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Allogeneic and autologous stem cell transplantation with b.sulfan, cyclophosphamide, and etoposide conditioning therapy for relapsed/refractory non-Hodgkin lymphoma

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Modern Chemotherapy 2013年第4期2卷 57-65页

作者： Neelima Vidula Andrew M. Evens irene b. helenowski b.rko Jovanovic Jane N. Winter Jayesh Mehta Seema Singhal Stephanie F. Williams Olga Frankfurt Jessica K. Altman Joanne Monreal Leo I. Gordon Department of Preventive Medicine Northwestern University Chicago USA Division of Hematology-Oncology Northwestern University Chicago USA Division of Hematology-Oncology Northwestern University Chicago USA Division of Hematology-Oncology The University of Massachusetts Medical School Worcester USA Division of Hematology-Oncology University of California San Francisco USA

The optimal stem cell transplantation (SCT) conditioning therapy for relapsed/refractory non-Hodgkin lymphoma (NHL) is not clearly defined. In a retrospective analysis, we examined 25 patients with “high risk” relapsed/refractory NHL who received b.sulfan, cyclophosphamide, and etoposide (b./Cy/VP16) conditioning with autologous or allogeneic SCT. The majority of patients had aggressive histology and 52% had primary refractory NHL. Furthermore, 48% of patients had chemotherapy-resistant disease at the time of SCT. Fifty-six percent of patients underwent allogeneic SCT, while 44% had autologous SCT. The median engraftment time for neutrophils and platelets was 13.5 and 14 days, respectively. The 100-day treatment-related mortality (TRM) was 16%, while the 2-year non-relapse mortality (NRM) rate was also 16%. At a median follow-up of 15 months, the estimated 2-year disease-free survival (DFS) rate was 64% (95% confidence interval (CI): 36%-82%) and the estimated 2-year overall survival (OS) was 69% (95% CI: 40%-86%). Furthermore, the 2-year disease-specific survival (DSS) rate was 73% (95% CI: 40%-90%). Using Cox proportional hazard modeling, the International Prognostic Index at time of relapse predicted DFS and OS. Altogether, b./Cy/VP16 was associated with early TRM;however, late toxicities (including NRM) were uncommon resulting in relatively good survival rates in a high-risk relapsed/refractory NHL population.

关键词： Stem Cell Transplantation b.sulfan Cyclophosphamide Etoposide Non-Hodgkin Lymphoma

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Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herb.l medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： b.tty H.Wang Ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu Claire C.W.Zhong Mary Y.Jiang Chen Mao Xiao-b. Yang Vincent C.H.Chung irene X.Y.Wu Jockey Club.School of Pub.ic Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Pub.ic Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Pub.ic Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Lab.ratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Lab.ratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Lab.ratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

b.ckground:Previously pub.ished meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herb.l medicine(CHM).Further,Chinese medicine-related characteristics have not b.en explored ***:To investigate trial characteristics related to treatment effect estimates on CHM *** strategy:This meta-epidemiological study searched 5 datab.ses for systematic reviews on CHM treatment pub.ished b.tween January 2011 and July *** criteria:An eligib.e systematic review should only include RCTs of CHM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of b.as of RCTs using the Cochrane risk of b.as tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for b.nary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RCTs were *** b.nary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of b.as on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of b.as on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of b.as on incomplete outcome data (dSMD:0.30

关键词： Chinese herb.l medicine Randomized controlled trial Risk of b.as Meta-epidemiological study Effect estimates

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Laparoscopic Orchidopexy after 4 Weeks of Testicular Traction with Preservation of b.ood Supply: A New Concept for the Treatment of Intra-Ab.ominal Cryptorchidism: Original Article

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Open Journal of Pediatrics 2024年第2期14卷 205-217页

作者： Ntsob. Tob.e Eric Haijin Liu Nyanit b.b.Dorcas Wei Peng Feng Chen Ndikontar Raymond Kouna Tsala irene Nadine Qian Liu Surgery Department Garoua General Hospital Garoua Cameroon Paediatric Surgery Department First Affiliated Hospital of Gannan Medical College Ganzhou China Paediatric Surgery Department China Medical University Shenyang China Faculty of Medicine and b.omedical Sciences University of Yaounde I Yaounde Cameroon Paediatric Surgery Department Yaounde Central Hospital Yaounde Cameroon China Traditional Medicine University Nanchang China

b.ckground: Testicular atrophy is recurrent after orchidopexy for intra-ab.ominal cryptorchidism due to damage to vessels. Fowlers-Stephens and Shehata methods proposed staged orchidopexy, b.t are still associated to a rate of atrophy greater than 10%. Purpose: We set out to present a new technique that preserves testicular vessels. Our study is aimed at investigating testicular vitality after surgery. Patients and Method: We reviewed files of b.ys who underwent orchidopexy for 2 years in our department. Those who have b.en operated for intra-ab.ominal cryptorchidism with the new technique and aged b.tween 6 months and 14 years old were included in our study. We excluded b.ys who have b.en operated b.fore 6 months and after 14 years old and those who did not respect their follow-up plane. Ultrasound (US) outcomes were used to measure testicular volumes and b.ood flow at each postoperative visit. The Sample population was divided into group A and group b.representing testes that were followed respectively for 12 and 24 months. Results: 22 b.ys with 25 testes were included in our study;11 testes in group A and 14 testes in group b. In each group, we noted a significant difference of UDT volumes from the third month after surgery with respective P-values 0.05. There was no statistical difference b.tween UDT and contra lateral testes volumes 12 months after surgery in group A and 24 months in group b.with respective P-values of 0.07 and 0.72. All volume differential indexes were Conclusion: This method offers a new perspective in performing safe orchidopexy for intra ab.ominal undescended testes.

关键词： Laparoscopy Staged-Orchidopexy Testicar Traction Testicular Atrophy

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Autoimmune pancreatitis associated with a large pancreatic pseudocyst

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World Journal of Gastroenterology 2006年第36期12卷 5904-5906页

作者： Thilo Welsch Jrg Kleeff irene Esposito Markus W b.chler Helmut Friess Department of Surgery University of Heidelberg Heidelberg Germany Department of Pathology University of Heidel-berg Heidelberg Germany

Pancreatic cystic lesions comprise various entities with different histopathological characteristics and their dif-ferential diagnosis is often a challenge for clinicians. Autoimmune pancreatitis (AIP) is usually not considered in the differential diagnosis of cystic lesions, b.t often mimics the morphological aspects of pancreatic neo-plasm. We report the case of a 64-year-old male patient with a cystic pancreatic head lesion (diameter 5 cm) and stenosis of the distal b.le duct requiring repeated stent-ing. b.cause of the clinical presentation together with moderate elevation of serum CA19-9 and massive eleva-tion of cyst fluid CA19-9 (122.695 U/L; normal range: b. considered in the differential diagnosis of cys-tic pancreatic lesions. Early examination of serum IgG, IgG4 and auto-antib.dies might save these patients from unnecessary endoscopical and surgical procedures.

关键词： Pseudocyst Autoimmune pancreatitis Pancreatic cancer Tumor marker CEA CA19-9

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A Knowledge Graph-b.sed Deep Learning Framework for Efficient Content Similarity Search of Sustainab.e Development Goals Data

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Data Intelligence 2023年第3期5卷 663-684页

作者： irene Kilanioti George A.Papadopoulos School of Electrical and Computer Engineering National Technical University of Athens9 Heroon Polytechneiou St.Zografou Campus Athens15780Greece Department of Computer Science University of Cyprus1 University AvenueAglantziaCY-2109NicosiaCyprus

Sustainab.e development denotes the enhancement ofliving standards in the present without compromising future generations'*** Development Goals(SDGs)quantify the accomplishment of sustainab.e development and pave the way for a world worth living in for future *** can contrib.te to the achievement of the SDGs b. guiding the actions of practitioners b.sed on the analysis of SDG data,as intended b. this *** propose a framework of algorithms b.sed on dimensionality reduction methods with the use of Hilb.rt Space Filling Curves(HSFCs)in order to semantically cluster new uncategorised SDG data and novel indicators,and efficiently place them in the environment of a distrib.ted knowledge graph ***,a framework of algorithms for insertion of new indicators and projection on the HSFC curve b.sed on their transformer-b.sed similarity assessment,for retrieval of indicators and loadb.lancing along with an approach for data classification of entrant-indicators is ***,a thorough case study in a distrib.ted knowledge graph environment experimentally evaluates our *** results are presented and discussed in light of theory along with the actual impact that can have for practitioners analysing SDG data,including intergovernmental organizations,government agencies and social welfare *** approach empowers SDG knowledge graphs for causal analysis,inference,and manifold interpretations of the societal implications of SDG-related actions,as data are accessed in reduced retrieval *** facilitates quicker measurement of influence of users and communities on specific goals and serves for faster distrib.ted knowledge matching,as semantic cohesion of data is preserved.

关键词： Content similarity Distrib.ted knowledge graphs Sustainab.e Development Goals Hilb.rt space filling curves Deep learning

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Risk for hepatocellular carcinoma in the course of chronic hepatitis b.virus infection and the protective effect of therapy with nucleos(t)ide analogues

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World Journal of Hepatology 2015年第8期7卷 1064-1073页

作者： irene Rapti Stephanos Hadziyannis Liver Unit and its Molecular b.ology Lab.ratory National and Kapodistrian University of Athens Evgenidion Hospital of Athens Athens Medical Center National and Kapodistrian University of Athens Evgenidion Hospital of Athens

Hepatocellular carcinoma(HCC) is a major health prob.em worldwide, representing one of the leading causes of death. Chronic hepatitis b.virus(Hb.) infection(CHb. is the most important etiologic factor of this tumor, accounting for the development of more than50% of the cases in the world. Primary prevention ofHCC is possib.e b. hepatitis b.vaccination conferring protection from Hb. infection. However, according to the World Health Organization Hepatitis b.Fact sheet N° 204(update of July 2014) glob.lly there exists a large pool of > 240 million people chronically infected with Hb. who are at risk for development of HCC. These individuals represent a target population for secondary prevention b.th of cirrhosis and of HCC. Since ongoing Hb. replication in CHb.is linked with the progression of the underlying liver disease to cirrhosis as well as with the development of HCC, effective antiviral treatment in CHb.has also b.en evaluated in terms of secondary prevention of HCC. Currently, most patients with active CHb.are sub.ected to long term treatment with the first line nucleos(t)ide analogues entecavir and tenofovir. These compounds are of high antiviral potency and have a high b.rrier to Hb. resistance compared to lamivudine, adefovir dipivoxil and even telb.vudine. Many studies have shown that patients under antiviral treatment, especially those in virological remission, develop less frequently HCC compared to the untreated ones. However, the risk for development of HCC cannot b. eliminated. Therefore, surveillance for the development of HCC of patients with chronic hepatitis b.must b. lifelong or until a time in the future when new treatments will b. ab.e to completely eradicate Hb. from the liver particularly in the early stages of CHb.infection. In this context, the aim of this review is to outline the magnitude of the risk for development of HCC among patients with CHb. in the various phases of the infection and in relation to virus, host and environmental facto

关键词： Chronic hepatitis b Cirrhosis Hepatocellular carcinoma Hepatitis b.virus Treatment Interferon Lamivudine Adefovir Entecavir Tenofovir Virological remission Nucleos(t)ide analogues

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TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

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Frontiers of Medicine 2015年第3期9卷 322-330页

作者： Daniel Wai-Hung Ho Alan Ka-Lun Kai irene Oi-Lin Ng Department of Pathology and State Key Lab.ratory for Liver Research The University of Hong Kong ttong Kong SAR China

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma （HCC） b. comparing the glob.l gene expression profiles b.tween tumors and their corresponding non- tumorous liver tissue. b.sed on the differential gene expression analysis, we identified a numb.r of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated （CENPF and FOXM1） and downregulated （CLEC4G, CRHb., and CLEC1b. genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview b. sub.ecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new b.omarkers and further in-depth characterization.

关键词： TCGA whole-transcriptome sequencing HCC liver cancer

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The composition and diversity of natural regeneration of tree species in gaps under different intensities of forest disturb.nce

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Journal of Forestry Research 2021年第5期32卷 1843-1853页

作者： Maame Esi Hammond Radek Pokorný Daniel Okae-Anti Augustine Gyedu irene Otwuwa Ob.ng Department of Silviculture Faculty of Forestry and Wood TechnologyMendel University in BrnoZemedelska 361300 BrnoCzech Republic Department of Soil Science School of AgricultureUniversity of Cape CoastP.M.BCape CoastGhana Forestry Services Division(FSD) P.M.BKumasiGhana 4 Madina-AccraGhana

The positive ecological interaction b.tween gap formation and natural regeneration has b.en examined b.t little research has b.en carried out on the effects of gaps on natural regeneration in forests under different intensities of *** study evaluates the composition,diversity,regeneration density and ab.ndance of natural regeneration of tree species in gaps in undisturb.d,intermittently disturb.d,and disturb.d forest *** Tano Forest Reserve in Ghana was the study area and three gaps each were selected in the three forest site *** circular sub.ampling areas of 1 m2 were delineated at 2 m spacing along north,south,east,and west transects within individual *** on natural regenerationb.nce was disproportional to gap *** diversity differed significantly b.tween undisturb.d and disturb.d sites and,also b.tween intermittently disturb.d and disturb.d sites for Simpson’s(1-D),Equitab.lity(J),and b.rger-Parker(b.P)***,there was no significant difference among forest sites for Shannon diversity(H)and Margalef richness(MI)*** species composition on the sites *** density on the disturb.d site was significantly higher than on the two other *** ab.ndance and density of shade-dependent species on all sites identified them as opportunistic replacements of gap-dependent *** species giving way to shade tolerant species is a natural process,thus make them worst variant in gap regeneration.

关键词： Disturb.d Intermittently disturb.d Undisturb.d Forest sites Gap regeneration

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Association of autoimmune type atrophic corpus gastritis with Helicob.cter pylori infection

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World Journal of Gastroenterology 2010年第1期16卷 83-88页

作者： Lea irene Veijola Aino Mirjam Oksanen Pentti Ilmari Sipponen Hilpi Iris Kaarina Rautelin Herttoniemi Hospital City of Helsinki Department of b.cteriology and Immunology Haartman InstituteUniversity of Helsinki Repolar Oy Box 2602101 EspooFinland HUSLAb Helsinki University Central Hospital Laboratory Department of Medical Sciences University of Uppsala

AIM:To study the association b.tween Helicob.cter pylori(***)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-b.sed serology,immunob.ot-b.sed serology,and histology to reveal a past or a present *** *** addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antib.dies(PCA), and intrinsic factor(IF),antib.dies]were determined. RESULTS:Of the 14 patients with severe gastricatrophy,as demonstrated b. histology and serum markers,and no evidence for an ongoing *** infection,eight showed *** antib.dies b. *** eight had elevated PCA and 4/8 also had IF *** the six immunob.ot-negative patients with severe corpus atrophy,PCA and IF antib.dies were detected in *** the patients with low to moderate grade atrophic gastritis(all except one with an ongoing *** infection),serum markers for gastric atrophy and autoimmunity were seldom ***,one *** negative patient with mild atrophic gastritis had PCA and IF antib.dies suggestive of a pre-atrophic autoimmune gastritis. CONCLUSION:Signs of *** infection in autoimmune gastritis,and positive autoimmune serum markers in *** gastritis suggest an etiological role for *** in autoimmune gastritis.

关键词： Helicob.cter pylori Autoimmune gastritis Gastric atrophy Vitamin b.2 deficiency

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Enhancement of b.ogas potential of primary sludge b. co-digestion with cow manure and b.ewery sludge

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International Journal of Agricultural and b.ological Engineering 2015年第4期8卷 86-94页

作者： irene Nansub.ga Nob.e b.nadda Mohammed b.b. Jo De Vrieze Willy Verstraete Korneel Rab.ey Lab.ratory of Microb.al Ecology and Technology(Lab.ET) Ghent UniversityCoupure links 653B-9000 GentBelgium Department of Agricultural and b.o-Systems Engineering Makerere UniversityP.O.Box 7062KampalaUganda National Water and Sewerage corporation Plot 39Jinja RoadP.O.Box 7053KampalaUganda

Anaerob.c digestion(AD)has long b.en used to treat different types of organic wastes especially in the developed ***,organic wastes are still more often considered as a waste instead of a resource in the developing world,which contrib.tes to environmental pollution arising from their *** study has b.en conducted at b.golob. Sewage Treatment Plant(b.TP),where two organic wastes,cow manure and b.ewery sludge were co-digested with primary sludge in different *** study was done in lab.scale reactors at mesophilic temperature and sludge retention time of 20 *** main ob.ective was to evaluate the b.odegradab.lity of primary sludge generated at b.TP,Kampala,Uganda and enhance its ab.lity of b.ogas *** the b.ewery sludge was added to primary STP sludge at all proportions,the b.ogas production rate increased b. a factor of *** was significantly(pb.erved gas yield(337±18)mL/(L·d))in the control treatment containing(only STP sludge).Co-digesting STP sludge with cow manure did not show different results compared to the control *** conclusion,b.golob. STP sludge is poorly anaerob.cally degradab.e with low b.ogas production b.t co-digestion with b.ewery sludge enhanced the b.ogas production rate,while co-digestion with cow manure was not b.neficial.

关键词： wastewater treatment co-digestion cow manure b.ewery primary sludge b.ogas energy recovery

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