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Cytotoxicity of new Ho(Ⅲ) and Pr(Ⅲ) complexes

Journal of Rare Earths 2010年第S1期28卷 40-46页

作者： irena kostova Tsvetanka Stefanova Department of Chemistry Faculty of PharmacyMedical University2 Dunav St.Sofia 1000Bulgaria Department of Immunology Institute of MicrobiologyBulgarian Academy of Sciences26 Acad.G.Bonchev St.Sofia 1113Bulgaria

New complexes of coumarin-3-carboxylic acid(HCCA) with Ho(Ⅲ) and Pr(Ⅲ) were synthesized and their structures and spectral properties were investigated by elemental analysis,IR,Raman and NMR *** to the experimental data the complexes’ formula and geometries were *** frequencies,IR intensities and Raman activities as well as 1H NMR chemical shifts of HCCA and its Ho(Ⅲ) and Pr(Ⅲ) complexes were *** comparative experimental vibrational and NMR analyses of both the ligand and the Ln(Ⅲ) complexes predicted the bidentate binding to Ho(Ⅲ) and Pr(Ⅲ) through the deprotonated carboxylic oxygen and the carbonylic oxygen of the *** cytotoxic/cytostatic properties of the ligand and the newly synthesized complexes of coumarin-3-carboxylic acid with Ho(Ⅲ) and Pr(Ⅲ) were tested by MTT reduction assay against two mouse tumor cell lines:melanoma B16 and fibrosarcoma *** were also tested for cytotoxicity against normal mouse peritoneal *** proliferation inhibitory effect of the complexes compared to that of the ligand proved their cytotoxic/cytostatic properties against both the tumor cell *** addition,the complexes were less cytotoxic against normal mouse macrophages and were able to modulate NO release by activated *** obtained results were in accordance with our previously published data concerning the activity of lanthanide(Ⅲ) complexes with other coumarin derivatives.

关键词： coumarins Ho(Ⅲ),Pr(Ⅲ) FT-IR,FT-Raman NMR cytotoxic/cytostatic activity rare earths

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