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Pharmacology & Pharmacy 2017年第1期8卷 1-14页

作者： Sumit Bhatt Gajendra singh Sanjeev Kumar Rachna paliwal Jeet singh Jangwan Chandra pal singh Department of Chemistry SRT Campus Badshahi Thaul Tehri Garhwal University Campus of HNB Garhwal Central University Shrinagar (Uttarakhand) India Sahu Jain P.G. College Najibabad Department of Chemistry MJP Rohilkhand University Bareilly (Uttar Pradesh) India Hindu College Moradabad Department of Chemistry MJP Rohilkhand University Bareilly (Uttar Pradesh) India

A series of sulpha/substituted derivatives of phenyl azo-1,2-diazole have been synthesized and tested as an anti-inflammatory and anti-bacterial activity in mature albino rats hind paw by taking Diclofenac sodium as standard. N1-(4-hydroxy benzoyl)-3-methyl-5-phenyl-4(N-4-chlorophenylazo)-1,2-diazole is synthesized by a two-step process. In the first step, synthesis of N1-4-chlorophenyl hydrazono-1-methyl-3-phenyl propane-1,3-dione by the reciprocal action of 1-methyl-5-phenylpropane-1,3-dione and diazonium salt solution of phenyl-chloride interacts with 4-hydroxybenzoic acid hydrazide to form the final compound. These diazoles, the heterocyclic compounds which contained electron withdrawing groups, were screened for analgesic activity by acetic acid induced writing method, and for anti-inflammatory activity carried on carrageenan-induced paw edema. The synthesized substituted Chlorophenylazo-1,2-diazole nucleus exhibited significant anti-bacterial, anti-cancer, anti-inflammatory activity, muscle relaxing and moderate activity in anti-proliferative studies.

关键词： 1 2-Diazole Diuretic Activity Muscle Relaxing Anti-Inflammatory Analgesic Antibacterial Activity Anti-Proliferative Studies

Prediction of Antagonistic Activity of <i>β</i>-Carboline and Its Derivatives Using Topological Descriptors

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Open Journal of Applied Sciences 2021年第5期11卷 577-584页

作者： Anil Kumar Soni Gajendra pal singh Vishnu Kumar Sahu Department of Chemistry Shia Post Graduate College Lucknow India Department of Chemistry Bareilly College Bareilly India Department of Chemistry Maharani Lal Kunwari Post Graduate College Balrampur India

Prediction of antagonistic activity of β-carboline and its thirteen derivatives has been made using topological descriptors viz, connectivity index, and kappa shape index of different orders. For evaluation of values of descriptor, molecular modeling and geometry optimization of all the compounds were carried out with CAChe Pro software by opting semiempirical PM3 method using MOPAC 2002. For prediction of activity multiple linear regression analysis (MLR) was performed. MLR analysis has been made by Project Leader Software associated with CAChe by using the above descriptors as independent variables and biological activity as dependent variables. We were performed leave-one-out methods and the result reflected a direct relationship between biological activity and connectivity index of zero order, while indirect relationship with connectivity index of second order and thus connectivity index is a reliable descriptor to predict the biological activity of β-carboline and its various derivatives.

关键词： β–carboline antagonistic activity PM3 connectivity index and kappa shape index

长丝市场——论当前的旦数细分和应用分支市场

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纺织导报 2009年第7期 67-69页

作者： Suprit pal singh Michael Korobczuk 澳大利亚墨尔本RMIT大学时尚和纺织学院欧瑞康巴马格公司

长丝市场在过去10年已经达到了前所未有的成熟，行业对其已有非常明确的细分。在这篇短文中，笔者将根据现有的市场架构按不同聚合物呈现相关长丝细分市场的一些数据。

关键词：细分市场长丝应用旦数聚合物

Evaluation of Topical Application of <i>Azadirachta indica</i>(Neem) in Prevention of Gingivitis: A Randomized Control Trial

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Open Journal of Stomatology 2019年第11期9卷 249-259页

作者： Vibha singh Anjani Kumar Pathak Kopal Goel Mahesh pal King George’s Medical University Lucknow India Department of Periodontology Faculty of Dental Sciences King George’s Medical University Lucknow India Sardar Patel Post Graduate Institute of Dental and Medical Sciences Lucknow India Phytochemistry Division CSIR-National Botanical Research Institute Lucknow India

Background: The purpose of the present study was to envisage the anti-plaque and anti-inflammatory properties of neem (Azadirachta) in the form of a mouth gel. Materials and Methods: A total of 60 subjects (33 males and 27 females) from age group 19 - 35 years, suffering from mild to moderate gingivitis were randomly divided into two groups. Group A (n = 30) participants were advised experimental (neem) gel and Group B (n = 30) participants were advised 0.2% chlorhexidine gel. All the clinical parameters (the gingival index by Loe and Silness [1], Plaque index by Silness and Loe [2] and sulcus bleeding index by Muhlemann H. R. and Sen S. [3]) were recorded at baseline, on the 14th day and 21st day by the same clinician in both groups. Results: on intragroup comparison the gingival index, plaque index and sulcus bleeding index decrease significantly in both the groups in all assessed periods. On intergroup comparison the indices did not differ significantly at baseline but after 2nd and 3rd week, the indices in Group B decrease more than the group A, which was statistically significant. Conclusion: Based on the observations of our study, it can be concluded that chlorhexidine gluconate as well as neem gel can be effectively used as an adjunct to mechanical plaque control in prevention of plaque and gingivitis. chlorhexidine gluconate gel has been found to be more effective when antiplaque and anti-inflammatory properties were considered. The effect of neem observed maybe because of its anti-inflammatory action. The antiplaque action of chlorhexidine gluconate is due to its substantivity. Substantivity of neem is required to be further studied.

关键词： Azadirachta Gingivitis. Anti Plaque

Adansonia digitata L.(baobab):a review of traditional information and taxonomic description

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Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 79-84页

作者： Jitin Rahul Manish Kumar Jain Shishu pal singh Rakesh Kant Kama Anuradha Aliya Naz Anup Kumar Gupta Sujeet Kumar Mrityunjay Centre of Mining Environment Department of Environmental Science&EngineeringIndian School of Mines Department of Botany Dayanand Brajendra Swarup College Centre of Mining Environment Department of Environmental Science&EngineeringIndian School of MinesDhanbad-826004JharkhandIndia

Adansonia digitata L.(Malvaceae) is commonly known as baobab tree native to *** is a multi-purpose tree which offers protection and provides food,clothing and medicine as well as raw material for many useful *** fruit pulp,seeds,leaves,***,and bark of baobab are edible and they have been studied by scientists for their useful *** fruit pulp have very high vitamin ***,phosphorus,carbohydrates,fibers,potassium,proteins and lipids content,which can be used in seasoning as an appetizer and also make *** contain appreciable quantities of phosphorus,magnesium,zinc,sodium,iron,manganese,whereas they have high levels of lysine,thiamine,calcium and *** has numerous biological properties including antimicrobial,anti-malarial,diarrhoea,anaemia,asthma,antiviral,anti-oxidant and anti-inflammatory activities amongst *** investigation revealed the presence of *** acids,fatty acids,vitamins and *** review summarizes the information on various aspects of traditional information,taxonomic description,medicinal properties and importantly nutritional value.

关键词： Adansonia digitata Baobab Traditional information Taxonomic description

Effect of Transmission Range on Ad Hoc on Demand Distance Vector Routing Protocol

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Journal of Computer and Communications 2016年第2期4卷 34-46页

作者： Mohammad Izharul Hasan Ansari Surendra pal singh Mohammad Najmud Doja Department of Computer Science & Engineering NIMS University Jaipur India Department of Computer Science & Engineering NIMS University Jaipur India Department of Computer Engineering JMI University New Delhi India

The necessary background as well as the details of simulation was presented to simulate and evaluate the performance of the ad hoc on-demand distance vector routing protocol in mobile ad hoc network with the help of the network simulator NS2 using the common transmission range to deliver the data packets at the destination node. The number of participating nodes played an important role to predict the conditions for the best performance of the protocol with respect to throughput, delay, packet delivery ratio, drop packets, consumed and residual energy of the network. Further, the efforts can be put to control the transmission range dynamically and overheads for reducing the energy consumption in the network and improving its lifetime of the nodes and the lifespan of the network.

关键词： MANET Routing Protocol Network Simulator Transmission Range Throughput Delay Packet Delivery Ratio Energy Consumption Efficiency and Lifetime

Nonunion of coronal shear fracture of femoral condyle

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Chinese Journal of Traumatology 2011年第3期14卷 143-146页

作者： Ajay pal singh Ish Kumar Dhammi Raju Vaishya Anil Kumar Jain Arun pal singh Prashant Modi Punjab Civil Medical Services Mukerian Punjab India Department of Orthopedics UCMS & GTB Hospital Delhi India Department of Orthopedics and Traumatology Indraprastha Apollo Hospital Delhi India S.P.N. Hospital Mukerian Punjab India

Isolated coronal fractures of femoral condyle are rare in adults and nonunion of Hoffa fracture is reported only a few times in the literature. We analyzed six cases of nonunion of Hoffa fractures over a period of three years. Three patients were treated conservatively and three patients had fixation failures. Delay of presentation was 2 months to one year. Treatment protocol consisted of open reduction, excision of pseudoarthrosis, bone grafting and internal fixation along with knee arthrolysis. Union wasachieved in all patients at mean 16 weeks. The treatment of nonunion of Hoffa fractures requires careful preoperative planning and meticulous surgical technique. The literature regarding the controversies in fracture management and surgical technique are reviewed.

关键词： Femoral fracture Fracture ftxation internal Retrospective studies

General-motors diet: A quick fix for steatotic live liver donors

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iLIVER 2023年第3期2卷 151-155页

作者： Anish Gupta Abhideep Chaudhary Gaurav Sood Niteen Kumar Imtiakum Jamir Aditya Shriya Vipin pal singh Rekha Subramaniyam Hitesh Soni Milind Mandwar Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation BLK MAX Super Specialty HospitalNew DelhiIndia

Background and aims:GM(General-Motors)diet is a low-calorie 7-day diet plan using complex carbohydrates used for quick weight *** optimisation is known to decrease steatosis and improve outcomes in liver *** evaluated the efficacy and feasibility of using GM diet in steatotic live liver donors(LLD).Methods:LLDs who either had BMI>30 kg/m^(2),Computerised tomography liver attenuation index(CT-LAI)10%were started on GM diet for 1 *** of these LLDs and their recipients were retrieved retrospectively and ***,liver function tests(LFT),MR fat-frac-tion,CT-LAI,hospital-stay and complications were analysed in LLDs while early graft dysfunction(EGD)and complications were assessed in ***:A total of 51 LLDs with mean age of 34.6?9.5 years with baseline mean weight of 80.6±10.8 kg and BMI of 29.1±2.78 kg/m^(2) were started on GM *** a week of following the GM diet,there was an average weight loss of 3.46±2.1 kg,a decrease in fat-fraction by 3.8%±2.7,and an improvement in CT-LAI by 6.7?3.7 *** patients could successfully undergo donor hepatectomy with an average postoperative ICU stay of 2.86±0.8 days and hospital stay of 6.82?0.81 *** donor had steatosis>10% on intraoperative Tru-cut biopsy and their post-operative outcomes were similar to normal liver *** were intra-abdominal collections in 2 donors requiring drainage and one required re-exploration for intestinal *** was EGD in 8 recipients(15.6%)and mortality in 1(1.9%)***:GM diet is safe and effective regimen to reduce steatosis and increase healthy LLD pool without compromising donor or recipient safety.

关键词： Steatosis GM diet weight loss donor optimization LDLT donor hepatectomy donor outcomes

A scientometric review of biochar research in the past 20 years(1998-2018)

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Biochar 2019年第1期1卷 23-43页

作者： Ping Wu Syed Tahir Ata-Ul-Karim Bhupinder pal singh Hailong Wang Tongliang Wu Cun Liu Guodong Fang Dongmei Zhou Yujun Wang Wenfu Chen Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China NSW Department of Primary Industries Elizabeth Macarthur Agricultural InstituteMenangleNSW 2568Australia Biochar Engineering Technology Research Center of Guangdong Province School of Environment and Chemical EngineeringFoshan UniversityFoshanGuangdong 528000China Key Laboratory of Soil Contamination Bioremediation of Zhejiang Province Zhejiang A&F UniversityHangzhouZhejiang 311300China Biochar Engineering and Technology Research Center of Liaoning Province Rice Research InstituteAgronomy CollegeShenyang Agricultural UniversityShenyang 110866LiaoningChina

Biochar is the carbon-rich product obtained from the thermochemical conversion of biomass under oxygen-limited *** has attained extensive attention due to its agronomical and environmental benefits in *** work adopts the scientometric analysis method to assess the development trends of biochar research based on the literature data retrieved from the Web of Science over the period of *** analysing the basic characteristics of 6934 publications,we found that the number of publications grew rapidly since *** on a keyword analysis,it is concluded that scholars have had a fundamental recognition of biochar and preliminarily found that biochar application had agronomic and environmental benefits during the period of *** clustering results of keywords in documents published during 2011-2015 showed that the main research hotspots were“biochar production”,“biochar and global climate change”,“soil quality and plant growth”,“organic pollutants removal”,and“heavy metals immobilization”.While in 2016-2018,beside these five main research hotspots,“biochar and composting”topic had also received greater attention,indicating that biochar utilization in organic solid waste composting is the current research ***,updated reactors(e.g.,microwave reactor,fixed-bed reactor,screw-feeding reactor,bubbling fluidized bed reactor,etc.)or technologies(e.g.,solar pyrolysis,Thermo-Catalytic Reforming process,liquefaction technology,etc.)applied for efficient energy production and modified biochar for environmental remediation have been extensively studied *** findings may help the new researchers to seize the research frontier in the biochar field.

关键词： Biochar CiteSpace Research hotspots Composting Energy Modification

Conductivity Studies in Proton Irradiated AgI-Ag2O-V2O5-TeO2 Super-Ionic Glass System

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Materials Sciences and Applications 2010年第2期1卷 59-65页

作者： Poonam Sharma Dinesh Kumar Kanchan Meenakshi Pant Karan pal singh 不详

The electrical properties of proton ion beam irradiated glass samples are carried out by impedance spectroscopy in the frequency range from 10 Hz to 32 MHz. The ion beam of energy 3 MeV and fluence of of 1014 particles cm-2 was chosen for irradiation. The conductivity of the super ionic glass samples increases after irradiation and other electrical parameters like dielectric constant, dielectric loss and modulus of the proton irradiated glass samples as a function of glass composition and temperature are observed to change. The dielectric constant and the dielectric losses are increased after irradiation and the modulus parameters confirm the non-Debye nature for irradiated samples also.

关键词： Proton-Irradiated Glass DC Conductivity Silver-Ion Scaling Modulus