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Newborn with Giant Non-Involuting Congenital Hemangioma: Mechanisms of Allodynia, Hyperalgesia and Treatment

Case Reports in Clinical Medicine 2023年第10期12卷 397-407页

作者： Valeria Bachiocco ilenia casini Andrea Gentili Anesthesia and Intensive Care Unit S Orsola Hospital University of Bologna Bologna Italy Department of Medicine Surgery and Neuroscience University of Siena Siena Italy

In a newborn affected by a non involuting congenital hemangioma we measured allodynia through the application of a standard tactile stimulus and hyperalgesia through the regular administration of the Comfort scale which rates pain intensity. The baby presented signs of these pathological events over long periods of the disease. They may be attributed to the high amount of the nociceptive ligands in the hemangioma microenviroment and to the elevated concentration of TNF-alpha and IL-6 in the blood. For a long time, the pain was relieved by a combination of opioids, adjuvants and paracetamol, but also by thalidomide and unexpectedly by interferon alpha. A mechanism-based pain treatment needs to take into account the processes underlying pain and also the ongoing pathology.

关键词： Pain Mechanisms Allodynia Hyperalgesia Newborn Treatment

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Soy-Enriched Bread, a Pilot Study to Determine Its Beneficial Effects in Menopause

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Open Journal of Endocrine and Metabolic Diseases 2022年第2期12卷 47-74页

作者： Daniela Giustarini Comasia Ricci Ilaria Ceccarelli Stefano Pieretti Paolo Andre Silvia Migliorini Lauretta Massai Paola Minosi ilenia casini Anna Maria Aloisi Department of Biotechnology Pharmacy and Biochemistry University of Siena Siena Italy Department of Life Sciences University of Siena Siena Italy Department of Medicine Surgery and Neuroscience University of Siena Siena Italy National Center for Drug Research and Evaluation Italian National Institute of Health Rome Italy

Menopause is the last step in the reproductive history of a woman. The ovaries stop producing hormones and the body reacts by lowering its functions, including the cognitive one. Phytoestrogens are plant products with the estrogen-like activity which are able to mimic many of estrogen’s functions. The aim of the present experiment was to study the effects of 30 days of regular consumption of soy-enriched bread containing a known amount of phytoestrogens (genistein and daidzein) in climacteric or menopausal women. Thirty women at different stages of menopause (climacteric, within 5 years of menopause, more than 5 years of menopause) were asked to include 200 g/die of bread containing 40 mg of phytoestrogens in their diet. The effect of the regular consumption of this bread on common menopausal symptoms and cognitive parameters was determined before and after 30 days through questionnaires and experimental tests. Phytoestrogens were measured in the urine. Twenty-five women completed the study. Independence of the menopause stage, there was a significant increase of phytoestrogens in the urine and a decrease of the classical symptoms (i.e., hot flushes). Moreover, the women showed a significant improvement in attentional performance tests, the quality of life index and pain intensity. Phytoestrogens would be an important supplement in aging women due to their ability to induce estrogen-like effects without the potential side effects of estrogens. Their presence in soy-enriched bread, a food commonly present in meals, avoids consideration of their consumption as a drug.

关键词： Menopause Women Phytoestrogens Bread Soy

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