检索结果-南通市图书馆

Safety and Feasibility of Topical Application of Limonene as a Massage Oil to the Breast

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2012年第5期3卷 749-754页

作者： Jessica A. Miller Patricia A. Thompson iman A. Hakim Ana Maria Lopez Cynthia A. Thomson Wade Chew Chiu-Hsieh Hsu H.-H. Sherry Chow Mel & Enid Zuckerman College of Public Health The University of Arizona Tucson USA The University of Arizona Cancer Center Tucson USA

Background: Limonene, a major component in citrus oil, has demonstrated anti-cancer effects in preclinical mammary cancer models. However, the effective oral dose translates to a human dose that may not be feasible for chronic dosing. We proposed to evaluate topical application of limonene to the breast as an alternative dosing strategy. Materials and Methods: We conducted a mouse disposition study to determine whether limonene would be bioavailable in the mammary tissue after topical application. SKH-1 mice received topical or oral administration of limonene in the form of orange oil every day for 4 weeks. Plasma and mammary pads were collected 4 hrs after the final dosing. We also conducted an exploratory clinical study to evaluate the safety and feasibility of topically applied limonene in the form of orange oil to the breast. Healthy women were recruited to apply orange oil containing massage oil to their breasts daily for four weeks. Safety and feasibility were assessed by reported adverse events, clinical labs, and usage compliance. Pre and post-intervention nipple aspirate fluid (NAF) and plasma were collected for limonene concentration determination. Results: The mouse disposition study showed that topical and oral orange oil administration resulted in similar mammary tissue disposition of limonene with no clinical signs of toxicity. In the clinical study, the topical application of limonene containing massage oil to the breast was found to be safe with high levels of usage compliance for daily application, although NAF and plasma limonene concentrations were not significantly changed after the massage oil application. Conclusions: Our studies showed that limonene is bioavailable in mammary tissue after topical orange oil application in mice and this novel route of administration to the breast is safe and feasible in healthy women.

关键词： Limonene Topical Application Safety

基于CBCT观察上颌阻生尖牙患者蝶鞍形态变异情况

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

口腔医学 2024年第2期44卷 105-109页

作者：缪世维严沁月胡丹艳曹丹 Izadikhah iman 严斌南京医科大学附属口腔医院正畸科江苏省口腔疾病研究重点实验室江苏省口腔转化医学工程研究中心江苏南京210029 南通大学附属南通第三医院南通市第三人民医院口腔科江苏南通226000 句容市中医院口腔科江苏镇江212400

目的利用锥形束CT(cone-beam computed tomography,CBCT)探讨上颌尖牙阻生与蝶鞍形态变异的相关性,从三维方向上评价蝶鞍变异对上颌尖牙阻生的临床预判。方法收集125例上颌阻生尖牙患者(研究组)和125例与之相匹配的尖牙正常萌出者(对... 详细信息

目的利用锥形束CT(cone-beam computed tomography,CBCT)探讨上颌尖牙阻生与蝶鞍形态变异的相关性,从三维方向上评价蝶鞍变异对上颌尖牙阻生的临床预判。方法收集125例上颌阻生尖牙患者(研究组)和125例与之相匹配的尖牙正常萌出者(对照组)。将所有样本CBCT数据导入Dolphin软件,进行重建头颅侧位片和三维图像,记录观察各组蝶鞍桥接(Ⅰ、Ⅱ、Ⅲ型)的类型分布和发生情况。使用SPSS 25.0软件对各组结果进行统计学分析。结果研究组蝶鞍桥接的发生率显著高于对照组(P=0.004),PIC(腭侧尖牙阻生)组蝶鞍桥接的发生率显著高于对照组(P=0.007),Ⅱ型和Ⅲ型蝶鞍桥接分布和对照组存在统计学差异(P=0.012)。而BIC(唇侧尖牙阻生)组和对照组蝶鞍桥接的发生情况无统计学差异。三维重建图像上各组间蝶鞍桥接发生率无统计学差异(P>0.05)。结论上颌尖牙阻生与蝶鞍桥接的发生情况有相关性,但仅上颌尖牙腭侧阻生患者更易发生蝶鞍桥接,而上颌尖牙唇侧阻生患者蝶鞍桥接的发生情况无变化。

关键词：锥形束CT 上颌阻生尖牙蝶鞍桥接

MEBT/MEBO治疗5岁以下儿童烧伤疗效评估

在线全文

学校读者我要写书评

暂无评论

中国烧伤创疡杂志 2017年第4期29卷 229-241页

作者： Hayam Sabry Hussein Saber Raouf Gomaa iman Labib Souad Farid Hassan Kholousy Mahmoud Sakr 埃及卡夫拉谢赫大学医学部外科系埃及卡夫拉谢赫埃及亚历山大大学医学部外科系埃及亚历山大埃及亚历山大大学医学部微生物学系埃及亚历山大

目的评估烧伤再生医疗技术(moist exposed burn therapy/moist exposed burn ointment,MEBT/MEBO)治疗儿童Ⅱ~Ⅲ度烧伤创面的临床疗效和安全性。方法 2015年9月—2016年8月埃及亚历山大大学总医院烧伤科收治的20例5岁以下Ⅱ度和/... 详细信息

目的评估烧伤再生医疗技术(moist exposed burn therapy/moist exposed burn ointment,MEBT/MEBO)治疗儿童Ⅱ~Ⅲ度烧伤创面的临床疗效和安全性。方法 2015年9月—2016年8月埃及亚历山大大学总医院烧伤科收治的20例5岁以下Ⅱ度和/或Ⅲ度烧伤患儿,均于入院后在全身综合治疗的基础上接受MEBT/MEBO治疗局部创面,其中Ⅱ度烧伤创面每天换药3次,直至创面愈合;Ⅲ度烧伤创面每天换药3次,待创面肉芽组织生长良好后,予以植皮术封闭创面。观察肉芽组织形成时间、创面愈合时间、瘢痕增生情况及药物不良反应,并检测治疗过程中创面细菌感染情况。结果肉芽组织的形成时间为10~19 d;浅Ⅱ度烧伤创面愈合时间为6~7 d,愈后皮肤弹性正常,无明显瘢痕增生及色素沉着;深Ⅱ度烧伤创面愈合时间为14~19 d,除2例患儿部分愈后皮肤留有非增生性软瘢痕外,其余患儿愈后皮肤均未见明显瘢痕增生;Ⅲ度烧伤创面均进行了皮肤移植,愈合情况良好;治疗3周后患儿创面感染率由入院时的70%下降至0;治疗过程中所有患儿均未出现药物不良反应;随访6个月,所有四肢烧伤患儿均无四肢功能障碍及畸形。结论MEBT/MEBO治疗儿童Ⅱ~Ⅲ度烧伤,可有效促进Ⅱ度烧伤创面的生理性再生愈合,恢复皮肤的正常组织结构及功能,避免植皮;可显著促进Ⅲ度烧伤创面焦痂的液化脱离以及肉芽组织的早期生长,为皮肤移植做好准备,提高移植皮片的成活率;可有效抑制细菌生长,防治创面感染;操作简便、安全可靠,可有效降低过敏反应及副反应的发生率。

关键词：再生疗法烧伤再生医疗技术湿润环境烧伤感染儿童创面愈合

Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第22期7卷 2418-2426页

作者： iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally Community Medicine Research Department National Research Center Child Health Department National Research Center Micro--biology and Immunology Department Faculty of Medicine (for girls)Al-Azhar University Pediatrics Department Faculty of MedicineAin-Shams University Dermatology and Venereology Department National Research Center Environmental and Occupational Medicine Department National Research Center

AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated ***:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory.

关键词： Hepatitis B virus Immunization Seroprotection Brea

Rare Case of Surviving Infant with Strawberry Yoghurt like Blood Diagnosed to Be Infantile Hypertriglyceridemia at 1 Month Old: A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2021年第4期11卷 777-785页

作者： Matei Mselle Aisa Shayo Ronald Mbwasi Faith Mosha Jeremia Pyuza Philip Mrindoko Nyemo Peter Elton Meleki Elise Kimambo Arnold Likiliwike Lucy Frisch Magreth Swai Zaituni Hatibu Ally iman Beatrice Maringo Linda Kissila Ikupa Minga Deborah Mchaile Department of Paediatrics and Child Health Kilimanjaro Christian Medical University College Moshi Tanzania Department of Paediatrics and Child Health Kilimanjaro Christian Medical Centre Moshi Tanzania Department of Clinical Laboratory Kilimanjaro Christian Medical Centre Moshi Tanzania

Background: Hypertriglyceridemia in children means increased plasma fasting Triglyceride levels above the 95th percentile for age and sex. For children aged 0 to 9 years, a triglyceride level greater than or equal to 100 mg/dl is considered above the 95th percentile. Hypertriglyceridemia can be mild to borderline high, moderate to high, very high, severe and very severe (>2000 mg/dl). We present the case of a 1 month and 3 weeks old baby who presented with difficulty in breathing. It was accidentally found to have strawberry yoghurt like blood during phlebotomy, of which upon investigation had very high triglyceride levels of >2000 mg/dl. Case Presentation: 1 month and 3 weeks old female baby, admitted as referral from nearby health centre presenting with difficulty in breath, her blood sample was incidentally found to appear as strawberry yoghurt like. Clinically the infant had features suggestive of respiratory distress, with no other systemic abnormalities noted. Chest X-ray that was don

关键词： Strawberry Yoghurt Like Blood Hypertriglyceridemia Tanzania

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用中文自由交流

孔子学院 2018年第2期 35-36页

作者：伊曼.丹西威廉.恩卢高中孔子课堂

在过去的一年半时间里,我能有机会学习汉语真是一件幸事。当我跨入高一,在陈老师的指导下开始汉语学习,我完全被精妙绝伦、博大精深的汉语所吸引。陈老师极力为学生们提供一种＂跨文化体验＂,从而展现丰富多彩、内涵深厚的中国历史,而... 详细信息

在过去的一年半时间里,我能有机会学习汉语真是一件幸事。当我跨入高一,在陈老师的指导下开始汉语学习,我完全被精妙绝伦、博大精深的汉语所吸引。陈老师极力为学生们提供一种＂跨文化体验＂,从而展现丰富多彩、内涵深厚的中国历史,而不仅仅局限于传授语法和词汇。

关键词：交流自由中文学习汉语汉语学习文化体验中国历史老师

图像配准技术在颞下颌关节紊乱病诊疗中的应用及展望

在线全文

学校读者我要写书评

暂无评论

口腔医学 2024年第10期44卷 770-774页

作者：谢玉婷唐雯吴玥曹立波马家俊 IZADIKHAH iman 陈艳曹丹严斌朱琳琳谢理哲南京医科大学口腔数字化医疗技术工程中心江苏南京210029 口腔疾病研究与防治国家级重点实验室培育建设点江苏南京210029 江苏省口腔转化医学工程研究中心江苏南京210029 南京医科大学口腔医学院江苏南京210029 南京医科大学生物医学工程与信息学院江苏南京211166 南京医科大学附属口腔医院正畸科江苏南京210029 东南大学网络空间安全学院江苏南京223300 淮安市第二人民医院医疗设备处江苏淮安211189 南京医科大学附属口腔医院第三门诊部江苏南京210029

随着影像学、内窥镜技术、手术治疗、细胞生物学和分子生物学的进步,人们对颞下颌关节紊乱病(temporomandibular joint disorders,TMD)的认识也在不断加深。颞下颌关节(temporomandibular joint,TMJ)是一个包含软组织和硬组织的复杂结构... 详细信息

随着影像学、内窥镜技术、手术治疗、细胞生物学和分子生物学的进步,人们对颞下颌关节紊乱病(temporomandibular joint disorders,TMD)的认识也在不断加深。颞下颌关节(temporomandibular joint,TMJ)是一个包含软组织和硬组织的复杂结构,在TMJ中,颞下颌关节盘是连接下颌骨和颅骨之间的软组织结构,为关节运动提供缓冲和稳定的作用。不同的成像技术在TMD诊疗中各有优势和局限性,因此,利用图像配准技术对关节盘的状况与位置进行评估,为评估TMD提供了新的研究思路,或有助于TMD的诊断和治疗。本文回顾了TMJ成像的最新进展,探讨了各种图像配准技术的应用,特别是在TMD诊疗中的应用及前景。文章结合国内外部分学者的研究结果和笔者的临床经验,旨在为临床医生提供有价值的见解。

关键词：颞下颌关节颞下颌关节紊乱病图像配准技术

基于CBCT三维形态分析的中国青少年颈椎骨成熟度定量方法研究

在线全文

学校读者我要写书评

暂无评论

口腔医学 2024年第5期44卷 321-328页

作者：吴玥唐雯张语嫣然袁玮煜潘逸菲陈新宇徐海洋吕云帆 IZADIKHAH iman 曹丹谢理哲严斌南京医科大学附属口腔医院正畸科口腔疾病研究与防治国家级重点实验室培育建设点(南京医科大学)江苏省口腔转化医学工程研究中心江苏南京210029

目的通过锥形束CT(CBCT)影像探究颈椎三维形态与骨骼成熟度之间的相关性,并建立基于颈椎三维形态的颈椎骨成熟度(CVM)定量评估模型。方法共收集358例(男175例,女183例)中国青少年患者的颅颌面CBCT影像,随机分为模型建立组(277例)及验证... 详细信息

目的通过锥形束CT(CBCT)影像探究颈椎三维形态与骨骼成熟度之间的相关性,并建立基于颈椎三维形态的颈椎骨成熟度(CVM)定量评估模型。方法共收集358例(男175例,女183例)中国青少年患者的颅颌面CBCT影像,随机分为模型建立组(277例)及验证组(81例)。定义并测量了21个颈椎三维形态学参数,纳入颈椎全部部位,包括颈椎椎体、横突、棘突、椎弓根、锥板、关节突。颈椎骨成熟指数(CVMI)由有经验的正畸医师测定并作为参考标准。采用Spearman等级相关系数和多元线性逐步分析确定相关性并构建回归模型。使用验证组数据检验各模型的评估可靠性并应用配对样本Wilcoxon符号秩检验比较模型评估值与参考标准。结果颈椎各部位的三维形态学变化与CVMI相关(P0.05)。结论颈椎三维形态与骨骼成熟度相关,本研究建立的CVM三维形态学评估方法及相应的回归模型具有良好的可信度,与专家的一致性较高。

关键词：骨骼成熟度颈椎骨成熟指数三维形态 CBCT

Sr-HT-Gahnite支架材料调控脂肪干细胞成骨/成血管分化活性促进大鼠颅骨缺损修复的实验研究

在线全文

学校读者我要写书评

暂无评论

Sr-HT-Gahnite支架材料调控脂肪干细胞成骨/成血管分化活性促进大...