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Effects of friction stir processing and nano-hydroxyapatite on the microstructure,hardness,degradation rate and in-vitro bioactivity of WE43 alloy for biomedical applications

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Journal of Magnesium and Alloys 2024年第1期12卷 209-224页

作者： Bo Wu Farazila Yusof Fuguo Li Huan Miao A.R.Bushroa mohd Ridha bin Muhamad Irfan Anjum Badruddin Mahmoud Z.ibrahim Department of Mechanical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur 50603Malaysia Centre of Advanced Manufacturing and Material Processing(AMMP Centre) Universiti MalayaKuala Lumpur 50603Malaysia Center of Foundation studies in Science Universiti MalayaKuala Lumpur 50603Malaysia State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Mechanical Engineering Department College of EngineeringKing Khalid UniversityAbha 61421Saudi Arabia Design and Production Engineering Faculty of EngineeringAin Shams UniversityCairo 11517Egypt

Nowadays,magnesium alloys are emerging in biomedical implants for their similar properties to natural ***,the rapid degradation of magnesium alloys in biological media hinders successful *** of microstructure,as well as reinforcement particles can significantly improve the degradation *** this work,multi-pass friction stir processing(FSP)was proposed to synthesize WE43/nano-hydroxyapatite(n HA)surface composite,the microstructure,reinforced particle distribution,micro-hardness,corrosion behavior and in-vitro bioactivity were *** subsequent FSP passes of WE43 alloy and WE43/n HA composite refined the grain size which was reduced by 94.29%and 95.92%(2.63 and 1.88μm,respectively)compared to base metal after three *** resulted in increasing the microhardness by 120%(90.86 HV0.1)and 135%(105.59 HV0.1)for the WE43 and WE43-n HA,*** is found that increasing FSP passes improved the uniform distribution of n HA particles within the composite matrix which led to improved corrosion resistance and less degradation *** corrosion rate of the FSPed WE43/n HA composite after three passes was reduced by 38.2%(4.13 mm/year)and the degradation rate was reduced by 69.7%(2.87 mm/y).This is attributed to secondary phase(Mg24Y5and Mg41Nd5)particle fragmentation and redistribution,as well as a homogeneous distribution of n ***,the growing Ca-P and Mg(OH)2layer formed on the surface represented a protective layer that reduced the degradation *** wettability test revealed a relatively hydrophilic surface with water contact angle of 49.1±2.2°compared to 71.2±2.1°for base ***,biomineralization test showed that apatite layer grew after immersion 7d in simulated body fluid with atomic ratio of Ca/P 1.60 approaching the stoichiometric ratio(1.67)indicating superior bioactivity of FSPed WE43/n HA composite after three *** results raise that the grain refinement by FSP and introduction of n HA partic

关键词： Friction stir processing Magnesium-based composite Nano-hydroxyapatite Corrosion behavior In-vitro bioactivity

Comparison of vergence mechanisms between university students with good and poor sleep quality

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 353-358页

作者： Pui Juan Woi Joyce Yi Ling Lu mohd Izzuddin Hairol Wan Nur Amirah ibrahim Optometry and Vision Science Programme Center for Community Health Studies(ReaCH)Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Centre of Optometry Studies Faculty of Health SciencesUniversiti Teknologi MARASelangor BranchPuncak Alam CampusSelangor 42300Malaysia

AIM:To compare the vergence mechanisms between good and poor sleepers in university ***:A total of 64 university students were recruited in this *** validated Malay version of Pittsburgh Sleep Quality Index questionnaire(PSQI-M)was used to measure the participants’sleep quality over the past *** were categorized as good sleepers(n=32)and poor sleepers(n=32)based on the PSQI-M *** and fusional vergences were measured at distance and ***-Whitney U test was used to compare heterophoria,negative fusional vergence(NFV),and positive fusional vergence(PFV)at distance and near between good and poor *** correlation analysis was used to study the relationship between PSQI-M score and PFV at ***:Both distance and near heterophorias were not significantly different between good and poor sleepers(P>0.05).There was a difference in distance PFV(P0.05).Distance PFV was negatively correlated with PSQI-M score(rs=-0.33,Pbinocular vision examination in university students is recommended.

关键词： binocular vision vergence sleep quality university students

Emerging Novel Therapeutic Approaches for the Treatment of Alzheimer’s Disease

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Advances in Alzheimer's Disease 2024年第3期13卷 65-94页

作者： Amit Panwar mohd. imran Khan Rajesh Kumar Rakesh Kumar Santosh Kumar Rai Anil Kumar New Drug Discovery Research Mankind Research Centre Mankind Pharma Limited Gurugram India

Alzheimer’s disease (AD) is caused by synaptic failure and the excessive accumulation of misfolded proteins especially Aβ and tau, and associated with memory loss and cognitive impairment. Treatment of AD mainly consists of symptomatic therapy and disease-modifying therapy (DMT). Several monotherapies including small molecules or antibodies have been evaluated through multiple clinical trials, but a very few have been approved by the USFDA to intervene the disease’s pathogenesis. Past research has shown multifactorial nature of AD, therefore, multi-target drugs were proposed to target different pathways at the same time, however, currently no rationally designed multi-target directed ligand (MTDL) has been clinically approved. Different combinations and bispecific antibodies are also under development. Novel approaches like stem cell-based therapies, microRNAs, peptides, ADCs and vaccines cast a new hope for AD treatment, however, a number of questions remained to be answered prior to their safe and effective clinical translation. This review explores the small molecules, MTDL, and antibodies (monospecific and bispecific) for the treatment of AD. Finally, future perspectives (stem cell therapy, PROTAC approaches, microRNAs, ADC, peptides and vaccines) are also discussed with regard to their clinical applications and feasibility.

关键词： Alzheimer’s Disease (AD) Disease-Modifying Therapy (DMT) MicroRNAs PROTAC

A Framework for Driver DrowsinessMonitoring Using a Convolutional Neural Network and the Internet of Things

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Intelligent Automation & Soft Computing 2024年第2期39卷 157-174页

作者： Muhamad Irsan Rosilah Hassan Anwar Hassan ibrahim Mohamad Khatim Hasan Meng Chun Lam Wan mohd Hirwani Wan Hussain School of Computing Telkom UniversityBandung40257Indonesia Faculty of Information Science and Technology Universiti Kebangsaan MalaysiaBangi43600Malaysia Department of Electrical Engineering College of EngineeringQassim UniversityAl-Gassim51411Saudi Arabia Graduated School of Business Universiti Kebangsaan MalaysiaBangi43600Malaysia

One of the major causes of road accidents is sleepy *** accidents typically result in fatalities and financial losses and disadvantage other road *** studies have been conducted to identify the driver’s sleepiness and integrate it into a warning *** studies have examined how the mouth and eyelids ***,this limits the system’s ability to identify drowsiness ***,this study designed an Accident Detection Framework(RPK)that could be used to reduce road accidents due to sleepiness and detect the location of *** drowsiness detectionmodel used three facial parameters:Yawning,closed eyes(blinking),and an upright head *** model used a Convolutional Neural Network(CNN)consisting of two *** initial phase involves video processing and facial landmark coordinate *** second phase involves developing the extraction of frame-based features using normalization *** these phases used OpenCV and *** dataset contained 5017 images with 874 open eyes images,850 closed eyes images,723 open-mouth images,725 closed-mouth images,761 sleepy-head images,and 1084 non-sleepy head *** dataset of 5017 images was divided into the training set with 4505 images and the testing set with 512 images,with a ratio of 90:*** results showed that the RPK design could detect sleepiness by using deep learning techniques with high accuracy on all three parameters;namely 98%for eye blinking,96%for mouth yawning,and 97%for head ***,the test results have provided an overview of how the developed RPK prototype can accurately identify drowsy *** findings will have a significant impact on the improvement of road users’safety and mobility.

关键词： Drowsy drivers convolutional neural network openCV microprocessor face detection

Unraveling the therapeutic mechanisms of myristic acid and luteolin 7-rutinoside in oral cancer: insights from network pharmacology and molecular docking analysis

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Pharmacology Discovery 2024年第2期4卷 1-9页

作者： Ansari Vikhar Danish Ahmad Misba Ruhi Syed Ayaz Ali Qazi Yasar mohd.Mukhtar Khan Subur W Khan Mohammed imran Anees Y.B.Chavan College of Pharmacy Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India Maulana Azad College Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India

Background:The compound Luteolin-7-rutinoside(L7R)is a flavone derivative of luteolin,predominantly identified in plant species belonging to the families ***,Myristic acid is characterized by its structure as a 14-carbon,unsaturated fatty *** this investigation,we endeavor to elucidate the putative mechanisms underlying the therapeutic effects of Myristic Acid and Luteolin 7-rutinoside in the context of oral cancer treatment,employing network pharmacology coupled with molecular docking ***:The protein targets of Myristic Acid and Luteolin 7-rutinoside were identified through a search on the Swiss Target ***,a compound-target network was constructed using Cytoscape *** associated with OC were retrieved from the OMIM and GeneCards *** overlap between compound targets and OC-related targets was determined,and the resulting shared targets were subjected to protein-protein interaction(PPI)network analysis using the STRING ***,gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were conducted on the identified *** docking were performed to investigate the interactions between the core target and the active ***:The component target network comprises 103 nodes and 102 *** the proteins in the protein-protein interaction(PPI)network,those with higher degrees are TNF,PPARG,and *** through Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways indicates that the treatment of OC with Myristic Acid and Luteolin 7-rutinoside primarily involves the regulation of miRNA transcription and inflammatory *** identified signaling pathways include Pathways in cancer,PPAR signaling pathway,EGFR signaling pathway,and TNF signaling *** docking studies reveal that Luteolin 7-rutinoside and Myristic acid exhibit higher affinity towards TNF,PPARG,TP53,and ***:This study

关键词： myristic acid luteolin 7-rutinoside network pharmacology oral cancer molecular docking

Eurycoma longifolia Jack in managing idiopathic male infertility

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Asian Journal of Andrology 2010年第3期12卷 376-380,I0010页

作者： mohd Ismail bin mohd Tambi M. Kamarul imran Wellmen Clinic Damai Service Hospital Kuala Lumpur 52100 Malaysia Department of Community Medicine School of Medical Sciences University Sains Malaysia Kbg Kerian Kelantan 16150 Malaysia

This study investigated the effect of treatment with the proprietary standardized, water-soluble extract of the root of the Malaysian plant, Eurycoma longifolia Jack, which is thought to enhance male fertility with regard to higher semen volumes, sperm concentrations, the percentage of normal sperm morphology and sperm motility in male partners of sub-fertile couples with idiopathic infertility. A total of 350 patients were given 200 mg of the extract daily and follow-up semen analyses were performed every 3 months for 9 months. Of these 350 patients, 75 patients completed one full cycle of 3 months. Follow-up semen analyses in these patients showed significant improvement in all semen parameters. The proprietary extract of Eurycoma longifolia Jack significantly improved the sperm quality in these patients, allowing for 11 （14.7%） spontaneous pregnancies.

关键词： male infertility medicinal herbs semen

Smart Objects Identification System for Robotic Surveillance

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International Journal of Automation and computing 2014年第1期11卷 59-71页

作者： Amir Akramin Shafie Azhar bin mohd ibrahim Muhammad Mahbubur Rashid Department of Mechatronics Engineering Faculty of EngineeringInternational Islamic University Malaysia

Video surveillance is an active research topic in computer *** this paper,humans and cars identifcation technique suitable for real time video surveillance systems is *** technique we proposed includes background subtraction,foreground segmentation,shadow removal,feature extraction and *** feature extraction of the extracted foreground objects is done via a new set of afne moment invariants based on statistics method and these were used to identify human or *** the partial occlusion occurs,although features of full body cannot be extracted,our proposed technique extracts the features of head *** proposed technique can identify human by extracting the human head-shoulder up to 60%–70%***,it has a better classifcation to solve the issue of the loss of property arising from human occluded easily in practical *** whole system works at approximately 16 29 fps and thus it is suitable for real-time *** accuracy for our proposed technique in identifying human is very good,which is 98.33%,while for cars identifcation,the accuracy is also good,which is 94.41%.The overall accuracy for our proposed technique in identifying human and car is at 98.04%.The experiment results show that this method is efective and has strong robustness.

关键词： Humans and cars identifcation partially occluded human afne moment invariants video surveillance systems machine vision

Preparation and Properties of Poly(vinyl alcohol)/Chitosan Blend Bio-nanocomposites Reinforced by Cellulose Nanocrystals

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Chinese Journal of Polymer Science 2014年第12期32卷 1620-1627页

作者： Susan Azizi Mansor bin Ahmad Nor Azowa ibrahim mohd Zobir Hussein Farideh Namvar Department of Chemistry Faculty of Science University Putra Malaysia Materials Synthesis and Characterization Laboratory Institute of Advanced Technology University Putra Malaysia Institute of Tropical Forestry and Forest Products Universiti Putra Malaysia Mashhad Branch Islamic Azad University

The aim of this paper is to report the effect of the addition of cellulose nanocrystals（CNCs） on the mechanical, thermal and barrier properties of poly（vinyl alcohol）/chitosan（PVA/Cs） bio-nanocomposites films prepared through the solvent casting process. The characterizations of PVA/Cs/CNCs films were carried out in terms of X-ray diffraction（XRD）, transmission electron microscopy（TEM）, scanning electron microscopy（SEM）, thermogravimetric analysis（TGA and DTG）, oxygen transmission rate（OTR）, and tensile tests. TEM and SEM results showed that at low loading levels, CNCs were dispersed homogenously in the PVA/Cs matrix. The tensile strength and modulus in films increased from 55.1 MPa to 98.4 MPa and from 395 MPa to 690 MPa respectively, when CNCs content went from 0 wt% to 1.0 wt%. The thermal stability and oxygen barrier properties of PVA/Cs matrix were best enhanced at 1.0 wt% of CNCs loading. The enhanced properties attained by incorporating CNCs can be beneficial in various applications.

关键词： Bio-nanocomposite Poly(vinyl alcohol)/chitosan Cellulose nanocrystals Mechanical properties Thermal properties.

Quran memorisation and heart rate variability:How do they correlate?

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World Journal of Clinical Cases 2024年第29期12卷 6275-6284页

作者： Ahmad Rohi Ghazali Nor Malia Abd Warif Noor Anisah A Yazit Norsham Juliana Ismarulyusda Ishak Farah Wahida ibrahim Arimi Fitri Mat Ludin Dzalani Harun Santibuana Abd Rahman Wan Nor Atikah Che Wan mohd Rozali Biomedical Science Programme Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Center for Toxicology and Health Risk Studies Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaNilai 71800Malaysia Center for Healthy Ageing and Wellness Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Center for Rehabilitation and Special Needs Studies Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Occupational Therapy Programme Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Pharmacy and Health Sciences Universiti Kuala Lumpur Royal College of Medicine PerakIpoh Perak 30450Malaysia

BACKGROUND Heart rate variability(HRV)was shown to be affected by performing religious *** To examine the relationship between the level of Quran(the holy book of Muslims)memorisation and HRV among *** This experimental study included 16 Tahfiz students and 16 non-Tahfiz students(n=32).The HRV was measured in three tasks:Recalling familiar verses,memorising new verses,and recalling the newly memorised verses of the *** analysis was done using these parameters:Standard deviation of N-N(heartbeat peak)interval;low frequency(LF);high frequency(HF)and LF/HF *** There were significant differences between tasks for all parameters(P<0.05).However,between the groups,only the LF/HF ratio had significant differences,with F=5.04,P<*** correlation showed a moderate positive correlation between the number of pages memorised and the LF/HF ratio(r=0.61,P<0.05).CONCLUSION Quran memorisation increased the HRV and our results suggested that this activity could be developed as an effective sympathovagal modulation training activity.

关键词： Heart rate variability Autonomic nervous system Quran memorisation Tahfiz student Heartbeat