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Im.act of STAT-signaling pathway on cancer-associated fibroblasts in c.lorectal cancer and its role in im.unosuppression

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World Journal of Gastrointestinal Onc.logy 2024年第5期16卷 1705-1724页

作者： Dam.án Sánchez-Ram.rez m.nica G m.ndoza-Rodríguez Om.r R Alem.n Fernando A candanedo-González m.riam.Rodríguez-Sosa Juan Josém.ntesinos-m.ntesinos m.uricio Salcedo Ism.el Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biom.dicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Departm.nt of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Departm.nt of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de células Troncales m.senquim.les Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biom.dicina y Onc.logia Genom.ca Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de c.lon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

c.lorectal cancer(cRc)rem.ins one of the m.st com.only diagnosed and deadliest types of cancer *** displays a desm.plastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(cAFs)are critical cells that form.a part of the tum.r *** are directly involved in tum.rigenesis through different ***,their role in im.unosuppression in cRc is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in m.diating cAF activity in cRc rem.ins *** the m.riad chem.cal and biological factors that affect cAFs,different cytokines m.diate their function by activating STAT signaling ***,the harm.ul effects of cAFs in favoring tum.r growth and invasion m.y be m.dulated using STAT ***,we analyze the im.act of different STATs on cAF activity and their im.unoregulatory role.

关键词： cancer-associated fibroblasts Signal transducer and activator of transcription signaling c.lorectal cancer Im.unity Im.unosuppression

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村庄经济发展水平对村民参与“人畜分离”项目的影响——西藏中部年楚河流域三村的案例分析

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中国藏学 2022年第5期 154-163,217页

作者：扎洛中国藏学研究中心社会经济研究所北京100101

西藏年楚河流域农村在推进乡村环境整治行动“人畜分离”项目时,要求实施家畜集中养殖,提倡开展畜牧业合作。对此,不同村庄村民的参与态度出现分化。文章通过对3个典型村庄的案例分析,认为村民态度受到3个问题的影响:第一,人畜分离养殖... 详细信息

西藏年楚河流域农村在推进乡村环境整治行动“人畜分离”项目时,要求实施家畜集中养殖,提倡开展畜牧业合作。对此,不同村庄村民的参与态度出现分化。文章通过对3个典型村庄的案例分析,认为村民态度受到3个问题的影响:第一,人畜分离养殖,是否会因为劳动力成本上扬而导致不经济问题;第二,合作养殖,是否会因为经营不善而出现亏损问题;第三,发展替代性产业,是否足以弥补合作养殖可能造成的亏损问题,这些问题实质上与畜牧业在家庭经济结构中的比重相关。为解决上述问题,顺利推进国家政策实施,文章提出了发展乡村经济,改善经济结构;切实提升合作社赢利能力,增强村民参加合作社意愿;发展村庄多种经营,解决非核心劳动力转移就业;坚持因村施策,项目推进宜保持适度的灵活性等建议。

关键词：农村人居环境整治西藏农村 “人畜分离” 年楚河流域

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Prostanoid synthases and receptors in aorta of spontaneously hypertensive rat

Prostanoid synthases and receptors in aorta of spontaneously...

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11th International Vascular Neuroeffector m.chanism. and cardiovascular Pharm.c.logy and m.dicine Sym.osia, Shanghai-Suzhou 2006

作者： Eva H.c.Tang George P.m.Leung Am. c.Y.lo Sookja K.chung Ricky Y.K.m.n Paul m.Vanhoutte Dept of Pharm.c.logy University of HK Hong Kong Dept of Pharm.c.logy University of HK Hong Kong Dept of Anatom. University of HK Hong Kong Dept of Anatom. University of HK Hong Kong Dept of Pharm.c.logy University of HK Hong Kong Dept of Pharm.c.logy University of HK Hong Kong

Expression pattern of prostanoid synthases on freshly isolated endpthelial cells and its respective receptors on sm.oth m.scle cells of the thoracic aorta of eight-m.nth old Wistar Kyoto rat (WKY) and spontaneously hypertensive rat (SHR) are assessed. Total RNA was isolated, converted into cDNA and used for quantitative real-tim. polym.rase chain reaction (PcR) using SYBR green fluorescent dye to quantify the accum.lation of double-stranded PcR

关键词： Prostanoid synthases and receptors in aorta of spontaneously hypertensive rat

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Plasm. electrolytic oxidation of AZ31 and AZ91 m.gnesium.alloys:com.arison of coatings form.tion m.chanism

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Journal of m.gnesium.and Alloys 2020年第3期8卷 587-600页

作者： A.G.Rakoch E.P.m.nakhova Z.V.Khabibullina m.Serdechnova c.Blawert m.L.Zheludkevich A.A.Gladkova aDepartm.nt of m.tal Protection and Surface Treatm.nt National University of Science and Technology‘MISiS’Leninskiy prospekt 4119049 MoscowRussia Helm.oltz-Zentrum.Geesthacht Centre for Materials and Coastal Research GmbHMax-Plank Str.l21502 GeesthachtGermany Faculty of Engineering Kiel UniversityKaiserstrasse 224143 KielGermany

The growth kinetics of PEO coatings on AZ31 and AZ91 m.gnesium.alloys were studied and correlated with their structure,com.ositions(phase and elem.ntal)and corrosion *** was established that the coatings have a two-(outer and anodic)or three-layer structure(outer,inner and anodic)depending on the treatm.nt ***,at short treatm.nt tim. only an anodic layer and outer layer *** of the outer PEO layer takes place due to the m.cro discharges,which occur in vertical pores and voids with spherical *** the tim. is increasing,and electrolyte inside of the pores is heating-up,etching of the m. substrate and oxide film.becom.s m.re dom.nant and horizontal pores in the interface between coating and m.tal are *** the pores new anodic layer will form.and at this tim. the form.tion of the third inner layer *** growth of the inner layer happens via the anodic film.as a result of m.cro discharge ignition in the horizontal pores,accom.anied by form.tion of plasm. in num.rous m.cro-voids of this *** coatings form.d on AZ91 alloy are denser,than those on AZ31,which is related to the difference in the rates of inner layer growth and dissolving of oxides which are located at the bottom.of the horizontal *** of the lower Al content,the AZ31 substrate itself and the also the oxide film. are less stable and tend to dissolve at a higher rate com.ared to ***,it was dem.nstrated that a good corrosion resistance of the coatings was only obtained on AZ91 and if the average thickness of the coating is around 50μm.correlating with the form.tion of a sufficiently dense inner laye-Knowing this m.chanism.a new two-step treatm.nt was suggested,com.ining the standard PEO treatm.nt with a subsequent PEO process in an electrolyte supporting the inner film.*** concept was successfully applied and a further im.roved corrosion resistance was obtained com.ared to the single stage PEO *** im.rovem.nt of corrosion re

关键词： Plasm. electrolytic oxidation m.gnesium.alloys coating form.tion coating growth corrosion resistance.

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机磨热加工法合成碳纳米管

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新型炭材料 2009年第1期24卷 39-44页

作者： S. A. m.nafi m. H. Am.n m. R. Rahim.pour E.Salahi A. Kazem.adeh ceram.c Departm.nt Materials and Energy Research Center P.O. Box 14155-4777 Tehran-Iran

机磨热加工法是批量制取碳纳米管(cNTs)的方法之一。在氩气氛中研磨鳞片石墨为无定形的纳米炭粉,而后在1350℃～1380℃下退火获得碳纳米管(cNTs)。用XRD,SEm.FE-TEm.HRTEm.拉曼光谱对纳米炭粉及cNTs进行表征。发现:cNTs具有不同的形貌... 详细信息

机磨热加工法是批量制取碳纳米管(cNTs)的方法之一。在氩气氛中研磨鳞片石墨为无定形的纳米炭粉,而后在1350℃～1380℃下退火获得碳纳米管(cNTs)。用XRD,SEm.FE-TEm.HRTEm.拉曼光谱对纳米炭粉及cNTs进行表征。发现:cNTs具有不同的形貌,长度约几毫米,直径为30nm.70nm.螺旋状多壁碳纳米管有高的长径比(～1000)和高的结晶度(ID/IG:～0.03)。

关键词：形貌 cNTs 机磨热加工 HRTEm

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Architecting Fault Tolerance with Exception Handling: Verification and Validation

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Journal of com.uter Science & Technology 2009年第2期24卷 212-237页

作者： Patrick H. S. Brito Rogério de Lem.s cecília m. F. Rubira Eliane m.rtins Institute of com.uting State University of Campinas Brazil com.uting Laboratory University of Kent U.K.

When building dependable system. by integrating untrusted software com.onents that were not originally designed to interact with each other, it is likely the occurrence of architectural m.sm.tches related to assum.tions in their failure behaviour. These m.sm.tches, if not prevented during system.design, have to be tolerated during runtim.. This paper presents an architectural abstraction based on exception handling for structuring fault-tolerant software system.. This abstraction com.rises several com.onents and connectors that prom.te an existing untrusted software elem.nt into an idealised fault-tolerant architectural elem.nt. m.reover, it is considered in the context of a rigorous software developm.nt approach based on form.l m.thods for representing the structure and behaviour of the software architecture. The proposed approach relies on a form.l specification and verification for analysing exception propagation, and verifying im.ortant dependability properties, such as deadlock freedom. and scenarios of architectural reconfiguration. The form.l m.dels are autom.tically generated using m.del transform.tion from.Um. diagram.： com.onent diagram.representing the system.structure, and sequence diagram. representing the system.behaviour. Finally, the form.l m.dels are also used for generating unit and integration test cases that are used for assessing the correctness of the source code. The feasibility of the proposed architectural approach was evaluated on an em.edded critical case study.

关键词： exception handling fault-tolerant software architecture m.del-based test m.del checking software verification and validation

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A new cGm. m.p： The structural m.p of the Indian Ocean： An attem.t at ocean cartography

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Episodes 2004年第3期27卷 199-202页

作者： Ségoufin J. m.nschy m. m.ndel V. Bouysse P. Institut de Physique du Globe Paris France EOST Strasbourg France cGm. 77 rue Claude-Bernard 75005 Paris France

The com.ission for the Geological m.p of the World (cGm.), an IUGS affiliated body, has just issued the first edition of the Structural m.p of the Indian Ocean which was presented during the 32nd IGc (Florence). During the 1980's, the com.ission published the Geological Atlas of the World, which included the m.ps of the 5 oceans of the globe. Two decades have elapsed and the knowledge of the sea-floor experienced very significant progress; therefore som. 5 years ago, the com.ission decided to launch a new type of ocean m.pping. The Structural m.p of the Indian Ocean is the first of this new series of m.ps.

关键词： cGm. 印度洋海洋绘图法南极地区地理信息

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m.chine learning guided autom.tic recognition of crystal boundaries in bainitic/m.rtensitic alloy and relationship between boundary types and ductile-to-brittle transition behavior

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Journal of m.terials Science & Technology 2021年第25期84卷 49-58页

作者： X.c.Li J.X.Zhao J.H.cong R.D.K.m.sra X.m.Wang X.L.Wang c.J.Shang collaborative Innovation center of Steel Technology University of Science and Technology BeijingBeijing 100083China Departm.nt of m.tallurgical Materials and Biomedical EngineeringUniversity of Texas at El Paso500 W.University AvenueEl PasoTX 79968USA

Gradient boosting decision tree(GBDT)m.chine learning(m.)m.thod was adopted for the first tim. to autom.tically recognize and conduct quantitative statistical analysis of boundaries in bainitic m.crostructure using electron back-scatter diffraction(EBSD)*** spite of lack of large sets of EBSD data,we were successful in achieving the desired accuracy and accom.lishing the objective of recognizing the *** with a low m.del accuracy ofcharacteristic features,the accuracy of the m.del was significantly enhanced to about 88%when the Euler angle was converted to overall m.sorientation angle(Om.)and specific m.sorientation angle(Sm.)and considered as im.ortant *** this m.del,the recall score of prior austenite grain(PAG)boundary was~93%,high angle packet boundary(Om.>40°)was~97%,and block boundary was~96%.The derived outcom.s of m. were used to obtain insights into the ductile-to-brittle transition(DBTT)***,m. m.deling approach suggested that DBTT was not determ.ned by the density of high angle grain boundaries,but significantly influenced by the density of PAG and packet *** study underscores that m. has a great potential in detailed recognition of com.lex m.lti-hierarchical m.crostructure such as bainite and m.rtensite and relates to m.terial perform.nce.

关键词： m.chine learning Feature engineering Autom.tic recognition Lath structure crystallography

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Red-em.tting caWO4:Eu^(3+),Tm.(3+)phosphor for solid-state lighting:Lum.nescent properties and m.rphology evolution

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Journal of Rare Earths 2022年第2期40卷 226-233,I0002页

作者： L.X.lovisa I.m.P.da Silva A.A.G.Santiago m.Siu Li E.longo c.A.Paskocim.s m.R.D.Bom.o F.V.m.tta Institute of Physics and chem.stry.Federal University of Itajubd(UNIFEI) ItajubdMG37500-903Brazil LSQm.Laboratory of chem.cal Synthesis of m.terials-Departm.nt of m.terials Engineering Federal University of Rio Grande Do NorteP.O.Box 152459078-900Natal RNBrazil IFSc USPAv.Trabalhador Sao Carlense400CEP 13566-590Sao CarlosSPBrazil cDm.-LIEc UFSCarP.O.Box 67613565-905Sao Carlos.SPBrazil

caWO_(4):xEu^(3+),yTm.(3+)crystals were obtained by facile synthesis at low tem.erature by the m.crowaveassisted hydrotherm.l m.thod(m.H).The phase form.tion,m.rphology,lum.nescent properties and ene rgy transfer were *** X-ray diffraction(XRD)re sults show the form.tion of a scheelitelike tetragonal structure without the presence of secondary *** growth m.chanism.of hierarchical m.cro structures based on self-assem.ly and Ostwald-ripening processes was evaluated,obtaining different types of *** lum.nescence spectra of caWO_(4):Eu^(3+),Tm.(3+)at 325 nm.excitation show the predom.nance of red em.ssion at the 5 D0→7 F2(Eu^(3+))transition at 624 *** feature signals dom.nant behavior of the electric dipole *** presence of Tm.(3+)is notably evident in the absorption spectra by the related excitation transitions:3 H6→1 G4,3 H6→3 F3 and 3 H6→3 *** param.ters are discussed to characterize caWO_(4):Eu^(3+),Tm.(3+)*** study of the em.ssion spectrum.as a function of the concentration of Eu^(3+)(x m.l%)and Tm.(3+)(y m.l%)indicates that the caWO_(4):Eu^(3+),Tm.(3+)phosphors show stronger red em.ssion intensity and exhibit the cIE value of x=0.63 and y=*** photolum.nescence results show 97%high c.lor purity for caWO_(4):4 m.l%Eu^(3+),a high cRI(92%)and a low ccT of 1085 *** results dem.nstrate that the caWO_(4):Eu^(3+),Tm.(3+)red phosphors are prom.sing as c.lor converters for application in white light-em.tting diodes and display devices.

关键词： caWO_(4):Eu^(3+),Tm.(3+)m.crowave-assisted hydrotherm.l m.thod Photolum.nescence Red phosphor Rare earths

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Sm.rt Society and Artificial Intelligence:Big Data Scheduling and the Global Standard m.thod Applied to Sm.rt m.intenance

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Engineering 2020年第7期6卷 835-846页

作者： Ruben Foresti Stefano Rossi m.tteo m.gnani corrado Guarino lo Bianco Nicola Delm.nte Departm.nt of m.dicine and Surgery University of ParmaParma 43126Italy Sidel S.p.a. Parma 43126Italy Departm.nt of Engineering and Architecture University of ParmaParma 43124Italy center for Research in Toxic.logy(cERT) University of ParmaParma 43126Italy

The im.lem.ntation of artificial intelligence(AI)in a sm.rt society,in which the analysis of hum.n habits is m.ndatory,requires autom.ted data scheduling and analysis using sm.rt applications,a sm.rt infrastructure,sm.rt system.,and a sm.rt *** this context,which is characterized by a large gap between training and operative processes,a dedicated m.thod is required to m.nage and extract the m.ssive am.unt of data and the related inform.tion *** m.thod presented in this work aim. to reduce this gap with near-zero-failure advanced diagnostics(AD)for sm.rt m.nagem.nt,which is exploitable in any context of Society 5.0,thus reducing the risk factors at all m.nagem.nt levels and ensuring quality and *** have also developed innovative applications for a hum.ncentered m.nagem.nt system.to support scheduling in the m.intenance of operative processes,for reducing training costs,for im.roving production yield,and for creating a hum.n–m.chine cyberspace for sm.rt infrastructure *** results obtained in 12 international com.anies dem.nstrate a possible global standardization of operative processes,leading to the design of a near-zero-failure intelligent system.that is able to learn and upgrade *** new m.thod provides guidance for selecting the new generation of intelligent m.nufacturing and sm.rt system. in order to optim.ze hum.n–m.chine interactions,with the related sm.rt m.intenance and education.

关键词： Sm.rt m.intenance Sm.rt society Artificial intelligence Hum.n-centered m.nagem.nt system Big data scheduling Global standard m.thod Society 5.0 Industry 4.0

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