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Immune checkpoints in targetedi-mmunotherapy of pancreatic cancer:New hope for clinical development

Acta Pharmaceutica Sinica B 2021年第5期11卷 1083-1097页

作者： Seyed Hossein Kiaie Mohammad Javad Sanaei Masoud Heshmati Zahra Asadzadeh iman azimi Saleh Hadidi Reza Jafari Behzad Baradaran Immunology Research Center Tabriz University of Medical SciencesTabriz ***Iran Nano Drug Delivery Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekord ***Iran School of Pharmacy and Pharmacology College of Health and MedicineUniversity of TasmaniaHobart 7001TasmaniaAustralia Clinical Biochemistry Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekord ***Iran Solid Tumor Research Center Cellular and Molecular Medicine InstituteUrmia University of Medical SciencesUrmia ***Iran Department of Immunology and Genetics School of MedicineUrmia University of Medical SciencesUrmia ***Iran

Immunotherapy has been recently considered as a promising alternative for cancer ***,targeting of immune checkpoint(ICP)strategies have shown significant success in human ***,despite remarkable success of cancer immunotherapy in pancreatic cancer(PCa),many of the developed immunotherapy methods show poor therapeutic outcomes in PCa with no or few effective treatment options thus *** this process,immunosuppression in the tumor microenvironment(TME)is found to be the main obstacle to the effectiveness of antitumor immune response induced by an immunotherapy *** this paper,the latest findings on the ICPs,which mediate immunosuppression in the TME have been *** addition,different approaches for targeting ICPs in the TME of PCa have been *** review has also synopsized the cutting-edge advances in the latest studies to clinical applications of ICP-targeted therapy in PCa.

关键词： Immune checkpoint Pancreatic cancer Tumor microenvironment Immunotherapy Clinical development

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