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Open Journal of Acoustics 2013年第3期3卷 43-53页

作者： Michel Darmon sylvain Chatillon CEA LIST Department of Imaging & Simulation for Nondestructive Testing Gif-Sur-Yvette France

This paper aims at describing the theoretical fundamentals of a reciprocity-based ultrasonic measurement model. This complete inspection simulation can be decomposed in two modeling steps, one dedicated to transducer radiation and one to flaw scattering and echo synthesis. The physical meaning of the input/output signals used in these two modeling tools is defined and the theoretical principles of both field calculation and echo computation models are then detailed. The influence on the modeling results of some changes in the simulated configuration (as the incident angle) or some input signal parameters (like the frequency) are studied: it is thus theoretically established that the simulated results can be compared between each other in terms of amplitude for numerous applications when changing some inspection parameters in the simulation but that a calibration for echo calculation is generally required.

关键词： Ultrasonic Modeling Transducer Radiation Defects Echoes Calibration

Weaning-associated feed deprivation stress causes microbiota disruptions in a novel mucin-containing in vitro model of the piglet colon(MPigut-IVM)

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1428-1450页

作者： Raphaële Gresse Frédérique Chaucheyras-Durand sylvain Denis Martin Beaumont Tom Van de Wiele Evelyne Forano Stéphanie Blanquet-Diot UniversitéClermont Auvergne INRAEUMR 454 MEDISF-63000 Clermont-FerrandFrance Lallemand SAS F-31702 BlagnacCedexFrance GenPhySE Universitéde ToulouseINRAEENVTF-31326 Castanet-TolosanFrance Ghent University Center for Microbial Ecology and TechnologyB-9000 GhentBelgium

Background:Risk factors for the etiology of post-weaning diarrhea,a major problem in swine industry associated with enormous economic losses,remain to be fully *** concordance with the ethical concerns raised by animal experiments,we developed a new in vitro model of the weaning piglet colon(MPigut-IVM)including a mucin bead compartment to reproduce the mucus surface from the gut to which gut microbes can ***:Our results indicated that the MPigut-IVM is able to establish a representative piglet archaeal and bacterial colon microbiota in terms of taxonomic composition and *** MPigut-IVM was consequently used to investigate the potential effects of feed deprivation,a common consequence of weaning in piglets,on the *** lack of nutrients in the MPigut-IVM led to an increased abundance of Prevotellaceae and Escherichia-Shigella and a decrease in Bacteroidiaceae and confirms previous in vivo *** top of a strong increase in redox potential,the feed deprivation stress induced modifications of microbial metabolite production such as a decrease in acetate and an increase in proportional valerate,isovalerate and isobutyrate ***:The MPigut-IVM is able to simulate luminal and mucosal piglet microbiota and represent an innovative tool for comparative studies to investigate the impact of weaning stressors on piglet ***,weaning-associated feed deprivation in piglets provokes disruptions of MPigut-IVM microbiota composition and functionality and could be implicated in the onset of post-weaning dysbiosis in piglets.

关键词： Colon Dysbiosis In vitro gut model Microbiota Mucin Piglet Weaning

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混合粉组成对烧结汽车零件尺寸稳定性的影响

粉末冶金技术 2003年第3期21卷 163-168页

作者：郭瑞金 Claude Gelinnas sylvain St-Laurent 印红羽魁北克金属粉末有限公司亚太区总部

粉末冶金工业正面临日益需要高力学强度以及高尺寸稳定性零部件应用的挑战。同步器齿毂、链轮和齿轮就是在汽车工业方面这种应用的例子。粉末冶金烧结零件的尺寸稳定性受许多因素的影响 :粉末混合粉组成、添加剂的选择、混合方法、运送... 详细信息

粉末冶金工业正面临日益需要高力学强度以及高尺寸稳定性零部件应用的挑战。同步器齿毂、链轮和齿轮就是在汽车工业方面这种应用的例子。粉末冶金烧结零件的尺寸稳定性受许多因素的影响 :粉末混合粉组成、添加剂的选择、混合方法、运送、压制、烧结和烧结后处理等。本文评价并量化了这样一些因素的影响 ,即混合料组成和添加剂类型对高性能材料制成的零件的尺寸稳定性的影响。使用统计学工具分析了影响尺寸稳定性的重要参数。

关键词：混合粉添加剂粉末冶金汽车零件稳定性同步器齿毂链轮齿轮

Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer

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World Journal of Gastroenterology 2010年第9期16卷 1150-1154页

作者： Boris Guiu Julie Vincent Séverine Guiu sylvain Ladoire Pablo Ortega-Deballon Jean-Pierre Cercueil Bruno Chauffert Franois Ghiringhelli Department of Radiology INSERM U866University of BurgundyUniversity Hospital Department of Hepatology INSERM U866University of BurgundyUniversity Hospital Department of Oncology INSERM U866AVENIR TeamUniversity of Burgundy Department of Digestive Surgery INSERM U866University of BurgundyUniversity Hospital

Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease,resulting in increased local drug *** we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic *** patient was treated with a combination of gemcitabine and oxaliplatin using *** tolerance was excellent and a radiological complete response was obtained after 8 cycles of *** rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this *** of gemcitabine-oxaliplatin should be evaluated in further clinical trials.

关键词： Hepatic artery Chemotherapy Colon cancer Liver metastasis Gemcitabine Oxaliplatin Contrast media Computed tomography

Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease

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Neural Regeneration Research 2021年第6期16卷 1099-1104页

作者： Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard sylvain Routier Sophie Sérrière Sylvie Chalon UMR 1253 iBrainUniversitéde ToursInsermToursFrance CHU Tours Service pharmacieToursFrance Institut de Chimie Organique et Analytique ICOAUMR CNRS 7311Universitéd’OrléansOrléansFrance

To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s *** was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s *** this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s *** animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 *** no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia ***,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia ***,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial *** study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014.

关键词： 6-hydroxydopamine astrocytes microglial activation neurodegeneration neuroinflammation nicotinicα7 receptor Parkinson’s disease PHA 543613 PRE-084 sigma-1 receptor

First steps on technological and genetic improvement of European abalone (<i>Haliotis tuberculata</i>) based on investigations in full-sib families

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Open Journal of Genetics 2013年第3期3卷 224-233页

作者： Valérie Roussel Julien Charreyron sylvain Labarre Alain Van Wormhoudt sylvain Huchette France Haliotis Plouguerneau France MNHN UMR 7208 BOREA Station de Biologie Marine Concarneau France

The European abalone Haliotis tuberculata is of economical importance in Europe, and recently in France where most of the consumed abalones remained wild animals fished on the coast. Recently, the creation of hatcheries allowed the production of cultured animals, and aquaculture is in progress. To optimize selective breeding programs, different studies were performed on adults and on their progenies. First, ten adult families, assumed to be bi-parental and produced in 2007 were analyzed. As these families were developed at the beginning of the hatchery production, the parentage of the individual necessitated to be tested. The progenies parentage assignment was done by using eight microsatellite DNA loci. In fine, the heritability was estimated from the analysis of variance of seven full-sib families which include from 23 to 27 progenies. Heritability estimate was the higher for length, width and weight (0.37, 0.29 and 0.40 respectively). A high correlation was also shown between these heritable traits which can be useful during animal breeding. Shell color traits were also analyzed, using image treatment procedure. Two traits were selected according to the global color of the shell: red color and hue. The distribution of these traits evidenced a polygenic genetic control of shell color and measure of heritability evidenced a high to medium value for red color (Cr) and Hue(H) (0.33 and 0.20 respectively). No correlation was shown between growth and this parameter. In a second time, juveniles families produced in 2010 were studied from parents issued of the first selection. A correlation between size and density at juvenile stage was established but a statistical analysis demonstrated, by using density as co-variable a significant effect of family on size. In these conditions, growth is highly heritable (0.74). This study is a first step toward the use of genetic markers for selection, but also a step toward the breeding improvement of European abalone.

关键词： European Abalone Microsatellite Heritability Morphological Traits Shell Color Traits Juvenile

Optical simulation of external quantum efficiency spectra of CuIn_(1-x)Ga_xSe_2 solar cells from spectroscopic ellipsometry inputs

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Journal of Energy Chemistry 2018年第4期27卷 1151-1169页

作者： Abdel-Rahman A.Ibdah Prakash Koirala Puruswottam Aryal Puja Pradhan Michael J.Heben Nikolas J.Podraza sylvain Marsillac Robert W.Collins Department of Physics & Astronomy and Center for Photovoltaics Innovation & Commercialization University of Toledo Virginia Institute of Photovoltaics Old Dominion University

Applications of in-situ and ex-situ spectroscopic ellipsometry （SE） are presented for the development of parametric expressions that define the real and imaginary parts （ε1, ε2） of the complex dielectric function spectra of thin film solar cell components. These spectra can then be utilized to analyze the structure of complete thin film solar cells. Optical and structural/compositional models of complete solar cells developed through least squares regression analysis of the SE data acquired for the complete cells enable simulations of external quantum efficiency （EQE） without the need for variable parameters. Such simulations can be compared directly with EQE measurements. From these comparisons, it becomes possible to understand in detail the origins of optical and electronic gains and losses in thin film photovoltaics （PC） technologies and, as a result, the underlying performance limitations. In fact, optical losses that occur when above-bandgap photons are not absorbed in the active layers can be distinguished from electronic losses when electron-hole pairs generated in the active layers are not collected. This overall methodology has been applied to copper indium-gallium diselenide （Culn1-xGaxSe2; CIGS） solar cells, a key commercialized thin film PV technology. CIGS solar cells with both standard thickness （〉2 μm） and thin （〈1 μm） absorber layers are studied by applying SE to obtain inputs for EQE simulations and enabling comparisons of simulated and measured EQE spectra. SE data analysis is challenging for CIGS material components and solar cells because of the need to develop an appropriate （ε1, ε2） database for the CIGS alloys and to extract absorber layer Ga profiles for accurate structural/compositional models. For cells with standard thickness absorbers, excellent agreement is found between the simulated and measured EQE, the latter under the assumption of 100% collection from the active layers, which include the CIGS bulk and CIGS/CdS heterojunction inter

关键词： Solar cells Thin-film Ellipsometry Spectroscopic Culn1-xGaxSe2(CIGS) Optical properties Quantum efficiency External Simulation Solar-cell

Effect of serum γ-glutamyltranferase and albumin levels on the response to cardiac resynchronization therapy in the elderly

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Journal of Geriatric Cardiology 2020年第6期17卷 313-320页

作者： Maciej Kubala Alexis Hermida Otilia Buiciuc Pierre-Marc Lallemand Geneviève Bertaina Frédéric Anselme Didier Klug Momar Diouf Jean-sylvain Hermida Centre Hospitalier Universitaire AmiensFrance Centre Hospitalier Régional Universitaire RouenFrance Centre Hospitalier Régional Universitaire LilleFrance

Background Several liver function tests have been identified as predictors of hospitalization for heart failure(HF) and death in patients with chronic HF. The relationship between serum γ-glutamyltranferase(GGT) and albumin(SA) levels with the response to cardiac resynchronization therapy(CRT) has not been reliably determined. The aim of the study was to evaluate the impact of liver function tests on the results of CRT in the elderly. Methods Baseline GGT and SA were assessed before CRT device implantation in the elderly(> 70-year-old) patients. The endpoints were:(1) CRT response defined as > 5% left ventricular ejection fraction improvement and no hospitalization for HF or cardiovascular death;(2) hospitalizations;and(3) mortality. Results Eighty of 138(58%) included patients were responders at nine months. Compared to responders, the SA levels were not significantly different(35.1 ± 5.4 vs. 33.6 ± 5.5 g/L, P = 0.103);but the GGT levels, higher(81.6 ± 69.3 vs. 54.7 ± 49.6 U/L, P = 0.013) in non-responders to CRT. GGT level was independently associated with non-response to CRT(P < 0.001, OR = 0.17;95% CI: 0.08–0.38, P < 0.001). GGT cut-off value ≥ 55 U/L was highly predictive of non-response [AUC = 0.65, 64% Sensitivity, 69% Specificity(95% CI: 0.56–0.74)]. GGT ≥ 55 U/L was also associated with higher risk of hospitalization for atrial fibrillation(AF)(95% vs. 83%, P = 0.024). Both SA and GGT had no impact on overall(P = 0.220, P = 0.723) mortality. Conclusions Higher level of GGT is an independent predictor of non-response to CRT in patients over age 70 years and is associated with higher risk of hospitalization for AF. Baseline serum levels of albumin and GGT and have no impact on mortality in elderly patients undergoing CRT.

关键词： Cardiac resynchronization therapy Heart failure Liver enzymes The elderly

Is non-host pollen suitable for generalist bumblebees？

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Insect Science 2018年第2期25卷 259-272页

作者： Maryse Vanderplanck sylvain Decleves Nathalie Roger Corentin Decroo Guillaume Caulier Gaetan Glauser Pascal Gerbaux Georges Lognay Aurore Richel Nathalie Escaravage Denis Michez Laboratory of Zoology Research Institute for Biosciences University of Mons--UMONS Mons Organic Synthesis and Mass Spectrom- etry Laboratory Interdisciplinary Center for Mass Spectrometry University of Mons--UMONS Mons Research Institute for Biosciences Biology of Marine Organisms and Biomimetics University of Mons--UMONS Mons Belgium Neuch＆tel Platform of Analytical Chem- istry University of Neuch＆tel Neuchtel Switzerland Laboratory of Analytical Chemistry University of Liege Gembloux Agro-Bio Tech Gembloux Unit of Biological and Industrial Chemistry （CBI） University of Liege Gembloux Agro-Bio Tech Gembloux Belgium Laboratoire Evolution et Diversity Biologique （EDB） CNRS ENFA UMR 5174 University Toulouse 3 Paul Sabatier Toulouse France

Current evidence suggests that pollen is both chemically and structurally protected. Despite increasing interest in studying bee-flower networks, the constraints for bee development related to pollen nutritional content, toxicity and digestibility as well as their role in the shaping of bee-flower interactions have been poorly studied. In this study we combined bioassays of the generalist bee Bombus terrestris on pollen of Cirsium, Trifolium, Salix, and Cistus genera with an assessment of nutritional content, toxicity, and digestibility of pollen. Microcolonies showed significant differences in their development, non-host pollen of Cirsium being the most unfavorable. This pollen was characterized by the presence of quite rare 37-sterols and a low digestibility. Cirsium consumption seemed increase syrup collection, which is probably related to a detoxification mixing behavior. These results strongly suggest that pollen traits may act as drivers of plant selection by bees and partly explain why Asteraceae pollen is rare in bee generalist diet.

关键词： bee-flower interactions generalist bees pollen defences

Nanoporous Vesicular Membranes of Amphiphilic Polymers Containing Trans/Cis Isomers

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CCS Chemistry 2022年第8期4卷 2651-2661页

作者： Hui Chen Xia Yu Yujiao Fan Xiangjun Xing sylvain Trépout Min-Hui Li Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyChaoyang DistrictBeijing 100029 Chimie ParisTech PSL University ParisCNRSInstitut de Recherche de Chimie ParisUMR824775231 Paris Cedex 05 Wilczek Quantum Center School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240 Institut Curie PSL UniversityUniversitéParis-SaclayCNRS UMS2016Inserm US43Multimodal Imaging Center91400 Orsay

Nanoporous membranes and vesicles are interesting systems with potential in applications offering channels for material ***,nanoporous membranes and polymersomes are developed by self-assembly of trans-and cis-stereoisomers of amphiphilic *** polymers,PEG550-TPEChol and PEG550-SS-TPE-SS-Chol,containing a central tetraphenylethene(TPE),a cholesterol(Chol),and a poly(ethylene glycol)(PEG550)are studied.

关键词： amphiphilic polymers stereoisomers aggregation-induced emission self-assembly porous membrane