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锶板近距放射治疗渗出性老年性黄斑变性:3年随机研究结果

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 43-44页

作者： jaakkola A. Heikkonen j. Tommila P. i. immonen 张鹏 Department of Opht halmology Helsinki University Central Hospital Haartmanink. 4C FIN-00029 HUS JP220 FinlandDr.

Objective: To determine the efficacy of strontium plaque (Sr90) brachytherapy for age-related macular degeneration (AMD) with subfoveal choroidal neovascular ization (CNV). Design: randomized clinical trial. Participants: Eighty-eight eyes of 86 patients with subfoveal CNV secondary to AMD were randomized either to plaque radiotherapy or to observation. intervention: radiotherapy was given as episcleral brachytherapy using Sr 90 plaques. Two different plaque types were used. Plaque i had a diameter of 8mm and delivered a dose of 15 Gy at a depth o f 1.75 mm in 54 minutes. With plaque ii, the corresponding values were 4 mm, 12. 6 Gy, and 11 minutes. The control group was observed without any treatment. Main Outcome Measures: The primary outcome measure was visual acuity at 6, 12, 24, a nd 36 months. Other outcome variables were contrast sensitivity, fluorescein ang iographic, and clinically evaluated changes in the macula. results: Eighty-two patients (84 eyes [95%]) completed the 1-year follow-up, and 80 (93%) and 74 (86%) patients completed the 2-and 3-year follow-ups, respectively. At 6 mo nths, visual loss of ines occurred in 20%of treated patients and 42%of co ntrol patients (P=0.031). At 12 months, a visual loss of ines occurred in 4 5%(treated) and 56%(controls) (P=0.325); at 24 months, in 73%and 71%(P=0.914 ); and at 36 months, in 80%and 84%of patients (P=0.591), respectively. Patient s irradiated with plaque i had better results: a visual loss of ines occurr ed in 6%at 6 months (P=0.008, relative to controls), in 18%at 12 months (P=0.0 07), in 59%at 24 months (P=0.348), and in 71%at 36 months (P=0.212). in patien ts treated with plaque ii, the corresponding values were 29%(P=0.032), 65%(P=0 .459), 83%(P=0.317), and 80%(P=0.687) at 6, 12, 24, and 36 months, respectivel y. Conclusions: The short-term clinical course of exudativeAMD is affected by S r90 brachytherapy, but by 12 months, there was no treatment benefit.

关键词：老年性黄斑变性随机研究渗出性放射治疗随机临床试验放射剂量对比敏感度荧光血管造影治疗作用临床病程

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1型糖尿病孕妇的血管调节因子和视网膜病变

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 13-13页

作者： Loukovaara S. immonen i.j. Yandle T.G. 潘佳鸿 Department of Ophthalmology Helsinki University Central Hospital Haartmaninkatu 4 C FIN- 00290 Helsinki Finland Dr.

Purpose: To evaluate the role of various vasoactive hormones in the evolution of diabetic retinopathy during pregnancy and postpartum. Methods: retinopathy wa s graded from fundus photographs of 45 pregnant women with type 1 diabetes and s even pregnant women without diabetes in a prospective study. Markers of renin-a ngiotensin-system (rAS), plasma renin activity (PrA), angiotensin ii (Angii), a ldosterone, natriuretic peptides (ANP, BNP, CNP) and adreonomedullin (AM) were m easured during the first and third trimesters and at 3 months postpartum. The wo men with diabetes were grouped by progression of retinopathy during pregnancy an d postpartum. results: Levels of PrA (p=0.001) and ANP (p=0.03) were significant ly lower in diabetes than in non-diabetes subjects throughout pregnancy and pos tpartum. No significant differences appeared in levels of Angii, aldosterone, AM , BNP or CNP between the two groups. in multivariate logistic regression analyse s with retinopathy progression by the third trimester as the dependent variable, only duration of diabetes qualified in the model (p=0.027, r=0.227, Exp(B)=1.28 ). Conclusions: Diabetic pregnancy is associated with lower levels of PrA and AN P compared to non-diabetic pregnancy. Lowered rAS activity may contribute to th e hyperdynamic blood flow and progression of Dr during diabetic pregnancy. Withi n the power of this study no clear associations between the vasoactive hormones and progression of retinopathy could be detected.

关键词：视网膜病变糖尿病孕妇调节因子眼底疾病肾上腺髓质激素血浆肾素活性利钠肽多变量患病时间于非

颅脑损伤周围区域脑血流变化与感觉运动障碍有关(英文)

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中华神经外科疾病研究杂志 2010年第2期9卷 141-141页

作者： immonen r Heikkinen T Thtivaara L Nurmi A Stenius TK Puolivli j Tuinstra T Phinney AL Van Vliet B Yrjnheikki j Grhn O

in the traumatic brain i.j.ry(TBi) the initial impact causes both primary i.j.ry,and launches secondary i.j.ry *** consequence,and a factor that may contribute to these secondary changes and functional outcome,is altered *** relative cerebral blood volume(CBV) changes in rat brain after severe controlled cortical impact i.j.ry were characterized to assess their interrelations with motor function *** resonance imaging(Mri) was performed 1,2,4 h,and 1,2,3,4,7,and 14 days after TBi to quantify CBV and water *** test was conducted before,and 2,7,and 14 days after the *** found distinct temporal profile of CBV in the perilesional area,hippocampus,and in the primary *** all regions,the first response was drop of *** CBV was reduced for over 4 days thereafter gradually *** the initial drop,the hippocampal CBV was increased for 2 *** demonstrated severely impaired motor functions 2 days after i.j.ry(33% decrease),which then slowly recovered in 2 *** recovery parallelled the recovery of perifocal *** Mri can detect cerebrovascular pathophysiology after TBi in the vulnerable perilesional area,which seems to potentially associate with time course of sensory-motor deficit.

关键词：神经外科疾病临床医学摘要