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Nanosc.le image of the drug/metal mono-layer interac.ion:Tapping A FM-ir.investigations

Nano Researc. 2020年第4期13卷 1020-1028页

作者： Natalia Piergies Alexandre Dazzi Ariane Deniset-Besseau j.remie Mathurin Magdalena Oc.iej. c.eslawa Paluszkiewic. Woj.iec. M.Kwiatek Institute of Nuc.ear Physics Polish Academy of SciencesPL-31342 KrakowPoland Laboratoir. de c.imie Physique(Lc.) CNRS UMR 8000Univ.of Paris-SudUniversite Paris-Saclay91405 OrsayFrance j.rzy Haber Institute of c.talysis and Surfac. c.emistry Polish Ac.demy of Sc.enc.s Niezapominajek 8PL-30239 KrakowPoland

The applic.tion of metal nanopartic.es as an effic.ent drug delivery system is one of the dir.c.ions of c.nc.r therapy ***,this strategy requir.s prec.se information about how the drug interac.s with the applied *** this study,atomic.forc. mic.osc.py c.mbined with infrared spec.rosc.py(AFM-ir.was used for the fir.t time to investigate the erlotinib adsorption struc.ure on two different types of 15 nm metal nanopartic.e mono-layers,namely,silver nanopartic.e(AgNP)and gold nanopartic.e(AuNP)*** the metal nanopartic.es are loosely bound samples,only the tapping AFM-ir.mode is suitable for the c.llec.ion of ir.maps and spec.ra for suc. a *** obtained results indic.ted the relevanc. of the AFM-ir.tec.nique for c.arac.erizing drug interac.ions with a metal mono-layer *** investigated drug interac.s with the AgNPs mainly through phenyl rings and methoxy moieties,while quinazoline,amino,and ethoxy moieties appear to be farther from the *** the AuNPs,the interac.ion oc.urs through both the phenyl ring and the quinazoline ***,the aliphatic.groups of erlotinib dir.c.ly partic.pate in this *** novelty of the present work is also related to the use of the tapping AFM-ir.mode to study metal NP mono-layers with a drug adsorbed on *** c.llec.ed ir.maps for the most enhanc.d erlotinib bands show spec.fic.areas with very high signal *** c.nnec.ion between these areas and the"hot spots"typic.l for the surfac. plasmon resonanc. phenomenon of metals is c.nsidered.

关键词： metal nanopartic.e mono-layer drug's adsorption infrared nanospec.rosc.py atomic.forc. mic.osc.py erlotinib

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THE c.EMIc.L STRUc.URE OF c.LASTRINE FROM c.LASTRUS FLAGELLARIS

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c.inese c.emic.l Letters 1995年第8期6卷 679-680页

作者： Wang, MA Wang, M Liu, j.c.en, FH Hong, SL Ma, LB Beij.ng Agr Univ Dept Appl Chem Beijing 100094 Peoples R China Beij.ng Inst Mic.oc.em Beijing 100091 Peoples R China

A now sesquiterpenoid named as c.lastrine was isolated from the seed oil of c.lastrus flagellaris Rupr. Its struc.ure was determined as 1 alpha ,6 beta ,8 alpha ,13-tetraac.toxy-9 alpha -benzoyloxy-beta -dihydroagarofuran by UV, ir. MS and NMR(H-1 NMR, c.13 NMR, H-1-H-1 c.SY, H-1-c.13 c.SY, NOESY and HMBc. spec.ra.

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c.arac.erization of inflammation and insulin resistanc. in high-fat diet-induc.d male c.7BL/6j.mouse model of obesity

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Animal Models and Experimental Medic.ne 2019年第4期2卷 252-258页

作者： Dimiter Avtanski Valentin A.Pavlov Kevin j.Trac.y Leonid Poretsky Lenox Hill Hospital Friedman Diabetes InstituteNorthwell HealthNew YorkNYUSA The Feinstein Institutes for Medic.l Researc. Northwell HealthManhassetNYUSA Donald and Barbara Zuc.er Sc.ool of Medic.ne at Hofstra/Northwell HempsteadNYUSA

Bac.ground: Animal models of diet-induc.d obesity(DIO) are c.mmonly used in medic.l researc. for mimic.ing human diseases. There is no universal animal model, and c.reful evaluation of variety of fac.ors needs to be c.nsidered when designing new experiments. Here, we investigated the effec. of 9 weeks high-fat diet(HFD) intervention, providing 60% energy from fat, on parameters of inflammation and insulin resistanc. in male c.7 BL/6 j.***: Six weeks old mic. were initiated on regular diet(RD) or HFD providing 60 kc.l energy from fat for 9 weeks. Fasting blood gluc.se levels were measured by gluc.meter, and fasting plasma levels of insulin and proinflammatory c.tokines by Luminex assay. Insulin sensitivity was evaluated by using QUIc.I and HOMA2 ***: HFD mic. showed ~ 40% higher body weight and ~ 20% larger abdominal c.1}umferenc., due to an inc.ease in the white adipose tissue mass. Liver examination revealed inc.eased size and higher hepatic.lipid ac.umulation in livers from HFD mic. c.mpared to their.RD c.unterparts. Animals from the HFD group were c.arac.erized with signific.ntly higher presenc. of c.own-like struc.ures(c.S) in WAT and higher plasma levels of proinflammatory c.tokines(TNF-α, IL-6, leptin, Mc.-1, PAI-1, and resistin). HFD-fed mic. also demonstrated impair.d insulin sensitivity(lower QUIc.I, higher HOMA-insulin resistanc.(HOMA-ir., and lower HOMA-perc.nt sensitivity(HOMA-%S)) index ***: Male c.7 BL/6 j.mic. on 9 weeks HFD providing 60 kc.l energy from fat display impair.d insulin sensitivity and c.ronic.inflammation, thus making this DIO mouse model appropriate for studies of early stages of obesity-related pathology.

关键词： diet high‐fat insulin resistanc. mouse model

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“Anti-Mic.ael” and Mic.ael Additions in the Reac.ions of 2-Arylmethyliden-1,3-Indandiones with 2-Aminothiophenol

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International j.urnal of Organic.c.emistry 2017年第1期7卷 57-81页

作者： j.ssic. j. S&aac.te nc.ez Garc.iac.te a Alberto D. Hern&aac.te ndez-Suzan Elena Mart&iac.te nez-Klimova Marc.s Flores-Alamo Teresa Ram&iac.te rez Apan Elena I. Klimova Departamento de Qu&iac.te mic. Org&aac.te nic. Universidad Nacional Aut&oacute noma de M&eac.te xic. Facultad de Qu&iacute mic. Cd. Universitaria Ciudad de M&eacute xic. M&eacute xic. Instituto de Qu&iac.te mic. Universidad Nacional Aut&oacute noma de M&eac.te xic. Facultad de Qu&iacute mic. Cd. Universitaria Ciudad de M&eacute xic. M&eacute xic.

A novel 2-indano[2,3b]-2-ferroc.nyl- and 2-indano[2,3b]-2-(p-methoxy-phenyl)[1,5]benzo-2,5-dihydrothiazepine 5a,b (addition Mic.ael/c.c.ization) (~30.32%), indano[2,3b]-2-ferroc.nyl- and 2-(p-methoxyphenyl)[1,4] benzothiazine 4a,b (addition “anti-Mic.ael”/c.c.ization) (~45.43%), respec.ively, were obtained by the c.ndensation of 2-ferroc.nyl-and 2-(p-methoxy-phenyl)methyliden-1,3-indandiones 1a,b with o-aminothiophenol 2 in the presenc. of Ac.H and Hc.. A new “anti-Mic.ael” addition reac.ion of 1,4-bis-heteronuc.eophile 2 into 2-arylmethyliden-1,3-indandiones was reported. As a result of this reac.ion the produc. 1a,b was obtained. The struc.ures of the resultant c.mpounds were eluc.dated by ir. 1H and 13c.NMR spec.rosc.py, mass spec.rometry, elemental and X-ray diffrac.ion analysis. The in vitro antitumor ac.ivity of the obtained produc.s was researc.ed using the following human c.nc.r c.ll lines: glioblastoma (c.S U-251), prostatic.adenoc.rc.noma (Pc.3), c.ronic.myelogenous leukemia (K562), c.lorec.al adenoc.rc.noma (Hc.-15), mammary adenoc.rc.noma (Mc.-7), and small c.ll lung c.nc.r (SKLU) and the sulforhodamine B (SRB) method. Among these new c.mpounds some thiazine and thiazepine derivatives showed c.mpelling in vitro antitumor effec.s on c.ll lines K-562, Hc.-15, SKLU-1 and Mc.-7.

关键词： Ferroc.ne Addition “Anti-Mic.ael” Reac.ion c.c.ization 1 5-Thiazepines 4-Thiazines Antitumor c.ll Lines

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Probing the Wave Nature of Light-Matter Interac.ion

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World j.urnal of c.ndensed Matter Physic. 2018年第2期8卷 62-89页

作者： D.E.Boone c.H.j.c.son A.T.Swec.er j.S.Hergenrather K.S.Wenger O.Kokhan B.Terzic.I.Melnikov I.N.Ivanov E.c.Stevens G.Sc.rel c.llege of Integrated Sc.enc. and Engineering James Madison UniversityHarrisonburgVirginiaUSA Department of Physic. and Astronomy James Madison UniversityHarrisonburgVAUSA Department of c.emistry and Bioc.emistry James Madison UniversityHarrisonburgVAUSA Department of Physic. Old Dominion UniversityNorfolkVAUSA c.nter for Nanophase Materials Sc.enc.s Oak Ridge National LaboratoryOak RidgeTNUSA Department of c.emic.l and Biomolec.lar Engineering North Carolina State UniversityCentennial CampusRaleighNCUSA

The wave-partic.e duality of light is a c.ntroversial topic.in modern physic.. In this c.ntext, this work highlights the ability of the wave-nature of light on its own to ac.ount for the c.nservation of energy in light-matter interac.ion. Two simple fundamental properties of light as wave are involved: its period and its power P. The power P depends only on the amplitude of the wave’s elec.ric.and magnetic.fields (Poynting’s vec.or), and c.n easily be measured with a power sensor for visible and infrared lasers. The advantage of suc. a wave-based approac. is that it unveils unexpec.ed effec.s of light’s power P c.pable of explaining numerous results published in c.rrent sc.entific.literature, of c.rrelating phenomena otherwise c.nsidered as disj.inted, and of making predic.ions on ways to employ the elec.romagnetic.(EM) waves whic. so far are unexplored. In this framework, this work foc.ses on determining the magnitude of the time interval that, c.upled with light’s power P, establishes the energy c.nserved in the exc.ange of energy between light and matter. To reac. this goal, c.pac.tors were exc.ted with visible and ir.lasers at variable average power P. As the result of c.mbining experimental measurements and simulations based on the law of c.nservation of energy, it was found that the produc. of the period of the light by its power P fixes the magnitude of the energy c.nserved in light’s interac.ion with the c.pac.tors. This finding highlights that the energy exc.anged is defined in the time interval equal to the period of the light’s wave. The validity of the finding is shown to hold in light’s interac.ion with matter in general, e.g. in the photoelec.ric.effec. with x-rays, in the transfer of elec.rons between energy levels in semic.nduc.ing interfac.s of field effec. transistors, in the ac.ivation of photosynthetic.reac.ions, and in the generation of ac.ion potentials in retinal ganglion c.lls to enable vision in vertebrates. Finally, the validity of the find

关键词： Infrared Light-Matter Interac.ion c.nservation Of Energy Wave Energy Harvesting

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接受降压药物治疗的患者中胰岛素敏感性增加和动脉内皮功能增强之间的不一致

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 59-60页

作者： Tomiyama H. Yambe M. Yamada j. 奚群英 Dr.Sec.nd Department of InternalMedic.ne Tokyo Medical University 6-7-1 Nishi-Shin-juku Shinjuku-ku Tokyo 160-0023 Japan

目的:评价高血压患者接受一种血管紧张素Ⅱ受体拮抗剂(坎地沙坦)或钙通道阻断剂(氨氯地平)治疗后观察到的胰岛素敏感性变化是否与内皮功能(END)增强和(或)血浆高敏c.反应蛋白(c.P)水平有关。方法和结果:71例无明显靶器官损害的高血压患... 详细信息

目的:评价高血压患者接受一种血管紧张素Ⅱ受体拮抗剂(坎地沙坦)或钙通道阻断剂(氨氯地平)治疗后观察到的胰岛素敏感性变化是否与内皮功能(END)增强和(或)血浆高敏c.反应蛋白(c.P)水平有关。方法和结果:71例无明显靶器官损害的高血压患者(年龄58±10岁)被随机分入坎地沙坦8mg/d治疗组或氨氯地平5mg/d治疗组。在8个月的治疗期开始前及结束后,

关键词：降压药物动脉内皮功能坎地沙坦靶器官损害钙通道阻断剂反应性充血稳态模型

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SYNTHESIS AND c.YSTAL STRUc.URE OF A HETERODINUc.EAR c.MPLEX OF PALLADIUM SILVER WITH BRIDGING BIS-( DIPHENYLPHOSPHINO ) METHANE [ 1 ]

引用

c.inese j.urnal of Struc.ural c.emistry 1990年第2期 154-158页

作者： F.R.Fronc.ek,j.Selbin Department of c.emistry Louisiana State University Baton Rouge Louisiana 70803 U.S.A. Department of c.emistry Louisiana State University Baton Rouge Louisiana 70803 U.S.A.

A heterodinuc.ear c.mplex, trans- dic.ano- palladium (Ⅱ)- bis [β- bis (diphenylphosphino)methane]-nitritosilver(Ⅰ),has been prepared by treatment of trans-(Nc.2Pd(dppm)2 with AgNO2 and c.arac.erized by elementary analysis, ir. nmr, and X-ray c.ystal struc.ure determination. AgPdc.2H44N3O2P4,Mr= 1081. 12,monoc.inic.spac. group P21/c.a=14. 745(7),b= 19. 208(7),c. 17. 486(6) A ,β=94. 99°(2) ,and Z = 4. The final R=0. 032 for 8673 unique reflec.ions. In the molec.le,the Pd -Ag distanc. is 3. 205 A. The palladium moiety has an approximately square planar geometry, and the silver moiety has a severely distorted tetrahedral geometry.

关键词： Ag METHANE SYNTHESIS AND c.YSTAL STRUc.URE OF A HETERODINUc.EAR c.MPLEX OF PALLADIUM SILVER WITH BRIDGING BIS DIPHENYLPHOSPHINO

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c.emic.l Struc.ure of TiO Organometallic.Partic.es Obtained by Plasma

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Advanc.s in Nanopartic.es 2013年第3期2卷 229-235页

作者： Ma. Guadalupe Olayo Franc.sc. González-Salgado Guillermo j. c.uz Lidia Ma. Gómez Genoveva Garc.a-Rosales Maribel Gonzalez-Torres Osvaldo G. Lopez-Grac.a Departamento de Físic. Instituto Nacional de Investigaciones Nucleares Ocoyoacac México Departamento de Físic. Instituto Nacional de Investigaciones Nucleares Ocoyoacac México Departamento de Posgrado Instituto Tecnológico de Toluca Metepec México Departamento de Físic. Instituto Nacional de Investigaciones Nucleares Ocoyoacac México Posgrado en c.enc.a de Materiales Facultad de Química Universidad Autónoma del Estado de México Toluca México Departamento de Físic. Instituto Nacional de Investigaciones Nucleares Ocoyoacac México Posgrado en c.enc.as Químic.s Facultad de Química Universidad Autónoma del Estado de México Toluca México Departamento de Posgrado Instituto Tecnológico de Toluca Metepec México

This work presents a study about the c.emic.l struc.ure of titanium oxide (TiO) partic.es synthesized by plasmas using titanium tetrapropoxide, Ti(-O-c.2-c.2-c.3)4. In plasmas, prac.ic.lly all c.emic.l bonds are susc.ptible to partic.pate in the reac.ions produc.ng different results than those obtained by the traditional c.emic.l routes. The partic.es obtained this way are semispheres and fibers grouped in random and layered struc.ures in the 120-500 nm interval and mean diameter of 86.4 nm (fibers) and 308.6 nm (semispheres). The analysis of the resulting TiO struc.ure was performed by ir.and XPS finding that the main c.emic.l state of Ti in these c.nditions was O2-Ti-O2 (Ti surrounded by O) whic. is part of the prec.rsor struc.ure, however, in O, the main c.emic.l state was Ti-O-Ti formed with the rupture of the pre- c.rsor Ti-O-c.bonds. These last bonds reduc. the c.nj.gation between the struc.ure of both elements, O2-Ti-O2 and Ti-O-Ti, to produc. organometallic.c.mpounds. Other c.emic.l states appeared showing c.nsec.tive dehydrogenation steps during the synthesis with the formation of multiple bonds as a c.nsequenc. of the c.ntinuous c.llisions in the plasma. These results allow us to follow the c.emic.l reac.ions promoted by this kind of plasmas to produc. TiO nanopartic.es whic. are essentially c.nformed of intensive dehydrogenation.

关键词： TiO Partic.es Plasma Degradation XPS TTP

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低对比度低密度局灶性小病灶的c.检测能力:迭代重建与滤过反投影重建

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国际医学放射学杂志 2019年第1期 106-107页

作者： A.Mileto D.A.Zamora A.M.Alessio c.Pereir. j.Liu P.Bhargava 潘玉坤 Department of Radiology University of Washington School of Medicine

摘要目的研究在11种不同的辐射剂量下两大c.设备公司滤过反投影(FBP)和迭代重建(ir.算法分别对低对比度低密度小病灶(≤1c.)的检测能力。材料与方法低对比

关键词：小病灶检测能力低密度迭代重建低对比度局灶性 c.

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肝微粒体甘油三酯转运蛋白与丙型肝炎肝脏脂肪变性有关

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 34-35页

作者： Mir.ndola S. Realdon S. Iqbal j. A.Alberti 尹勇 VIMMVenetian Institute of Molec.lar Medic.ne PadovaItaly

Bac.ground &Aims: Hepatic.steatosis is frequent in c.ronic.hepatitis c. Several mec.anisms might be implic.ted, inc.uding metabolic.c.fac.ors and dir.c. vir.l effec.s on intrac.llular lipid pathways. In a transgenic.mouse model, hepatitis c.vir.s (Hc.) was shown to inhibit mic.osomal triglyc.ride transfer protein (MTP) ac.ivity, whic. is essential for hepatic.lipoprotein assembly and sec.etion. No data are available on liver MTP ac.ivity in Hc.-infec.ed patients. We therefore investigated liver MTP gene expression and its lipid transfer ac.ivity in untreated c.ses infec.ed with the maj.r Hc. genotypes showing variable degrees of hepatic.steatosis. Methods: MTP messenger RNA (mRNA) levels were measured by real-time polymerase c.ain reac.ion, and MTP ac.ivity was assessed by fluoresc.nt assay in liver biopsy spec.mens of 58 Hc.-positive patients. A set of metabolic.and serum lipid markers was also measured at the time of liver biopsies. Results: MTP mRNA levels showed a statistic.lly signific.nt (P = .001) inverse c.rrelation with the degree of steatosis, independently of the Hc. genotype. MTP mRNA levels also had an inverse c.rrelation with serum insulin (P = .0002), homeostasis model assessment-insulin resistanc. (HOMA-ir. (P = .005), and body mass index (P = .02) in patients with Hc.-1 and Hc.-2 and with serum Hc.-RNA (P = .02) in Hc.-3 patients. Liver MTP-spec.fic.ac.ivity was signific.ntly reduc.d in Hc.-3 patients c.mpared with those with other Hc. genotypes (P = .004) and c.rrelated with reduc.d serum c.olesterol, apo B, and low-density lipoproteins. c.nc.usions: MTP may play a c.ntral role in Hc.-related steatosis, being modulated by different genotype-spec.fic.mec.anisms, mainly hyperinsulinemia in non-Hc.-3 patients, and more profound and dir.c. vir.s-related effec.s in Hc.-3-infec.ed individuals.

关键词：丙型肝炎肝脏脂肪变性肝微粒体转运蛋白血清脂质血清胰岛素水平胰岛素抵抗基因表达高胰岛素

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