitope was more sensitive to osteopontin antibody. Between total motility and osteopontin, Kolbroek boar semen preserved in Kobidil, Citrate, BTS and Tris extenders revealed positive correlations of 0.564, 0.471, -0.960 and 0.330, respectively. Large white boars semen showed correlations of -0.043, 0.655, 0.778, and 0.202 Kobidil, Citrate, BTS and Tris, respectively. For rapid motility and osteopontin, Kolbroek boar semen revealed positive correlations of 0.842, 0.601, 0.164 and 0.202, respectively while large white boars semen showed correlations of -0.909, -0.144, -0.210, and 0.089, respectively. Only BTS and Kobidil showed high negative correlations between osteopontin and viability in Kolbroek (-0.975) and Large white (-0.746) boar semen, respectively. No significant correlations with osteopontin were observed when Tris extender was used in both breeds. In conclusion, Kolbroek boar semen requires osteopontin in Kobodil extender while large white boar semen requires osteopontin in BTS extender.

关键词： Extenders Osteopontin Boar Semen Kolbroek Large White

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A global meta-analysis of woody plant responses to elevated CO_(2):implications on biomass,growth,leaf N content,photosynthesis and water relations

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Ecological Processes 2022年第1期11卷 723-743页

作者： mthunzi mndela Julius T.Tjelele Ignacio C.madakadze mziwanda mangwane Igshaan m.Samuels Francuois muller Hosia T.Pule Applied Behavioural Ecology and Ecosystem Research Unit(ABEERU) Department of Environmental SciencesUNISAPrivate Bag X6Florida 1710South Africa Agricultural Research Council APIP/Bag X02IrenePretoria 0062South Africa University of Pretoria P/Bag X20HatfieldPretoria 0028South Africa

Background:Atmospheric CO_(2)may double by the year 2100,thereby altering plant growth,photosynthesis,leaf nutrient contents and water ***,atmospheric CO_(2)is currently 50%higher than pre-industrial levels and is projected to rise as high as 936μmol mol^(−1)under worst-case scenario in *** objective of the study was to investigate the effects of elevated CO_(2)on woody plant growth,production,photosynthetic characteristics,leaf N and water ***:A meta-analysis of 611 observations from 100 peer-reviewed articles published from 1985 to 2021 was *** selected articles in which elevated CO_(2)and ambient CO_(2)range from 600–1000 and 300–400μmol mol^(−1),*** CO_(2)was categorized into700μmol mol^(−1)***:Total biomass increased similarly across the three elevated CO_(2)concentrations,with leguminous trees(LTs)investing more biomass to shoot,whereas non-leguminous trees(NLTs)invested to root *** area index,shoot height,and light-saturated photosynthesis(A_(max))were unresponsive atmol mol^(−1),but increased significantly at 700 and>700μmol mol^(−1).However,shoot biomass and A_(max)acclimatized as the duration of woody plants exposure to elevated CO_(2)*** rate of photosynthetic Rubisco carboxylation(V_(cmax))and apparent maximum rate of photosynthetic electron transport(J_(max))were *** CO_(2)reduced stomatal conductance(g_(s))by 32%on average and increased water use efficiency by 34,43 and 63%for700μmol mol^(−1),*** N content decreased two times more in NLTs than LTs growing at elevated CO_(2)than ambient CO_(2).Conclusions:Our results suggest that woody plants will benefit from elevated CO_(2)through increased photosyn-thetic rate,productivity and improved water status,but the responses will vary by woody plant traits and length of exposure to elevated CO_(2).

关键词： Atmospheric CO_(2) Biomass production Leaf nitrogen content meta-analysis Photosynthetic rate Stomatal conductance Water use efficiency Woody plants

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