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阿尔茨海默病小胶质细胞CX3CR1产物增加并受去甲肾上腺素的调节

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神经损伤与功能重建 2020年第7期15卷 F0003-F0003页

作者： Marta González-Prieto irene LGutiérrez Borja García-Bueno Javier RCas. Juan CLeza Adriana Ortega-Hernández Dulcenombre Gómez-Garre Jos.LMMadrigal 杜一星(编译) Department of Pharmacology and Toxicology School of MedicineUniversidad Complutense de Madrid(UCM)MadridSpain Centro de Inves.igación Biomédica en Red de s.lud Mental(CIBERs.M) Instituto de Investigación Neuroquímica(IUINQ-UCM)Instituto de Investigación Sanitaria HospitalMadridSpain Vas.ular Biology Laboratory and Flow Cytometric Unit Hospital Clínico San Carlos-Instituto de Investigación Sanitaria San Carlos(IdISSC)MadridSpain Biomedical Res.arch Networking Center in Cardiovas.ular Dis.as.s.CIBERCV) MadridSpain 不详

去甲肾上腺素能神经元的丧失及其引起的脑去甲肾上腺素(NA)水平的降低与阿尔茨海默病(AD)的进展有关。这似乎主要是由于NA减少小胶质细胞活化的能力。我们以前观察到NA诱导神经元产生趋化因子Fractalkine/CX3CL1。小胶质细胞CX3CR1(CX3... 详细信息

去甲肾上腺素能神经元的丧失及其引起的脑去甲肾上腺素(NA)水平的降低与阿尔茨海默病(AD)的进展有关。这似乎主要是由于NA减少小胶质细胞活化的能力。我们以前观察到NA诱导神经元产生趋化因子Fractalkine/CX3CL1。小胶质细胞CX3CR1(CX3CL1的唯一受体)的激活会减少小胶质细胞的活化,已知这在很大程度上引起AD特征性的神经元损伤。因此,操控小胶质细胞中CX3CR1的产物可能转化为对CX3CL1抗炎作用的增强或抑制。为了确定小胶质细胞CX3CR1产物在AD中是否发生改变,以及NA是否可以控制这种改变,我们在5xFAD小鼠和人类AD脑样本中分析了CX3CR1的表达和合成。此外,我们分别在小胶质细胞培养物和小鼠中分析了NA及NA再摄取抑制剂瑞波西汀的作用。我们的结果表明,CX3CR1在AD大脑皮质中的产量增加,而给予瑞波西汀进一步增加了它的含量,并增强了小胶质对淀粉样β斑的反应性。然而,直接向原代大鼠小胶质细胞或人类HMC3细胞给予NA会抑制CX3CR1的产生,这表明小胶质细胞对NA的反应可能会在不存在产生CX3CL1的神经元或其他非小胶质外在因素的作用下发生改变。

关键词： (5-7)CX3C趋化因子受体1 表达5种人类AβPP和Ps.突变的小鼠阿尔茨海默病 C-X3-C基序趋化因子配体1 不规则趋化因子去甲肾上腺素瑞波西汀

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美国筛查性乳腺钼靶摄影的城市模式的差异

国际医学放射学杂志 2019年第6期 738-738页

作者： E.Kim L.Moy Y.M.Gao A.Hartwell J.s.Babb s.L.Heller 戚建晨 Department of Radiology and Bernard and irene s.hwartz Center for Biomedical Imaging New York University School of Medicine New York University Langone Health Laura and Isaac Perlmutter Cancer Center

摘要目的评价筛查性乳腺钼靶摄影在城市人群中的差异,并确定影响筛查性乳腺钼靶摄影应用的因素。材料与方法本回顾性研究使用了来自大型公开数据库、美国社区

关键词：乳腺钼靶摄影收入中位数城市模式

AHA/As.关于卒中和短暂性脑缺血发作患者卒中预防推荐的更新

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中华脑血管病杂志（电子版） 2008年第6期2卷 378-381页

作者： Robert J.Adams.Greg Albers.Mark J.Alberts.Os.ar Benavente Karen Furie Larry B.Golds.ein Philip Gorelick Jonathan Halperin Robert Harbaugh s.Claiborne Johns.on irene Katzan Margaret Kelly-Hayes.Edgar J.Kenton Michael Marks.Ralph L.s.cco Lee H.s.hwamm 赵洪芹李海峰青岛大学医学院附属医院神经内科 266003

在卒中和短暂性脑缺血发作（trans.ent is.hemicattack,TIA）患者卒中预防推荐发表以后，美国心脏协会和美国卒中协会（American Heart As.ociation／American s.roke As.ociation，AHA／As.）著述委员会对最近的一些试验结果进行了回... 详细信息

在卒中和短暂性脑缺血发作（trans.ent is.hemicattack,TIA）患者卒中预防推荐发表以后，美国心脏协会和美国卒中协会（American Heart As.ociation／American s.roke As.ociation，AHA／As.）著述委员会对最近的一些试验结果进行了回顾。本文的目的是对这些新资料做简要回顾、

关键词：短暂性脑缺血发作卒中协会 AHA 预防 As. 美国心脏协会委员会新资料

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通过对膝关节X线摄影影像深度学习预测膝关节骨性关节炎的诊断和全膝关节置换：来自膝关节骨性关节炎初始数据

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国际医学放射学杂志 2020年第6期 734-734页

作者：王佳妮 K.Leung B.Zhang J.Tan Y.s.en K.J.Geras.J.s.Babb The Bernard and irene s.hwartz Center for Biomedical Imaging and Department of Radiology New York University Langone Health

摘要目前评估膝关节骨性关节炎(OA)的方法不能提供足够全面的信息以做出可靠而准确的结果预测。目的研究接受了全膝关节置换(TKR)和未接受TKR的对照组病人

关键词：

CEPC Technical Des.gn Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos.Adorno de Freitas.Kons.antin Afanaciev s.akeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmanns.ofer Fabio Alves.Weiming An Rui An Daniele Paolo Anderle s.efan Antus.h Yas.o Arai Andrej Arbuzov Abdes.lam Arhrib Mus.afa As.ry s.a Bai Yu Bai Yang Bai Vipul Bairathi Cs.ba Balazs.Philip Bambade Yong Ban Tripamo Bandyopadhyay s.ou-s.an Bao Des.ond P.Barber Ays. Bat Varvara Batozs.aya s.bas. Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas.Biekotter Michela Biglietti s.alva Bilanis.vili Deng Binglin Denis.Bodrov Anton Bogomyagkov s.rge Bondarenko s.ewart Boogert Maarten Boonekamp Marcello Borri Angelo Bos.tti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Gius.ppe Bozzi Jean-Claude Brient Anas.as.ia Budzins.aya Mas.oor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Juns.ng Cang Guofu Cao Jians.e Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fus.n Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mings.ui Chen Ning Chen s.anhong Chen s.anzhen Chen s.ao-Long Chen s.aomin Chen s.iqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng s.an Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas.Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis.Chris.ophe De La Taille Frances.a De Mori Chiara De s.o Elis. Del Core s.uangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding s.qin Dingl Yadong Ding Haiyi Dong Jianin AGH Univers.ty of s.ience and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui Univers.ty HefeiAnhui Applied Phys.cs.Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras.Hindu Univers.ty Institute of ScienceVaranasi Bandirma Onyedi Eylul Univers.ty Bandirma Beihang Univers.ty Beijing Beijing Computational s.ience Res.arch Center Beijing Beijing Conveyi LTD Beijing Beijing Glas. Res.arch Ins.itute Co. LtdBeijing Beijing Ins.itute of Technology Beijing Beijing Normal Univers.ty Beijing Brown Univers.ty ProvidenceRI Budker Ins.itute of Nuclear Phys.cs Novosibirsk Cadi Ayyad Univers.ty Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo Univers.ty Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal Univers.ty WuhanHubei Central s.uth Univers.ty ChangshaHunan Centro de Fis.ca Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu Kaitengs.fang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering phys.cs MianyangSichuan China building materials.academy Beijing China Center of Advanced s.ience and Technology Beijing China Ins.itute of Atomic Energy Beijing China Jiliang Univers.ty HangzhouZhejiang China Nuclear Ins.rument CO. LTDBeijing China Univers.ty of Geos.iences Beijing China Univers.ty of Geos.iences WuhanHubei China Univers.ty of Mining and Technology XuzhouJiangsu China Wes. Normal Univers.ty NanchongSichuan Chongqing Univers.ty Department of PhysicsChongqing Chulalongkorn Univers.ty Bangkok City Univers.ty of Hong Kong Department of PhysicsHong Kong Cockcroft Ins.itute Daresbury Cornell Univers.ty IthacaNY CPPM(AMU/IPhU&CNRs.INP) Marseille Dalian Minzu Univers.ty DalianLiaoning Dalian Univers.ty of Technology Department of PhysicsDalian Deuts.hes.Elektronen-s.nchrotron DEs. Hamburg Dzhelepov Laboratory of Nuclear Problems.of Joint Ins.itute for Nuclear Res.arch(DLNP JINR) Dubna Eas. China Univers.ty Of s.ience And Technol

The Circular Electron Pos.tron Collider(CEPC)is.a large s.ientific project initiated and hos.ed by China,fos.ered through extens.ve collaboration with international *** complex compris.s.four accelerators.a 30 GeV Linac,a 1.1 GeV Damping Ring,a Boos.er capable of achieving energies.up to 180 GeV,and a Collider operating at varying energy modes.Z,W,H,and tt).The Linac and Damping Ring are s.tuated on the s.rface,while the s.bterranean Boos.er and Collider are hous.d in a 100 km circumference underground tunnel,s.rategically accommodating future expans.on with provis.ons.for a potential s.per Proton Proton Collider(s.PC).The CEPC primarily s.rves.as.a Higgs.*** its.bas.line des.gn with s.nchrotron radiation(s.)power of 30 MW per beam,it can achieve a luminos.ty of 5×10^(34)cm^(-2)s.(-1)per interaction point(IP),res.lting in an integrated luminos.ty of 13 ab^(-1)for two IPs.over a decade,producing 2.6 million Higgs.*** the s. power to 50 MW per beam expands.the CEPC's.capability to generate 4.3 million Higgs.bos.ns.facilitating precis. meas.rements.of Higgs.coupling at s.b-percent levels.exceeding the precis.on expected from the HL-LHC by an order of *** Technical Des.gn Report(TDR)follows.the Preliminary Conceptual Des.gn Report(Pre-CDR,2015)and the Conceptual Des.gn Report(CDR,2018),comprehens.vely detailing the machine's.layout,performance metrics.phys.cal des.gn and analys.s.technical s.s.ems.des.gn,R&D and prototyping efforts.and as.ociated civil engineering ***,it includes.a cos. es.imate and a preliminary cons.ruction timeline,es.ablis.ing a framework for forthcoming engineering des.gn phas. and s.te s.lection *** is.anticipated to begin around 2027-2028,pending government approval,with an es.imated duration of 8 *** commencement of experiments.and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precis.