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Imaging Rock Density Distribution beneath Liwa Fracture Zone in the Southern Part of the Great Sumatran Fault System, Indonesia

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International Journal of Geosciences 2016年第4期7卷 598-614页

作者： Djedi S. Widarto Tedi Yudistira Jun-Ichi Nishida ikuo Katsura Eddy Z. Gaffar Susumu Nishimura Upstream Technology Center PT Pertamina (Persero) Jakarta Indonesia Department of Geophysical Engineering Bandung Institute of Technology Bandung Indonesia Faculty of Literary Ohtani University Kyoto Japan Kyoto Institute of Natural History Kyoto Japan Research Centre for Geotechnology—LIPI Bandung Indonesia

We have imaged rock density distribution beneath Liwa fracture zone in the southern part of the the Sumatran Fault Zone by modelling and inverting Bouguer gravity data in two-and three-dimensional environments, respectively. The purpose of this study is aimed to figure out the subsurface distribution of rock densities associated with subsurface basement structure representing the evidence of trans-tensional tectonic product in the SF. In the gravity modeling, to eliminate distortions to the measured gravity values before modelling and inverting the data, Bouguer anomalies obtained in field measurements are reduced to the horizontal plane of z = +800 m as a representation of the average elevation in Liwa. For the inversion, we used algorithm implementing depth-and minimum volume weighting parameters in order to obtain a smooth model with better vertical resolution. The two-dimensional models show clearly surface topography of the basement rocks and the presence of normal faults. The reduced Bouguer anomaly of +800 m elevation shows the presence of structural lineaments extending primarily in a northwest-southeast direction, parallel to Sumatran Fault Zone and older graben faults showing a negative flower structure. From the three-dimensional inversion, the model illustrates an increase of density contrast, lower values being found near the surface and higher values in the deeper parts. The lower density contrast of 0.15 to 0.3 g/cm3 found in the rock groups at depths of 2 km and less is characteristic of relatively homogeneous and poorly compacted rocks. Rocks with moderate to high density contrast (>1.0 g/cm3) are recognized at depths of over 2 km. This model suggests a change of basement morphology as a function of depth, and delineates structural lineaments extending in northwest-southeast direction. This study supports the previous thought that Liwa area is underlain by graben structures, formed by trans-tensional tectonic events. Higher-den

关键词： Gravity Imaging Rock Density Fracture Zone 2D Modeling 3D Inversion Density Contrast

The New Molecular Entity Evolocumab, One Kind of PCSK9 Inhibitor, Reduce Plasma Small Size LDL-Cholesterol Levels by Using a New Standardized Method of Measuring LDL Size

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Open Journal of Molecular and Integrative Physiology 2017年第1期7卷 1-23页

作者： ikuo Inoue Ryo Kubota Shohan Yanagi Masumi Akita Takanari Nakano Shigehiro Katayama Akira Shimada Mistuhiko Noda Department of Endocrinology and Diabetology Saitama Medical University Saitama Japan Department of Health Sciences Saitama Prefectural University Saitama Japan Research and Development Department Advanced Materials Development Sector Tokyo Metropolitan Industrial Technology Research Institute Tokyo Japan Division of Morphological Science Biomedical Research Center Saitama Medical University Saitama Japan Department of Biochemistry Saitama Medical University Saitama Japan

Aims: There has been no evidence on the effects of evolocumab, protein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, on small size LDL. We observationally investigated the efficacy and side effects of evolocumab on the LDL subfraction particle diameter using PAGE system for lipoprotein analysis. Methods: We defined 30 patients with high-risk hyperlipidemia. As for analysis of LDL subfraction profile, we used polyacrylamide gel electrophoresis three methods: 1) 3% nondenatured poly-acrylamide gel electrophoresis method (3%PAGE), 2) 2% - 16% nondenatured poly-acrylamide gradient gel electro-phoresis method (2% - 16% GGE) and 3) 2.7% - 5% GGE. Evolocumab 140 mg/day administered together with statin significantly improved serum total cholesterol (TC), triglyceride (TG), high-dense lipoprotein-cholesterol (HDL-C), and LDL-C after four-week treatment. Results: TC, TG, HDL-C and LDL-C levels were improved by, respectively, 33%, 20%, 10%, and 54%. The mean LDL size significantly increased from 25.6 ± 0.4 nm to 26.4 ± 0.8 nm. The small dense LDL-cholesterol (sdLDL-C), large buoyant LDL-cholesterol (lbLDL-C), and mid-band lipoprotein-cholesterol were reduced, respectively. Therefore, the preliminary study on this paper can be the first step into a new insight on the world of lipid metabolism. Conclusion: Short-term administration of evolocumab addedons to statin therapy, significantly reduced small size LDL levels.

关键词： PCSK9 Inhibitor Evolocumab LDL Heterogeneicity Small Size LDL 3% PAGE 2% - 16% GGE

Cocktail of Theileria equi antigens for detecting infection in equines

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亚太热带生物医学杂志：英文版 2015年第12期5卷 977-981页

作者： Shimaa Abd El-Salam El-Sayed Mohamed Abdo Rizk Mohamed Alaa Terkawi Ahmed Mousa El Said El Shirbini El Said Gehad Elsayed Mohamed Fouda Naoaki Yokoyama ikuo Igarashi National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary Medicine Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary Medicine Mansoura University Department of Internal Medicine and Infectious Diseases Faculty of Veterinary Medicine Mansoura University Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary Medicine Sadat City University

Objective:To use two diagnostic antigens belonging to the frequently associated in Theileria domain,Theileria equi(***)protein 82(Te 82)and *** 104 k Da microneme-rhoptry antigen precursor(Te 43),to diagnose *** infection in horses as compared with equi merozoite antigen-2(EMA-2).Methods:In the current study,we applied a cocktail-ELISA containing two antigens(EMA-2+Te 82)to diagnose *** infection either in experimentally infected horses or in field ***:Our findings have revealed that a cocktail formula of EMA-2+Te 82 provided a more practical and sensitive diagnostic candidate for diagnosing *** infection in horses as compared with Te 82 or Te 43 ***:The ELISA technique using a cocktail formula of EMA-2+Te 82 offers a practical and sensitive diagnostic tool for diagnosing *** infection in horses and using of this promising cocktail formula will be applicable for epidemiological surveys and will help control the infection in horses.

关键词： Theileria equi Equi merozoite antigen-2 Theileria

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曲格列酮对大鼠肝细胞氧化性损伤的研究

中国新药杂志 2005年第6期14卷 701-705页

作者：王堃于学炜仲来福 Inoue Tomaki Shindoh Hidtoshi Horii ikuo 大连医科大学药理教研室大连116027 大连市第三人民医院泌尿外科大连116021 大连医科大学卫生学教研室大连116027 Nippon Roche Research Center Japan

目的:研究曲格列酮的肝细胞毒性及其可能的机制。方法:在原代大鼠肝细胞模型和其他3种不同来源非肝细胞系,用WST-1法、乳酸脱氢酶释放法、荧光检测法、生物发光法等方法,观察曲格列酮对肝细胞的损伤作用。结果:不同剂量曲格列酮作用后,... 详细信息

目的:研究曲格列酮的肝细胞毒性及其可能的机制。方法:在原代大鼠肝细胞模型和其他3种不同来源非肝细胞系,用WST-1法、乳酸脱氢酶释放法、荧光检测法、生物发光法等方法,观察曲格列酮对肝细胞的损伤作用。结果:不同剂量曲格列酮作用后,其在原代培养大鼠肝细胞的IC_(50)值最低,即其对原代肝细胞毒性最大。曲格列酮诱导活性氧(ROS)生成,并引起还原型谷胱甘肽(GSH)和ATP水平比对照细胞显著降低。不同剂量的曲格列酮作用5h后诱发肝细胞凋亡、坏死。结论:曲格列酮对大鼠肝细胞的毒性作用强于对其他非肝细胞来源细胞的毒性作用。曲格列酮可以引起肝细胞氧化性损伤,肝细胞凋亡和坏死。

关键词：曲格列酮肝细胞毒性氧化性损伤凋亡

奥林匹克主义的理想与学校教育:鼓励学生热情的尝试(英文)

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奥林匹克主义的理想与学校教育:鼓励学生热情的尝试(英文)

北京论坛（2008）文明的和谐与共同繁荣——文明的普遍价值和发展趋向

作者： ikuo Abe Professor University of Tsukuba

Father Henri Didon’s proverb,"Citius,Altius,Fortius" is a well-known motto that has been quoted in the Olympic ***,nowadays,the motto seems to be generally understood by sportsmen and people,mainly form the context of sporting activities. I used to deliver ten minutes speech to all school,once a week,as the principal of a junior high school,since 2003 till 2008.I found it at the meeting of ten minutes speech that the introduction and interpretation of the mottos and proverbs relating to Olympic movement or Olympism were very effective to encourage junior-high students’ aspiration.I often emphasized that "Citius,Altius,Fortius" is not only a motto for sports and the Olympics Games but also a fundamental motto for every-day life that could encourage one’s aspiration and self-improvement. I would like to introduce my educational experiment that ideals of Olympism could be a powerful every-day’s instrument for the encouragement of everyone’s aspiration and self-improvement.

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日本国立大学的发展趋势

大学教育科学 2012年第4期03卷 98-106页

作者：天野郁夫张雪丽厦门大学·高等教育发展研究中心

在日本高等教育改革的进程中,国立大学处于改革的风口浪尖。本文以"远山计划"为切入口深入分析了日本国立大学改革中存在的问题及改革可能带来的影响:随着国立大学结构改革方针发生变化,重组与合并问题被提上日程,大学办学将引入民营理... 详细信息

在日本高等教育改革的进程中,国立大学处于改革的风口浪尖。本文以"远山计划"为切入口深入分析了日本国立大学改革中存在的问题及改革可能带来的影响:随着国立大学结构改革方针发生变化,重组与合并问题被提上日程,大学办学将引入民营理念和第三方参与的评价机制,法人化改革中将面临挑战并呈现自身特征。这些改革措施会对国立大学和私立大学产生一定影响。

关键词：日本国立大学改革

Expression of Fab fragment of catalytic antibody 6D9 in an Escherichia coli in vitro coupled transcription/translation system

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Expression of Fab fragment of catalytic antibody 6D9 in an E...

海洋沉积环境中深层地下水溶性天然气开采引起的地面沉降

The Eighth China-Japan-Korea Joint Symposium on Enzyme Engineering

作者： XiuPing Jiang Muhamad Ali Yuji Ookubo ikuo Fujii Hideo Nakano Tsuneo Yamane Laboratory of Molecular Biotechnology Graduate School of Biological and Agricultural SciencesNagoya University

＜正＞*** Since a complete antibody such as IgG is a large molecule,much smaller functional domains（Fv,Fab fragments）retaining antigen-binding activity can be applied for a number of practical uses（1）.Because of the small size and useful properties,single-chain Fv（scFv）,which is composed of the variable heavy chain（VH）,a

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岩石力学与工程学报 2006年第6期25卷 1094-1098页

作者：沈水龙许烨霜陶野郁雄上海交通大学船舶海洋与建工学院上海200030 日本山形大学理学院地球环境系

日本东京周围的关东地区的地层是由海洋环境经数十万乃至数百万年沉积而成。由于大量的海洋生物沉积于地下,经数十万乃至上百万年的地质作用,形成质量上乘的水溶性天然气与医药用碘。自20世纪二三十年代起在东京附近就有天然气的开采活... 详细信息

日本东京周围的关东地区的地层是由海洋环境经数十万乃至数百万年沉积而成。由于大量的海洋生物沉积于地下,经数十万乃至上百万年的地质作用,形成质量上乘的水溶性天然气与医药用碘。自20世纪二三十年代起在东京附近就有天然气的开采活动。自1956年起在东京东侧的日本千叶县房总半岛东部的九十九里平原地区,开始了大规模天然气与碘的开采活动。野外开采活动主要通过从地下500～2000m深处抽取地下水而获得。20世纪60年代在该地区发现有地面沉降,1969年起开始地面沉降的观测。在过去的35a中地面最大累积沉降达0.85m,发现沉降范围的面积近800km2。九十九里观光地的海岸线后退近20～50m。2002年的大范围的地面沉降达2cm。最后从日本关东地下水盆的向斜构成式构造出发,讨论分析减缓地面沉降的途径。

关键词：海洋资源与开发深海沉积物水溶性天然气地下水抽取地面沉降现场测试

应用昆虫介体细胞单层快速检测水稻矮缩病毒的侵染

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植物医学 1986年第4期 32-34页

作者： ikuo KIMURA 陈剑平

水稻病毒,诸如水稻矮缩病毒,(Rice-gall dwarf virus)水稻瘤矮病毒(Ric-egall dwarf virus)和水稻短暂性黄化病毒(Rice transitory virus),已知都由其叶蝉介体传播到奇主植物上,而不能用其它方法进行机械传播。这些病毒的侵染力只能通... 详细信息

水稻病毒,诸如水稻矮缩病毒,(Rice-gall dwarf virus)水稻瘤矮病毒(Ric-egall dwarf virus)和水稻短暂性黄化病毒(Rice transitory virus),已知都由其叶蝉介体传播到奇主植物上,而不能用其它方法进行机械传播。这些病毒的侵染力只能通过人工注射少量病毒悬浮液到介体叶蝉腹腔内进行测定。用这种方法而获得

关键词：水稻矮缩病毒叶蝉介体