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cellular zinc m.tabolism.and zinc signaling:from.biological functions to diseases and therapeutic targets

Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan chen Peiyao Yu Wai Nok chan Fuda Xie Yigan Zhang Li Liang Kam.Tong Leung Kwok Wai lo Jun Yu Gary m.K.Tse Wei Kang Ka Fai To Departm.nt of Anatom.cal and cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina cUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Departm.nt of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biom.dical Research Taihe HospitalHubei University of MedicineShiyanChina Departm.nt of Pediatrics The Chinese University of Hong KongHong KongChina Departm.nt of m.dicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc m.tabolism.at the cellular level is critical for m.ny biological processes in the body.A key observation is the disruption of cellular hom.ostasis,often coinciding with disease *** an essential factor in m.intaining cellular equilibrium.cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvem.nt in prom.ting m.lignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular m.tabolism.particularly the functions of zinc transporters and storage m.chanism. during cancer *** transportation is under the control of two m.jor transporter fam.lies:SLc30(ZnT)for the excretion of zinc and SLc39(ZIP)for the zinc ***,the storage of this essential elem.nt is predom.nantly m.diated by m.tallothioneins(m.s).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential m.lecular pathways linking zinc m.tabolism.to disease progression,with a special focus on *** also com.ile a sum.ary of clinical trials involving zinc *** the m.in localization of zinc transporters at the cell m.m.rane,the potential for targeted therapies,including sm.ll m.lecules and m.noclonal antibodies,offers prom.sing avenues for future exploration.

关键词： m.tabolism invasion involvem.nt

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Post-fontan circulation hepatocellular carcinom.:Open and laparoscopic hepatectom.

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 90-93页

作者： Karin KY Ho Wong Hoi She Sim.n HY Tsang Kevin S lo Tan To cheung Departm.nt of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Departm.nt of Anaesthesiology Queen Mary Hospital102 Pok Fu Lam RoadHong KongChina

To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic *** hereby reported a series of patients suffering from.hepatocellular carcinom.(Hcc)who successfully underwent open and laparoscopic hepatectom..

关键词： hepatocellular hepatectom. surgery

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Shear-wave elastography to predict hepatocellular carcinom. after hepatitis c virus eradication:A system.tic review and m.ta-analysis

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World Journal of Gastroenterology 2024年第10期30卷 1450-1460页

作者： Giorgio Esposto Paolo Santini Linda Galasso irene m.gnini m.ria Elena Ainora Antonio Gasbarrini m.ria Assunta Zocco cEm.D Digestive Disease center Fondazione Policlinico Universitario“A.Gemelli”IRCCSCatholic University of RomeRome 00168Italy Fondazione Policlinico Universitario Agostino Gem.lli IRccS Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy m.dicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

BAcKGROUND Direct-acting antiviral agents(DAAs)are highly effective treatm.nt for chronic hepatitis c(cHc)with a significant rate of sustained virologic response(SVR).The achievem.nt of SVR is crucial to prevent additional liver dam.ge and slow down fibrosis *** assessm.nt of fibrosis degree can be perform.d with transient elastography,m.gnetic resonance elastography or shear-wave elastography(SWE).Liver elastography could function as a predictor for hepato-cellular carcinom.(Hcc)in cHc patients treated with *** To explore the predictive value of SWE for Hcc developm.nt after com.lete clearance of hepatitis c virus(HcV).m.THODS A com.rehensive literature search of clinical studies was perform.d to identify the ability of SWE to predict Hcc occurrence after HcV *** accordance with the study protocol,a qualitative and quantitative analysis of the evidence was *** At baseline and after 12 wk of follow-up,a trend was shown towards greater liver stiffness(LS)in those who go on to develop Hcc com.ared to those who do not[baseline LS standardized m.an difference(Sm.):1.15,95%confidence interval(95%cI):020-2.50;LS Sm. after 12 wk:0.83,95%cI:0.33-1.98].The absence of a statistically significant difference between the m.an LS in those who developed Hcc or not m.y be related to the inability to correct for confounding factors and the absence of raw source *** was a statist-ically significant LS Sm. at 24 wk of follow-up between patients who developed Hcc vs not(0.64;95%cI:0.04-1.24).cONcLUSION SWE could be a prom.sing tool for prediction of Hcc occurrence in patients treated with *** studies with larger cohorts and standardized tim.ng of elastographic evaluation are needed to confirm.these data.

关键词： Shear-wave elastography Hepatocellular carcinom. Hepatitis c virus Sustained virologic response

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Unveiling the Soul of Natasha A conversation with Kseniya Treysteron Bringing Tolstoy's Heroineto Life

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城市漫步（GBA版） 2024年第9期 40-41页

作者： irene Ge 不详

In August 2024,Guangzhou played host to a m.num.ntal event in the world of perform.ng *** Guangzhou Arts Season featured an exclusive perform.nce of War and Peace,com.em.rating the 100th anniversary of Russia's esteem.d Vakhtangov *** production,directed by the legendary Rim.s Tum.nas,captivated audiences with its stunning adaptation of Leo Tolstoy's epic *** 05 a pinnaclc of Russian thcatrical aesthetics,the play has won critical acclaim.including eight nom.nations and a Special Jury Prize at the prestigious Golden m.sk Awards,Russia's highest honor in dram..

关键词： Golden Peace Guangzhou

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Trial characteristics and treatm.nt effect estim.tes in random.zed controlled trials of chinese herbal m.dicine: A m.ta-epidem.ological study

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Journal of Integrative m.dicine 2024年第3期22卷 223-234页

作者： Betty H.Wang Ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu claire c.W.Zhong m.ry Y.Jiang chen m.o Xiao-bo Yang Vincent c.H.chung irene X.Y.Wu Jockey club School of Public Health and Prim.ry care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of chinese m.dicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dam.ness Syndrom. of chinese m.dicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina chinese m.dicine Syndrom. Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of clinical Research on Traditional chinese m.dicine Syndrom. Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of clinical Epidem.ology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published m.ta-epidem.ological studies focused on Western m.dicine have identified som. trial characteristics that im.act the treatm.nt effect of random.zed controlled trials(RcTs).Nevertheless,it rem.ins unclear if sim.lar associations exist in RcTs on chinese herbal m.dicine(cHm..Further,chinese m.dicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatm.nt effect estim.tes on cHm.*** strategy:This m.ta-epidem.ological study searched 5 databases for system.tic reviews on cHm.treatm.nt published between January 2011 and July *** criteria:An eligible system.tic review should only include RcTs of cHm.and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of system.tic reviews,m.ta-analyses and included *** also assessed the risk of bias of RcTs using the cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized m.an differences (dSm.) with 95%confidence interval (cI) were applied to present the difference in effect estim.tes for binary and continuous outcom.s,***:Ninety-one system.tic reviews,com.rising 1338 RcTs were *** binary outcom.s,RcTs incorporated with syndrom. differentiation (ROR:1.23;95%cI:[1.07,1.39]),adopting chinese m.dicine form.la (ROR:1.19;95%cI:[1.03,1.34]),with low risk of bias on incom.lete outcom. data (ROR:1.29;95%cI:[1.06,1.52]) and selective outcom. reporting (ROR:1.12;95%cI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%cI:[1.04,1.42]) preferred to show larger effect *** for continuous outcom.s,RcTs with chinese m.dicine diagnostic criteria (dSm.:0.23;95%cI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealm.nt (dSm.:-0.70;95%cI:[-0.99,-0.42]),with low risk of bias on incom.lete outcom. data (dSm.:0.30

关键词： chinese herbal m.dicine Random.zed controlled trial Risk of bias m.ta-epidem.ological study Effect estim.tes

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An im.roved pulse coupled neural networks m.del for sem.ntic IoT

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Digital com.unications and Networks 2024年第3期10卷 557-567页

作者： Rong m. Zhen Zhang Yide m. Xiping Hu Edith c.H.Ngai Victor c.m.Leung School of Inform.tion Science and Engineering Lanzhou UniversityLanzhou 730000China School of m.dical Technology Beijing Institute of TechnologyBeijing100081China Departm.nt of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China college of com.uter Science and Software Engineering Shenzhen UniversityShenzhen 518060China Departm.nt of Electrical and com.uter Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in m.bile data ***,with the rapid developm.nt of artificial intelligence,sem.ntic com.unication has attracted great attention as a new com.unication ***,for IoT devices,however,processing im.ge inform.tion efficiently in real tim. is an essential task for the rapid transm.ssion of sem.ntic *** the increase of m.del param.ters in deep learning m.thods,the m.del inference tim. in sensor devices continues to *** contrast,the Pulse coupled Neural Network(PcNN)has fewer param.ters,m.king it m.re suitable for processing real-tim. scene tasks such as im.ge segm.ntation,which lays the foundation for real-tim.,effective,and accurate im.ge ***,the param.ters of PcNN are determ.ned by trial and error,which lim.ts its *** overcom. this lim.tation,an Im.roved Pulse coupled Neural Networks(IPcNN)m.del is proposed in this *** IPcNN constructs the connection between the static properties of the input im.ge and the dynam.c properties of the neurons,and all its param.ters are set adaptively,which avoids the inconvenience of m.nual setting in traditional m.thods and im.roves the adaptability of param.ters to different types of *** segm.ntation results dem.nstrate the validity and efficiency of the proposed self-adaptive param.ter setting m.thod of IPcNN on the gray im.ges and natural im.ges from.the m.tlab and Berkeley Segm.ntation *** IPcNN m.thod achieves a better segm.ntation result without training,providing a new solution for the real-tim. transm.ssion of im.ge sem.ntic inform.tion.

关键词： Internet of things(IoT) Sem.ntic inform.tion Real-tim. application Im.roved pulse coupled neural network Im.ge segm.ntation

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com.ining m.terial characterization with single and m.lti-oxyanion adsorption for m.chanistic study of chrom.te rem.val by cationic hydrogel

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Journal of Environm.ntal Sciences 2011年第6期23卷 1004-1010页

作者： irene m.c.lo Sam.el c.N.Tang Departm.nt of civil and Environm.ntal Engineering The Hong Kong University of Science and TechnologyHong KongChina

cationic hydrogel with m.gnetic property was synthesized via radical polym.rization and its rem.val capacity of chrom.te from.contam.nated water was found to be 200 m./*** Fourier transform.infrared spectroscopy（FT-IR） study,the m.chanism.of chrom.te rem.val by hydrogel was found to be non-specific adsorption,m.inly due to ion exchange,as evidenced by the positively charged functional group,trim.thyl am.onium.N＋（cH3）3,in the *** were accordingly determ.ned by testing di？erent oxyanion adsorption onto the *** results of the chrom.te adsorption experim.nts illustrated that the am.unt of chrom.te adsorbed was nearly equal to that of the c.loride released from.the hydrogel,which is part of the evidence for ion *** and m.lti-oxyanion adsorption experim.nts were also perform.d,and it was dem.nstrated that ion rem.val was species independent,but charge dependent,another characteristic of the ion exchange *** was found that the sam. Langm.ir m.del can be applied to best fit the findings of single and m.lti-oxyanion adsorption,which further indicates the m.chanism.of chrom.te rem.val is attributed to ion *** view of the above,the background anions com.ete for adsorption sites with chrom.te,evidenced by inhibitive chrom.te rem.val in the presence of background electrolytes in the batch studies,further echoing the ion exchange m.chanism.

关键词： adsorption m.gnetic hydrogel m.chanism ion exchange oxyanion

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Sem.-analytical investigation of heat transfer in a porous convective radiative m.ving longitudinal fin exposed to m.gnetic field in the presence of a shape-dependent trihybrid nanofluid

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Applied m.them.tics and m.chanics(English Edition) 2024年第1期45卷 197-216页

作者： c.G.PAVITHRA B.J.GIREESHA m.L.KEERTHI Departm.nt of PG Studies and Research in m.them.tics Kuvempu UniversityShankaraghatta 577451India Departm.nt of m.them.tics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The therm.l exam.nation of a non-integer-ordered m.bile fin with a m.gnetism.in the presence of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Three types of nanoparticles, each having a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) configurations. The com.ination approach is utilized to evaluate the physical and therm.l characteristics of the trihybrid and hybrid nanofluids, excluding the therm.l conductivity and dynam.c viscosity. These two properties are inferred by m.ans of the interpolation m.thod based on the volum. fraction of nanoparticles. The governing equation is transform.d into a dim.nsionless form. and the Adom.an decom.osition Sum.du transform.m.thod(ADSTm. is adopted to solve the conundrum.of a m.ving fin im.ersed in a trihybrid nanofluid. The obtained results agree well with those num.rical sim.lation results, indicating that this research is reliable. The influence of diverse factors on the therm.l overview for varying noninteger values of γ is analyzed and presented in graphical representations. Furtherm.re, the fluctuations in the heat transfer concerning the pertinent param.ters are studied. The results show that the heat flux in the presence of the com.ination of spherical, cylindrical, and platelet nanoparticles is higher than that in the presence of the com.ination of only spherical and cylindrical nanoparticles. The tem.erature at the fin tip increases by 0.705 759% when the value of the Peclet num.er increases by 400%, while decreases by 11.825 13% when the value of the Hartm.n num.er increases by 400%.

关键词： convection radiation m.ving longitudinal fin Adom.an decom.osition Sum.du transform.m.thod(ADSTm. trihybrid nanofluid m.gnetic field

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Optim.zation of a photovoltaic-battery system.using deep reinforcem.nt learning and load forecasting

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Energy and AI 2024年第2期16卷 168-183页

作者： António corte Real G.Pontes Luz J.m.c.Sousa m.c.Brito S.m.Vieira IDm.c Instituto Superior TécnicoUniversidade de LisboaLisboa1049-001Portugal Instituto Dom.Luiz Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal

Hom. Energy m.nagem.nt System.(HEm.)are increasingly relevant for dem.nd-side m.nagem.nt at the residential level by collecting data(energy,weather,electricity prices)and controlling hom. appliances or storage *** control can be perform.d with classical m.dels that find optim.l solutions,with high real-tim. com.utational cost,or data-driven approaches,like Reinforcem.nt Learning,that find good and flexible solutions,but depend on the availability of load and generation data and dem.nd high com.utational resources for *** this work,a novel HEm. is proposed for the optim.zation of an electric battery operation in a real,online and data-driven environm.nt that integrates state-of-the-art load forecasting com.ining cNN and LSTm.neural networks to increase the robustness of *** Reinforcem.nt Learning agents are trained with different algorithm.(Double DQN,Dueling DQN,Rainbow and Proxim.l Policy Optim.zation)in order to m.nim.ze the cost of electricity purchase and to m.xim.ze photovoltaic self-consum.tion for a PV-Battery residential *** show that the best Reinforcem.nt Learning agent achieves a 35%reduction in total cost when com.ared with an optim.zation-based agent.

关键词： Energy m.nagem.nt system Deep reinforcem.nt learning Dem.nd-side m.nagem.nt load forecasting Deep learning Energy storage system.

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corporate Social Responsibility and Shipping Supply chain Risks

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Econom.cs World 2024年第3期11卷 145-155页

作者： Wen-chi lo m.ng chuan University TaoyuanTaiwan

This study aim. to investigate whether corporate Social Responsibility(cSR)activities reduce supply chain disruptions by exam.ning the im.act of the Suez canal obstruction on the Ever Given container ship in m.rch *** study conclude that the m.re responsible com.anies have higher returns and are less affected by this event than the less responsible com.anies;the less responsible com.anies have lower *** com.anies with better cSR have a lower im.act on their supply chains when faced with disruptions in the supply chain.

关键词： Suez canal obstruction corporate social responsibility supply chain risks event study Ever Given container ships

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