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Stroke-like onset of brain stem degeneration presents with unique MRI sign and heterozygous NMNAT2 variant:a case report

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Translational Neurodegeneration 2016年第1期5卷 181-185页

作者： Alexander Schulz Franziska Wagner Martin Ungelenk ingo Kurth Christoph Redecker Hans Berger Department of Neurology Jena University HospitalFriedrich Schiller University JenaJena 07747Germany Department of Genetics and Program in Cellular Neuroscience Neurodegeneration and RepairYale University School of MedicineNew HavenCT 06510USA Institute of Human Genetics Jena University HospitalFriedrich-Schiller-University JenaJena 07743Germany Institute of Human Genetics Uniklinik RWTH AachenAachen 52074Germany

Background:Acute-onset neurodegenerative diseases in older patients are rare clinical cases,especially when the degeneration only affects specific regions of the nervous *** neurological disorders have been described in which the degeneration of brain parenchyma originates from and/or primarily affects the brain *** diagnosis in these patients,however,is often complicated due to a poor understanding of these diseases and their underlying *** presentation:In this manuscript we report on a 73-year-old female who had experienced a sudden onset of complex neurological symptoms that progressively worsened over a period of 2 *** evaluation had suggested a MRI-negative stroke as underlying *** combination of patient’s medical history,clinical examination and exceptional pattern of brain stem degeneration presenting as“kissing swan sign”in MR imaging was strongly suggestive of acute onset of Alexander’s *** leukoencephalopathy is caused by GFAP(glial fibrilary acidic protein)gene mutations and may present with brain stem atrophy and stroke-like onset of symptoms in elderly ***,a pathognomonic GFAP gene mutation could not be identified by Sanger ***:After an extended differential diagnosis and exclusion of other diseases,a definite diagnosis of the patient’s condition presently remains ***,whole-exome sequencing performed from patient’s blood revealed 12 potentially disease-causative heterozygous variants,amongst which several have been associated with neurological disorders in vitro and in vivo–in particular the axon degeneration-related NMNAT2 gene.

关键词： Brain stem atrophy Dementia Alexander’s disease Whole-exome sequencing Kissing swan sign NMNAT2 Axon degeneration

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Effect of Biofertilizer on Growth, Productivity, Quality and Economics of Rainfed Organic Ginger （Zingiber officinale Rosc.） Bhaisey cv. in North-Eastern Region of India

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Journal of Agricultural Science and Technology(A) 2013年第2期3卷 83-98页

作者： Nongmaithem Jyotsna Mainak Ghosh Dulal Chandra Ghosh Wahengbam ingo Meitei Jagadish Timsina College of Agriculture Central Agricultural University Imphal Manipur 795001 India Department of Agronomy Bihar Agricultural University Bihar 813210 India Institute of Agriculture Visva-Bharati Sriniketan-731236 West Bengal India IRRI-Bangladesh Office Banani DOHS Dhaka-1206 Bangladesh

Ginger yields in the NorthEastern region of India are low because the extremely poor farmers of the region can not afford to apply any chemical fertilizers and hence apply only the locally-available farmyard manures to ginger fields. Biofertilizers may be a cheap source of fertilizers for ginger cultivation as they can increase nutrient availability and improve rhizome quality and are required in small quantity. An investigation was thus undertaken to study the effect of different biofenilizers on growth, productivity, quality and economics of organic ginger grown under rainfed condition in NorthEastern region of India. Seed treatment with biofertilizers enhanced growth, increased rhizome yield by 19.0% and resulted in 32.4% higher net profit over control. Among the seed treatments, Azotobacter 5.0 kg ha＂l, Azospirillum 3.75 kg hal and Phosphotica 3.75 kg ha-1 were found optimum in improving most of the growth attributes, increasing yield components and yield of rhizome by 5.6%-13.5%. They also improved rhizome quality by increasing specific gravity, oleoresin and dry matter content and by decreasing crude fibre in rhizome. They resulted in higher net return by 4.0%-12.0% as compared to their other levels. Combined use of Azotobacter 5.0 kg hal along with Phosphotica 3.75 kg ha＂l was found to be the best treatment combination which greatly improved growth and yield attributes of ginger and ultimately recorded markedly higher productivity （2.0%-23.5%） over other combinations. This treatment combination improved the quality of the produce and resulted in the highest gross return （$4,905 hal）, net return （$3,525 hal） and return per dollar （3.55） invested in ginger cultivation. It appears that growing organic ginger by treating the seed rhizome with Azotobacter 5.0 kg ha-~ along with Phosphotica 3.75 kg ha-1 can result in good growth and high productivity of improved quality rhizome and ultimately result in maximum net profit and thus can be recommended for the NorthEas

关键词： Biofertilizers growth productivity quality economics ginger (Zingiber officinale Rosc.).

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Foreword to the Special Issue on "Tip-and Laser-Based 3D Nanofabrication in Extended Macroscopic Working Areas"

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Nanomanufacturing and Metrology 2021年第3期4卷 131-131页

作者： Eberhard Manske Rene Theska Thomas Frohlich ingo Ortlepp Technische Universitat Ilmenau IlmenauGermany

The semiconductor industry has been following Moore’s law with astonishing continuation for 55 years *** is advancing from precision manufacturing,micromanufacturing,and nanomanufacturing toward atomic and close-to-a... 详细信息

关键词： continuation law manufacturing

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Rejection of Experimental Hodgkins Lymphoma by T-Cells Engineered with a CD19 Chimeric Antigen Receptor

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Journal of Cancer Therapy 2012年第5期3卷 553-561页

作者： Anna Swanson Eleanor Cheadle David Gilham Dorothy Crawford Simon Talbot ingo Johannessen 5Laboratory Medicine (Virology) Royal Infirmary of Edinburgh Edinburgh UK The University of Edinburgh Centre for Infectious Diseases Edinburgh UK The University of Edinburgh Division of Pathway Medicine Chancellor’s Building Edinburgh UK The University of Manchester Clinical and Experimental Immunology Group Manchester UK

T cells engineered to express chimeric antigen receptors (CARs) combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) signaling domain for triggering cell activation are being used for immunotherapeutic targeting of tumor cells in a non-HLA restricted manner. In this study we transduced T cells with a CD19-CAR construct containing a truncated CD34 gene (tCD34) marker and used these to target the B cell antigen CD19 on the surface of a Hodgkin’s lymphoma (HL) cell line (L591) both in vitro and in vivo. Levels of tCD34 expression in transduced peripheral blood mononuclear cells (PBMCs) ranged from 6% - 20% and this was increased to 82% after selection for transduced tCD34+ cells. In vitro cytotoxicity testing on a CD19+ HL cell line (L591) showed specific cell lysis initiated by the CD19-CAR transduced PBMCs. Importantly, CD19-CAR T cells prevented the growth of L591 HL tumor cells when co-injected subcutaneously (sc) in 6/6 severe combined immunodeficient (SCID) mice. There was no evidence of anti-tumor activity when CD19-CAR T cells were infused intravenously (iv) at the same time as L591 HL tumor cells were injected sc. However, 3/6 SCID mice showed tumor rejection within 83 days after iv infusion of CD19-CAR T cells 3 - 9 days after establishment of L591 HL tumors, while all control animals succumbed to tumors within 60 days. Interestingly, immuno-histochemical analysis of L591 HL tumors demonstrated that CD19-CAR T cells were detected not earlier than 11 days after infusion within the tumor mass. These results suggest that CD19 is a potentially attractive target for the immunotherapy of HL.

关键词： Hodgkin’s Lymphoma CD19 Chimeric Antigen Receptor Immunotherapy

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Effect of Biofertilizer on Biomass Productivity, Nutrient Balance and Soil Fertility in Rainfed Organic Ginger Production System

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Journal of Agricultural Science and Technology(A) 2013年第1期3卷 10-19页

作者： Nongmaithem Jyotsna Mainak Ghosh Dulal Chandra Ghosh, Wahengbam ingo Meitei Jagadish Timsina College of Agriculture Central Agricultural University Imphal Manipur 795001 India Department of Agronomy Bihar Agricultural University Sabour 813210 Bihar India Institute of Agriculture Visva-Bharati Sriniketan 731236 West Bengal India IRRI-Bangladesh Office Banani DOHS Dhaka 1206 Bangladesh

Farmers of North-Eastern India grow ginger organically and obtain low yield. Biofertilizer may help in increasing yield and maintaining soil fertility. An investigation made with different biofertilizers showed that seed treatment with biofertilizer increased biomass by 18.3%, enhanced N, P and K removal and improved short-term soil fertility status by increasing N and P balance and reducing negative K balance over control plots. Use of high dose （5.0 kg haL） of Azotobacter （a3） and medium dose （3.75 kg hal） of both Azospirillum （b2） and Phosphotica （c2） increased rhizome biomass by 6.8%-12.5% and shoot biomass by 5.6%-14.3% over other levels. They enhanced N, P and K removal by both rhizome and shoot when compared with other levels. The above biofertilizer treatments improved organic carbon and available N and P status of the soil by increasing N and P balance. The result showed overall strong negative K balance; but biofertilizer treatments greatly reduced the negative K balance in soil as compared to the control plots. Seed treatment with high level of Azotobacter along with medium level of Phosphotica （a3c2） produced the highest biomass yield （7.4 t hal）, increased N and P balance and fertility status in spite of hizh N, P and K removal.

关键词： Biofertilizer ginger productivity nutrient balance soil fertility.

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FAT(法特)自硬树脂砂机械再生设备节约运营成本改善产品质量

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铸造技术 2016年第1期 1-2页

作者： Frank Woldert und ingo Groβ 范骞昊法特设备制造(北京)有限公司

1型砂再生设备的市场需求铸造作为一种历史悠久的金属加工工艺,在基础工业领域始终占有举足轻重的地位。随着现代工业的发展,铸件在各类机械产品中得到了越来越广泛的应用。然而,伴随技术的改进及需求的增长,市场对铸件的品质,复杂度以... 详细信息

1型砂再生设备的市场需求铸造作为一种历史悠久的金属加工工艺,在基础工业领域始终占有举足轻重的地位。随着现代工业的发展,铸件在各类机械产品中得到了越来越广泛的应用。然而,伴随技术的改进及需求的增长,市场对铸件的品质,复杂度以及随之而来的成本上涨也提出了更高的要求。众所周知,在砂型铸造领域,型砂本身的品质会对铸件成品质量产生决定性作用。因此,如何改善铸造用型砂品质就显得更加有意义。近些年来,新

关键词： FAT 法特铸件再生设备热砂

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Utilizing the Potato Genome for Applied and Fundamental Research into Diverse Aspects of Disease Resistance

Utilizing the Potato Genome for Applied and Fundamental Rese...

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2019年中国马铃薯大会

作者： Miles Armstong Xinwei Chen Micha Bayer ingo Hein Cell and Molecular Sciences The James Hutton Institute School of Life Sciences The University of Dundee

Potato is the most important non-cereal food crop worldwide and consumed by more than a billion *** and pathogens represent a serious and continuing threat to potato *** of the most widespread and economically significant diseases are late blight,nematodes and *** ability to withstand multiple biotic and abiotic stresses is critical for wild *** the availability of significant germplasm resources including the Commonwealth Potato Collection(CPC)at the James Hutton Institute and improved genomics methods,the potential to exploit natural biodiversity is considerable to secure potatoes as a major food source in the *** the potato genome has provided unprecedented insight into the distribution and organisation of genes that underpin *** have developed a gene-specific target enrichment and sequencing platform,RenSeq,to more rapidly map and clone functional NB-LRR genes that are effective against the major potato *** resistance gene enrichment sequencing(dRenSeq)enables the high-confidence identification and complete sequence validation of functional resistance genes in *** have shown that the technology can direct parental selection in potato breeding programs,confirms transgene integrity in GM crops and enables high-throughput allele *** study reveals a very limited base of utilised resistances in all major potato cultivars but has identified additional and currently very effective resistances in potato varieties that could be combined with the help of the *** combine the most complementary resistances,we can assess the diversity of the Phytophthora *** pathogen populations through a similar enrichment-sequencing based approached referred to as *** combination of dRenSeq and PenSeq enables,for the first time,a comprehensive Pathogen/Crop coevolution study on a global scale.

关键词： RenSeq PenSeq plant-pathogen co-evolution NLR gene deployment

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捻针时真、假穴不同中枢激活效应的脑功能MRI

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中华放射学杂志 2004年第12期38卷 1281-1284页

作者：方继良 Timo Krings Juergen Weidemann ingo Meister Armin Thron 中国中医研究院广安门医院放射科 Department of Neuroradiology University Hospital of the University of TechnologyAachen(Pauwelsstrasse3052057AachenGermany) Department of Neuroradiology University Hospital of the University of TechnologyAachen(Pauwelsstrasse3052057AachenGermany Department of Neurology University Hospital of the University of TechnologyAachen(Pauwelsstrasse3052057AachenGermany)

目的　利用功能磁共振 (fMRI)观察捻针针刺方法对大脑的作用。方法　用盲法随机分别针刺 13例正常人左侧太冲、丘墟和假穴 ,手法采用捻针和不捻针 ,利用 1 5TMR仪行全脑功能成像 ,用SPM99b分析图像。结果　发现只在真穴捻针针刺时有更... 详细信息

目的　利用功能磁共振 (fMRI)观察捻针针刺方法对大脑的作用。方法　用盲法随机分别针刺 13例正常人左侧太冲、丘墟和假穴 ,手法采用捻针和不捻针 ,利用 1 5TMR仪行全脑功能成像 ,用SPM99b分析图像。结果　发现只在真穴捻针针刺时有更强的激活效应 ,有显著性意义的Brodmann激活区域为 :针刺太冲穴激活了左右顶叶BA4 0区 ,右额叶BA4 7和 10区 ,右丘脑 ,左小脑 ;针刺丘墟穴激活了左右顶叶BA4 0区 ,右顶叶BA2区 ,左额叶BA9、10、4 4区 ,左岛叶BA13区 ,左颞叶BA2 2区 ,右颞叶BA4 2区 ,右壳核 ,左小脑。两真穴激活部位部分相同 ,部分不同。在假穴捻针对不捻针的研究中 ,未见到有显著性意义的激活区。结论　真穴捻针时可能对皮层神经活动有较特异的作用 ,而假穴未观察到此种现象 ,推测这可能是针刺治疗作用的机制之一。

关键词：激活针刺 MRI 中枢颞叶 BA 脑功能图像 TMR 显著性

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固态锂金属电池中不均匀离子通量介导的正负极耦合失效机制

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Science Bulletin 2023年第8期68卷 813-825,M0004页

作者：郑越张舒马君孙富 Markus Osenberg AndréHilger Henning Markötter Fabian Wilde ingo Manke 胡中波崔光磊 Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China Shandong Energy Institute Qingdao 266101China Institute of Applied Materials Helmholtz-Zentrum Berlin für Materialien und EnergieBerlin 14109Germany Department of Non-Destructive Testing Bundesanstalt für Materialforschung und-PrüfungBerlin 12205Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502Germany

本文通过联用无损三维同步辐射X射线断层扫描成像技术(SXCT)和其他非原位测试技术及有限元模拟,深入研究了LiNi0.8Co0.1Mn0.1O2|Li6PS5Cl|Li全固态电池的衰退机制.研究发现正极电化学-机械力学耦合失效诱导的反应异质性产生不均匀的锂... 详细信息

本文通过联用无损三维同步辐射X射线断层扫描成像技术(SXCT)和其他非原位测试技术及有限元模拟,深入研究了LiNi0.8Co0.1Mn0.1O2|Li6PS5Cl|Li全固态电池的衰退机制.研究发现正极电化学-机械力学耦合失效诱导的反应异质性产生不均匀的锂离子通量并传输到负极,进而导致不均匀的锂沉积、溶解行为及死锂的产生等.锂负极不均匀的电化学反应行为又反作用于正极并强化其反应异质性,形成一种正负极衰退互相促进的正强化机制.随着电池继续循环,正负极的不均匀反应加剧造成其结构破坏,同时正负极体积缩胀引起电解质巨大塑性变形,最终致使电池失效.对比实验表明采用LiZr_(2)(PO_(4))_(3)(LZP)对正极进行改性,不仅有效抑制了正极的电化学-机械力学耦合失效,而且显著提高了负极锂沉积-溶解均匀性和电解质的结构完整性.该研究首次提出了全固态金属锂电池正负极相互依赖、相互关联的失效机制,为提升全固态金属锂电池性能提供了新思路.

关键词： Current density distribution Lithium ion flux Solid-state lithium metal batteries Codependent failure mechanism Cathode deactivation

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Analysis of Metabolite Content in Arabidopsis GABA Shunt Mutants

Analysis of Metabolite Content in Arabidopsis GABA Shunt Mut...

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The Second International Symposium on Plant Neurobiology

作者： Anke Hüser Ulf-ingo Flügge Frank Ludewig Botanical Instiute University of Cologne Gyrhofstr15D-50931 CologneGermany Botanical Instiute University of Cologne Gyrhofstr15D-50931 CologneGermany Botanical Instiute University of Cologne Gyrhofstr15D-50931 CologneGermany

＜正＞GABA （gamma-ammo butyric acid） is a four carbon ammo acid, found in all organisms. In plants, mutants of both catabolic genes （gaba-t and ssadh） display phenotypic deviations to WT. ssadh knock-out plants are severely affected in growth. probably due to the accumulation of a toxic compound. Two candidate substances （GHB and SSA）. that can be converted into each other, were examined for their capacity to affect plant growth.

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