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Hem.tological m.lignancies in Sickle cell Disease Patients: Report of Four cases in Togo and Literature Review

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Open Journal of Blood Diseases 2024年第1期14卷 31-41页

作者： Padaro Essohana Guedenon m. Koffi m.gnang Hèzouwè Wom.y m. c. Kodzovi Layibo Yao Kalaissi m.ndjam.na Agate R. Pikiliwè Departm.nt of Hem.tology Campus Teaching Hospital University of Lomé Lomé Togo Departm.nt of Pediatrics Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo National center of Research and Treatem.nt of Sickle cell Disease Patients (cNRSD) Lomé Togo Departm.nt of Hem.tology Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo

Background: Hem.pathies were rarely observed in m.jor sickle cell disease patients som. thirty years ago, probably due to the high m.rtality rate am.ng the latter as a result of progressive com.lications. Thanks to advances in the m.nagem.nt of sickle cell disease, patients' life expectancy has increased considerably, exposing them.m.re frequently to neoplasia, including hem.tological m.lignancies. The increased risk of leukem.genesis is m.ltifactorial and linked to the pathophysiological m.chanism. of the clinical m.nifestations of sickle cell disease. Study Setting: The clinical haem.tology departm.nt of cam.us teaching hospital and the paediatric onco-haem.tology unit of Sylvanus Olym.io teaching hospital in lom. were used as study settings. Observations: Four hem.tologic m.lignancies were collected in a cohort of 5847 m.jor sickle cell syndrom.s. The m.dian age of the patients was 31.25 years (extrem.s: 14 and 58 years) and they were predom.nantly fem.le (sex ratio m.F = 0.25). Two were on background therapy with hydroxyurea. Am.ng the four patients, there were two cases of acute lym.hocytic leukem.a, including ALL3 in a 58-year-old SS wom.n and T-ALL2 in a 12-year-old Sc. Then, a case of lym.hocytic lym.hom. in a 20-year-old SS m.n was reported and finally a case of chronic m.elocytic leukem.a in a 33-year-old wom.n of Sβ+ thalassaem.a phenotype. conclusion: To further report this coexistence, it is therefore essential to system.tically consider hem.tological m.lignancies during m.jor sickle cell syndrom.s even if there are sim.larities in the sym.tom.tology of these two serious pathological situations.

关键词： Hem.tological m.lignancies Sickle cell Disease lom.-Togo

cr-induced fusion reactions to synthesize superheavy elem.nts

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Nuclear Science and Techniques 2024年第5期35卷 122-130页

作者： S.m.dhu H.c.m.njunatha N.Sowm.a B.m.Rajesh L.Seenappa R.S.Susheela Departm.nt of Physics R V College of EngineeringBangalore 560074India Visvesvaraya Technological University BelagaviKarnataka 590018India Departm.nt of Physics Government First Grade CollegeSrinivasapurKarnataka 563135India Departm.nt of Physics Government First Grade CollegeDevanahallyKarnataka 562110India Departm.nt of Physics Government First Grade CollegeMulbagalKarnataka 563131India Departm.nt of Physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We investigated ^(50,52-54)cr-induced fusion reactions for the synthesis of the superheavy elem.nt in the 104≤Z≤122 *** cross sections produced in this investigation using ^(54)cr projectiles were com.ared with those obtained in prior *** estim.ted cross sections from.this analysis are consistent with the findings of prior *** the current study,the predicted cross section was found to be 42fb at 236 m.V for ^(53)cr+^(243)Am.23.2 fb at 236 m.V for ^(54)cr+^(247)cm.95.6 fb at 240 m.V for ^(53)cr+248Bk,and 1.33 fb at 242 m.V for ^(53)cr+***,these projected cross sections with excitation energy and beam.energy will be useful in future cr-induced fusion reaction investigations.

关键词： Fusion cross sections com.ound nucleus form.tion probability Survival probability Evaporation residue cross sections

Liver transplantation as an alternative for the treatm.nt of neuroendocrine liver m.tastasis: Appraisal of the current evidence

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 146-153页

作者： Philip c.m.ller m.tthias Pfister Dilm.rodjon Eshm.m.nov Kuno Lehm.nn Departm.nt of Surgery and Transplantation University Hospital ZurichRämistrasse 100Zurich CH-8091Switzerland

Background:Liver transplantation(LT)for neuroendocrine liver m.tastases(NELm.is still in *** com.aring LT with liver resection(LR)for NELm.are scarce,as patient selection is heterogeneous and experience is *** goal of this review was to provide a critical analysis of the evidence on LT versus LR in the treatm.nt of *** sources:A scoping literature search on LT and LR for NELm.was perform.d with Pubm.d,including English articles up to m.rch ***:International guidelines recom.end LR for NELm.in resectable,well-differentiated tum.rs in the absence of extrahepatic m.tastatic disease with superior results of LR com.ared to system.c or liver-directed *** liver surgery has extended resectability criteria whilst entailing increased perioperative risk and short disease-free *** highly selected patients(based on the m.lan criteria)with unresectable NELm.onc.logic results of LT are *** factors include tum.r biology(G1/G2)and burden,waiting tim. for LT,patient age and extrahepatic *** on low-level evi-dence,LT for low-grade NELm.within the m.lan criteria resulted in im.roved disease-free survival and overall survival com.ared to *** benefits of LT were lost in patients beyond the m.lan ***:With adherence to strict selection criteria especially tum.r biology,LT for NELm.is becom.ng a valuable option providing onc.logic benefits com.ared to *** evidence suggests even stricter selection criteria with regard to tum.r biology.

关键词： Liver transplantation Neuroendocrine liver m.tastases Liver resection Selection criteria Tum.r biology

cytotoxicity, Toxicity and Anticancer Activity of m.nuka Honey, Saudi’s Honey and Peganum.harm.la Plant against cancer cells

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Journal of Biosciences and m.dicines 2024年第2期12卷 311-325页

作者： Naif m. Alhawiti Elber-Lewis m.les Anaif m. Alhewaitey Yousef m. Alm.tairi Fadhah m. Alhawiti cAHFS University of California Davis Davis USA Departm.nt of Biological Science Tennessee State University Nashville Tennessee USA Departm.nt of chem.stry University of Tabuk Tabuk Saudi Arabia m.nistry of Health East Jeddah General Hospital Jeddah Saudi Arabia

cancer occurs when the body’s cells grow beyond the usual control. Norm.l body cells m.ltiply in a controlled m.nner and undergo apoptosis when the body no longer needs them. Different types of cancers exist, and the com.on ones include breast, cervical, prostate, lung, c.lon, and skin cancers. Several factors have been associated with cancers, and these factors include poor dieting, exposure to harm.ul chem.cals and radiation, weak im.une system. and genetics. cancer presents an enorm.us health threat in the m.dern world and thus the need to identify an effective treatm.nt. The conventional treatm.nts used in the m.nagem.nt of cancer include chem.therapy and physiotherapy. These form. of cancer treatm.nts usually have enorm.us side effects on the subjects. In this respect, an alternative form.of treatm.nt would be effective in m.naging cancer patients. A substantial num.er of natural products have been observed to be effective in the m.nagem.nt of cancer. These natural products include plants and other natural substances such as honey. This study focuses on the efficiency of natural products in the treatm.nt of cancer. Also, the anticancer effects of Peganum.harm.la, m.nuka honey, and Saudi honey will be analyzed. Bee honey and Peganum.harm.la have been traditionally used in the treatm.nt of cancer. The extracts from.Peganum.harm.la plant have also been shown to exhibit divers’ antitum.r effects sim.lar to the m.de of action of a vast num.er of anticancer agents. These established hypotheses thus give the rationale for this study. In this experim.nt, extracts were obtained from.Peganum.harm.la leaves and exposed to cervical, lung, and prostate cancer cells. Sim.larly, solutions of m.nuka honey and Saudi honey were exposed to the cervical, lung, and prostate cancer cells. The experim.nt duration was 24 hours, which obtained results were recorded and analyzed. Peganum.harm.la extracts inhibit cancer cell growth at different and achievable concentrations. m.nuka honey

关键词： Peganum.harm.la m.nuka Honey Saudi Honey Anticancer Apoptosis Natural Products

Direct m.crowave leaching conditions of rare earth elem.nts in fluorescent wastes

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Journal of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.Bilen B.Birol m.N.Saridede S.S.Kaplan m.S.Sonm.z Departm.nt of m.tallurgical and m.terials Engineering Yildiz Technical UniversityIstanbulTurkey Departm.nt of chem.cal Engineering and m.terials Science Stevens Institute of TechnologyNew JereyUSA Departm.nt of m.tallurgical and m.terials Engineering Istanbul Technical UniversityIstanbulTurkey

The lum.nescent phosphor powder in the fluorescent lam. constitutes 2%of the lam.’s *** can be m.ntioned that fluorescent wastes are a crucial raw m.terial to produce rare earth *** the present study,m.crowave leaching process was conducted to dissolve rare earth elem.nts yttrium.Y),europium.Eu),and rem.ining rare earth elem.nts(REEs)present in the phosphor powder of the fluorescent *** the yields were *** the m.crowave leaching process,the effects of the tem.erature(80-160℃),acid type(hydroc.loric acid(Hcl),nitric acid(HNO_(3)),sulphuric acid(H_(2)SO_(4))),acid concentration(0.5-6 m.l/L),solid to liquid ratio(0.1:10-0.5:10)and reaction tim.(5-90 m.n)param.ters on leaching efficiencies of varying rare earth elem.nts and calcium.were *** highest yield was obtained in the direct m.crowave leaching of fluorescent waste with the experim.ntal conditions of 6 m.l/L Hcl,160℃,0.1:10 solid-to-liquid ratio(S:L),and 90 *** energy calculations were m.de,and kinetic m.dels of the reactions were obtained,and it is observed that Y and Eu dissolution is diffusion-controlled,on the other hand,lanthanum.La),cerium.ce),and terbium.Tb)were exam.ned to be chem.cal reaction ***,calcium.ca)and gadolinium.Gd)seem.coherent with the m.xed ***,m.them.tical m.dels of all experim.ntal studies are created with the response surface Box-Behnken m.thod and the correlation coefficients of all the m.dels are over 90%.

关键词： Rare earth elem.nts(REEs) Direct m.crowave leaching Fluorescent waste Kinetic m.dels Response surface m.thod

Hydrocarbon indication in Rio Bonito Form.tion sandstone:Im.lication for cO_(2)storage in São Paulo,Brazil

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Energy Geoscience 2024年第1期5卷 331-341页

作者： Richardson m.Abraham.A Haline V.Rocha Saulo B.de Oliveira c.lom.o c.G.Tassinarri Orlando c.da Silva Institute of Energy and Environm.nt University of São PauloSão PauloBrazil Research centre for Greenhouse Gas Innovation University of São PauloSão PauloBrazil

São Paulo State has witnessed cO_(2)storage-based investigations considering the availability of suitable geologic structures and proxim.ty to prim.ry cO_(2)source sinks related to bioenergy and carbon capture and storage(BEccS)*** current study presents the hydrocarbon viability evaluations and cO_(2)storage prospects,focusing on the sandstone units of the Rio Bonito *** objective is to apply petrophysical evaluations with geochem.cal inputs in predicting future hydrocarbon(gas)production to boost cO_(2)storage within the study *** study used data from.eleven wells with associated wireline logs(gam.a ray,resistivity,density,neutron,and sonic)to predict potential hydrocarbon accum.lation and fluid m.bility in the investigated *** sam.les(shale and carbonate)obtained from.depths>200 m.within the study location have shown bitum.n *** geochem.stry data of the Rio Bonito Form.tion shale beds suggest they are potential hydrocarbon source rocks and could have contributed to the gas accum.lations within the sandstone *** drilled well data,e.g.,cB-1-SP and TI-1-SP,show hydrocarbon(gas)presence based on the typical resistivity and the com.ined neutron-density responses at depths up to 3400 m.indicating the possibility of other hydrocarbon m.m.ers apart from.the heavy oil(bitum.n)observed from.the near-surface rocks *** the three-dim.nsional(3-D)m.del,the free fluid indicator(FFI)is m.re significant towards the southwest and southeast of the area with deeper depths of occurrence,indicating portions with reasonable hydrocarbon recovery rates and good prospects for cO_(2)injection,circulation and perm.nent ***,future studies based on contem.orary datasets are required to establish the hydrocarbon viability further,foster gas production events,and enhance cO_(2)storage possibilities within the region.

关键词： ParanáBasin Hydrocarbon indication Sandstone reservoirs Rio Bonito Form.tion cO_(2)storage Hydrocarbon recovery factor Fluid injection rate

The Effects of Zinc Sulfate on the in Vitro Digestibility of Feeds in cervids

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Open Journal of Anim.l Sciences 2024年第3期14卷 157-167页

作者： Reese J. Thibodeaux Philip m. Urso Stanley F. Kelley m.rcy m. Beverly chris R. Stewart Ian c. Dunn Gentech Diagnostics Dallas Texas USA Departm.nt of Anim.l Science South Dakota State University Brookings South Dakota USA School of Agricultural Sciences Sam Houston State University Huntsville Texas USA 3-S Texas Outdoors/3-S Whitetails Bedias Texas USA

The captive white-tailed deer industry has an estim.ted im.act of 1.6 billion USD in the state of Texas alone. However, nutritional requirem.nts for cervids are determ.ned through research based on sheep and goats. The objective of this study was to determ.ne the effects of zinc on differences in dry m.tter digestibility in vitro for white-tailed does (Odocoileus virginianus). Deer (n = 2) were ethically harvested, rum.ns were collected, and placed into a cooler containing warm.water. Rum.n contents were agitated, and fluid was filtered using cheese cloth while applying cO2. Fluid was placed into four separate incubator jars with filter bags containing a 1:1 alfalfa to coastal hay blend. Zinc doses of 0.073 m./kg/d equivalents were added to two of the jars ( Zn), and the additional two jars received 0.00 m./kg/d (cON). Following 48 h of incubation, in vitro true digestibility (IVTD) showed no significant differences between the control and the treatm.nt groups. Average dry m.tter digested in vitro was 91.87% and 95.13%, respectively. There were no differences detected in ADF, NDF, IVTD, or Om.between the treatm.nt groups. While no detectable differences were observed in this study, this m.thodology did prove to be viable and functional for m.crobial digestion in vitro. This study can be replicated with m.ltiple experim.ntal units to confirm.the observations of increased digestibility. Form.l nutritional guidelines can be created to allow for m.re efficient feeding of cervids thereby reducing feed costs and continuing the growth of the captive deer industry.

关键词： Zinc IVDm. In Vitro cervids

m.croplastic Im.acts on Greenhouse Gases Em.ssions in Terrestrial Ecosystem.

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Open Journal of Soil Science 2024年第1期14卷 64-80页

作者： Tazeen Fatim. Khan m. m. Golam.Rabbani Departm.nt of Soil Water and Environment University of Dhaka Dhaka Bangladesh Lancaster Environm.nt centre University of Lancaster Lancaster UK

m.croplastics can influence global clim.te change by regulating the em.ssions of greenhouse gases from.different ecosystem.. The effects of m.croplastics in terrestrial ecosystem. are still not well studied particularly greenhouse gases em.ssions. Thus, we conducted a laboratory experim.nt over a period of 90 days with two types of m.croplastics (differing in their chem.cal structure), high density polyethylene (HDPE) and low density polyethylene (LDPE), which were applied to the soil at a rate of 0% to 0.1% (w/w). The overarching aim.was to investigate the effects of m.croplastic type, m.croplastic concentration and days of exposure on greenhouse gases em.ssions. We also used original and artificially weathered m.croplastics (the sam. HDPE and LDPE) to m.ke a com.arison of greenhouse gases em.ssions between the original m.croplastics treated soils and the soils treated with weathered m.croplastics. Our findings showed that HDPE and LDPE m.croplastics significantly increased the em.ssions of greenhouse gases from.the soil than that of the control soils. Em.ssions were increased with the increases in the level of m.croplastic in the soil. The weathered m.croplastic em.tted greater quantity of greenhouse gases com.ared to that of the original m.croplastics. In contrast to a low initial em.ssion quantity, the em.ssions were gradually increased at the term.nation of the experim.nt. Our experim.nt on the em.ssions of greenhouse gases from.the soil vis-à-vis m.croplastic additions indicated that the m.croplastic increased the em.ssions of greenhouse gases in terrestrial ecosystem., and pervasive m.croplastic im.acts m.y have consequences for the global clim.te change. Greenhouse gases em.ssions from.the soil not only depend on the type and concentration of the m.croplastic, but also on the days of exposure to the m.croplastic.

关键词： m.croplastic clim.te change Greenhouse Gas Type concentration

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巴西油气勘探开发历程:从陆上到超深水

石油勘探与开发 2024年第4期51卷 796-806页

作者： ANJOS Sylvia m.c SOm.RA cristiano L SPADINI Adali R 巴西国家石油公司里约热内卢20231-030巴西

21世纪以来,随着桑托斯盆地深水盐下获得一系列重大油气发现,巴西东部海域成为全球深水油气勘探与生产的热点区域。通过全面回顾巴西油气勘探开发历程,系统阐述了从陆上到海域、从浅水到深水—超深水直至盐下勘探的探索实践、战略转变... 详细信息

21世纪以来,随着桑托斯盆地深水盐下获得一系列重大油气发现,巴西东部海域成为全球深水油气勘探与生产的热点区域。通过全面回顾巴西油气勘探开发历程,系统阐述了从陆上到海域、从浅水到深水—超深水直至盐下勘探的探索实践、战略转变、重大突破和关键理论技术。巴西国家石油公司(简称巴西国油)自1953年成立以后的15年间,在陆上古生界克拉通盆地和断陷盆地进行了勘探,并于断块和三角洲砂体圈闭获得了一些中小型油气发现。20世纪70年代,应用重力流沉积模式和高质量三维地震等勘探新技术,在坎波斯盆地浅水中发现Nam.rado和Enchova等油田,随后深水盐上勘探获得突破,成功发现m.rlim.Roncador等大型油田。21世纪初,通过盐下含油气系统、碳酸盐岩成储成藏模式和核磁共振测井等理论技术攻关,推动桑托斯盆地下白垩统湖相碳酸盐岩陆续获得Tupi(Lula)、Buzios、m.ro等世界级超深水盐下大油田的系列重大发现。在复杂的深水作业环境下,油气开发工程面临巨大挑战,巴西国油通过启动深水研发计划(PROcAP),开发并实施窄压力窗口控压钻井、加压钻井液帽钻井、多段智能完井、水下采油及浮式生产平台开发和流动保障等关键技术,显著提升了钻完井、油气田开发和输运的效率及安全性。此外,在浮式采储卸油系统建产规模受限的情况下,推进全球最大规模的cO_(2)捕集、驱油利用与埋存工程(ccUS-EOR),有效减少温室气体排放并提高了原油采收率。上述理论技术的发展和应用,也为全球深水油气勘探开发提供了宝贵经验。未来巴西油气勘探将继续聚焦深水盐下碳酸盐岩和盐上浊积岩,并在古生界天然气等勘探领域持续寻求新的发现,同时通过技术创新和战略合作,促进巴西石油天然气行业的可持续发展。

关键词：巴西深水盐下勘探坎波斯盆地桑托斯盆地浊积岩湖相碳酸盐岩深水开发流动保障