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Novel electrospun poly-hydroxybutyrate scaffolds as carriers for the wound healing agents alkannins and shikonins

Regenerative Biomaterials 2021年第3期8卷 94-109页

作者： Athanasios S.Arampatzis Konstantina Giannakoula Konstantinos N.Kontogiannopoulos Konstantinos Theodoridis Eleni Aggelidou Angelique Rat Elli Kampasakali Anne Willems Dimitrios Christofilos Aristeidis Kritis Vassilios P.Papageorgiou ioannis tsivintzelis Andreana N.Assimopoulou Laboratory of Organic Chemistry School of Chemical EngineeringAristotle University of Thessaloniki(AUTh)Thessaloniki 54124Greece Natural Products Research Centre of Excellence(NatPro-AUTh) Center of Interdisciplinary Research and Innovation of Aristotle University of Thessaloniki(CIRI-AUTh)Thessaloniki 57001Greece Department of Physiology and Pharmacology School of MedicineFaculty of Health SciencesAristotle University of Thessaloniki(AUTh)ThessalonikiGreece Laboratory of Microbiology Faculty of SciencesGhent UniversityGhent 9000Belgium Faculty of Engineering School of Chemical Engineering and Physics LaboratoryAristotle University of ThessalonikiThessaloniki 54124Greece Physical Chemistry Laboratory School of Chemical EngineeringAristotle University of ThessalonikiThessaloniki 54124Greece

The aim of this study was to investigate the potential of novel electrospun fiber mats loaded with alkannin and shikonin(A/S)derivatives,using as carrier a highly biocompatible,bio-derived,ecofriendly polymer such as poly[(R)-3-hydroxybutyric acid](PHB).PHB fibers containing a mixture of A/S derivatives at different ratios were successfully fabricated via *** evidenced by scanning electron microscopy,the fibers formed a bead-free mesh with average diameters from 1.25 to 1.47 *** measurements suggest that electrospinning marginally increases the amorphous content of the predominantly crystalline PHB in the fibers,while a significant drug amount lies near the fiber surface for samples of high total A/S *** scaffolds displayed satisfactory characteristics,with the lower concentrations of A/S mixture-loaded PHB fiber mats achieving higher porosity,water uptake ratios,and entrapment *** in vitro dissolution studies revealed that all samples released more than 70%of the encapsulated drug after 72 *** PHB scaffolds tested by cell viability assay were proven non-toxic for Hs27 fibroblasts,with the 0.15 wt.%sample favoring cell attachment,spreading onto the scaffold surface,as well as cell ***,the antimicrobial activity of PHB meshes loaded with A/S mixture was documented for Staphylococcus epidermidis and ***.

关键词： electrospinning polyhydroxyalkanoates alkannin shikonin wound healing

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