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Histological Assessment of Bone Regeneration in the Maxilla with Homologous Bone Graft:A Feasible Option for Maxillary Bone Reconstruction

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Journal of Renewable Materials 2024年第1期12卷 131-148页

作者： Sergio Henrique Gonçalves Motta Ana Paula Ramos soares Juliana Campos Hasse fernandes Gustavo Vicentis Oliveira fernandes Graduate Center of Faculdade Redentor CLIVORio de JaneiroBrazil Periodontics and Oral Medicine Department University of Michigan School of DentistryAnn ArborMI48109USA Centre for Interdisciplinary Research in Health(CIIS) Universidade Católica PortuguesaViseu3504-505Portugal

Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ***,the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB(lyophilized)graft and verify its *** individuals were included from 2014 to *** first surgery was performed to install homologous bone blocks in the *** period of the second intervention varied between 5 months and 15 days to 11 months(≈7.93 months).The biopsies were taken from the central region of the matured graft during the surgery for implant *** patients presented clinical and radiographic conditions for the installation of dental *** was a 100%of survival *** histological assessment showed that the homologous block bone graft was an osteoconductive biomaterial,with connective tissue present,and newly formed bone juxtaposed on its *** were bone trabeculae with osteocytes and active osteoblasts with connective tissue in the mineralization process;the remodeling process can be found through the reverse lines.A limited focus of necrosis with fibrosis was detected,with small resorption and areas of inflammatory infiltrate,but without clinical *** homologous block bone graft can be considered a feasible option to substitute the autogenous bone graft(gold standard),with predictable clinical and favorable histological *** patients had a shorter surgical period,low morbidity,and an unlimited amount of biomaterial available at an accessible cost.

关键词： Regeneration bone graft histology homologous allogenous autogenous

Congenital heart diseases trends in S?o Paulo State,Brazil:a national live birth data bank analysis

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World Journal of Pediatrics 2022年第7期18卷 472-481页

作者： Paola soares fernandes Larissa Rosario Magalhaes Tainara Rita Pezzini Edige Felipe de Sousa Santos Mauricio Giusti Calderon Medical School Nine of July University(Uni9).Sao Bernardo do CampoSPBrazil Epidemiology Department Public Health SchoolSao Paulo University(USP)Sao PauloSPBrazil Pediatric Surgery Department Hospital Benficencia Portuguesa de Sao PauloRua Maestro Cardim768Sao PauloSP CEP 01323-011Brazil Pediatric Surgery Department Hospital Santa Catarina PaulistaAv.Paulista200.Sao PauloSP CEP:01310-000Brazil

Background Congenital heart diseases(CHD)are the most common type of birth defects,affecting millions of newborns every year;no prevalence data are available in S?o Paulo State,Brazil's most populous *** objective is to identify trends in prevalence and risk factors for CHD in Sao Paulo State,*** We developed a population-based study to estimate the CHD trend of prevalence in recent years,stratified by maternal age and geographical clusters,using all cases of CHD identified by the Live Births Information System(SINASC-Sistema de Informa??o Sobre Nascidos Vivos)from January 1,2005,to December 31,*** calculated the trends of prevalence,the regression coefficient(β),the annual percent change(APC),and 95%confidence interval using the Prais-Winsten regression model,with the Durbin-Watson *** We found 10,594 cases of CHD among 8,536,101 live births(LB),a prevalence of 12.4/10,000 *** was no difference in the sex distribution;they are primarily Caucasian(60.2%),75.2%born at term,and 74.4%weight>2500 g,66.9%of births were by cesarean section.S?o Paulo State presented an increasing CHD trend of prevalence(APC=18.9%).The highest CHD prevalence rate was in mothers aged≥35 years(22.2/10,000 LB).There were 12,271 specific congenital heart defects among 10,594 patients(1.16 CHD/patient).Atrial septal defect has the highest number of cases(3835),with a prevalence of 4.49/10,000 LB,corresponding to 31.3%of all *** CHD had an increasing prevalence trend in recent years,being highest in S?o Paulo City and≥35-year mothers.

关键词： Congenital abnormalities Epidemiology Heart defects Interrupted time series PrevalencePublic health

Direct Electrochemical Determination of Glyphosate Herbicide Using a Screen-Printed Carbon Electrode Modified with Carbon Black and Niobium Nanoparticles

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Journal of Analysis and Testing 2023年第4期7卷 425-434页

作者： Julia Oliveira fernandes Cassiano Augusto Rolim Bernardino Juliana dos Santos fernandes Claudio Fernando Mahler Bernardo Ferreira Braz Luiz Henrique Carpenter dos Santos Rodrigo JoséCorrêa Ricardo Erthal Santelli Braulio soares Archanjo Emerson Schwingel Ribeiro Fernando Henrique Cincotto Departament of Analytical Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Departament of Civil Engineering COPPEFederal University of Rio de JaneiroRio de Janeiro 21941-598Brazil National Institute of Science&Technology of Bioanalytics(INCTBio) CampinasSão Paulo 13083-862Brazil Departament of Inorganic Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Unesp National Institute of Alternative Technologies for DetectionToxicological Assessment and Removal of Micropollutants and Radioactives(INCT-DATREM)AraraquaraSão Paulo 14800-060Brazil National Institute of Metrology Quality and TechnologyInmetroAv.Nossa Senhora das Graças50XerémDuque de Caxias 25250-020Brazil

Glyphosate is a herbicide that has been widely used worldwide and is used in agricultural areas to control weeds and unwanted *** sensors developed from different nanomaterials have high efficiency,excellent cost-benefit,and fast analysis time for detecting traces of environmental *** study aimed to produce an electrochemical sensor with disposable screen-printed electrodes based on carbon black modified with niobium nanoparticles to determine glyphosate in aqueous *** morphology,structure and electrochemical performance of the sensor were characterized by scanning electron microscopy,energy-dispersive X-ray spectroscopy,X-ray diffraction and cyclic *** pulse voltammetry in BR buffer solution at pH 5.0 allowed the generation of a method to quantify glyphosate concentration in a linear range of 5.90-172.30μmol/L(1.00-29.13μg/mL),with a limit of detection calculated at 3.07μmol/L(0.52μg/mL).The method efficiently quantified glyphosate in real water samples and showed no interference from K^(+),Na^(+),Ca^(2+),Mg^(2+)ions or thiamethoxam,imidacloprid and carbendazim pesticides.

关键词： Glyphosate Electrochemical sensor Carbon black Niobium nanoparticles

Nutritional supplements use in high-performance athletes is related with lower nutritional inadequacy from food

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Journal of Sport and Health Science 2016年第3期5卷 368-374页

作者： Mónica Sousa maria J.fernandes Pedro Carvalho José soares Pedro Moreira Vitor Hugo Teixeira Centre of Research Education Innovation and Intervention in Sport Faculty of Sport University of Porto Faculty of Nutrition and Food Sciences University of Porto Research Centre on Physical Activity Health and Leisure Faculty of Sport University of Porto

Background: The use of nutritional supplements(NS) among athletes is widespread. However, little is known about the relationship between nutritional adequacy and NS usage. The aims of this study were to evaluate the NS usage and to compare the nutritional intake from food and prevalence of micronutrient inadequacy(PMI) between NS users and ***: Portuguese athletes from 13 sports completed an NS usage questionnaire and a semi-quantitative food-frequency questionnaire assessing information over the previous 12 months. The estimated average requirement cut-point method was used to calculate PMI. General linear models were used to compare nutritional intake and NS usage. Chi-squared tests and logistic regression were performed to study, respectively,relationships and associations between PMI and NS ***: From the 244 athletes(66% males, 13–37 years), 64% reported NS usage. After adjustment, NS users showed a higher intake from food(p < 0.05), for at least 1 gender, for energy, and for 7 of the 17 studied nutrients. The highest PMI were seen for vitamins D and E, calcium, folate,and magnesium. After adjustment, NS users, irrespective of gender, reported lower PMI for calcium(OR = 0.28, 95%CI: 0.12–0.65), and female users for magnesium(OR = 0.06, 95%CI: 0.00–0.98).Conclusion: Athletes using NS reported a higher nutritional intake from food, and a lower PMI for several nutrients. Perhaps, those who were taking NS were probably the ones who would least benefit from it.

关键词： Carbohydrates Minerals Proteins Sport Vitamins

Technical Evaluation of Hybrid Clones of Corymbia spp. to Produce Market Pulp

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Paper And Biomaterials 2022年第3期7卷 1-6页

作者： Marcelo Moreira da Costa Ricardo de Carvalho Bittencourt Thales Augusto Pinto Coelho Nogueira Larissa soares Silva Weslley Henrique Martins da Silva Sebastião Renato Valverde Gleison Augusto Dos Santos Daniel Alexander fernandes Coelho Claudilene Aparecida Alves Pena Department of Forest Sciences Federal University of VicosaVicosaMinas Gerais36570900Brazil Aperam BioEnergia Co. CapelinhaMinas Gerais39680000Brazil

This study presents hybrid clones of Corymbia *** by Aperam BioEnergia as potential substitutes for Eucalyptus wood in the pulp *** biomass of Eucalyptus *** compared with that of Corymbia *** performing modified kraft pulping and basic density *** were made by analyzing their respective mean annual increments of cellulose(MAI_(cel))and specific wood consumption(SWC),estimated using a kappa number of(19±1).The results showed that one of the hybrid clones(Corymbia citriodora×Corymbia torelliana,ID 4)had higher basic wood density,higher screened yield,better MAI_(cel#k19),and lower SWC than the other samples,reaching values of 0.608 t/m^(3),54.1%,24.6 ADt/ha/year(i.e.,air dry ton/hectare/year),and 2.74 m^(3)/ADt,***,clone ID 4 had the highest MAI_(cel)/SWC ratio score(8.98).Given its high forest productivity and low industrial cost compared with other samples,as well as its advantages over Eucalyptus ***,we concluded that clone ID 4 has great potential as an alternative biomass for pulp production.

关键词： Corymbia hybrids modified kraft pulping mean annual increments of cellulose(MAIcel) specific wood consumption(SWC)

Brazilian biosafety law and the new breeding technologies

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Frontiers of Agricultural Science and Engineering 2020年第2期7卷 204-210页

作者： Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI maria Sueli soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno fernandes Embrapa Soybean Londrina 86001970Brazil Catholic University of Brasilia Brasilia 70790160Brazil Embrapa Agroenergy Biological Station ParkBrasilia 70770901Brazil Paulista State University Julio de Mesquita Filho Botucatu Faculty of Agronomic SciencesBotucatu 18610307Brazil Embrapa Biotechnology and Genetic Resources—Biological Station Park Brasilia 70770900Brazil Sao Paulo University Veterinary FacultySao Paulo 05508900Brazil Londrina State University Microbiology DepartmentUniversity CampusLondrina 86051990Brazil Espirito Santo Federal University Biotechnology Post GraduationVitoria 29040090Brazil CTNBio(National Biosafety Technical Commission) Brasilia 70610200Brazil

Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two *** this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to *** recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food *** Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and ***,most of new breeding technologies did not exist at that time and were not considered in this ***2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation ***,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk *** the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing ***,152 GM products are commercially approved in *** 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six *** is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops.

关键词： Brazilian legislation CTNBio genetically modified crops

Physical Activity Alters Superoxide Dismutase Activity and Intercellular Adhesion Molecule 1 Levels in Diabetes Mellitus Type 2 Patients

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Journal of Biosciences and Medicines 2023年第7期11卷 140-150页

作者： Anderson Martins Tavares Leonardo Matta Jaslana Hainfellner da Silva Christiane de Oliveira Bensusan Carla do Nascimento Giselle fernandes Taboada Rodrigo soares Fortunato Luciene de Carvalho Cardoso-Weide Postgraduate Program in Medical Sciences School of Medicine UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Carlos Chagas Filho Institute of Biophysics UFRJ-Federal University of Rio de Janeiro Rio de Janeiro Brazil School of Biology University Salgado de Oliveira Rio de Janeiro Brazil Endocrinology Unit Department of Internal Medicine School of Medicine UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Medical School Department of Pathology UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Luciene de Carvalho Cardoso Weide Medical School Department of Pathology UFF-Universidade Federal Fluminense Rio de Janeiro Brazil

Background: Oxidative stress and inflammation are related to the pathophysiology of diabetes mellitus (DM), being involved in the development of micro-and macrovascular complications. Physical activity is beneficial for DM patients, but little is known about the relationship between redox and inflammation biomarkers and the level of physical activity in these patients. Based on this, this research aims to evaluate the effects of physical activity level on redox stress parameters and inflammatory markers in T2DM patients. Methods: Eighty-four patients with T2DM were divided according to their physical activity level: group A (n = 48), sedentary;group B (n = 11) active (3 times a week, 150 min) and group C (n = 25), highly active (5 times a week, 150 - 300 mins, at least). Anthropometric and biochemical parameters, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, as well as GSH, sRAGE and ICAM-1 levels were assessed. Results: Glycated haemoglobin, total cholesterol, and LDL-cholesterol levels were lower in the highly active group in comparison to other groups. Plasma SOD activity was higher in group C compared to Group A, while ICAM-1 levels were significantly higher in group B when compared to other groups. Conclusion: Our results suggest that the practice of physical activity is beneficial to T2DM patients, especially at high volume and frequency.

关键词： Cardiovascular Risk Exercise Health Inflammation Oxidative Stress

Venous thrombosis and prothrombotic factors in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第17期20卷 4857-4872页

作者： Fernando Magro Jo?o-Bruno soares Dália fernandes Gastroenterology Department of Centro Hospitalar S?o Jo?o 4200-319 PortoPortugal Institute of Pharmacology and Therapeutics Faculty of MedicineUniversity of Porto4200-319 PortoPortugal IBMC Institute for Molecular and Cell BiologyUniversity of Porto4150-180 PortoPortugal Gastroenterology Department of Hospital de Braga 4710-243 BragaPortugal Gastroenterology Department of Centro Hospitalar da Cova da Beira 6200-251 Covilh?Portugal

Patients with inflammatory bowel disease(IBD)may have an increased risk of venous thrombosis(VTE).PubMed,ISI Web of Knowledge and Scopus were searched to identify studies investigating the risk of VTE and the prevalence of acquired and genetic VTE risk factors and prothrombotic abnormalities in ***,IBD patients have a two-to fourfold increased risk of VTE compared with healthy controls,with an overall incidence rate of 1%-8%.The majority of studies did not show significant differences in the risk of VTE between Crohn’s disease and ulcerative *** acquired factors are responsible for the increased risk of VTEin IBD:inflammatory activity,hospitalisation,surgery,pregnancy,disease phenotype(e.g.,fistulising disease,colonic involvement and extensive involvement)and drug therapy(mainly steroids).There is also convincing evidence from basic science and from clinical and epidemiological studies that IBD is associated with several prothrombotic abnormalities,including initiation of the coagulation system,downregulation of natural anticoagulant mechanisms,impairment of fibrinolysis,increased platelet count and reactivity and dysfunction of the *** genetic alterations are not generally found more often in IBD patients than in nonIBD patients,suggesting that genetics does not explain the greater risk of VTE in these *** VTE may have clinical specificities,namely an earlier first episode of VTE in life,high recurrence rate,decreased efficacy of some drugs in preventing further episodes and poor *** should be aware of these risks,and adequate prophylactic actions should be taken in patients who have disease activity,are hospitalised,are submitted to surgery or are undergoing treatment.

关键词： Acquired Genetic Prothrombotic Venous thrombosis R

微波等离子体化学气相沉积法在硅片上同时生长碳化硅和金刚石

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新型炭材料 2008年第3期23卷 250-258页

作者：唐春玖符连社 A.J.S.fernandes M.J.soares Gil Cabral A.J.Neves J.Grácio Center for Mechanical Technology and Automation and Department of Mechanical Engineering University of Aveiro Department of Physics and CICECO University of Aveiro Department of Physics University of Aveiro

研究了衬底温度、核化密度、衬底表面预处理等工艺参数对微波等离子体化学气相沉积法在硅片上同时生长碳化硅和金刚石的影响。采用扫描电镜、X-射线衍射、喇曼光谱和红外光谱对样品进行了表征。结果表明:从高核化密度生长的金刚石膜中... 详细信息

研究了衬底温度、核化密度、衬底表面预处理等工艺参数对微波等离子体化学气相沉积法在硅片上同时生长碳化硅和金刚石的影响。采用扫描电镜、X-射线衍射、喇曼光谱和红外光谱对样品进行了表征。结果表明:从高核化密度生长的金刚石膜中探测不到碳化硅;不论对硅衬底进行抛光预处理还是未抛光预处理,从低核化密度生长的金刚石厚膜中总能探测到碳化硅。碳化硅生长在硅衬底上未被金刚石覆盖的地方,或者是在金刚石晶核之间的空洞处。碳化硅形成和金刚石生长是同时发生的两个竞争过程。此研究结果为制备金刚石和碳化硅复合材料提供了一种新的方法。

关键词：碳化硅金刚石厚膜红外光谱微波等离子体气相化学沉积