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重建可持续未来——相互理解如何强化建筑对2030年议程的贡献

Sixteenth Congress of the International Union of Crystallography

作者： Ethan Merrit Tita K.Sixma Focco van den Akker Steve Sarfaty Stewart Turley Kor H.Kalk ingeborg feil Wim G.J.Hol The Biomolecular Structure Program Department of Biological StructureSM-20University of WashingtonSchool of MedicineSeattleWashington 98195 U.S.A.

＜正＞Choleratoxin（CT） and heat-labile enterotoxin of ***（LT） are two closely related major virulence factors of two bacterial species responsible for the death of hundreds of thousands of people annually,in particular,young children in third world *** toxins are heterohexamers with a B pentamer responsible for binding to the carbohydrate moieties of the gut epithelial *** single enzymatic A subunit carries out an ADP-ribosylation of Gsα,causing

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世界建筑 2024年第1期 10-13页

作者：英格博格·豪孙斯坦(译) 丹麦皇家建筑艺术学院建筑与技术研究所

将6000名从事可持续建筑工作的专业人士聚集到哥本哈根是一项不小的投入。这不仅需要大量时间来策划,还要求每位参与者投入时间、精力和财力,更不用说整个项目所带来的巨大碳足迹。当大会的主题是“2030年议程”和“联合国17项可持续发... 详细信息

将6000名从事可持续建筑工作的专业人士聚集到哥本哈根是一项不小的投入。这不仅需要大量时间来策划,还要求每位参与者投入时间、精力和财力,更不用说整个项目所带来的巨大碳足迹。当大会的主题是“2030年议程”和“联合国17项可持续发展目标”,并且题目为“可持续未来——不让任何一个人掉队”时,这或许显得有些自相矛盾。在世界上最昂贵的城市之一举办这样一场资源密集型的盛会,如何促进可持续发展呢?

关键词：资源密集型可持续发展目标可持续未来可持续建筑哥本哈根碳足迹相互理解专业人士

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Differential effects of energy balance on experimentally-induced colitis

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World Journal of Gastroenterology 2012年第7期18卷 627-636页

作者： Sarah J McCaskey Elizabeth A Rondini ingeborg M Langohr Jenifer I Fenton Department of Food Science and Human Nutrition Michigan State UniversityEast LansingMI 48824United States Department of Pathobiology and Diagnostic Investigation Michigan State UniversityEast LansingMI 48824United States College of Osteopathic Medicine Michigan State UniversityEast LansingMI 48824United States

AIM： To characterize the influence of diet-induced changes in body fat on colitis severity in SlVlAD3-/- mice.METHODS： SMAD3-/- mice （6-8 wk of age） were ran- domly assigned to receive a calorie restricted （30% of control; CR）, control （CON）, or high fat （HF） diet for 20 wk and were gavaged with sterile broth or with Helicobacter hepaticus （H. hepaticus） to induce colitis. Four weeks after infection, mice were sacrificed and the cecum and colons were processed for histological evaluation.RESULTS： Dietary treatment significantly influenced body composition prior to infection （P 〈 0.05）, with CR mice having less （14%±2%） and HF-fed mice more body fat （32% ± 7%） compared to controls （22%±4%）. Differences in body composition were associated with alterations in plasma levels of leptin （HF 〉 CON 〉 CR） and adiponectin （CON 〉 HF 〉/ CR）（P 〈 0.05）. There were no significant differences in colitis scores between CON and HF-fed mice 4 wk post-infection. Consistent with this, differences in proliferation and in- flammation markers （COX-2, iNOS）, and infiltrating cell types （CD3^＋ T lymphocytes, macrophages） were not observed. Unexpectedly, only 40% of CR mice survived infection with H. hepaticus, with mortality observed as early as I wk following induction of colitis.CONCLUSION： Increased adiposity does not influence colitis severity in SMAD3-/- mice. Importantly, caloric restriction negatively impacts survival following pathogen challenge, potentially due to an impaired immune response.

关键词： SMAD3 Colitis Adipokine Obesity Calorierestriction

Core-shell particles of C-doped CdS and graphene: A noble metal-free approach for efficient photocatalytic H_(2) generation

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Green Energy & Environment 2020年第4期5卷 461-472页

作者： Muhammad Zubair Estelle Marie M.Vanhaecke ingeborg-Helene Svenum Magnus RФnning Jia Yang Department of Chemical Engineering Norwegian University of Science and Technology(NTNU)Sem Sælands vei 4TrondheimNO7491Norway SINTEF Industry P.O.Box 4760 TorgardenTrondheimNO7465Norway

To achieve efficient photocatalytic H_(2) generation from water using earth-abundant and cost-effective materials,a simple synthesis method for carbon-doped CdS particles wrapped with graphene(C-doped CdS@G)is *** doping effect and the application of graphene as cocatalyst for CdS is studied for photocatalytic H_(2) *** most active sample consists of CdS and graphene(CdS-0.15G)exhibits promising photocatalytic activity,producing 3.12 mmol g^-(1) h^-(1) of H_(2) under simulated solar light which is^4.6 times superior than pure CdS nanoparticles giving an apparent quantum efficiency(AQY)of 11.7%.The enhanced photocatalytic activity for H_(2) generation is associated to the narrowing of the bandgap,enhanced light absorption,fast interfacial charge transfer,and higher carrier density(N_(D))in C-doped CdS@G *** is achieved by C doping in CdS nanoparticles and the formation of a graphene shell over the C-doped CdS *** stability test,the spent catalysts sample was also characterized to investigate the nanostructure.

关键词： C-doped CdS@G Core-shell nanostructure Photocatalytic H2 generation Graphene Carbon doping in CdS Bandgap narrowing

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建筑的绝对可持续性视角

世界建筑 2024年第1期 20-25页

作者：安妮·贝姆英格博格·豪叶扬(译) 丹麦皇家建筑艺术学院建筑与技术研究所工业化建筑中心丹麦皇家建筑艺术学院建筑与技术研究所不详

前文《何谓绝对可持续性》介绍了我们在思考建造可持续性时对其含义产生的新理解。在本文中,我们将讨论相关策略对未来的建筑环境和我们的生活条件可能有哪些影响(图1)。新的可持续实践将如何影响我们思考、设计和建造建筑的方式?基于... 详细信息

前文《何谓绝对可持续性》介绍了我们在思考建造可持续性时对其含义产生的新理解。在本文中,我们将讨论相关策略对未来的建筑环境和我们的生活条件可能有哪些影响(图1)。新的可持续实践将如何影响我们思考、设计和建造建筑的方式?基于地球边界的概念,绝对可持续性的审美和感官体验将是怎样的?在建筑世界中,绝对可持续性看上去、闻起来和给人的感受将是怎样的?

关键词：感官体验可持续性持续实践相关策略建筑

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Towards a multiscale model of colorectal cancer

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World Journal of Gastroenterology 2007年第9期13卷 1399-1407页

作者： ingeborg MM van Leeuwen Carina M Edwards Mohammad Ilyas Helen M Byrne Centre for Mathematical Medicine and Biology School of Mathematical Sciences University of Nottingham Nottingham NG7 2RD United Kingdom Centre for Mathematical Biology Oxford Centre for Industrial and Applied Mathematics Mathematical Institute University of Oxford Oxford OX1 3LB United Kingdom Division of Pathology School of Molecular Medical SciencesQueen’s Medical Centre University of Nottingham Nottingham NG7 2UHUnited Kingdom

Colorectal cancer (CRC) is one of the best characterised cancers, with extensive data documenting the sequential gene mutations that underlie its development. Complementary datasets are also being generated describing changes in protein and RNA expression, tumour biology and clinical outcome. Both the quantity and the variety of information are inexorably increasing and there is now an accompanying need to integrate these highly disparate datasets. In this article we aim to explain why we believe that mathematical modelling represents a natural tool or language with which to integrate these data and, in so doing, to provide insight into CRC.

关键词： Intestinal epithelium Crypt fission APC mutations Mathematical modelling Stem cell niche Wnt signalling

Immobilization of Lactobacillus plantarum NCIMB 8826 ameliorates Citrobacter rodentium induced lesions and enhances the gut inflammatory response in C57BL/6 weanling mice

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Food Production, Processing and Nutrition 2022年第1期4卷 447-458页

作者： Emmanuel Kyereh Diana Coulon ingeborg Langohr Anne Raggio Michael Keenan Subramaniam Sathivel School of Nutrition and Food Sciences Louisiana State University Agriculture Center220 H.D.Wilson LaboratoriesLSU Agricultural CenterBaton RougeLA 70803USA Bioassay Core Laboratory Agricultural CenterLouisiana State UniversityBaton RougeLAUSA Department of Pathobiological Sciences Louisiana State UniversityBaton RougeLAUSA Department of Biological and Agriculture Engineering Louisiana State UniversityBaton RougeLAUSA

Infectious diarrhea is a major cause of infant mortality in most developing countries. In this research, we evaluated the potential of immobilized Lactobacillus plantarum NCIMB 8826 on weanimix infant cereal and its effectiveness in reducing the severity of Citrobacter rodentium-induced diarrhea in weanling mice. Thirty-six C57BL/6 weanling mice were placed into four groups (n = 9 each;negative, positive, prevention and cure). Mice received either L. plantarum (109 CFU/g) immobilized on weanimix infant cereal 3 days before C. rodentium (109 CFU/ ml) infection (Prevention) or 3 days after C. rodentium infection (Cure). A positive control group was infected with C. rodentium only, while a nega-tive control group received neither L. plantarum nor C. rodentium. Positive control mice showed colonic mucosal and submucosal inflammation, erosion, and mucosal epithelia hyperplasia with the C. rodentium infection. Mice in the prevention and cure groups had less severe histologic alterations in the colon. Some beneficial effect of L. plantarum was observed in cecal short-chain fatty acid concentrations, which stimulates water and electrolytes absorption to reduce diarrhea. Our findings demonstrated that L. plantarum NCIMB 8826 could be immobilized on weanimix infant cereal to help reduce diarrhea during weaning.

关键词： Probiotics Citrobacter rodentium Lactobacillus plantarum Inflammation Weanimix

On the Importance of the Stokes-Brinkman Equations for Computing Effective Permeability in Karst Reservoirs

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Communications in Computational Physics 2011年第10期10卷 1315-1332页

作者： Marcin Krotkiewski ingeborg S.Ligaarden Knut-Andreas Lie Daniel W.Schmid Physics of Geological Processes University of OsloP.O.Box 1048 BlindernNO-0316 OsloNorway SINTEF ICT Department of AppliedMathematicsP.O.Box 124 BlindernNO-0314 OsloNorway Center of Mathematics for Applications University of OsloP.O.Box 1053 BlindernNO-0316 OsloNorway

Cavities and fractures significantly affect the flow paths in carbonate reservoirs and should be accurately accounted for in numerical ***,we consider the problem of computing the effective permeability of rock samples based on high-resolution 3DCT scans containingmillions of *** use the Stokes-Brinkman equations in the entire domain,covering regions of free flow governed by the Stokes equations,porous Darcy flow,and transitions between *** presence of different length scales and large(ten orders of magnitude)contrasts in permeability leads to highly ill-conditioned linear systems of equations,which are difficult to *** obtain a problem that is computationally tractable,we first analyze the relative importance of the Stokes and Darcy terms for a set of idealized 2D *** find that,in terms of effective permeability,the Stokes-Brinkman equations are only applicable for a special parameter set where the effective free-flow permeability is less than four orders of magnitude different from the matrix *** other cases can be accurately modeled with either the Stokes or the Darcy end-member flows,depending on if there do or do not exist percolating free-flow *** insights obtained are used to perform a direct computation of the effective permeability of a rock sample model with more than 8 million cells.

关键词： Upscaling Stokes equation Brinkman equation porous media

Im Himmel und auf Erden

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德语人文研究 2008年第4期 14-18+13页

作者： ingeborg Bachmann

ber die Stirne Amelies lief ein roter *** trat vom Spiegel zurück und schloss die *** war die Spur für einen Augenblick vergangen,die Justins Handüber ihr Gesicht gezogen *** hatte sie nur einmal geschlagen und s... 详细信息

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Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis

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World Journal of Gastroenterology 2012年第13期18卷 1459-1469页

作者： Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton Department of Food Science and Human Nutrition College of Osteopathic MedicineMichigan State UniversityEast LansingMI 48824United States Department of Food Science Human Nutrition Michigan State UniversityEast LansingMI 48824United States Department of Pathobiology and Diagnostic Investigation Michigan State UniversityEast Lansing MI 48824United States

AIM： To identify and characterize drosophila mothers against decapentaplegic （SMAD）3-dependent changes in immune cell populations following infection with He- Iicobacter hepaticus （H. hepaticus）. METHODS： SMAD3/ （n = L9） and colitis-resistant SMAD3＋/ （n = 24） mice （8-10 wk of age） were in- fected with/-/, hepaticus and changes in immune cell populations [T lymphocytes, natural killer （NK） cells, T regulatory cells] were measured in the spleen and mesenteric lymph nodes （MsLNs） at 0 d, 3 d, 7 d and 28 d post-infection using flow cytometry. Genotype-dependent changes in T lymphocytes and granzyme B＋ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry. RESULTS： As previously observed, SMAD3＋, but not SMAD3＋/- mice, developed colitis, peaking at 4 wk post-infection. No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point. However, CD4＋ and CD8＋/ CD62L＋＋ cells, an effector T lymphocyte population, as well as NK cells （NKp46/DX5＋） were significantly higher in the MsLNs of SMAD3/ mice at 7 d and 28 d post-in- fection. In the colon, a higher number of CD3＋ cells were present in SMAD3＋ compared to SMAD3＋/- mice at base- line, which did not significantly change during infection. However, the number of granzyme B＋ cells, a marker of cytolytic lymphoo/tes, significantly increased in SMAD3＋ mice 28 d post-infection compared to both SMAD3＋/- mice and to baseline values. This was consistent with more severe colitis development in these animals. CONCLUSION： Data suggest that defects in SMAD3 signaling increase susceptibility to H. hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphoo/tes.

关键词： Transforming growth factor-J3 Colitis Dro-sophila mothers against decapentaplegic Colon cancer T lymphocytes