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De novo serine synthesis regulates chondrocyte proliferation during bone development and repair

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Bone Research 2022年第2期10卷 274-285页

作者： Steve Stegen Shauni Loopmans ingrid Stockmans Karen Moermans Peter Carmeliet Geert Carmeliet Laboratory of Clinical and Experimental Endocrinology Department of Chronic Diseases and MetabolismKU Leuven3000 LeuvenBelgium Laboratory of Angiogenesis and Vascular Metabolism VIB Center for Cancer Biology3000 LeuvenBelgium Laboratory of Angiogenesis and Vascular Metabolism Department of Oncology and Leuven Cancer InstituteKU Leuven3000 LeuvenBelgium State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen UniversityGuangzhou 510080China

The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous *** cells, or chondrocytes, survive, proliferate and synthesize extracellular matrix in an avascular environment, but the metabolic requirements for these anabolic processes are not fully understood. Here, using metabolomics analysis and genetic in vivo models, we show that maintaining intracellular serine homeostasis is essential for chondrocyte function. De novo serine synthesis through phosphoglycerate dehydrogenase(PHGDH)-mediated glucose metabolism generates nucleotides that are necessary for chondrocyte proliferation and long bone growth. On the other hand, dietary serine is less crucial during endochondral bone formation, as serine-starved chondrocytes compensate by inducing PHGDH-mediated serine ***, this metabolic flexibility requires ATF4, a transcriptional regulator of amino acid metabolism and stress *** demonstrate that both serine deprivation and PHGDH inactivation enhance ATF4 signaling to stimulate de novo serine synthesis and serine uptake, respectively, and thereby prevent intracellular serine depletion and chondrocyte dysfunction. A similar metabolic adaptability between serine uptake and de novo synthesis is observed in the cartilage callus during fracture ***, the results of this study reveal a critical role for PHGDH-dependent serine synthesis in maintaining intracellular serine levels under physiological and serine-limited conditions, as adequate serine levels are necessary to support chondrocyte proliferation during endochondral ossification.

关键词： synthesis starting thereby

An evaluation of intraoperative and postoperative outcomes of torsional mode versus longitudinal ultrasound mode phacoemulsification:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 890-897页

作者： Pia Leon ingrid Umari Alessandro Mangogna Andrea Zanei Daniele Tognetto University Eye Clinic of Trieste Ospedale MaggioreTrieste34125Italy Department of Medicine Surgery and Health SciencesUniversity of TriesteTrieste 34149Italy

AIM： To evaluate and compare the intraoperative parameters and postoperative outcomes of torsional mode and longitudinal mode of phacoemulsification. METHODS： Pertinent studies were identified by a computerized MEDLINE search from January 2002 to September 2013. The Meta-anaiysis is composed of two parts. In the first part the intraoperative parameters were considered： ultrasound time （UST） and cumulative dissipated energy （CDE）. The intraoperative values were also distinctly considered for two categories （moderate and hard cataract group） depending on the nuclear opacity grade. In the second part of the study the postoperative outcomes as the best corrected visual acuity （BCVA） and the endothelial cell loss （ECL） were taken in consideration. RESULTS： The UST and CDE values proved statistically significant in support of torsional mode for both moderate and hard cataract group. The analysis of BCVA did not present statistically significant difference between the two surgical modalities. The ECL count was statistically significant in support of torsional mode （P〈0.001）. CONCLUSION： The Meta -analysis shows the superiority of the torsional mode for intraoperative parameters （UST, CDE） and postoperative ECL outcomes.

关键词： conventional (longitudinal) phacoemulsi-fication phacoemulsification torsional phacoemulsification

A MODEL FOR PROGRAMMING DESIGN INTERVENTIONS AIMED AT REDUCING THERMAL DISCOMFORT IN URBAN OPEN SPACES:A Case Study on the Politecnico di Milano Campus

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Journal of Green Building 2008年第4期3卷 119-129页

作者： Anna Mangiarotti ingrid Paoletti Eugenio Morello BEST Politecnico di MilanoMilanoItaly. DIAP Politecnico di MilanoMilanoItaly. SENSEable City Laboratory MITCambridgeMAUSA.

The environmental quality of urban spaces is strongly related to the thermal comfort perceived by people in open *** the micro-scale of neighbourhoods,the mitigation of the heat island effect can improve both the well-being of cityusers in the public realm and the energy performance of buildings.A model intended for urban designers is presented,and it sets out to evaluate critical areas in the city context and define sustainable design solutions and concrete actions on the physical environment,in order to increase thermal *** particular,variables used in the model are basically related to urban geometry,such as the accessibility of sunlight,sky view factors,aspect ratios of street canyons,and to the physical materials in the city,such as the albedo of horizontal and vertical surfaces and vegetation *** technique is based on the use of algorithms defi ned in a Matlab environment and derived from image processing of Digital Elevation Models(DEMs)of the urban *** application was tested on the case study of the Politecnico di Milano’s main campus,located in the city of *** in the case of limited resources,the results of the analysis suggest how public administrators and decision-makers could benefi t from programming specific site interventions,based on the identification of critical weaknesses emerging at several points in the ***,the study focuses on the application of cool surfaces,the role of building layout(shape and size)and the effects of increasing the *** in the absence of expensive thermal imagery from remote sensing,but simply referring to available cartography,this low-cost technique makes it possible to very quickly set up feasible environmental strategies over extensive urban ***,this tool proves to be useful for existing urban areas,as well as for simulating the impact of new design schemes.

关键词： thermal comfort urban heat island cool surfaces Digital Elevation Models environmental quality

THE INFLUENCE OF IMPURITIES ON THE DISSOLUTION OF CA- AND SR-BEARING BARITE AT ROOM TEMPERATURE

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Chinese Journal Of Geochemistry 2006年第1期25卷 71-84页

作者：张学洪朱义年 ingrid STOBER KURT BUCHER FACULTY OF URBAN CONSTRUCTION AND ENVIRONMENTAL ENGINEERING CHONGQING UNIVERSITY CHONGQING 400044 CHINADEPT. OF RESOURCE AND ENVIRONMENTAL ENGINEERING GUILIN UNIVERSITY OF TECHNOLOGY GUILIN 541004 CHINA DEPT. OF RESOURCE AND ENVIRONMENTAL ENGINEERING GUILIN UNIVERSITY OF TECHNOLOGY GUILIN 541004 CHINAINSTITUTE FOR MINERALOGY PETROLOGY AND GEOCHEMISTRY UNIVERSITY OF FREIBURG ALBERTSTR.23B 79104 FREIBURG GERMANY GEOLOGICAL SURVEY BADEN-WüRTTEMBERG ALBERTSTR.5 79104 FREIBURG GERMANY INSTITUTE FOR MINERALOGY PETROLOGY AND GEOCHEMISTRY UNIVERSITY OF FREIBURG ALBERTSTR.23B 79104 FREIBURG GERMANY

The reaction path in the (Ba, Sr, Ca)SO-4 solid-solution aqueous-solution (SSAS) system was experimentally studied using a batch-reactor method. The effect of the impurities "fluorite" and "iron sulfides" admixed in a natural barite sample on the reaction path was followed by analyzing the aqueous solution continuously. The dissolution and precipitation of the impurity "fluorite" affected strongly the reaction path in the SSAS system, especially the Ca/Sr/Ba ratio in the aqueous solution. This influence became stronger with decreasing CaSO-4 in the solid solution. The dissolution and precipitation of fluorite could hinder the CaSO-4 component from dissolving into water, and reduce the release rate of SO{2-}-4 from the solid solution to the aqueous solution and the removing rate of Ba{2} from the aqueous solution. In the presence of fluorite and sulfides, the aqueous Ba{2} and Sr{2} concentrations were controlled by the dissolution-precipitation of the end-members BaSO-4 and SrSO-4, respectively; the aqueous F-, Ca{2} and SO{2-}-4 concentrations were controlled by the dissolution-precipitation of fluorite. The incongruent dissolution of the (Ba, Sr, Ca)SO-4 solid solution caused the solid phase to become progressively more enriched in the more insoluble component (BaSO-4), while the aqueous composition shifted towards the more soluble end-members (SrSO-4 and CaSO-4) as equilibrium was approached to.

关键词：杂质溶解作用重晶石温度矿床

Genes, emotions and gut microbiota:The next frontier for the gastroenterologist

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World Journal of Gastroenterology 2017年第17期23卷 3030-3042页

作者： Arturo Panduro ingrid Rivera-Iniguez Maricruz Sepulveda-Villegas Sonia Roman Department of Molecular Biology in Medicine Civil Hospital of Guadalajara“Fray Antonio Alcalde” Health Sciences Center University of Guadalajara

Most medical specialties including the field of gastroenterology are mainly aimed at treating diseases rather than preventing them. Genomic medicine studies the health/disease process based on the interaction of the human genes with the environment. The gastrointestinal(GI) system is an ideal model to analyze the interaction between our genes, emotions and the gut microbiota. Based on the current knowledge, this mini-review aims to provide an integrated synopsis of this interaction to achieve a better understanding of the GI disorders related to bad eating habits and stress-related disease. Since human beings are the result of an evolutionary process, many biological processes such as instincts, emotions and behavior are interconnected to guarantee survival. Nourishment is a physiological need triggered by the instinct of survival to satisfy the body's energy demands. The brain-gut axis comprises a tightly connected neuralneuroendocrine circuitry between the hunger-satiety center, the dopaminergic reward system involved in the pleasure of eating and the gut microbiota that regulates which food we eat and emotions. However, genetic variations and the consumption of high-sugar and high-fat diets have overridden this energy/pleasure neurocircuitry to the point of addiction of several foodstuffs. Consequently, a gut dysbiosis generates inflammation and a negative emotional state may lead to chronic diseases. Balancing this altered processes to regain health may involve personalized-medicine and genome-based strategies. Thus, an integrated approach based on the understanding of the gene-emotions-gut microbiota interaction is the next frontier that awaits the gastroenterologist to prevent and treat GI disorders associated with obesity and negative emotions.

关键词： Genes Emotions Brain reward system Gut microbiota Gastrointestinal disease Personalized medicine Genome-based nutrition Nutrigenetics Food decision-making Obesity

Development of Business Strategy of the Start-up Ultimeapps Company

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Development of Business Strategy of the Start-up Ultimeapps ...

作者： EPEZAGNE ASSAMALA ingrid RUTH 江苏大学

学位级别：硕士

在过去的十年里,许多初创公司在全球范围内成立并运营。虽然它们中也有极少数成为大公司,甚至成为行业领先的公司,但大多数初创公司存活时间都不超过两年,有些公司甚至从未获得任何投资回报,因此为初创企业制定生存和发展战略是非常重... 详细信息

在过去的十年里,许多初创公司在全球范围内成立并运营。虽然它们中也有极少数成为大公司,甚至成为行业领先的公司,但大多数初创公司存活时间都不超过两年,有些公司甚至从未获得任何投资回报,因此为初创企业制定生存和发展战略是非常重要的一项工作。Ultimeapps公司是一家位于加纳的信息技术初创公司,本人是该公司的创始团队成员之一。本研究在了Ultimeapps公司的内外环境和公司的现状的基础上,运用相关管理工具、理论和概念来分析和评估了公司近期的战略目标以及为实现该目标所选择的发展战略和竞争战略,并进一步就该战略实施的保障措施进行了深入的探讨。本研究的成果一方面可以指导Ultimeapps公司近期的经营管理工作,另一方面对类似的初创公司制定发展战略也有一定的参考价值。

关键词：战略发展营销资源价值

Rhythmical massage improves autonomic nervous system function:a single-blind randomised controlled trial

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Journal of Integrative Medicine 2018年第3期16卷 172-177页

作者： Georg Seifert Jenny-Lena Kanitz Carolina Rihs ingrid Krause Katharina Witt Andreas Voss Department of Pediatric Oncology and Hematology Charité-Universit?tsmedizin Berlin Institute of Innovative Health Technologies Ernst-Abbe-Hochschule University of Applied Sciences

Background： Rhythmical massage therapy（RMT） is a massage technique used in anthroposophic ***： The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate variability（HRV）.Design, setting, participants and intervention： This study was a randomised, controlled and single-blinded trial, involving 44 healthy women（mean age：（26.20 ± 4.71） years）. The subjects were randomised to one of three arms： RMT with aromatic oil（RA）, RMT without aromatic oil（RM） or standardised sham massage（SM）. In the study the subjects were exposed to a standardised stress situation followed by one of the study techniques and Holter electrocardiograms（ECGs） were recorded for 24 *** outcome measures： HRV parameters were calculated from linear（time and frequency domain） and nonlinear dynamics（symbolic dynamics, Poincare plot analysis） of the 24-h Holter ECG ***： Short-and long-term effects of massage on autonomic regulation differed significantly among the three groups. Immediately after an RMT session, stimulation of HRV was found in the groups RA and RM. The use of an aromatic oil produced greater short-term measurable changes in HRV compared with rhythmic massage alone, but after 24 h the effect was no longer distinguishable from the RM *** lowest stimulation of HRV parameters was measured in the SM ***： RMT causes specific and marked stimulation of the autonomic nervous system. Use of a medicinal aromatic oil had only a temporary effect on HRV, indicating that the RM causes the most relevant long-term effect. The effect is relatively specific, as the physiological effects seen in the group of subjects who received only SM were considerably less pronounced.

关键词： Sham massage Well-being Mood Alertness Relaxation Stress Heart rate variability Randomised controlled trial

Regeneration of pitch pine (Pinus rigida) stands inhibited by fire suppression in Albany Pine Bush Preserve, New York

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Journal of Forestry Research 2019年第1期30卷 233-242页

作者： Chang-Seok Lee George R.Robinson ingrid P.Robinson Hansol Lee Department of Bio and Environment Technology Seoul Women's University State University of New York at Albany State University of New York

The Pine Barrens in New York State are dominated by pitch pine(Pinus ridgida) and scrub oaks(Quercus ilicifolia and Q. prinoides). With fire suppression over the last 90 years or so, P. rigida regeneration has become sparse, even in areas set aside to preserve this type of vegetation. We evaluated the effects of fire and an alternative disturbance(mechanical removal of vegetation)for increasing P. rigida regeneration in the Albany Pine Bush Preserve in eastern New York State. By comparing cover, diameter and height of P. rigida, Q. ilicifolia, ***, and Vaccinium spp.(blueberry) growing on the sites with a known fire history, we documented structural and compositional changes in the vegetation since its establishment. We also compared sites on which Quercus sprouts were controlled through mechanical removal. In the years following a disturbance, height and cover of Q. ilicifolia increased continuously and the species became increasingly competitive. Both the density of P. rigida seedlings and Vaccinium cover decreased significantly as the diameter and height of Quercus increased. Our results confirmed that the dominance by P. rigida could be attributed to periodic fires at intervals of 20–25 years. We conclude that removing Q. ilicifolia can favor P. rigida dominance on the barren without fire by releasing pine seedlings from competition.

关键词： Fire Mechanical removal Pine barren Pinus rigida Quercus ilicifolia Quercus prinoides Regeneration Safe site

Are we giving biologics too late? The case for early versus late use

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World Journal of Gastroenterology 2008年第36期14卷 5523-5527页

作者： Elena Ricart Orlando García-Bosch ingrid Ordás Julián Panés Gastroenterology Department Hospital Clinic CIBER- EHD C/Villarroel 170 Barcelona 08036 Spain

Corticosteroids and immunomodulators have been the mainstay therapies for Crohn’s disease. Corticosteroids are highly effective to control symptoms in the short- term, but they are not effective in maintaining remission, they heal the mucosa in a reduced proportion of cases, and long-time exposure is associated with an increased risk of infections and mortality. Immunomodulators, azathioprine and methotrexate, heal the mucosa in a higher proportion of patients that corticosteroids but their onset of action is slow and they benefit less than half of patients with Crohn’s disease. In the last decade, medical therapy for Crohn’s disease has experienced a remarkable change due to the introduction of biologic therapy, and particularly the use of anti-tumour necrosis factor-alpha agents. Infliximab, adalimumab, and certolizumab pegol have demonstrated efficacy for induction and maintenance of remission in active Crohn’s disease. These agents have raised the bar for what is a suitable symptomatic response in Crohn’s disease and modification of the natural history of the disease has become a major goal in the treatment of Crohn’s disease. There are several data in the literature that suggest that early use of biologic therapy and achievement of mucosal healing contribute to disease course modification. However, many questions on early biological therapy for Crohn’s disease remain still unanswered.

关键词： Biologic therapy Crohn's disease Corticosteroids Immunomodulators