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Risk factors and urinary biomarkers of non-albuminuric and albuminuric chronic kidney disease in patients with type 2 diabetes

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World Journal of Diabetes 2019年第11期10卷 517-533页

作者： Anton I Korbut vadim v Klimontov ilya v vinogradov vyacheslav v Romanov Laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL-Branch of IC&G SB RAS)Novosibirsk 630060Russia Clinical Laboratory “MBU-Technology”ltd.Novosibirsk 630090Russia

BACKGROUND A number of recent studies indicate a transformation in the natural course of chronic kidney disease(CKD)in type 2 diabetes(T2D)patients:an increasing prevalence of declined renal function without proceeding to the accompanying elevation of *** has been suggested that albuminuric and nonalbuminuric CKD patterns could be different in their phenotypes and pathogenic *** To identify the risk factors and biomarkers of albuminuric and non-albuminuric patterns of CKD in patients with *** Three hundred sixty patients with T2D duration≥10 years were included in this observational cross-sectional *** associations of a panel of demographic and clinical characteristics,complications,comorbidities,and metabolic and hematology parameters with albuminuric and non-albuminuric CKD patterns were *** urinary excretion of nephrin and podocin,two podocytespecific markers,and WAP-four-disulfide core domain protein 2(WFDC-2),a marker of tubulointerstitial fibrosis,was determined by ELISA in comparison with healthy *** Non-albuminuric CKD was associated with age≥65 years(P=0.0001),female sex(P=0.04),diabetes duration≥15 years(P=0.0009),and the use of diuretics(P=0.0005).Male sex(P=0.01),smoking(P=0.01),waist-to-hip ratio>1.0(P=0.01)and hemoglobin A1c(HbA1c)>8.0%(P=0.005)were risk factors for elevated albuminuria not accompanied by a decrease in estimated glomerular filtration rate(eGFR).Duration of diabetes≥15 years and the use of calcium channel blockers were risk factors for albuminuria with decreased eGFR(both P=0.01).In multivariate logistic regression analysis,age,HbA1c,female sex and diuretics were significant predictors for reduced eGFR,while waist-to-hip ratio,HbA1c and male sex were associated with elevated urinary albumin-to-creatinine ratio(UACR).Excretion of nephrin and podocin was increased in patients with albuminuria,regardless of decline in renal function(Pvely with *** urin

关键词： Diabetes mellitus Chronic kidney disease Albuminuria Glomerular filtration rate Podocytes Risk factors Biomarkers

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Experimental Study of Liquid Metal Flow for the Development of a Contact-Less Control Technique

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1553-1564页

作者： Aleksandr Poluyanov ilya Kolesnichenko Laboratory of Technological Hydrodynamics Institute of Continuous Media Mechanics of the Ural Branch of Russian Academy of Science(ICMM UB RAS)Perm614018Russia

The article presents an experimental study on the flow of an eutectic gallium alloy in a cylindrical cell,which is placed in an alternating magnetic *** magnetic field is generated by a coil connected to an alternating current *** coil is located at a fixed height in such a way that its plane is perpendicular to the gravity vector,which in turn is parallel to the axis of the *** position of the cylinder can vary in height with respect to the *** forced flow of the considered electrically conductive liquid is generated due to the action of the localized electromagnetic *** is assumed that under the action of the alternating magnetic field,the liquid is heated uniformly,and the resulting heat is quickly absorbed by the forced flow,so that liquid free convection can be *** experiment is carried out using an ultrasonic Doppler *** transducer is installed in the axially located cylinder sluice and the other transducer is placed in the near-wall *** to the results,a velocity profile,corresponding to a two-tori flow pattern can be hardly obtained in the low frequency range of the power ***,this is possible in the high frequency *** average velocity profiles depend essentially on the location of the coil relative to the *** spectral analysis of velocity signals shows that the amplitude of the velocity pulsations is comparable to the average value of the flow *** experimental results and their verification through comparison with numerical calculations are intended to support the development of new methods for reducing the intensity of vortex flows during the electromagnetic separation of impurities through an electromagnetic induction mechanism(able to produce an electromotive force that displaces particles).

关键词： Ultrasonic doppler velocimeter electrically conductive medium azimuthal pinch experiment in liquid metal magnetohydrodynamics

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Structural correlation and chemistry of molten NaF-ScF_(3) with dissolved metal aluminium:TG/DTA,XRD,NMR and molecular dynamics simulations

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Rare Metals 2024年第7期43卷 3356-3369页

作者： Aydar Rakhmatullin Frantisek simko Didier Zanghi Zuzana Netriová ilya BPolovov Ayrat Dimiev Konstantin v.Maksimtsev Catherine Bessada Michal Korenko Conditions Extrêmes et Materiaux:Haute Température et Irradiation CEMHTIUPR 3079-CNRS Univ Orleans45071 OrleansFrance Department of Molten Systems Institute of Inorganic ChemistrySlovak Academy of Sciencess84536BratislavaSlovakia Centre of Excellence for Advanced Materials Application-CEMEA Slovak Academy of Sciences84511Bratislava.Slovakia Department of Rare Metals and Nanomaterials Institute of Physics and TechnologyUral Federal UniversityUral Federal University620002 EkaterinburgRussia Alexander Butlerov Institute of Chemistry Kazan Federal University420008KazanRussia

For the first time,the mechanism of metal aluminum dissolution in NaF-ScF_(3) eutectic melts and the chemical interaction between the constituents of this mixture have been thoroughly studied by a combination of differential thermal analysis(DTA),high temperature and solid-state nuclear magnetic resonance(NMR),and X-ray diffraction(XRD) coupled with the molecular dynamic *** formation of an insoluble Al_(3)Sc alloy in molten(NaF-ScF_(3))_(eut)system was proven,and the chemical mechanism of this aluminothermic Al_(3)Sc alloy production was *** ex situ examinations bring to light the formation of NaScF_4 and solid solution of Na_(3)(Al,Sc)F_(6) in cooled *** molecular dynamics calculations of the bath allow us to construct the structural model and to predict viscosity,density and electrical conductivity of the reagent melt to help to optimize the conditions of the alloy synthesis.

关键词： Scandium Alloy Molten salts NMR Molecular dynamics

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Inversion of walkaway vSP data in the presence of lateral velocity heterogeneity

Energy Geoscience

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Energy Geoscience 2024年第2期5卷 304-313页

作者： vladimir Grechka ilya Tsvankin Pedro Contreras CWP Department of GeophysicsColorado School of MinesGoldenCO80401USA PDvSA-INTEvEP Apartado 76343Caracas1070AVenezuela Borehole Seismic LLC USA Department of Physics ULAVenezuela

Multi-azimuth walkaway vertical seismic profiling is an established technique for the estimation of in situ slowness surfaces and inferring anisotropy ***,this technique requires the assumption of lateral homogeneity,which makes the horizontal slowness components at depths of downhole receivers equal to those measured at the *** violations of this assumption,such as lateral heterogeneity or nonzero dip of intermediate interfaces,lead to distortions in reconstructed slowness surfaces and,consequently,to errors in estimated anisotropic *** this work,we relax the assumption of lateral homogeneity and discuss how to correct vertical seismic profile data for weak lateral *** describe a procedure of downward continuation of recorded traveltimes that accounts for the presence of both vertical inhomogeneity and weak lateral heterogeneity,which produces correct slowness surfaces at depths of downhole receivers,noticing that sufficiently dense receiver coverage along a borehole is required to separate influences of vertical and lateral heterogeneity on measured traveltimes and obtain accurate estimates of the slowness *** the slowness surfaces are found and a desired type of anisotropic model to be inverted is selected,the corresponding anisotropic parameters,providing the best fit to the estimated slownesses,can be *** invert the slowness surfaces of P-waves for parameters of the simplest anisotropic model describing dipping fractures(transversely isotropic medium with a tilted symmetry axis).Five parameters of this model,namely,the P-wave velocity v0 in the direction of the symmetry axis,Thomsen's anisotropic coefficients e and d,the tilt n,and the azimuth b of the symmetry axis,can be estimated in a stable manner when maximum source offset is greater than half of receiver depth.

关键词： Walkaway vertical seismic profile Lateral velocity heterogeneity Anisotropic parameter estimation vertical inhomogeneity

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Recent innovations in laser additive manufacturing of titanium alloys

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International Journal of Extreme Manufacturing 2024年第3期6卷 2-37页

作者： Jinlong Su Fulin Jiang Jie Teng Lequn Chen Ming Yan Guillermo Requena Lai-Chang Zhang Y Morris Wang ilya v Okulov Hongmei Zhu Chaolin Tan College of Materials Science and Engineering Hunan UniversityChangsha 410082People’s Republic of China Singapore Institute of Manufacturing Technology(SIM Tech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Institute of Materials Research German Aerospace Center(DLR)Linder Höhe51147 CologneGermany Centre for Advanced Materials and Manufacturing Edith Cowan University270 Joondalup DriveJoondalupPerthWestern Australia 6027Australia Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 900095United States of America Leibniz Institute for Materials Engineering-IWT Badgasteiner Str.328359 BremenGermany Faculty of Production Engineering University of BremenBadgasteiner Str.128359 BremenGermany Key Laboratory of Hunan Province of Equipment Safety Service Technology under Extreme Environment University of South ChinaHengyangPeople’s Republic of China RWTH Aachen University Metallic Structures and Materials Systems for Aerospace EngineeringD-52062 AachenGermany

Titanium(Ti)alloys are widely used in high-tech fields like aerospace and biomedical *** additive manufacturing(LAM),as an innovative technology,is the key driver for the development of Ti *** the significant advancements in LAM of Ti alloys,there remain challenges that need further research and development *** recap the potential of LAM high-performance Ti alloy,this article systematically reviews LAM Ti alloys with up-to-date information on process,materials,and *** feasible solutions to advance LAM Ti alloys are reviewed,including intelligent process parameters optimization,LAM process innovation with auxiliary fields and novel Ti alloys customization for *** auxiliary energy fields(***,acoustic,mechanical deformation and magnetic fields)can affect the melt pool dynamics and solidification behaviour during LAM of Ti alloys,altering microstructures and mechanical *** kinds of novel Ti alloys customized for LAM,like peritecticα-Ti,eutectoid(α+β)-Ti,hybrid(α+β)-Ti,isomorphousβ-Ti and eutecticβ-Ti alloys are reviewed in ***,machine learning in accelerating the LAM process optimization and new materials development is also *** review summarizes the material properties and performance envelops and benchmarks the research achievements in LAM of Ti *** addition,the perspectives and further trends in LAM of Ti alloys are also highlighted.

关键词： additive manufacturing titanium alloys auxiliary field machine learning aerospace materials lightweight materials novel alloys

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Large-scale error-tolerant programmable interferometer fabricated by femtosecond laser writing

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Photonics Research 2024年第3期12卷 I0028-I0040页

作者： ilya KONDRATYEv vERONIKA IvANOvA SUREN FLDZHYAN ARTEM ARGENCHIEv NIKITA KOSTYUCHENKO SERGEY ZHURAvITSKII NIKOLAY SKRYABIN IvAN DYAKONOv MIKHAIL SAYGIN STANISLAv STRAUPE ALEXANDER KORNEEv SERGEI KULIK Quantum Technology Centre and Faculty of Physics M.V.Lomonosov Moscow State UniversityMoscow 119991Russia Russian Quantum Center Moscow 121205Russia Laboratory of Quantum Engineering of Light South Ural State UniversityChelyabinsk 454080Russia

We introduce a programmable eight-port interferometer with the recently proposed error-tolerant architecture capable of performing a broad class of *** interferometer has been fabricated with femtosecond laser writing,and it is the largest programmable interferometer of this kind to *** have demonstrated its advantageous error tolerance by showing an operation in a broad wavelength range from 920 to 980 nm,which is particularly relevant for quantum photonics due to efficient photon sources existing in this wavelength *** work highlights the importance of developing novel architectures of programmable photonics for information processing.

关键词： interferometer laser femtosecond

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化学及碳、硫同位素组成约束川东地区上石炭统-下三叠统天然气成因

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中国科学:地球科学 2024年

作者：蔡春芳 ilya KUTUZOv 梅文华王道伟罗冰黄士鹏何冰 Alon AMRANI 中国石油大学油气资源和工程国家重点实验室中国科学院地质与地球物理研究所岩石圈演化与环境演变全国重点实验室中国科学院大学地球与行星科学学院 Institute of Earth Sciences The Hebrew University 榆林学院中国石油西南油气田公司中国石油天然气股份有限公司石油勘探开发研究院

以甲烷为主的天然气是最清洁的能源资源之一,但是目前还没直接的方法用以确定其烃源岩.为此,本研究分析了川东地区天然气地球化学和地震资料,确定热化学硫酸盐还原（TSR）等次生过程对天然气的改造作用,并探讨了天然气的来源.研究结果表... 详细信息

以甲烷为主的天然气是最清洁的能源资源之一,但是目前还没直接的方法用以确定其烃源岩.为此,本研究分析了川东地区天然气地球化学和地震资料,确定热化学硫酸盐还原（TSR）等次生过程对天然气的改造作用,并探讨了天然气的来源.研究结果表明,第一类天然气分布于开江-梁平地区周围上二叠统-下三叠统（P3ch-T1f）,其挥发性有机硫化合物（vOSCs）δ34S值与伴生H2S相近,可能经历了以甲烷为主的TSR作用;随着TSR程度的增强,甲烷δ13C1值发生正偏移.第二类来自川东地区的下石炭统-中二叠统（C2h-P2q）以及南部地区的天然气,未受到明显的TSR影响,天然气中某些vOSCs与干酪根之间的δ34S值相似,可能来自下志留统和中二叠统的烃源岩.本研究提出vOSCs的δ34S值可作为非TSR改造天然气与烃源岩直接对比的指标.天然气和烃源岩地球化学数据与地震数据相结合,可以作为一种有效勘探天然气藏的方法.

关键词：硫同位素可挥发性有机硫化合物热化学硫酸盐还原四川盆地气-源岩对比

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Solvability and Construction of a Solution to the Fredholm Integral Equation of the First Kind

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Journal of Applied Mathematics and Physics 2024年第2期12卷 720-735页

作者： Aisagaliev Serikbai Nurmagambetov Dias Sevryugin ilya Differential Equations and Control Theory Al-Farabi Kazakh National University Almaty Kazakhstan Department of Mathematics Prairie View A&M University Prairie View USA

The issues of solvability and construction of a solution of the Fredholm integral equation of the first kind are considered. It is done by immersing the original problem into solving an extremal problem in Hilbert space. Necessary and sufficient conditions for the existence of a solution are obtained. A method of constructing a solution of the Fredholm integral equation of the first kind is developed. A constructive theory of solvability and construction of a solution to a boundary value problem of a linear integrodifferential equation with a distributed delay in control, generated by the Fredholm integral equation of the first kind, has been created.

关键词： Integral Equations Solvability Solution Construction Controllability Minimizing Sequences

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B-L model with D_(4)×Z_(4)×Z_(2)symmetry for fermion mass hierarchies and mixings

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Chinese Physics C 2024年第6期48卷 11-30页

作者： v.v.vien Department of Physics Tay Nguyen UniversityDaklakVietnam

We constructed a gauge B-L model with D_(4)×Z_(4)×Z_(2)symmetry to explain the quark and lepton mass hierarchies and their mixings with realistic CP phases via the type-I seesaw *** quark mases,three quark mixing angles,and the CP phase in the quark sector take the central values whereas Yukawa couplings in the quark sector are diluted in a range of difference of three orders of magnitude by the perturbation theory at the first *** the neutrino sector,a small neutrino mass is achieved by the type-I seesaw *** inverted and normal neutrino mass hierarchies are consistent with the experimental *** predicted sum of neutrino masses for normal and inverted hierarchies,the effective neutrino masses,and the Dirac CP phase are also consistent with recently reported limits.

关键词： flavor symmetries quark and lepton masses and mixing extensions of electroweak gauge sector neutrino mass and mixing non-standard-model neutrinos right-handed neutrinos D4 discrete symmetry

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Active and passive modulation of solar light transmittance in a uniquely multifunctional dual-band single molecule for smart window applications

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Journal of Energy Chemistry 2024年第1期88卷 293-305,I0007页

作者： Pooja v.Chavan Pramod v.Rathod Joohyung Lee Sergei v.Kostjuk Hern Kim Department of Energy Science and Technology Environmental Waste Recycle InstituteMyongji UniversityYonginGyeonggi-do 17058Republic of Korea Department of Chemical Engineering Myongji UniversityYonginGyeonggi-do 17058Republic of Korea Research Institute for Physical Chemical Problems of the Belarusian State University MinskBelarus

Functional materials may change color by heat and electricity separately or simultaneously in smart *** materials have not only demonstrated remarkable potential in the modulation of solar radiation but are also leading to the development of indoor environments that are more comfortable and conducive to improving individuals'quality of ***,dual-responsive materials have not received ample research attention due to economic and technological *** a consequence,the broader utilization of smart windows faces *** address this new generational multistimulus responsive chromic materials,our group has adopted a developmental strategy to create a poly(NIPAM)n-Hv as a switchable material by anchoring active viologen(Hv)onto a phase-changing poly(NIPAM)n-based smart material for better utility and *** constructed smart windows facilitate individualistic reversible switching,from a highly transparent state to an opaque state(thermochromic)and a red state(electrochromic),as well as facilitate a simultaneous dual-stimuli response reversible switching from a clear transparent state to a fully opaque(thermochromic)and orange(electrochromic)*** privacy can be attained in smart windows designed for exclusive settings by achieving zero *** unique chromic mode operates independently and modulates visible and near-infrared(NIR)light in a distinct ***,these smart windows with thermal and electric dual-stimuli responsiveness demonstrate remarkable heat regulation capabilities,rendering them highly attractive for applications in building facades,energy harvesting,privacy protection,and color display.

关键词： Smart windows Thermochromism Electrochromism Energy saving Dual-responsive material

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