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De novo serine synthesis regulates chondrocyte proliferation during bone development and repair

Bone Research 2022年第2期10卷 274-285页

作者： Steve Stegen Shauni Loopmans ingrid Stockmans Karen Moermans Peter Carmeliet Geert Carmeliet Laboratory of Clinical and Experimental Endocrinology Department of Chronic Diseases and MetabolismKU Leuven3000 LeuvenBelgium Laboratory of Angiogenesis and Vascular Metabolism VIB Center for Cancer Biology3000 LeuvenBelgium Laboratory of Angiogenesis and Vascular Metabolism Department of Oncology and Leuven Cancer InstituteKU Leuven3000 LeuvenBelgium State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen UniversityGuangzhou 510080China

The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous *** cells, or chondrocytes, survive, proliferate and synthesize extracellular matrix in an avascular environment, but the metabolic requirements for these anabolic processes are not fully understood. Here, using metabolomics analysis and genetic in vivo models, we show that maintaining intracellular serine homeostasis is essential for chondrocyte function. De novo serine synthesis through phosphoglycerate dehydrogenase(PHGDH)-mediated glucose metabolism generates nucleotides that are necessary for chondrocyte proliferation and long bone growth. On the other hand, dietary serine is less crucial during endochondral bone formation, as serine-starved chondrocytes compensate by inducing PHGDH-mediated serine ***, this metabolic flexibility requires ATF4, a transcriptional regulator of amino acid metabolism and stress *** demonstrate that both serine deprivation and PHGDH inactivation enhance ATF4 signaling to stimulate de novo serine synthesis and serine uptake, respectively, and thereby prevent intracellular serine depletion and chondrocyte dysfunction. A similar metabolic adaptability between serine uptake and de novo synthesis is observed in the cartilage callus during fracture ***, the results of this study reveal a critical role for PHGDH-dependent serine synthesis in maintaining intracellular serine levels under physiological and serine-limited conditions, as adequate serine levels are necessary to support chondrocyte proliferation during endochondral ossification.

关键词： synthesis starting thereby

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Profile of Full-Term Births in Maternity Wards of Public Hospitals in Douala Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 705-720页

作者： Henri Essome Merlin Boten Bounyom Astrid Ndolo Kondo ingrid Doriane Ofakem Ilick Fulbert Mangala Nkwele Irène Cyrielle Edjoa Mboe Michel Roger Ekono Alphonse Ngalame Nyong Robert Tchounzou Moustapha Bilkissou Junie Ngaha Yaneu Marga Vanina Ngono Akam Gervais Mounchikpou Ngouhouo Grâce Tocki Toutou Théophile Nana Njamen Valère Mve Koh Pascal Foumane Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Laquintinie Hospital Douala Cameroon Faculty of Health Sciences University of Bamenda Bamenda Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Medicine and Biomedical Sciences University of Yaound&#233 1 Yaound&#233 Cameroon Faculty of Medicine and Pharmaceutical Sciences of Sangmelima University of Ebolowa Ebolowa Cameroon

Introduction: Pregnancy as much as childbirth constitutes a risky situation, potentially fraught with sometimes dramatic complications: maternal death. Objective: We conducted this study with the aim of establishing the profile of those giving birth in our context with the aim to anticipate operationally in the future on morbidity but more on maternal deaths. Methodology: We conducted, using a structured questionnaire, a prospective descriptive study in representative maternity wards in the city of Douala;the study variables were socio-economic, anthropometric, obstetrical and clinical. Statistical analyses were carried out with CS Pro 7.3 and SPSS version 25.0 software. The Student, Chi-square and Fischer tests were used to compare the means of the variables and the percentages. Results: We recruited 305 births for our study. The average age of our births was 28.7 years ± 6.1 with an average height of 161.6 cm ± 5.06;an average body mass index at the start of pregnancy of 28.0 kilograms/square meter and 31.3 kilograms/square meter at delivery;the average weight gain was 8.4 g ± 5.37;an average gestation of 2.84±1.90;an average parity of 2.2 ± 2.1 with an average birth interval of 27.7 months ± 23.7. The average gestational age was 39.2 weeks ± 1.21 with pregnancy pathology dominated by malaria;85.9% began their prenatal follow-up before the 14th week of amenorrhea. Conclusion: The profile of childbirth in urban Cameroon does not seem potentially dystocic compared to that of the same regional and racial area.

关键词： Profile Delivery Term Malaria Douala

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Cross Border Terrorism in Lake Chad Basin ——A Case Study of the Far North of Cameroon

Cross Border Terrorism in Lake Chad Basin ——A Case Study o...

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作者： Dankam Winnie ingrid 华中师范大学

学位级别：硕士

21世纪被公认为是全球恐怖主义的时代。本篇论文的研究也属于这一范畴:暴动已成为某些组织向政府提出自己主张的新沟通方式。“群Sunnah说教和人民圣战”或一般称为博科圣地在同一模式入侵乍得盆地湖。他们声称,除了他们教徒,其余都是... 详细信息

21世纪被公认为是全球恐怖主义的时代。本篇论文的研究也属于这一范畴:暴动已成为某些组织向政府提出自己主张的新沟通方式。“群Sunnah说教和人民圣战”或一般称为博科圣地在同一模式入侵乍得盆地湖。他们声称,除了他们教徒,其余都是异族。喀麦隆属于乍得湖盆地地区,因此受到始于原伊斯兰教派成员国——尼日利亚现状的影响。因此本研究的目的是通过分析喀麦隆远北地区的各种恐怖袭击案例阐述跨境叛乱的详情。这也是对喀麦隆政府回应恐怖分子的一种考验。研究证明,军方可以有效地解决不安全感及暴力的局面,但同时也表明了非洲甚至全世界恐怖袭击事件因政府或某些州对人民的不公平的社会待遇而日益增多,因此我们应该将尊重人权、保证人们受教育和工作的权利,以及保障使人民有机会实现自己的梦想的权利作为解决各种恐怖袭击的开始,那么他们的民族主义和维和感也将得以收到保护。Leon KOUNGOU也持有相同的观点,并不断强调:“军队是一把锤子,但所有的麻烦不是钉子”。

关键词：起义博科圣地安全喀麦隆乍得盆地湖

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An evaluation of intraoperative and postoperative outcomes of torsional mode versus longitudinal ultrasound mode phacoemulsification:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 890-897页

作者： Pia Leon ingrid Umari Alessandro Mangogna Andrea Zanei Daniele Tognetto University Eye Clinic of Trieste Ospedale MaggioreTrieste34125Italy Department of Medicine Surgery and Health SciencesUniversity of TriesteTrieste 34149Italy

AIM： To evaluate and compare the intraoperative parameters and postoperative outcomes of torsional mode and longitudinal mode of phacoemulsification. METHODS： Pertinent studies were identified by a computerized MEDLINE search from January 2002 to September 2013. The Meta-anaiysis is composed of two parts. In the first part the intraoperative parameters were considered： ultrasound time （UST） and cumulative dissipated energy （CDE）. The intraoperative values were also distinctly considered for two categories （moderate and hard cataract group） depending on the nuclear opacity grade. In the second part of the study the postoperative outcomes as the best corrected visual acuity （BCVA） and the endothelial cell loss （ECL） were taken in consideration. RESULTS： The UST and CDE values proved statistically significant in support of torsional mode for both moderate and hard cataract group. The analysis of BCVA did not present statistically significant difference between the two surgical modalities. The ECL count was statistically significant in support of torsional mode （P〈0.001）. CONCLUSION： The Meta -analysis shows the superiority of the torsional mode for intraoperative parameters （UST, CDE） and postoperative ECL outcomes.

关键词： conventional (longitudinal) phacoemulsi-fication phacoemulsification torsional phacoemulsification

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Genes, emotions and gut microbiota:The next frontier for the gastroenterologist

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World Journal of Gastroenterology 2017年第17期23卷 3030-3042页

作者： Arturo Panduro ingrid Rivera-Iniguez Maricruz Sepulveda-Villegas Sonia Roman Department of Molecular Biology in Medicine Civil Hospital of Guadalajara“Fray Antonio Alcalde” Health Sciences Center University of Guadalajara

Most medical specialties including the field of gastroenterology are mainly aimed at treating diseases rather than preventing them. Genomic medicine studies the health/disease process based on the interaction of the human genes with the environment. The gastrointestinal(GI) system is an ideal model to analyze the interaction between our genes, emotions and the gut microbiota. Based on the current knowledge, this mini-review aims to provide an integrated synopsis of this interaction to achieve a better understanding of the GI disorders related to bad eating habits and stress-related disease. Since human beings are the result of an evolutionary process, many biological processes such as instincts, emotions and behavior are interconnected to guarantee survival. Nourishment is a physiological need triggered by the instinct of survival to satisfy the body's energy demands. The brain-gut axis comprises a tightly connected neuralneuroendocrine circuitry between the hunger-satiety center, the dopaminergic reward system involved in the pleasure of eating and the gut microbiota that regulates which food we eat and emotions. However, genetic variations and the consumption of high-sugar and high-fat diets have overridden this energy/pleasure neurocircuitry to the point of addiction of several foodstuffs. Consequently, a gut dysbiosis generates inflammation and a negative emotional state may lead to chronic diseases. Balancing this altered processes to regain health may involve personalized-medicine and genome-based strategies. Thus, an integrated approach based on the understanding of the gene-emotions-gut microbiota interaction is the next frontier that awaits the gastroenterologist to prevent and treat GI disorders associated with obesity and negative emotions.

关键词： Genes Emotions Brain reward system Gut microbiota Gastrointestinal disease Personalized medicine Genome-based nutrition Nutrigenetics Food decision-making Obesity

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Rhythmical massage improves autonomic nervous system function:a single-blind randomised controlled trial

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Journal of Integrative Medicine 2018年第3期16卷 172-177页

作者： Georg Seifert Jenny-Lena Kanitz Carolina Rihs ingrid Krause Katharina Witt Andreas Voss Department of Pediatric Oncology and Hematology Charité-Universit?tsmedizin Berlin Institute of Innovative Health Technologies Ernst-Abbe-Hochschule University of Applied Sciences

Background： Rhythmical massage therapy（RMT） is a massage technique used in anthroposophic ***： The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate variability（HRV）.Design, setting, participants and intervention： This study was a randomised, controlled and single-blinded trial, involving 44 healthy women（mean age：（26.20 ± 4.71） years）. The subjects were randomised to one of three arms： RMT with aromatic oil（RA）, RMT without aromatic oil（RM） or standardised sham massage（SM）. In the study the subjects were exposed to a standardised stress situation followed by one of the study techniques and Holter electrocardiograms（ECGs） were recorded for 24 *** outcome measures： HRV parameters were calculated from linear（time and frequency domain） and nonlinear dynamics（symbolic dynamics, Poincare plot analysis） of the 24-h Holter ECG ***： Short-and long-term effects of massage on autonomic regulation differed significantly among the three groups. Immediately after an RMT session, stimulation of HRV was found in the groups RA and RM. The use of an aromatic oil produced greater short-term measurable changes in HRV compared with rhythmic massage alone, but after 24 h the effect was no longer distinguishable from the RM *** lowest stimulation of HRV parameters was measured in the SM ***： RMT causes specific and marked stimulation of the autonomic nervous system. Use of a medicinal aromatic oil had only a temporary effect on HRV, indicating that the RM causes the most relevant long-term effect. The effect is relatively specific, as the physiological effects seen in the group of subjects who received only SM were considerably less pronounced.

关键词： Sham massage Well-being Mood Alertness Relaxation Stress Heart rate variability Randomised controlled trial

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Physical Properties in Drying of Food Products with Combined Sublimation and Evaporation

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Chinese Journal of Chemical Engineering 2004年第6期12卷 814-817页

作者： Ingvald Strфmmen Odilio Alves-Filho Trygve M.Eikevik ingrid C.Claussen Department of Refrigeration and Air Conditioning The Norwegian University of Science and Technology (NTNU) Trondheim NorwaySINTEF Energy Research Department of Refrigeration and Air Conditioning Trondheim NorwaySINTEF Energy Research Department of Refrigeration and Air Conditioning Trondheim NorwayDepartment of Refrigeration and Air Conditioning The Norwegian University of Science and Technology (NTNU) Trondheim Norway

Drying is an important unit operation in processing of biological resources. The drying process may influence the product properties and quality, which may shrink, break or undergo rheological, physical and biochemical changes. The important parameters responsible for such changes are drying conditions, type of drying technology and residence drying time. Thermal conductivity, thermal-mass diffusivity, enthalpy, porosity and density are the main material property and heat-mass transfer parameters, which are essential for understanding the changes in product quality and for designing and dimensioning the drying processes. In this paper physical properties of food products undergoing a combined sublimation and evaporation were studied. Pieces of vegetables and potatoes were dried in a heat pump fluidized bed dryer at combined modes with temperatures below the freezing point in the beginning and a final drying step at temperatures above the freezing point. Samples of products were tested at different moisture contents with respect to physical properties. Physical properties of leek and potato samples were measured and mass diffusivities were determined from drying kinetic data. Based on bulk density and rehydration measurements it was clearly observed that drying temperature and modes influenced the final product physical properties. The potato cube run dried with initial atmospheric freeze-drying step had rehydration ability 430%above a run dried only above the freezing point. The average effective mass diffusivity for 5 mm slabs of leek was 0.5 x 10-11m2·s-1 for the sublimation stage and 2.2 x 10-11m2·s-1 for the evaporation stage.

关键词： physical properties dying food products sublimation evaporation

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Regeneration of pitch pine (Pinus rigida) stands inhibited by fire suppression in Albany Pine Bush Preserve, New York

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Journal of Forestry Research 2019年第1期30卷 233-242页

作者： Chang-Seok Lee George R.Robinson ingrid P.Robinson Hansol Lee Department of Bio and Environment Technology Seoul Women's University State University of New York at Albany State University of New York

The Pine Barrens in New York State are dominated by pitch pine(Pinus ridgida) and scrub oaks(Quercus ilicifolia and Q. prinoides). With fire suppression over the last 90 years or so, P. rigida regeneration has become sparse, even in areas set aside to preserve this type of vegetation. We evaluated the effects of fire and an alternative disturbance(mechanical removal of vegetation)for increasing P. rigida regeneration in the Albany Pine Bush Preserve in eastern New York State. By comparing cover, diameter and height of P. rigida, Q. ilicifolia, ***, and Vaccinium spp.(blueberry) growing on the sites with a known fire history, we documented structural and compositional changes in the vegetation since its establishment. We also compared sites on which Quercus sprouts were controlled through mechanical removal. In the years following a disturbance, height and cover of Q. ilicifolia increased continuously and the species became increasingly competitive. Both the density of P. rigida seedlings and Vaccinium cover decreased significantly as the diameter and height of Quercus increased. Our results confirmed that the dominance by P. rigida could be attributed to periodic fires at intervals of 20–25 years. We conclude that removing Q. ilicifolia can favor P. rigida dominance on the barren without fire by releasing pine seedlings from competition.

关键词： Fire Mechanical removal Pine barren Pinus rigida Quercus ilicifolia Quercus prinoides Regeneration Safe site

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Are we giving biologics too late? The case for early versus late use

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World Journal of Gastroenterology 2008年第36期14卷 5523-5527页

作者： Elena Ricart Orlando García-Bosch ingrid Ordás Julián Panés Gastroenterology Department Hospital Clinic CIBER- EHD C/Villarroel 170 Barcelona 08036 Spain

Corticosteroids and immunomodulators have been the mainstay therapies for Crohn’s disease. Corticosteroids are highly effective to control symptoms in the short- term, but they are not effective in maintaining remission, they heal the mucosa in a reduced proportion of cases, and long-time exposure is associated with an increased risk of infections and mortality. Immunomodulators, azathioprine and methotrexate, heal the mucosa in a higher proportion of patients that corticosteroids but their onset of action is slow and they benefit less than half of patients with Crohn’s disease. In the last decade, medical therapy for Crohn’s disease has experienced a remarkable change due to the introduction of biologic therapy, and particularly the use of anti-tumour necrosis factor-alpha agents. Infliximab, adalimumab, and certolizumab pegol have demonstrated efficacy for induction and maintenance of remission in active Crohn’s disease. These agents have raised the bar for what is a suitable symptomatic response in Crohn’s disease and modification of the natural history of the disease has become a major goal in the treatment of Crohn’s disease. There are several data in the literature that suggest that early use of biologic therapy and achievement of mucosal healing contribute to disease course modification. However, many questions on early biological therapy for Crohn’s disease remain still unanswered.

关键词： Biologic therapy Crohn's disease Corticosteroids Immunomodulators

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Development of Business Strategy of the Start-up Ultimeapps Company

Development of Business Strategy of the Start-up Ultimeapps ...

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作者： EPEZAGNE ASSAMALA ingrid RUTH 江苏大学

学位级别：硕士

在过去的十年里,许多初创公司在全球范围内成立并运营。虽然它们中也有极少数成为大公司,甚至成为行业领先的公司,但大多数初创公司存活时间都不超过两年,有些公司甚至从未获得任何投资回报,因此为初创企业制定生存和发展战略是非常重... 详细信息

在过去的十年里,许多初创公司在全球范围内成立并运营。虽然它们中也有极少数成为大公司,甚至成为行业领先的公司,但大多数初创公司存活时间都不超过两年,有些公司甚至从未获得任何投资回报,因此为初创企业制定生存和发展战略是非常重要的一项工作。Ultimeapps公司是一家位于加纳的信息技术初创公司,本人是该公司的创始团队成员之一。本研究在了Ultimeapps公司的内外环境和公司的现状的基础上,运用相关管理工具、理论和概念来分析和评估了公司近期的战略目标以及为实现该目标所选择的发展战略和竞争战略,并进一步就该战略实施的保障措施进行了深入的探讨。本研究的成果一方面可以指导Ultimeapps公司近期的经营管理工作,另一方面对类似的初创公司制定发展战略也有一定的参考价值。

关键词：战略发展营销资源价值

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