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Genetic and epigenetic risks of intracytoplasmic sperm injection method

Asian Journal of Andrology 2006年第6期8卷 643-673页

作者： Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis Konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis Motoaki Saito ikuo miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios Giannakis Michael Fatouros Nikolaos Sofikitis Laboratory of Molecular Urology and Genetics of Human Reproduction Department of Urology loannina University School of Medicine loannina 45110 Greece Cytogenetics Unit Laboratory of General Biology Medical School University of loannina loannina 45110 Greece Department of Urology Tottori University School of Medicine Yonago 683 Japan Department of Molecular Pharmacology Tottori University School of Medicine Yonago 683 Japan

Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection （ICSI） procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent thatconsequences of the genetic abnormalities underlying male subfertility （or infertility） and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.

关键词： genetic risks epigenetic risks intracytoplasmic sperm injection testis male infertility

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Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events

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Stroke & Vascular Neurology 2024年第2期9卷 108-125,I0001-I0005页

作者： Miao Lin Liubing Hu Si Shen Jiyue Liu Yanyan Liu Yixian Xu Honglin Chen Kazuo Sugimoto Jianshuang Li ikuo Kamitsukasa Takaki Hiwasa Hao Wang Anding Xu Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouChina Department of Anesthesiology The First Affiliated HospitalJinan UniversityGuangzhouChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhouChina Department of Radiology Medical Imaging CenterThe First Affiliated HospitalJinan UniversityGuangzhouChina Department of Biochemistry and Genetics Graduate School of MedicineChiba UniversityChibaJapan Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Department of Neurology Chiba Rosai HospitalChibaJapan Department of Neurology Chibaken Saiseikai Narashino HospitalChibaJapan Department of Neurological Surgery Graduate School of MedicineChiba UniversityChibaJapan

Background Atherosclerosis(AS)and tumours are the leading causes of death worldwide and share common risk factors,detection methods and molecular ***,searching for serum markers shared by AS and tumours is beneficial to the early diagnosis of *** The sera of 23 patients with AS-related transient ischaemic attack were screened by serological identification of antigens through recombinant cDNA expression cloning(SEREX),and cDNA clones were *** function enrichment analysis was performed on cDNA clones to identify their biological pathways and determine whether they were related to AS or ***,gene–gene and protein–protein interactions were performed and AS-associated markers would be *** expression of AS biomarkers in human normal organs and pan-cancer tumour tissues were ***,immune infiltration level and tumour mutation burden of various immune cells were *** curves analysis could show the expression of AS markers in *** AS-related sera were screened by SEREX,and 83 cDNA clones with high homology were *** functional enrichment analysis,it was found that their functions were closely related to AS and tumour *** multiple biological information interaction screening and the external cohort validating,poly(A)binding protein cytoplasmic 1(PABPC1)was found to be a potential AS *** assess whether PABPC1 was related to pan-cancer,its expression in different tumour pathological stages and ages was *** AS-associated proteins were closely related to cancer immune infiltration,we investigated and found that PABPC1 had the same role in ***,analysis of Kaplan-Meier survival curves revealed that high PABPC1 expression in pan-cancer was associated with high risk of *** Through the findings of SEREX and bioinformatics pan-cancer analysis,we concluded that PABPC1 might serve as a potential biomarker for the

关键词： diagnosis cancer organs

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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed Mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary ikuo Igarashi Mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Impairment of innate immune responses in cirrhotic patients and treatment by branched-chain amino acids

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World Journal of Gastroenterology 2014年第23期20卷 7298-7305页

作者： ikuo Nakamura Department of Gastroenterology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology Saitama Medical CenterJichi Medical UniversitySaitama 330-8503Japan

It has been reported that host defense responses, such as phagocytic function of neutrophils and natural killer (NK) cell activity of lymphocytes, are impaired in cirrhotic patients. This review will concentrate on the impairment of innate immune responses in decompensated cirrhotic patients and the effect of the treatment by branched-chain amino acids (BCAA) on innate immune responses. We already reported that phagocytic function of neutrophils was significantly improved by 3-mo BCAA supplementation. In addition, the changes of NK activity were also significant at 3 mo of supplementation compared with before supplementation. Also, Fisher’s ratios were reported to be significantly increased at 3 mo of BCAA supplementation compared with those before oral supplementation. Therefore, administration of BCAA could reduce the risk of bacterial and viral infection in patients with decompensated cirrhosis by restoring impaired innate immune responses of the host. In addition, it was also revealed that BCAA oral supplementation could reduce the risk of development of hepatocellular carcinoma in cirrhotic patients. The mechanisms of the effects will also be discussed in this review article.

关键词： Branched-chain amino acids Liver cirrhosis Innate immunity Natural killer cell activity of lymphocytes Phagocytic function of neutrophils

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Advances in diagnostic testing for gastroesophageal reflux disease

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World Journal of Gastroenterology 2010年第30期16卷 3750-3756页

作者： Andrew J Gawron ikuo Hirano Division of Gastroenterology Department of MedicineNorthwestern University Feinberg School of MedicineChicagoIL 60611-2951United States

Gastroesophageal reflux disease (GERD) contributes substantially to morbidity and to costs in the United States health care system. The burden of this disease has resulted in attempts at improving diagnosis and characterizing patients. Numerous research and technical advances have enhanced our understanding of both the utility and limitations of a variety of diagnostic modalities. The purpose of this review is to highlight recent advances in GERD diagnostic testing and to discuss their implications for use in clinical practice. Topics addressed include esophageal pH monitoring, impedance testing, symptom association analyses, narrow-band imaging, and histopathology.

关键词： Gastroesophageal reflux disease pH impedance pH monitoring Symptom association

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A study on particle breakage behavior during pile penetration process using acoustic emission source location

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Geoscience Frontiers 2020年第2期11卷 413-427页

作者： Wuwei Mao Shogo Aoyama ikuo Towhata Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji UniversityShanghai 200092China Kiso-Jiban Consultants Co. Ltd.TokyoJapan Department of Civil Engineering University of TokyoTokyoJapan

Particle breakage is a common occurrence in granular systems when the external stress exceeds the individual particle strength.A large number of experimental evidences suggested that particle breakage may significantly influence the soil *** the case of pile foundations,the subsoil below the pile tip experiences considerable high stress and consequently prone to *** to the lack of sufficient understanding on particle breakage mechanism,there is currently no consentaneous theoretical background for particle breakage analysis during the pile penetration *** study aims to clarify the location of particle breakage and its evolving characteristics with the aid of acoustic emission(AE)source location *** spatial distribution of AE hypocenters is interpreted to be associated with the mechanism of particle *** showed that the AE sources were not uniformly distributed,but concentrated within certain zones below the pile *** AE concentration zone was pushed downward with the advancing pile tip,and its distance from the real time pile tip position decreased after certain depth of pile *** location of particle breakage interpreted from AE source location was verified with posttest excavations and the insights on the particle breakage evolution zone were further discussed.

关键词： Acoustic emission Source location Sand Particle breakage Pile

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On improving strigolactone mimics for induction of suicidal germination of the root parasitic plant Striga hermonthica

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aBIOTECH 2021年第1期2卷 1-13页

作者： ikuo Takahashi Kosuke Fukui Tadao Asami Graduate School of Agricultural and Life Sciences The University of TokyoTokyo 113-8657Japan

Strigolactones(SLs)are plant hormones that regulate the branching of plants and seed germination stimulants of root parasitic *** root parasites are a great threat to agricultural production,the use of SL agonists could be anticipated to provide an efficient method for regulating root parasites as suicidal germination inducers.A series of phenoxyfuranone-type SL mimics,termed debranones,has been reported to show potent bioactivities,including reduction of the tiller number on rice,and stimulation of seed germination in the root parasite Striga *** exert both activities,two substituents on the phenyl ring of the molecules were important but at least a substituent at the 2-position must be an electron-withdrawing ***,little is known about the effect of the properties of the substituents at the 2-position on ***,we found that different substituents at the 2-position give different preferences for *** debranones were more effective than the others and SL agonist GR24 for inhibiting rice tiller but far less effective in the induction of *** ***,nitrile and methyl derivatives clearly stimulated the germination of *** *** their IC_(50) values were 100 times higher than that of GR24 in the receptor competitive binding assay,their physiological activities were approximately 1/10 of *** differences could be due to their uptake in plants and/or their physicochemical stability under our experimental *** findings could support the design of more potent and selective SL agonists that could contribute to solving big agricultural issues.

关键词： Agonist Rice Root parasitic weed Seed germination Strigolactone Tillering

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Development of thermodynamic and kinetic databases in micro-soldering alloy systems and their applications

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Progress in Natural Science:Materials International 2011年第2期21卷 97-110页

作者： ikuo OHNUMA Ryosuke KAINUMA Kiyohito ISHIDA Department of Materials Science Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan

Recent progress in the development of thermodynamic and kinetic databases of micro-soldering alloys,which were constructed within the framework of the Thermo-Calc and DICTRA software,was ***,a thermodynamic tool, ADAMIS(alloy database for micro-solders) was developed by combining the thermodynamic databases of micro-solders with Pandat,a multi-component phase diagram calculation software *** contains 11 elements,namely,Ag,Al,Au,Bi,Cu, In,Ni,Sb,Sn,Zn and Pb,and can handle all combinations of these elements in the whole composition *** obtained thermodynamic and kinetic databases can not only provide much valuable thermodynamic information such as phase equilibria and phase fraction,but also shows the kinetics and the evolution of microstructures when they are combined with some appropriate software programs and models,such as the phase field method and ADSTEFAN *** the viewpoints of computational thermodynamics and kinetics,some technical examples were given to demonstrate the great utility of these databases for the applications in the development of micro-soldering *** databases are expected to be powerful tools for the development of micro-solders and Cu substrate materials,as well as for promoting the understanding of interfacial phenomena and microstructure evolution between solders and substrates in electronic packaging technology.

关键词： micro-soldering alloys thermodynamics kinetics

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A complete introduction to the SCJ proposal and its commentary on the development of seismically resilient cities

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Earthquake Engineering and Engineering Vibration 2018年第4期17卷 677-691页

作者： Akira Wada ikuo Towhata Kazuo Tamura Qu Zhe Tokyo Institute of Technology Tokyo 152-8550 Japan University of Tokyo Tokyo 153-8914 Japan Faculty of Engineering Chiba Institute of Technology Chiba 275-0016 Japan Institute of Engineering Mechanics China Earthquake Administration Harbin 150080 China

In modern society, the population, wealth and social functions are increasingly concentrated in a few large cities. Such concentration brings about efficiency while at the same time it increases the vulnerability of the society. To address this issue, the Science Council of Japan（SCJ） published a proposal entitled ＂Shape Cities and Societies Safer against Severe Earthquakes＂. It makes a variety of suggestions for enhancing the seismic resilience of large cities, including：（1） comprehensive thinking based on the latest scientific knowledge and rich imagination;（2） selection of sites suitable for residence and social activities;（3） introducing the urban seismic coefficient;（4） promoting the enhancement of the seismic performance of buildings and civil structures;（5） easing the concentration of population and functions;（6） building communities that enable shelter and escape;（7） resilient technology of information and communication system and its effective utilization;（8） preparation and implementation of emergency response after earthquakes;（9） development and application of new structural seismic technology;（10） learning from domestic and foreign earthquake disasters and launching of international cooperation and knowledge sharing and（11） taking actions from a multidisciplinary perspective. The proposal is introduced in this paper.

关键词： large earthquake large city urban disaster resilience society earthquake engineering

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Platinum–P(BFPy) 3 -catalyzed regioselective diboration of terminal alkynes with (pin)B–B (aam)

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Organic Chemistry Frontiers 2022年第5期9卷 1370-1374页

作者： ikuo Kageyuki Jialun Li Hiroto Yoshida Graduate School of Advanced Science and Engineering Hiroshima UniversityHigashi-Hiroshima 739-8526Japan

An unsymmetrical diboron,(pin)B–B(aam),is smoothly added across a carbon–carbon triple bond of various terminal alkynes under platinum catalysis,resulting in the regio-and stereoselective formation of cis-vic-diborylalkenes via B(aam)-installation at the terminal *** use of a highly electron-deficient triarylphosphine ligand,P(BFPy)_(3),is indispensable for the regiocontrol,and electron-deficiency in ligands has been proven to be closely correlated with the regioselectivity.

关键词： smoothly catalyzed boron

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