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Proteasome regulators in pancreatic cancer

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 38-54页

作者： Nirosha J Murugan ioannis A Voutsadakis Department of Biology Algoma UniversitySault Sainte Marie P6A3T6ONCanada Department of Medical Oncology Sault Area HospitalSault Sainte Marie P6A3T6ONCanada

Pancreatic adenocarcinoma is one of the most lethal cancers with rising *** progress in its treatment,with the introduction of more effective chemotherapy regimens in the last decade,prognosis of metastatic disease remains inferior to other cancers with long term survival being the *** characterization of pancreatic cancer has elucidated the landscape of the disease and has revealed common lesions that contribute to pancreatic *** of proteostasis is critical in cancers due to increased protein turnover required to support the intense metabolism of cancer *** proteasome is an integral part of this regulation and is regulated,in its turn,by key transcription factors,which induce transcription of proteasome structural *** include FOXO family transcription factors,NFE2L2,hHSF1 and hHSF2,and *** that encompass proteasome regulators and transduction pathways dysregulated in pancreatic cancer such as the KRAS/BRAF/MAPK and the Transforming growth factor beta/SMAD pathway contribute to pancreatic cancer *** review discusses the proteasome and its transcription factors within the pancreatic cancer cellular *** also consider the role of stemness in carcinogenesis and the use of proteasome inhibitors as therapeutic agents.

关键词： Pancreatic adenocarcinoma Proteasome Transcription factors Regulation Unfolded protein response Cancer stem cells

Response of colour and hygroscopic properties of Scots pine wood to thermal treatment

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Journal of Forestry Research 2013年第3期24卷 571-575页

作者： Vasiliki Kamperidou ioannis Barboutis Vasileios Vasileiou Aristotle University of Thessaloniki Faculty of Forestry and Natural Environment Laboratory of Wood Products and Furniture Technology54124 Thessaloniki Greece

The effect of heat treatment on the surface colour and hygro- scopic properties of pine wood were investigated in this study. Boards of Scots pine wood （Pinus sylvestris L.） were subjected to thermal treatment at 200℃, for 4, 6, and 8 h. The change of equilibrium moisture content and density values of the specimens in order to facilitate the understand- ing of the treated material behavior. The colour parameters L＊ a＊ and b＊, used to depict the total colour change （dE） of wood surface, were shown to change proportionally to the treatment intensity. Moreover, swelling in the tangential and radial directions and absorption of the specimens ap- peared to be enhanced in great extent by the thermal treatment process. The mean value of swelling percentage in the tangential direction de- creased 10.26%, 17.22%, and 19.60% for specimens treated for 4, 6, and 8 h, respectively, referring to the final measurement after 72 h of immer- sion. In radial direction, mean value of swelling percentage decreased 19.56%, 32.75%, and 34.65% for treated for 4, 6 and 8 h, respectively, after 72 h immersion, which attests the decrease in swelling and im- provement in the hygroscopic behavior of Scots pine wood.

关键词： Colour Hygroscopic properties Modification Thermaltreatment Scots pine

COVID-19 and hyperglycemia/diabetes

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World Journal of Diabetes 2021年第5期12卷 642-650页

作者： Konstantinos Michalakis ioannis Ilias Private Practice Athens GR-11521Greece Department of Endocrinology Diabetes and MetabolismElena Venizelou HospitalAthens GR-11521Greece

In early studies regarding coronavirus disease 2019(COVID-19),type 2 diabetes mellitus was considered to contribute substantially to the disease’s inflammatory ***,even hyperglycemia,regardless of insulin resistance or diabetes mellitus,was found to be additionally *** studies have shown inflammation of the pancreaticβcells in COVID-19,even leading to new onset diabetes *** hereby summarize core literature on glycemia and COVID-19,and present implicated pathways and mechanisms.

关键词： COVID-19 Humans SARS-CoV-2 Risk factors Glucose Inflammation Diabetes

Targeted treatments for metastatic esophageal squamous cell cancer

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World Journal of Gastrointestinal Oncology 2013年第5期5卷 88-96页

作者： Antonia Digklia ioannis A Voutsadakis Centre Pluridisci-plinaire d’Oncologie Centre Hospitalier Universitaire Vaudois

Squamous cell carcinoma, one of the two major subtypes of esophageal carcinomas, constitutes the great majority of tumors in the upper and middle third of the organ. Declining in incidence in western countries, it continues to be a significant public health problem in the far east. Targeted treatments are novel therapies introduced in the clinical therapeutic armamentarium of oncology in the last 10-15 years. They represent a rational way of treating various cancers based on their molecular lesions. Although no such agent has been approved so far for the treatment of esophageal squamous cell carcinomas (ESCC), several are in clinical trials and several others have displayed pre-clinical activity that would justify the efforts and risks of pursuing their clinical development in this disease. This paper discusses some of these targeted agents in more advanced development in metastatic ESCC, as well as some promising drugs with pre-clinical or initial clinical data in the disease.

关键词： Esophageal carcinoma Squamous Targeted therapies Clinical trials Epidermal growth factor receptor Vascular endothelial growth factor receptor Mammalian target of rapamycin

Spectroscopic investigations on the effect of humic acid on the formation and solubility of secondary solid phases of Ln_2(CO_3)_3

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Journal of Rare Earths 2011年第6期29卷 516-521页

作者： Stella Antoniou ioannis Pashalidis Andre Gessner Michael U Kumke Department of Chemistry University of Cyprus P.O. Box 20537 1678 Nicosia Cyprus Chemistry Department/Physical Chemistry University of Potsdam Karl- Liebknecht-Str. 24-25 14476 Potsdam-Golm Germany

The formation of secondary Ln（III） solid phases （e.g., Nd2（CO3）3 and Sm2（CO3）3） was studied as a function of the humic acid concentration in 0.1 mol/L NaClO4 aqueous solution in the neutral pH range （5–6.5）. The solid phases under investigation were prepared by alkaline precipitation under 100% CO2 atmosphere and characterized by attenuated total reflectance Fourier transform infrared spectroscopy （ATR-FTIR）, X-ray diffraction （XRD）, time-resolved laser fluorescence spectroscopy （TRLFS）, diffuse reflectance ultraviolet-visible （DR-UV-Vis）, Raman spectroscopy, and solubility measurements. The spectroscopic data obtained indicated that Nd2（CO3）3 and Sm2（CO3）3 were stable and remained the solubility limiting solid phases even in the presence of increased humic acid concentration （0.5 g/L） in solution. Upon base addition in the Ln（III）-HA system, decomplexation of the previously formed Ln（III）-humate complexes and precipitation of two distinct phases occurred, the inorganic （Ln2（CO3）3） and the organic phase （HA）, which was adsorbed on the particle surface of the former. Nevertheless, humic acid affected the particle size of the solid phases. Increasing humic acid concentration resulted in decreasing crystallite size of the Nd2（CO3）3 and increasing crystallite size of the Sm2（CO3）3 solid phase, and affected inversely the solubility of the solid phases. However, this impact on the solid phase properties was expected to be of minor relevance regarding the chemical behavior and migration of trivalent lanthanides and actinides in the geosphere.

关键词： lanthanide ions humic acid solid phase solubility Raman TRLFS DR-UV-Vis rare earths

Advances and challenges in laparoscopic surgery in the management of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2017年第12期9卷 233-245页

作者： ioannis A Ziogas Georgios Tsoulfas Medical School Aristotle University of Thess-aloniki 1~(st) Department of Surgery Aristotle University of Thessaloniki

Hepatocellular carcinoma is the fifth most common malignancy and the third most common cause of cancer-related mortality worldwide. From the wide variety of treatment options, surgical resection and liver transplantation are the only therapeutic ones. However, due to shortage of liver grafts, surgical resection is the most common therapeutic modality implemented. Owing to rapid technological development, minimally invasive approaches have been incorporated in liver surgery. Liver laparoscopic resection has been evaluated in comparison to the open technique and has been shown to be superior because of the reported decrease in surgical incision length and trauma, blood loss, operating theatre time, postsurgical pain and complications, R0 resection, length of stay, time to recovery and oral intake. It has been reported that laparoscopic excision is a safe and feasible approach with near zero mortality and oncologic outcomes similar to open resection. Nevertheless, current indications include solid tumors in the periphery < 5 cm, especially in segments Ⅱ through Ⅵ, while according to the consensus laparoscopic major hepatectomy should only be performed by surgeons with high expertise in laparoscopic and hepatobiliary surgery in tertiary centers. It is necessary for a surgeon to surpass the 60-cases learning curve observed in order to accomplish the desirable outcomes and preserve patient safety. In this review, our aim is to thoroughly describe the general principles and current status of laparoscopic liver resection for hepatocellular carcinoma, as well as future prospects.

关键词： Hepatocellular carcinoma Laparoscopic liver resection Minimally invasive surgery Laparoscopic hepatectomy Liver malignant disease Surgical excision

Up-to-date intraoperative computer assisted solutions for liver surgery

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World Journal of Gastrointestinal Surgery 2019年第1期11卷 1-10页

作者： Apollon Zygomalas ioannis Kehagias Surgical Oncology OLYMPION General Clinic of Patras Department of Surgery University Hospital of Patras

Computer assisted surgical planning allowed for a better selection of patients,evaluation of operative strategy, appropriate volumetric measurements,identification of anatomical risks, definition of tumour resection margins and choice of surgical approach in liver oncologic resections and living donor liver transplantations. Although preoperative computer surgical analysis has been widely used in daily clinical practice, intraoperative computer assisted solutions for risk analysis and navigation in liver surgery are not widely available or still under clinical evaluation. Computer science technology can efficiently assist modern surgeons during complex liver operations, mainly by providing image guidance with individualized 2 D images and 3 D models of the various anatomical and pathological structures of interest. Intraoperative computer assisted liver surgery is particularly useful in complex parenchyma-sparing hepatectomies, for intraoperative risk analysis and for the effective treatment of colorectal metastases after neoadjuvant therapy or when they are multiple. In laparoscopic liver surgery, intraoperative computer aid is definitively more important as, apart from a restricted field of view, there is also loss of the fine haptic feedback. Intraoperative computer assisted developments face challenges that prevent their application in daily clinical practice. There is a vast variety of studies regarding intraoperative computer assisted liver surgery but there are no clear objective measurements in order to compare them and select the most effective solutions. An overview of up-to-date intraoperative computer assisted solutions for liver surgery will be discussed.

关键词： Computer assisted surgery Liver Intraoperative 3D models Navigation Image guidance Augmented reality Hepatic surgery Hepatectomy

Histone deacetylase inhibitors and pancreatic cancer:Are there any promising clinical trials?

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World Journal of Gastroenterology 2013年第8期19卷 1173-1181页

作者： ioannis Koutsounas Constantinos Giaginis Stamatios Theocharis Department of Forensic Medicine and Toxicology Medical SchoolUniversity of AthensGR-11527 AthensGreece Department of Food Science and Nutrition University of the AegeanGR-81400 LemnosGreece

Pancreatic cancer,although not very frequent,has an exceptionally high mortality rate,making it one of the most common causes of cancer mortality in developed *** cancer is difficult to diagnose,allowing few patients to have the necessary treatment at a relatively early *** a marginal benefit in survival,the overall response of pancreatic cancer to current systemic therapy continues to be poor,and new therapies are desperately *** deacetylase(HDAC) enzymes play an important role in the development and progression of cancer and HDAC inhibitors(HDACIs) have been shown to induce differentiation and cell cycle arrest,activate the extrinsic or intrinsic pathways of apoptosis,and inhibit invasion,migration and angiogenesis in different cancer cell *** a result of promising preclinical data,various HDACIs are being tested as either monotherapeutic agents or in combination regimens for both solid and hematological *** was the first HDACI approved by the Food and Drug Administration for patients with cutaneous T-cell *** use of HDACIs in clinical trials,in pretreated and relapsed patients suffering from advanced pancreatic cancer is ***,clinical data for HDACIs in patients with pancreatic cancer are inadequate,because only a few studies have included patients suffering from this type of neoplasm and the number of pancreatic cancer patients that entered HDACIs phase Ⅱ/Ⅲ trials,among others with advanced solid tumors,is very *** studies recruiting patients with pancreatic cancer remain to determine the efficiency of these therapies.

关键词： Pancreatic cancer Histone deacetylases Histone deacetylase inhibitors Clinical trials

Liver function in transgender persons:Challenges in the COVID-19 era

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World Journal of Clinical Cases 2023年第2期11卷 299-307页

作者： Charalampos Milionis ioannis Ilias Eftychia Koukkou Department of Endocrinology Diabetes and MetabolismElena Venizelou HospitalAthens GR-11521Greece

Transgender persons constitute a non-negligible percentage of the general *** gender-transitioning in trans persons is mainly achieved with hormonal cross-sex therapy and sex reassignment surgeries that aim to align bodily appearance with gender *** treatment acts via suppressing the secretion of the endogenous sex hormones and replacing them with the hormones of the desired *** administration of testosterone is the typical masculinizing treatment in trans men,whilst trans women are routinely treated with estradiol agents in combination with anti-androgens or gonadotrophinreleasing hormone agonists if testes are *** androgenic steroids,estradiol agents,and anti-androgens have been implicated in a series of hepatotoxic ***,liver integrity is a major concern with the long-term administration of cross-sex *** tissue is susceptible to coronavirus disease 19(COVID-19)through various pathophysiological *** consideration should be paid to minimize the risk of hepatic damage from the potential cumulative effect of COVID-19 and gender-affirming treatment in transgender *** care is significant,with continuous laboratory monitoring,clinical observation and,if needed,specific treatment,especially in severe cases of infection and in persons with additional liver *** pandemic can be an opportunity to provide equal access to care for all and increase the resilience of the transgender population.

关键词： Transgender persons Drug induced liver injury COVID-19