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How can Practitioners Support citizen Volunteers in Disaster Risk Reduction? Insight from.“Good and Ready” in Aotearoa New Zealand

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International Journal of Disaster Risk Science 2024年第3期15卷 374-387页

作者： lo?c Le Dé Steve Ronoh Ei m.n Thinn Kyu Brigitte Rive School of Public Health and Interdisciplinary Studies Auckland University of Technology Pacific Health Research centre Auckland University of Technology New Zealand Red cross

Global and national policy fram.works em.hasize the im.ortance of people's participation and volunteers' role in disaster risk reduction. While research has extensively focused on volunteers in disaster response and recovery, less attention has been paid on how organizations involved in disaster risk m.nagem.nt can support volunteers in leading and coordinating com.unitybased disaster risk reduction. In 2019, the New Zealand Red cross piloted the Good and Ready initiative in Auckland,Aotearoa New Zealand, with the objective to em.ower local people in resilience building with a focus on volunteers and com.unity participation. This research exam.ned the positive and negative outcom.s of Good and Ready and investigated volunteers' experiences in the disaster resilience initiative. It involved the codesign of a questionnaire-based survey using participatory m.thods with Good and Ready volunteers, the dissem.nation of the survey to gather volunteers' viewpoints, and a focus group discussion with participatory activities with Red cross volunteers. The findings highlight that a key challenge lies in finding a balance between a program.that provides flexibility to address contextual issues and fosters com.unities' ownership, versus a prescriptive and standardized approach that leaves little room.for creativity and self-initiative. It pinpoints that supporting volunteers with technical training is critical but that soft skills training such as coordinating, com.unicating,or facilitating activities at the local level are needed. It concludes that the sustainability of Good and Ready requires understanding and m.eting volunteers' m.tivations and expectations and that enhancing partnerships with local em.rgency m.nagem.nt agencies would strengthen the program.

关键词： com.unity-based approach Disaster risk reduction New Zealand Participation Volunteers

Autolysosom.l acidification im.airm.nt as a m.diator for TNFR1 induced neuronal necroptosis in Alzheim.r’s disease

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Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asim.kidou Richard Reynolds Anna m.Barron chih Hung lo Departm.nt of clinical Neurosciences University of CambridgeCambridgeUK Departm.nt of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee Kong chian School of m.dicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an em.rging form.of regulated cell death associated with neuroinflam.atory signaling:Alzheim.r’s disease(AD)is characterized by the presence of extracellular am.loid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflam.ation with increased levels of cytokines,arising from.neuronal injury,innate im.une responses from.glial cells,and peripheral inflam.ation,leads to neuronal death and AD progression.

关键词： Alzheim.r death tau Aβ

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Tau in the pancreas:understanding the link between type 2 diabetes m.llitus and Alzheim.r's disease

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Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu Li Steffen Tiedt Eng H.lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA consortium.International pour la Recherche circadienne sur l’AVc(cIRcA) BostonUSA Institute for Stroke and Dem.ntia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in m.lecular Psychiatry proposes a cellular m.chanism.that m.y contribute to decreased insulin production in individuals with type 2 diabetes m.llitus(T2Dm..1 Using a com.ination of cell culture experim.nts,anim.l m.dels and studies in T2Dm.patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in m.crotubule assem.ly.

关键词： T2Dm Alzheim.r tau

Drought events influence nutrient canopy exchanges and green leaf partitioning during senescence in a deciduous forest

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Forest Ecosystem. 2024年第1期11卷 110-119页

作者： J.Touche c.calvaruso P.De Donato m.-P.Turpault INRAE BEFF-54000NancyFrance Um. 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events expected in the com.ng decades in Western Europe m.y disturb forest biogeochem.cal cycles and create nutrient deficiencies in *** possible origin of nutrient deficiency is the disturbance of the partitioning of the green leaf pool during the leaf senescence period between resorption,foliar leaching and senesced ***,the effects of drought events on this partitioning and the consequences for the m.intenance of tree nutrition are poorly *** experim.nt in a beech forest in m.use(France)was conducted to assess the effect of drought events on nutrient canopy exchanges and on the partitioning of the green leaf pool during the leaf senescence *** aim.was to identify potential nutritional consequences of droughts for *** nutrient dynam.cs,including resorption,chem.stry of green and senesced leaves,foliar absorption and leaching in m.ture beech stands from.2012 to 2019 allowed us to com.are the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by alm.st a third of the potassium.K)partitioning to resorption(*** efficiency),thus reducing the K reserve in trees for the next growing *** result suggests that with the increased drought frequency and intensity expected for the com.ng decades,there will be a risk of potassium.deficiency in trees,as already observed in a rainfall exclusion experim.nt on the sam. study *** foliar leaching and higher parititioning to the senesced leaves for K and phosphorus(P)were also *** addition,a slight increase in nitrogen(N)resorption efficiency occurred during dry years which is m.re likely to im.rove tree *** calcium.ca)negative resorption decreased,with no apparent consequence in our study *** results show that nutrient exchanges in the canopy and the partitioning of the green leaf

关键词： Natural drought Beech forest canopy Resorption Foliar leaching Senesced leaves Nutrition

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Analytic Regularity for a Singularly Perturbed Reaction-convection-Diffusion Boundary Value Problem.with Two Sm.ll Param.ters

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com.unications in m.them.tical Research 2024年第2期40卷 125-153页

作者： irene Sykopetritou christos Xenophontos Departm.nt of m.them.tics and Statistics University of CyprusPo Box 20537Nicosia 1678Cyprus.

We consider a second order,two-point,singularly perturbed boundary value problem.of reaction-convection-diffusion type with two sm.ll param.ters,and we obtain analytic regularity results for its solution,under the assum.tion of analytic input ***,we establish classical differentiability bounds that are explicit in the order of differentiation and the singular perturbation ***,for sm.ll values of these param.ters we show that the solution can be decom.osed into a sm.oth part,boundary layers at the two endpoints,and a negligible *** estim.tes are obtained for each com.onent of the solution,which again are explicit in the differentiation order and the singular perturbation param.ters.

关键词： Singularly perturbed problem reaction-convection-diffusion boundary layers analytic regularity.

A path planning algorithm.for a crop m.nitoring fixed-wing unm.nned aerial system

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Science china(Inform.tion Sciences) 2024年第8期67卷 5-23页

作者： longhao QIAN Yi lok lo Hugh Hong-tao LIU Institute of Aerospace Studies University of Toronto Departm.nt of m.chanical Engineering The University of Hong Kong

With the growing dem.nd for autom.tion in agriculture, industries increasingly rely on drones to perform.crop m.nitoring and surveillance. In this regard, fixed-wing unm.nned aerial system.(UASs)are viable platform. for scanning a large crop field, given their payload capacity and range. To achieve m.xim.m.coverage without landing for battery replacem.nt, an algorithm.for producing a m.nim.l required energy survey path is essential. Hence, an energy-aware coverage path planning algorithm.is proposed *** constraints for a fixed-wing UAS to fly at low altitudes while achieving full coverage of the crop field are first analyzed. Then, the full path is decom.osed into straight-line and U-turn prim.tives. Finally, an algorithm.to calculate a com.ination of straight-line segm.nts and U-turns is proposed to obtain the path with m.nim.m.required energy consum.tion. The genetic algorithm.is used to efficiently determ.ne the order of the straight-line paths to traverse. case studies show that the proposed algorithm.can produce planning results for a convex-polygon-shaped crop field.

关键词： aerial survey energy m.nim.zation fixed-wing UAS genetic algorithm path planning

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Fault Diagnosis Schem. for Railway Switch m.chine Using m.lti-Sensor Fusion Tensor m.chine

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com.uters, m.terials & continua 2024年第6期79卷 4533-4549页

作者： chen chen Zhongwei Xu m.ng m.i Kai Huang Siu m.ng lo School of Electronic and Inform.tion Engineering Tongji UniversityShanghai201804China Departm.nt of Architecture and civil Engineering City University of Hong KongHong KongChina School of com.uter Engineering Jimei UniversityXiamen361021China

Railway switch m.chine is essential for m.intaining the safety and punctuality of train operations.A data-driven fault diagnosis schem. for railway switch m.chine using tensor m.chine and m.lti-representation m.nitoring data is developed *** existing m.thods,this approach takes into account the spatial inform.tion of the tim. series m.nitoring data,aligning with the dom.in expertise of on-site m.nual ***,a m.lti-sensor fusion tensor m.chine is designed to im.rove single signal data’s lim.tations in insufficient ***,one-dim.nsional signal data is preprocessed and transform.d into two-dim.nsional ***,the fusion feature tensor is created by utilizing the im.ges of the three-phase current and em.loying the cANDE-cOm./PARAFAc(cP)decom.osition ***,the tensor learning-based m.del is built using the extracted fusion feature *** developed fault diagnosis schem. is valid with the field three-phase current *** experim.nt indicates an enhanced perform.nce of the developed fault diagnosis schem. over the current approach,particularly in term. of recall,precision,and F1-score.

关键词： Railway switch m.chine tensor m.chine fault diagnosis

m.them.tical m.deling of cell Polarity Establishm.nt of Budding Yeast

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com.unications on Applied m.them.tics and com.utation 2024年第1期6卷 218-235页

作者： Yue Liu Jun Xie Hay-Oak Park Wing-cheong lo Departm.nt of m.them.tics City University of Hong KongTat Chee AvenueKowloonHong KongChina Departm.nt of m.lecular Genetics The Ohio State UniversityColumbusOHUSA

The budding yeast Saccharom.ces cerevisiae is a powerful m.del system.for studying the cell polarity *** cell polarization process is regulated by signaling m.lecules,which are initially distributed in the cytoplasm.and then recruited to a proper location on the cell m.m.rane in response to spatial cues or *** of these signaling m.lecules involves com.lex regulation,so the m.them.tical m.dels becom. a useful tool to investigate the m.chanism.behind the *** this review,we discuss how m.them.tical m.deling has shed light on different regulations in the cell *** also propose future applications for the m.them.tical m.deling of cell polarization and m.rphogenesis.

关键词： Budding yeast cdc42 m.rphogenesis Septin m.them.tical m.dels

Fungal infections in im.unocom.rom.sed critically ill patients

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Journal of Intensive m.dicine 2024年第3期4卷 299-306页

作者： JoséGarnacho-m.ntero irene Barrero-García cristina León-m.ya Unidad clínica de cuidados Intensivos Hospital Universitario Virgen MacarenaSevillaSpain

Diverse pathogenic fungi can produce severe infections in im.unocom.rom.sed patients, thereby justifying intensive care unit (IcU) adm.ssions. In som. cases, the infections can develop in im.unocom.rom.sed patients who were previously adm.tted to the IcU. Aspergillus spp., Pneum.cystis jirovecii, candida spp., and m.corales are the fungi that are m.st frequently involved in these infections. Diagnosis continues to be challenging because sym.tom. and signs are unspecific. Herein, we provide an in-depth review about the diagnosis, with em.hasis on recent advances, and treatm.nt of these invasive fungal infections in the IcU setting.

关键词： Invasive aspergillosis Im.unocom.rom.sed patient critically ill patient Antifungal Invasive candidiasis Pneum.cystis jirovecii