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Prospects of DNA microarray application in management of chronic obstructive pulmonary disease:A systematic review

Frigid Zone Medicine 2023年第1期3卷 5-12页

作者： Litvinova Anastasiia Bykov ilia Department of Bioinformatics Harbin Medical UniversityHarbin 150081China Department of Public health and Healthcare Far Eastern State Medical UniversityKhabarovsk 680000Russia

Chronic obstructive pulmonary disease(COPD)is incurable chronic disease which kills 3.3 million each year *** of global cases of COPD is steadily rising alongside with life expectancy,disproportionally hitting middle-income countries like Russia and China,in such conditions,new approaches to the COPD management are desperately *** microarray technology is a powerful genomic tool that has the potential to uncover underlying COPD biological alteration and brings up revolutionized treatment option to *** executed systematic review studies of studies published in last 10 years regarding DNA microarray application in COPD management,with complacence to PRISMA criteria and using PubMed and Medline data bases as data *** of 920 identified papers,39 were included in the final *** concluded that Genome-wide expression profiling using DNA microarray technology has great potential in enhancing COPD *** studied proofed this method is reliable and possesses many potential applications such as individual at risk of COPD development recognition,early diagnosis of disease,COPD phenotype identification,exacerbation prediction,personalized treatment optioning and prospect of oncogenesis evaluation in patients with *** all the proofed benefits of this technology,researchers are still in the early stage of exploring it’s ***,large clinical trials are still needed to set up standard for DNA microarray techniques usage implementation in COPD management guidelines,subsequently giving opportunity to clinicians for controlling or even eliminating COPD entirely.

关键词： chronic obstructive pulmonary disease biomarker expression profiling DNA microarray

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Review: Isomer Separation, Chiral Resolution, and Structure Elucidation Analyses Are the Future of Analytical Supercritical Fluid Chromatography—Mass Spectrometry

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International Journal of Analytical Mass Spectrometry and Chromatography 2014年第1期2卷 15-24页

作者： ilia Brondz Anton Brondz Department of Chemistry Norwegian University of Science and Technology Trondheim Norway Norwegian Drug Control and Drug Discovery Institute (NDCDDI) Ski Norway

In 1822, almost 200 years ago, Baron Charles Cagniard de Latour (1777-1859) discovered the critical phenomena or critical state [1] [2]. At that time, it was described as a curiosity. However, it is now used as an advanced extraction and analytical technology in industry and research. Extraction with supercritical fluids (SFs) was welcome from the very beginning. In the present paper, the application to chromatography of the critical phenomena of compressed gases or overheated liquids as supercritical fluids will be discussed. Supercritical Fluid Chromatography (SFC) received an uneasy welcome, mainly because of the lack of commercially available analytical instruments. Even today, only a small number of industrial companies are manufacturing SFC instrumentation. A very small spectrum of columns is manufactured specially for SFC. SFC is not accepted by Pharmacopeia committees for the analysis of drugs and medical forms to the same extent as Gas Chromatography, High-Performance Liquid Chromatography or even Thin Layer Chromatography. The present status and future perspectives for SFC will be discussed.

关键词： Critical Phenomena Critical Stat Supercritical Fluids Supercritical Fluid Chromatography

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Necessity for Vitamin D Screening among Urban Bedouin Women of Childbearing Age

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Health 2015年第5期7卷 560-565页

作者： Inna Rudoy ilia Volkov Department of Family Medicine Sial Research Center for Family Medicine and Primary Care Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva Israel Clalit Health Services Southern District Beer-Sheva Israel

Vitamin D (Vit D) plays multiple roles in bodily functions. Vit D deficiency is a common, but often under-diagnosed condition with possible serious complications. According to some research, Vit D is important particularly among women and children. No data were found concerning the Vit D status among urban Bedouin women of childbearing age. The research study is retrospective and descriptive. We analyzed 202 medical histories of patients undergoing blood tests for Vit D level for various reasons. The main objectives of the research were: 1) determining the prevalence of the Vit D deficiency among the Bedouin women of childbearing age;2) identifying the causes for the physicians’ reasons for suspecting Vit D deficiency: the complaints or symptoms which cause the doctor to test for Vit D level. As a result, in 80.7% of those tested for Vit D, levels were less than 10 ng/ml, and in 19.3%, levels of 10 to 20 ng/ml were found. In lieu of our findings and in order to prevent serious health problems, Vit D screening plan should be seriously considered and discussed in the Bedouin population with high risk of deficiency.

关键词： Vitamin D Vitamin D Deficiency Vitamin D Deficiency in Women Prevalence of Vitamin D Deficiency Bedouin Population

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Supercritical Fluid Chromatography—Mass Spectrometry (SFC-MS) and MALDI-TOF-MS of Heterocyclic Compounds with Trivalent and Pentavalent Nitrogen in Cough Relief Medical Forms Tuxi and Cosylan

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American Journal of Analytical Chemistry 2012年第12期3卷 870-876页

作者： ilia Brondz Anton Brondz Department of Biology University of Oslo Oslo Norway Department of Chemistry Norwegian University of Science and Technology Trondheim Norway

Alkaloids are natural, semisynthetic or synthetic organic compounds, normally polar with basic chemical properties and containing at least one nitrogen atom in a heterocyclic ring. Some synthetic or semisynthetic substances resemble the alkaloid architecture. Trivalent nitrogen in these substances is normal;however, some natural and semisynthetic alkaloids have pentavalent nitrogen. The drug pholcodine is a derivative of morphine. Pholcodine has very little addiction- developing effect. It is a semisynthetic alkaloid that was first synthesized in 1950 by Chabrier et al. Pholcodine possesses antitussive (cough relief) properties similar to codeine, morphine and ethylmorphine. The drug was used in liquid formulations as Tuxi and Tuxi Forte, and it is in present use in Tuxidrin as liquid mixture and in tablet form. Pholcodine is an Active Pharmacological Ingredient (API) in tablets and liquid mixtures. Leiras International and Weifa in Norway manufacture medical forms with pholcodine. Several impurities in pholcodine were described by J. Roe in 1997 and by Denk et al. in 2000 and 2002. In addition, several degradation products may be formed in liquid formulations under storage. Some of these products are related not to the original production of pholcodine but rather to its oxidation under storage. The appearance of degradation products strongly depends on the storage temperature and pH of the liquid phase. Pholcodine-N-oxide and pholcodine-N,N’-dioxide are among the degradation (oxidation) products;pholcodine can also degrade to morphine. There is little information about the toxicity of the N-oxide and no information on the N,N’-di- oxide of pholcodine. In this study, the fact that morphine is generated during the storage of formulations containing pholcodine is presented. Another antitussive mixture under the name Cosylan was analyzed to examine the oxidation of ethylmorphine to ethylmorphine-N-oxide. Ethylmorphine is the API in Cosylan.

关键词： SFC Trivalent Nitrogen Pentavalent Nitrogen Pholcodine-N-oxide Pholcodine-N N’-dioxide Morphine Cosylan Tuxi Tuxi Forte Tuxidrin

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Recent enhancement of the immunity in AIDS and other immunocompromised patients by hyperforin an antibiotic from Hypericum perforatumL. (in vitromodel) part I

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Journal of Biophysical Chemistry 2012年第4期3卷 304-310页

作者： ilia Brondz Anton Brondz Department of Biology University of Oslo Oslo Norway Department of Chemistry Norwegian University of Science and Technology Trondheim Norway

Today, Hypericum perforatum L. is probably one of the best-characterized medicinal plants, and hyperforin is its best-characterized constituent. Extracts from H. perforatum are widely used as antidepressants;however, less attention has been given to other properties of hyperforin, such as antitumor, fungicidal, antiviral and antibacterial action, or its possible use as a substance with immunomodulation properties. The present study summarizes results that describe the influence of hyperforin as an immunomodulation agent on phagocytosis and the breakdown of Escherichia coli by human polymorphonuclear neutrophils (PMNs). Hyperforin at 1 - 100 μg/mL concentrations was found to have a major influence on phagocytosis and the breakdown of E. coli by PMNs in vitro. A 100 μg/mL solution of hyperforin increased the uptake of non-opsonized E. coli almost 50-fold, and the uptake of IgG-opsonized E. coli more than threefold;on the other hand, the uptake of serum-opsonized bacteria was reduced to approximately 60% of that of the control. Hyperforin seems to bind to both PMNs and E. coli and acts like an opsonin. The elimination of remnants of IgG-opsonized E. coli from the PMNs was stimulated by hyperforin, while the elimination of remnants from non-op-so nized and serum-opsonized material was unaffected by the drug. Hyperforin exhibited clear immunomodulation ability as a phagocytosisstimulating agent. Hyperforin is probably inactive against human immunodeficiency virus (HIV) and most Gram-negative bacteria. However, it can protect acquired immunodeficiency syndrome (AIDS) patients and other immunocompromised patients by its antibacterial activity against Gram-positive bacteria and by enhancement of phagocytosis of Gram-positive and Gram-negative bacteria;some Gram-negative bacteria, such as Neisseria, are sensitive to hyperforin. Hyperforin has the ability to penetrate the blood-brain barrier (BBB) and blood-testis barrier (BTB) and is a valuable antibacterial agent against me

关键词： Immunomodulation Phagocytosis AIDS E. coli Hyperforin Hypericum perforatum L.

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The Technology for Preparation of Generic (Monoenantiomeric) Antimalarial Drug Primaquine by Using Supercritical Fluid Chromatography. Separation of Primaquine from Quinocide: Simultaneous Resolution of the Enantiomers of Primaquine and Their Separation from Quinocide in One Run

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American Journal of Analytical Chemistry 2012年第12期3卷 884-890页

作者： ilia Brondz Anton Brondz Department of Biology University of Oslo Oslo Norway Department of Chemistry Norwegian University of Science and Technology Trondheim Norway

Malaria is one of the most harmful diseases on the globe. According to the World Health Organization (WHO), several million people die every year from malaria, and most of them are children. Hundreds of millions of fresh cases of ma- laria are registered by the WHO every year, and more than one-third of the earth’s population lives in malaria-endemic areas. Primaquine is an important antimalarial drug because it has gametocytocidal properties and prevents relapse in most cases. However, primaquine is a highly toxic substance, especially to the Negroid race (in Africa, Australia and North, Latin and South America) and some others. Negroid male children are most vulnerable to the toxic effects of primaquine. The toxicity of primaquine can be enhanced in mixtures with other antimalarial drugs. In the present study, unprocessed primaquine and primaquine tablets highly contaminated with quinocide (I. Brondz, Historical Overview of Chromatography and Related Techniques in Analysis of Antimalarial Drug Primaquine (Editor I. Brondz), Nova Sci- ence Publishers, Inc. (2011) ISSN 978-1-61761-944-1) are discussed versus monoenantiomeric primaquine as a drug. The contamination of primaquine with quinocide enhances the toxicity of primaquine by additive or synergistic action. The use of contaminated primaquine can be harmful. Development of a useful antimalarial vaccine can take a decade or longer. This paper describes the possibility of preparing antimalarial generic monoenantiomeric primaquine, free of both quinocide contamination and the ineffective enantiomer of primaquine, using fractionation by supercritical fluid chromatography equipped with a new experimental High Resolution Isomer Column (HRIC). By this approach, it is pos- sible to produce a significant amount of pharmacologically active enantiomer of primaquine at relatively low cost for a broad range of patients sensitive to contaminated primaquine. Leading pharmacopoeias should no longer deny the pre- sence of the to

关键词： Primaquine Quinocide High Resolution Isomer Column Monoenantiomeric Primaquine Malaria SFC New Technology Column HRIC

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The Principal Component Transform of Parametrized Functions

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Applied Mathematics 2017年第4期8卷 453-475页

作者： ilia Zabrodskii Arcady Ponosov Department of Science and Technology Norwegian University of Life Sciences &Aring s Norway

Many advanced mathematical models of biochemical, biophysical and other processes in systems biology can be described by parametrized systems of nonlinear differential equations. Due to complexity of the models, a problem of their simplification has become of great importance. In particular, rather challengeable methods of estimation of parameters in these models may require such simplifications. The paper offers a practical way of constructing approximations of nonlinearly parametrized functions by linearly parametrized ones. As the idea of such approximations goes back to Principal Component Analysis, we call the corresponding transformation Principal Component Transform. We show that this transform possesses the best individual fit property, in the sense that the corresponding approximations preserve most information (in some sense) about the original function. It is also demonstrated how one can estimate the error between the given function and its approximations. In addition, we apply the theory of tensor products of compact operators in Hilbert spaces to justify our method for the case of the products of parametrized functions. Finally, we provide several examples, which are of relevance for systems biology.

关键词： Principal Component Analysis Discretization of Functions Metamodeling Latent Parameters

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Suppression of immunity by some pesticides, xenobiotics, and industrial chemicals. In vitromodel

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Journal of Biophysical Chemistry 2011年第3期2卷 226-232页

作者： ilia Brondz Anton Brondz Department of Biology University of Oslo Blindern 0316 Oslo Norway

In recent years, attention has focused on suppression of immunity in immunocompromised patients. The definition of immunocompromise is impairment of the immune system caused by a disease or treatment. In addition to disease and treatment, other factors such as exposure to pesticides or toxic chemicals can damage the immune system. An in vitro test was used to assess the ability of monochloroacetic acid (MCA) (CAS number 79-11-8), dichloroacetic acid (DCA) (CAS number 79-43-6), trichloroacetic acid (TCA) (CAS number 76-03-9), and 2,2- dichloropropionic acid sodium salt (2,2-DCPANa, Dalapon) (CAS number 127-20-8) to suppress bacteriolysis by hen egg white lysozyme (HEWL). The system for bacteriolysis of Gram-negative bacteria Actinobacillus, Haemophilus, and Pasteurella in Tris-maleate buffer supplemented with EDTA and HEWL developed by Brondz et al. [1–4] was used to monitor bacteriolysis of Gram-negative bacteria in the Actinobacillus–Haemophilus–Pasteurella group. The halogenated acetic acid DCA is produced as a toxic artifact of the degradation of TCA and by disinfection of drinking and pool water and industrial waste. Nearly all humans consume DCA in drinking water during their lifetime;the concentration of DCA in drinking water can be higher than that associated with the upper-bound excess life-time cancer risk of 10–4 (40μg/L) [5]. Lysozyme found in tears, saliva, nasal secretions, and excretions from all mucous membranes can break down the cell walls of bacteria and destabilize bacterial membranes. Lysozyme is involved in innate (nonspecific) immunity;the innate immune system is the first line of defense against invading organisms. Actinobacillus actinomy- cetemcomitans (ATCC29522), a Gram-negative bacterium whose primary ecological niche is the respiratory tract and oral cavity, provided the peptidoglycan substrate for HEWL. The optical density (OD) of a standardized suspension of A. actinomycetemcomitans decreased from 100% (OD 0.6 at 540 nm) to 23.5% after

关键词： Immunosuppression Immunotoxicity Chlorinated Aliphatic Acids Dalapon

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Analytic Methods for Quality Control of Scientific Publications Part VII: Providing High-Quality Academic English—OnLine English

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International Journal of Analytical Mass Spectrometry and Chromatography 2020年第1期8卷 1-6页

作者： ilia Brondz Paul Harrison Drug Control and Drug Discovery Institute (NDCDDI) Ski Norway OnLine English Hobart Australia

Correct grammar, coherent structure, fluent expression, and clear presentation are necessities for academic literature in the sciences and humanities. For scientific papers, these parameters are important to authors as well as to readers, especially for scientists who wish to understand the theory or to replicate the results. Today, most scientific and humanities journals are published in English. There are journals in Chinese, German, Hindi, Russian and other languages;however, for international use in science, business, and computer hardware and software, English is the dominant language. English is also used in diplomacy and for all kinds of international communications by people who have various other native languages. In this paper, we will present one of the leading international providers of high-quality academic English—OnLine English (OLE) and some of the functions of this service will be described.

关键词： Scientific English Academic Language OnLine English Functional Services

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Porta-caval fibrous connections-the lesser-known structure of intrahepatic connective-tissue framework:A unified view of liver extracellular matrix

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World Journal of Hepatology 2021年第11期13卷 1484-1493页

作者： Leila Patarashvili Salome Gvidiani Elza Azmaipharashvili Keti Tsomaia Marom Sareli Dimitri Kordzaia ilia Chanukvadze Department of Clinical Anatomy and Operative Surgery Ivane Javakhishvili Tbilisi State UniversityTbilisi 0159Georgia Faculty of Medicine Ivane Javakhishvili Tbilisi State UniversityTbilisi 0159Georgia Clinical Anatomy and Experimental Modeling Institute of MorphologyIvane Javakhishvili Tbilisi State UniversityTbilisi 0159Georgia Department of Surgical Oncology(Surgery C) Chaim Sheba Medical Center at HaShomerRamat GanTel Aviv 52621Israel Faculty of Medicine Tbilisi State Medical UniversityTbilsi 0177Georgia

Knowledge about the connective-tissue framework of the liver is not systematized,the terminology is inconsistent and some perspectives on the construction of the hepatic matrix components are *** addition,until the last two decades of the 20th century,the connective-tissue sheaths of the portal tracts and the hepatic veins were considered to be independent from each other in the liver and that they do not make contact with each *** results of the research carried out by Professor Shalva Toidze and his colleagues started in the 1970s in the Department of Operative Surgery and Topographic Anatomy at the Tbilisi State Medical Institute have changed this *** particular,Chanukvadze I showed that in some regions where they intersect with each other,the connective tissue sheaths of the large portal complexes and hepatic veins *** areas of such fusion are called porta-caval fibrous connections(PCFCs).This opinion review aims to promote a systematic understanding of the hepatic connective-tissue skeleton and to demonstrate the hitherto underappreciated PCFC as a genuine structure with high biological and clinical *** components of the liver connective-tissue framework—the capsules,plates,sheaths,covers—are described,and their intercommunication is *** analysis of the essence of the PCFC and a description of its various forms are *** is also mentioned that analogs of different forms of PCFC are found in different mammals.

关键词： Hepatic capsule Hilar plate Perivascular fibrous sheath Glissonean pedicle Portal tract Caval port

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