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Dimebon对小鼠中型多棘神经元NMDA激活电流的影响

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中国临床解剖学杂志 2015年第1期33卷 89-92页

作者：许晓利李琴宋露 ilya bezprozvanny 江汉大学医学院基础部武汉430056 美国德州大学西南医学中心生理系达拉斯75390

目的探讨药物Dimebon在阿尔茨海默氏病(AD)和亨廷顿氏病(HD)的药理作用。方法采用膜片钳技术在培养的小鼠纹状体中型多棘神经元(medium spiny striatal neurons,MSN)上观察不同浓度的Dimebon对NMDA(N-methyl-D-aspartic acid)受体激活... 详细信息

目的探讨药物Dimebon在阿尔茨海默氏病(AD)和亨廷顿氏病(HD)的药理作用。方法采用膜片钳技术在培养的小鼠纹状体中型多棘神经元(medium spiny striatal neurons,MSN)上观察不同浓度的Dimebon对NMDA(N-methyl-D-aspartic acid)受体激活电流的影响。结果高浓度的Dimebon抑制NMDA激活电流,而低浓度的Dimebon增强NMDA激活电流,从而下调NMDA受体。结论 Dimebon对NMDA受体激活电流的影响有双重作用,依Dimebon浓度的不同而不同,为临床用药提供依据。

关键词： Dimebon 中型多棘神经元 NMDA受体激活电流

Leaner小鼠P/Q型钙通道功能及其在海马神经元突触传递中的作用

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华中科技大学学报（医学版） 2016年第1期45卷 33-38页

作者：许晓利杨友华李琴 ilya bezprozvanny 江汉大学医学院基础医学部武汉430056 美国德克萨斯州立大学西南医学中心生理学系达拉斯75390

目的研究P/Q型钙通道在小鼠海马神经元的突触传递中的重要作用。方法 1培养小鼠海马神经元用于研究,采用全细胞膜片钳记录技术,记录培养的对照组并趾症小鼠(oligosyndactyly,OS)和Leaner小鼠海马神经元钙离子电流;2刺激突触前细胞,记录... 详细信息

目的研究P/Q型钙通道在小鼠海马神经元的突触传递中的重要作用。方法 1培养小鼠海马神经元用于研究,采用全细胞膜片钳记录技术,记录培养的对照组并趾症小鼠(oligosyndactyly,OS)和Leaner小鼠海马神经元钙离子电流;2刺激突触前细胞,记录突触后神经元抑制性突触后电流,观察对照组OS抑制性突触后电流对钙离子浓度的依赖性。3比较对照组OS和Leaner小鼠的突触后电流中各种钙通道在突触传递中所占比例。4转染长片段P/Q型质粒以恢复Leaner小鼠细胞因突变而引起的C末端过短所造成的功能缺失。结果 1抑制性突触后电流中P/Q型钙通道与钙浓度密切相关,在正常钙浓度的条件下,细胞外钙浓度为2mmol/L时,P/Q型钙通道起主要作用,当细胞外钙浓度升高到4mmol/L后,P/Q型钙通道功能所占比例部分由N型通道代替。2对照组OS和Leaner小鼠培养的海马神经元钙通道中P/Q型钙通道有很大的不同,突变小鼠中P/Q型钙通道功能减低,由其它通道补偿代替。3在培养的海马神经元记录的突触后电流显示Leaner小鼠的P/Q功能基本丧失,由N型和其他型所取代。4通过外源性转染含长片段P/Q型通道的质粒可以基本补偿P/Q型钙通道功能。结论 Leaner小鼠海马P/Q型钙通道功能降低是导致突触传递功能减少的重要因素。

关键词： Leaner小鼠海马神经元 P/Q型钙通道抑制性突触后电流突触传递

Monocotyledon-like Leaves from the Middle Jurassic of East Siberia(Russia)

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Acta Geologica Sinica(English Edition) 2022年第6期96卷 1884-1896页

作者： Andrey FROLOV ilya ENUSHCHENKO Institute of the Earth’s Crust Siberian Branch of the Russian Academy of SciencesIrkutsk 664033Russia Limnological Institute Siberian Branch of the Russian Academy of SciencesIrkutsk 664033Russia

Leaf fragments of Herbifolia antiqua *** et Enushchenko *** *** the Middle Jurassic(Aalenian)of the Irkutsk Coal Basin(Eastern Siberia,Russia)are *** following features are characteristic of *** *** ***.:the presence of leaf sheaths,linear smooth-edged leaves with parallel venation,anastomoses between the veins,anomocytic stomata,rhomb-shaped ordinary epidermal *** a combination of characters is widespread in modern monocotyledonous plants and is absent in fossil and modern cryptogam and *** to the lack of evidence of an enclosed ovule in *** *** ***.,we attribute it to a typological angiosperm,based on its unique leaf structure characteristic of *** leaf epidermal structure of Herbifolia *** most similar to those of modern Asparagales and Liliales.

关键词： monocotyledons leaf epidermis new taxa Jurassic angiosperm Irkutsk Coal Basin

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功能与美学贝尔格莱德IT公司办公室

室内设计与装修 2025年第1期 16-21页

作者：无 Svetlana Dudina Dilyara Mukhamedova Vasilina Pavlova Evegeniya Sviridova Elena Menshikova ilya Ivanov(摄影) 夏花(编译) Nefa Architects 不详

该项目坐落在贝尔格莱德,是为一家国际IT公司设计的办公空间。项目的设计主旨不仅要能重现当地城市的景观多样性,也要体现其文化和历史的特质。设计师从南斯拉夫时期粗犷主义与现代主义的经典建筑风格中汲取灵感,通过原始混凝土元素,展... 详细信息

该项目坐落在贝尔格莱德,是为一家国际IT公司设计的办公空间。项目的设计主旨不仅要能重现当地城市的景观多样性,也要体现其文化和历史的特质。设计师从南斯拉夫时期粗犷主义与现代主义的经典建筑风格中汲取灵感,通过原始混凝土元素,展现城市的力量与质感;与此同时,设计融入明亮的色彩点缀,其灵感源于贝尔格莱德丰富的街头艺术作品。这些鲜明的艺术符号不仅为空间注入活力,还增强了视觉冲击力,使办公环境与城市特色无缝衔接,赋予空间独特的文化价值。

关键词：办公空间建筑风格街头艺术艺术符号办公环境无缝衔接注入活力景观多样性

Large-scale molecular characterization and analysis of gastric cancer

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Chinese Journal of Cancer 2014年第8期33卷 369-370页

作者： ilya Shmulevich ISB/MDACC Genome Data Analysis Center TCGA Gastric Cancer Working GroupInstitute for Systems Biology

The recent effort by The Cancer Genome Atlas(TCGA)Network has revealed that gastric cancer,which is a leading cause of cancerrelated deaths worldwide with a 5-year survival rate less than 25%,is a much more heterogeneous disease than previously *** yet,conventional treatment approaches and clinical trials have assumed it is a single disease.

关键词：胃癌细胞特征和分子基因组图谱临床试验分类方案生存率异质性

Degenerations of Jordan Algebras and“Marginal”Algebras

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Algebra Colloquium 2021年第2期28卷 281-294页

作者： ilya Gorshkov Ivan Kaygorodov Yury Popov Sobolev Institute of Mathematics NovosibirskRussia Universidade Federal do ABC CMCCSanto AndreBrazil Universidade Estadual de Campinas CampinasBrazil

We describe all degenerations of the variety ■3 of Jordan algebras of dimension three over *** particular,we describe all irreducible components in ■*** every n we define an n-dimensional rigid“marginal”Jordan algebra of level ***,we discuss marginal algebras in associative,alternative,left alternative,non-commutative Jordan,Leibniz and anticommutative cases.

关键词： Jordan algebra degeneration rigid algebra irreducible component marginal algebra

Experimental Study of Liquid Metal Flow for the Development of a Contact-Less Control Technique

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1553-1564页

作者： Aleksandr Poluyanov ilya Kolesnichenko Laboratory of Technological Hydrodynamics Institute of Continuous Media Mechanics of the Ural Branch of Russian Academy of Science(ICMM UB RAS)Perm614018Russia

The article presents an experimental study on the flow of an eutectic gallium alloy in a cylindrical cell,which is placed in an alternating magnetic *** magnetic field is generated by a coil connected to an alternating current *** coil is located at a fixed height in such a way that its plane is perpendicular to the gravity vector,which in turn is parallel to the axis of the *** position of the cylinder can vary in height with respect to the *** forced flow of the considered electrically conductive liquid is generated due to the action of the localized electromagnetic *** is assumed that under the action of the alternating magnetic field,the liquid is heated uniformly,and the resulting heat is quickly absorbed by the forced flow,so that liquid free convection can be *** experiment is carried out using an ultrasonic Doppler *** transducer is installed in the axially located cylinder sluice and the other transducer is placed in the near-wall *** to the results,a velocity profile,corresponding to a two-tori flow pattern can be hardly obtained in the low frequency range of the power ***,this is possible in the high frequency *** average velocity profiles depend essentially on the location of the coil relative to the *** spectral analysis of velocity signals shows that the amplitude of the velocity pulsations is comparable to the average value of the flow *** experimental results and their verification through comparison with numerical calculations are intended to support the development of new methods for reducing the intensity of vortex flows during the electromagnetic separation of impurities through an electromagnetic induction mechanism(able to produce an electromotive force that displaces particles).

关键词： Ultrasonic doppler velocimeter electrically conductive medium azimuthal pinch experiment in liquid metal magnetohydrodynamics

Power absorption,plasma parameters and wave structure in inductive RF plasma source with low value external magnetic field

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Plasma Science and Technology 2020年第11期22卷 60-73页

作者： Elena KRALKINA Konstantin VAVILIN ilya ZADIRIEV Alexander NIKONOV Physical Electronics Department Faculty of PhysicsLomonosov Moscow State UniversityMoscow 119991Russia

The efficiency of radio-frequency(RF)power absorption,RF magnetic field structure and plasma parameters were measured in cylindrical inductive RF plasma sources 20 cm in diameter and 22,32,53 cm in length with a low value external magnetic *** experiments were carried out in argon at pressures of 13-140 m *** RF power supply changed from 200 W to 800 *** spiral antenna was used for sustaining the *** was shown that efficiency of RF power absorption depended nonlinearly on the external magnetic field *** maximal values of the RF power absorption efficiency,the axial distributions of longitudinal Bzand azimuthal Bφcomponents of RF magnetic field manifested the formation of the partially standing wave with a half wavelength close to 8 *** the same conditions,the axial dependence of the radial RF magnetic field component Brdiffered *** was concluded that the Bz and Bφamplitudes were largely determined by the RF field of Trivelpiece-Gould wave,while Br amplitude represented the radial RF field of the helicon wave.

关键词： radio-frequency plasma helicon Trivelpiece-Gould waves inductive discharge

Can we treat neurodegenerative diseases by preventing an age-related decline in microRNA expression?

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Neural Regeneration Research 2017年第10期12卷 1602-1604页

作者： ilya A.Vinnikov Andrii Domanskyi Laboratory of Molecular Neurobiology Sheng Yushou Center of Cell Biology and ImmunologyDepartment of Genetics and Developmental BiologySchool of Life Science and BiotechnologyShanghai Jiao Tong University Institute of Biotechnology Hi LIFEUniversity of Helsinki

MicroRNA pathway is down-regulated in aged dopaminergic neurons： Parkinson＇s disease （PD） is the most frequent motor neuro- degenerative disorder and is morphologically mainly associated with progressive dopaminer... 详细信息

关键词： RNA Can we treat neurodegenerative diseases by preventing an age-related decline in microRNA expression