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Chronic obstructive pulmonary disease as a risk factor for lung cancer

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World Journal of Clinical Oncology 2014年第4期5卷 660-666页

作者： Yuichi Takiguchi ikuo Sekine Shunichiro Iwasawa Ryota Kurimoto Koichiro Tatsumi Department of Medical Oncology Graduate School of Medicine Chiba University Department of Respirology Graduate School of Medicine Chiba University

The association between chronic obstructive pulmonary disease(COPD) and lung cancer has long been a subject of intense debate. The high prevalence of COPD in elderly smokers inevitably strengthens their coincidence. In addition to this contingent coincidence, recent studies have revealed a close association between the two diseases that is independent of the smoking history; that is, the existence of COPD is an independent risk factor for the development of lung cancer. Molecular-based evidence has been accumulating as a result of the efforts to explain the underlying mechanisms of this association. These mechanisms may include the following: the retention of airborne carcinogens followed by the activation of oncogenes and the suppression of tumor suppressor genes; the complex molecular mechanism associated with chronic inflammation in the distal airways of patients with COPD; the possible in-volvement of putative distal airway stem cells; and gel netic factors that are common to both COPD and lung cancer. The existence of COPD in patients with lung l cancer may potentially affect the process of diagnosis, surgical resection, radiotherapy, chemotherapy, and end-of-life care. The comprehensive management of COPD is extremely important for the appropriate treatment of lung cancer. Surgical resections with the aid of early interventions for COPD are often possible, even for patients with mild-to-moderate COPD. New challenges, such as lung cancer CT screening for individuals t at high risk, are now in the process of being implemented. Evaluating the risk of lung cancer in patients with COPD may be warranted in community-based lung cancer screening.

关键词： Chronic obstructive pulmonary disease Airflow limitation Inflammation Lung cancer Carcinogenesis Cancer screening Computed tomography screening Early intervention

Calcified Nodule Formation <i>in Vitro</i>Using Rat Mandibular Incisor Pulp Cells

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Journal of Biomedical Science and Engineering 2018年第12期11卷 327-337页

作者： Hideaki Ikenaga Masataka Yoshikawa Ayano Miyamoto Hitomi Nakama ikuo Nishikawa Satoshi Teramoto Hiroaki Aso Nozomi Matsuo Hiroshi Maeda Department of Endodontics Osaka Dental University Osaka Japan

One great advantage of bone marrow is that a large number of stem cells can be obtained. However, stem cells cannot be taken from the bone marrow of a patient for the purpose of regenerating teeth. In dental practice, it may not be practical to obtain mesenchymal stem cells for the regeneration of the tooth from iliac bone marrow, as in orthopedics. Therefore, establishment of a cell source for tooth regeneration is one of the important problems in the field of regenerative medicine. Although the isolation of undifferentiated mesenchymal stem cells or odontoblasts from dental pulp may be difficult, dental pulp may be a favorable source for stem cells to regenerate a tooth via tissue engineering. As a fundamental study for tooth regeneration, this study was performed in order to clarify the culture periods for proliferation and differentiation using rat dental pulp-derived cells. The results of this study were as follows: Primary culture of the dental pulp cells does not require a long period of time. However, for sufficient proliferation of dental pulp cells to form a calcified nodule in the secondary culture, a long culture period is required. Dexamethasone was essential for the formation of calcified nodules by dental pulp-derived cells. Calcified nodule formation by dental pulp-derived cells in vitro required more than one month. The duration of the secondary culture for the dental pulp-derived cells will be much longer.

关键词： Calcified Nodule In Vitro Dental Pulp Cells Bone Marrow Cells Dexamethasone

Preparation and Evaluation of Poly-γ-Glutamic Acid Hydrogel Mixtures with Basic Drugs or Acidic Drugs: Effect on Ease of Swallowing and Taste Masking

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Pharmacology & Pharmacy 2019年第10期10卷 427-444页

作者： Honami Kojima Saeri Ikegami Shiho Nakamura Haruka Nishikawa Tamami Haraguchi Miyako Yoshida Minoru Ozeki ikuo Kawasaki Takahiro Uchida Faculty of Pharmaceutical Sciences Mukogawa Women’s University Nishinomiya Japan

The purpose of this study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to examine its ease of swallowing using texture profile analysis (TPA) and to evaluate its taste-masking effects on basic or acidic drugs using the artificial taste sensor. Using TPA, 0.5% and 1.0% PGA gels, 0.5% and 1.0% agar and 1.0% ι-carrageenan in the absence of drug was examined the hardness, adhesiveness and cohesiveness, ranked according to permission criteria published by the Japanese Consumers Affairs Agency. 0.5% PGA gel and 1.0% agar were classified into grade II. In the taste sensor measurement, the bitterness suppressions by 0.5% PGA gel were larger than that by 1.0% agar in all drugs and the bitterness suppressions of basic drugs in 0.5% PGA gel were more potent than those of acidic drugs in 0.5% PGA gel. 1H-nuclear magnetic resonance spectroscopic analysis was carried out to examine the difference in mechanism of bitterness suppression between basic drugs and acidic drugs mixed with PGA gel. The signals of the proton nearest to the nitrogen atom of basic drugs shifted clearly upfield, suggesting an interaction between the amino group of basic drugs and the carboxyl group of PGA gel. In conclusion, PGA gel is expected to be a useful excipient in formulations contained various drugs, especially basic drugs;it also has advantage for not only increasing ease of swallowing but also masking the bitterness of drugs even though a small amount of a single drug dose might be preferred.

关键词： Poly-γ-Glutamic Acid Hydrogel Bitterness Taste Sensor

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日本短期大学的危机

大学教育科学 2013年第6期6卷 30-39页

作者：天野郁夫[日] 陈武元(译) 厦门大学高等教育发展研究中心不详

日本的短期大学是二战以后日本学制改革的产物。曾经在推进高等教育大众化方面发挥了重要作用。但是，由于短期大学创办初期定位不明的问题一直不为政府和短期大学相关人员所重视，而且短期大学自20世纪60年代～80年代一直处于发展的黄... 详细信息

日本的短期大学是二战以后日本学制改革的产物。曾经在推进高等教育大众化方面发挥了重要作用。但是，由于短期大学创办初期定位不明的问题一直不为政府和短期大学相关人员所重视，而且短期大学自20世纪60年代～80年代一直处于发展的黄金时代，导致其推迟了应对高等教育世界正在发生结构性变化的努力。进入20世纪90年代后，伴随着18岁人口的下降（即少子化），短期大学在与四年制大学或专修学校的竞争中，办学定位不明的问题不仅阻碍了其进一步发展。而且使其陷入了生存危机。如何化解短期大学的危机，本文通过与美国的社区学院进行比较，并结合日本的国情，提出了以下重要主张，即“私立短期大学能够发挥的作用，或许最重要的是公民的教养教育和职业教育，以及专业教育。其中公民教养的教育或许是今后短期大学最能发挥个性的作用所在”。

关键词：日本短期大学危机

RNAi-Mediated Resistance to Cucumber Mosaic Virus (CMV) in Genetically Engineered Tomato

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American Journal of Plant Sciences 2014年第5期5卷 554-572页

作者： Valentine Otang Ntui Kynet Kong Pejman Azadi Raham Sher Khan Dong Poh Chin Tomoko Igawa Masahiro Mii ikuo Nakamura Laboratory of Plant Cell Technology Graduate School of Horticulture Chiba University Chiba Japan

Cucumber mosaic virus is one of the most constraints to the production of tomato and other vegetable crops worldwide. Here, we generated an RNAi construct containing inverted repeat of 1138 bp fragment of a partial replicase gene of CMV-O and used it to produce transgenic tomato plants expressing CMV-specific dsRNA of the replicase gene. Inoculation of transgenic plants with CMV strain O discriminated three categories of plants: plants that showed complete resistance, which were free of symptoms;highly resistant plants, which had mild symptoms, but later recovered because new leaves that emerged were free of symptoms;and susceptible plants, which showed severe symptoms similar to wild-type plants. The completely resistant lines were selected and challenged with a closely related strain, CMV-Y. Interestingly, the transgenic plant lines either remained immune or showed high levels of resistance to the strain. No virus could be detected in uninoculated new leaves of the resistant lines after RT-PCR and Dot immunobinding assay (DIBA) analyses. We could show that the resistance is correlated with post-transcriptional gene silencing because of the production of transgenic specific siRNA.

关键词： CMV dsRNA PTGS Replicase Gene RNAi Tomato

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冶金因素对提高钢帘线强度的影响

金属制品 1993年第A11期19卷 6-16页

作者： ikuo Ochiai Seiki Nishida Hitoshi Tashiro 赵峰

随着轮胎朝着更轻更高性能方向发展的趋势,对钢帘线强度的要求也随之提高。迄今为止,在提高钢帘线的强度方面,已经做到的只是采用共析钢(作原料)

关键词：钢帘线强度影响因素

Influence of Psychiatric Problems on Clinical Outcomes during the First 12 Months after Primary Total Knee Arthroplasty

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Open Journal of Orthopedics 2022年第5期12卷 242-252页

作者： Takehiko Sugita Naohisa Miyatake Seiya Miyamoto Akira Sasaki ikuo Maeda Makiko Okumoto Nozomi Itou Masayuki Kamimura Takashi Aki Toshimi Aizawa Department of Orthopaedic Surgery Tohoku Orthopaedic and Dental Clinic Sendai Japan Division of Rehabilitation Tohoku Orthopaedic and Dental Clinic Sendai Japan Department of Orthopaedic Surgery Tohoku University Graduate School of Medicine Sendai Japan

Background: Total knee arthroplasty (TKA) is a useful treatment option for advanced knee osteoarthritis. Excellent clinical outcomes after TKA have been widely recognized, but the influence of psychiatric problems on them has not been focused on until quite recently. This study aimed to assess the influence of psychiatric problems on clinical outcomes after TKA in Japanese patients using two assessment scales developed in Japan because the Japanese cultural lifestyle is specifically characterized by bending to the floor and standing up. Methods: Clinical outcomes and psychiatric problems were evaluated using the Japanese Knee Osteoarthritis Measure (JKOM) and Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP), respectively. A total of 115 TKA patients were evaluated preoperatively and at 3, 6, and 12 months after TKA. The patients were classified into four groups (groups A-D) based on the BS-POP score. The JKOM scores were then compared between the two groups (groups A and D) with the worst and least psychiatric problems. The JKOM improvement rate between pre- and postoperative status in both groups A and D was also calculated. Results: The total JKOM score was significantly poorer in group A than in group D preoperatively and at 3, 6, and 12 months after TKA. The improvement rate showed no significant difference between groups A and D. Conclusion: Psychiatric problems influence both the poorer post- and preoperative clinical outcomes. However, a similar improvement rate in both groups A and D has indicated that TKA can be an effective treatment even for patients with psychiatric problems.

关键词： Clinical Outcomes Improvement Rate Knee Osteoarthritis Psychiatric Prob-lems Total Knee Arthroplasty

Clinicolopathological, Cytogenetic, and Radiographical Analysis of Waldenstrom Macroglobulinemia in Japan: Unique Disease Manifestation

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Journal of Cancer Therapy 2012年第6期3卷 1037-1044页

作者： Naohiro Sekiguchi Naoki Takezako Miyuki Wagatsuma Chen AKunihiro Akihisa Nagata Ichiro Fukuda Satoshi Noto ikuo Saito Kazuaki Yamada Akiyoshi Miwa Division of Hematology National Hospital Organization Disaster Medical CenterTokyoJapan Division of Pathology National Hospital Organization Disaster Medical CenterTokyoJapan Division of Radiology National Hospital Organization Disaster Medical CenterTokyoJapan Division of Pathology National Hospital Organization Sagamihara HospitalSagamiharaJapan Hematology Division National Center for Global Health and MedicineTokyoJapan

Waldenstr?m macroglobulinemia (WM) is a rare lymphoid malignancy. Many studies, including clinicopathological, cytogenetic, gene expression profile, and therapy studies have been reported from the US and Europe, although only a few reports are available from East Asia, including Japan. To further clarify the clinicopathological, radiological, and cytogenetic features of WM in Japan, we performed a retrospective analysis of WM in our institute between March 2007 and January 2012. Clinical data, laboratory data, the results of flow cytometric analysis (FCM), and chromosomal abnormalities were analyzed, and a radiological review was performed. The treatment regimen, response, and survival were also estimated. Six patients were enrolled in this study. The median age was 71 years. All patients were symptomatic, 3 had hyperviscosity syndrome, 1 had bone lesions, and 1 had an extra-medullary mass. FCM data showed that all patients were positive for CD38, while 2 were positive for CD56. Four had chromosomal abnormalities including some abnormalities also reported in myeloma. On radiological review, four showed diffuse invasion of the retro-peritoneum. Five patients received treatment, 4 of which achieved a response. At a median follow-up of 527 days, 4 were alive and 2 died because of disease progression. The present study revealed that WM in Japan might be heterogeneous and have a unique disease manifestation. Invasion sites other than bone marrow were very common, and the results of clinical, FCM, and cytogenetic studies revealed that WM in Japanese cases might have manifestations of both myeloma and B-cell lymphoma.

关键词： Lymphoplasmacytic Lymphoma Woldenstrom Macroglobulinemia Lymphadenopathy Flow Cytometry Pathology Cytogenetics Japan

Endoscopic retrograde cholangiopancreatography for bile duct stones in patients with a performance status score of 3 or 4

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World Journal of Gastrointestinal Endoscopy 2022年第4期14卷 215-225页

作者： Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura ikuo Matsushita Tatsuyuki Kakuma Shuji Tada Department of Gastroenterology Kumamoto City HospitalKumamoto City 862-8505Japan Department of Gastroenterology Tsuruta HospitalKumamoto City 862-0925Japan Department of Gastroenterology Kumamoto Chuo HospitalKumamoto City 862-0965Japan Department of Gastroenterology Saiseikai Kumamoto HospitalKumamoto City 861-4193Japan Department of Gastroenterological Surgery Kumamoto Chuo HospitalKumamoto City 862-0965Japan Department of Biostatics Kurume UniversityKurume City 8300011Japan

BACKGROUND As the aging population grows worldwide,the rates of endoscopic retrograde cholangiopancreatography(ERCP)for common bile duct stones(CBDS)in older patients with a poor performance status(PS)have been ***,the data on the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4 are lacking,with only a few studies having investigated this issue among patients with poor *** To examine the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or *** This study utilized a retrospective multi-centered design of three institutions in Japan for 8 years to identify a total of 1343 patients with CBDS having native papillae who underwent therapeutic *** a result,1113 patients with a PS 0-2 and 230 patients with a PS 3-4 were ***-to-one propensity-score matching was performed to compare the safety and efficacy of ERCP for CBDS between patients with a PS 0-2 and those with a PS *** The overall ERCP-related complication rates in all patients and propensity score-matched patients with a PS 0-2 and 3-4 were 9.0%(100/1113)and 7.0%(16/230;P=0.37),and 4.6%(9/196)and 6.6%(13/196;P=0.51),*** the propensity score-matched patients,complications were significantly more severe in the group with a PS 3-4 than in the group with a PS 0-2 group(P=0.042).Risk factors for complications were indications of ERCP and absence of antibiotics in the multivariate *** success rates,including complete CBDS removal and permanent biliary stent placement,in propensity score-matched patients with a PS 0-2 and 3-4 were 97.4%(191/196)and 97.4%(191/196),respectively(P=1.0).CONCLUSION ERCP for CBDS can be effectively performed in patients with a PS 3 or ***,the indication for ERCP in such patients should be carefully considered with prophylactic antibiotics.

关键词： Endoscopic retrograde Cholangiopancreatography Complication Performance status Risk factor