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Non-improvement of atrophic gastritis in cases of gastric cancer after successful Helicobacter pylori eradication therapy

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World Journal of Clinical Cases 2024年第14期12卷 2342-2349页

作者： Yuto Suzuki Yasumi Katayama Yo Fujimoto ikuhiro kobori Masaya Tamano Department of Gastroenterology Dokkyo medical University Saitama Medical CenterKoshigayaSaitama 343-8555Japan Endoscopy Center Dokkyo Medical University Saitama Medical CenterKoshigayaSaitama 343-8555Japan

BACKGROUND Helicobacter pylori(***)infection is closely related to the development of gastric cancer(GC).However,GC can develop even after *** ***,it would be extremely useful if GC could be predicted after *** Kyoto classification score for gastritis(GA)is closely related to cancer ***,how the score for GC changes after eradication before onset is not well *** To investigate the characteristics of the progression of Kyoto classification scores for GC after *** *** Eradication of *** was confirmed in all patients using either the urea breath test or the stool antigen *** Kyoto classification score of GC patients was evaluated by endoscopy at the time of event onset and three years *** ad-dition,the modified atrophy score was evaluated and compared between the GC group and the control GA *** In total,30 cases of early GC and 30 cases of chronic GA were *** pathology of the cancer cases was differentiated adenocarcinoma,except for one case of undifferentiated *** total score of the Kyoto classifi-cation was significantly higher in the GC group both at the time of cancer onset and three years earlier(4.97 vs 3.73,P=0.0034;4.2 vs 3.1,P=0.0035,respectively).The modified atrophy score was significantly higher in the GC group both at the time of cancer onset and three years earlier and was significantly improved only in the GA group(5.3 vs 5.3,P=0.5;3.73 vs 3.1,P=0.0475,respectively).CONCLUSION The course of the modified atrophy score is useful for predicting the onset of GC after *** with severe atrophy after *** eradication require careful monitoring.

关键词： Helicobacter pylori Kyoto classification Gastritis Eradication therapy Gastric cancer

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Progress of ulcerative colitis patients during the COVID-19 pandemic

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世界临床病例杂志 2023年第23期11卷 5462-5467页

作者： Toshikuni Suda Morio Takahashi Yasumi Katayama Koichi Soga ikuhiro kobori Yumi Kusano Masaya Tamano Division of Gastroenterology Dokkyo Medical University Saitama Medical CenterSaitama 343-8555Japan Division of Gastroenterology Morio ClinicSaitama 343-0808Japan

BACKGROUND We have previously demonstrated that the first wave of the coronavirus disease 2019(COVID-19)pandemic caused exacerbations in ulcerative colitis(UC)patients,probably through psychological and physical ***,successive waves of the COVID-19 pandemic continuously followed the *** effects of this chronic stress on the disease condition in UC patients are of *** To clarify the effect of chronic stress from COVID-19 on disease condition in patients aggravated after the first *** Our previous study investigated 289 consecutive UC outpatients treated in one center during March and April 2020,the period of the first wave of the COVID-19 *** this study,an identical group of 289 UC patients was evaluated using UC-disease activity index(UC-DAI),endoscopic mucosal appearance score,and Matts pathological grade *** Of the 289 UC patients included in the study in 2020,10 patients dropped out as of 2021 and another 11 patients dropped out as of 2022,making three groups for 2020,2021 and *** significant differences in characteristics were found among the three ***-DAI scores had aggravated during the period of the first wave of the COVID-19 pandemic,but significantly recovered in 2021 and remained stable in *** grade scores significantly recovered in 2021 from those in 2020 and remained stable in *** Disease activity of UC patients recovered in 2021 and remained stable in 2022,aggravated by the stress of the first wave of COVID-19 in 2020 despite persistence of the pandemic.

关键词： Ulcerative colitis COVID-19 Exacerbation Stress Ulcerative colitis disease activity index Matts grade

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Endoscopic submucosal dissection as excisional biopsy for anorectal malignant melanoma:A case report

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World Journal of Clinical Cases 2019年第13期7卷 1652-1659页

作者： Shigeo Manabe Yoshio Boku Michiyo Takeda Fumitaka Usui ikuhiro Hirata Shuji Takahashi Department of Gastroenterology Kouseikai Takeda Hospital Kyoto 600-8558 Japan Fujita Clinic 67 Gokiya-cho Oomiya-dori Shichijo-kudaru Shimogyo-ku Kyoto 600-8267 Japan

BACKGROUND Anorectal malignant melanoma(AMM)is a rare disorder with an extremely poor *** there is currently no consensus on the treatment methods for AMM,surgical procedures have been the most common treatment methods used until *** recently encountered a case of AMM that we diagnosed using endoscopic submucosal dissection(ESD).To our knowledge,this is the first case of ESD for AMM,suggesting that ESD can potentially be a diagnostic and treatment method for *** S UMA/MARY A 77-year-old woman visited our hospital with a chief complaint of anal bleeding and a palpable rectal *** revealed a 20-mm protruded lesion in the lower *** obtaining biopsy specimens from the lesion,although a malignant rectal tumor was suspected,a definitive diagnosis was not *** ultrasonography revealed tumor invasion into the submucosal layer but not the muscular ***,we performed an excisional biopsy using *** examination of the ESD-resected specimen revealed tumor cells positive for Human Melanin Black-45,Melan-A,and ***,the tumor cells lacked melanin pigment;thus,a diagnosis of amelanotic AMM was *** the AMM had massively invaded the submucosal layer and both lymphatic and venous invasion were present,we closely monitored the patient without any additional therapy on the basis of her *** months after ESD,local recurrence was detected,and the patient consented to wide local *** USION It is suggested that ESD is a potential diagnostic and treatment method for AMM.

关键词： Endoscopic submucosal dissection Anorectal malignant melanoma Endoscopic mucosal resection Case report

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Gastric adenocarcinoma of fundic gland type spreading to heterotopic gastric glands

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World Journal of Gastroenterology 2017年第38期23卷 7047-7053页

作者： Shigeo Manabe Ken-ichi Mukaisho Takayuki Yasuoka Fumitaka Usui Tatsuzo Matsuyama ikuhiro Hirata Yoshio Boku Shuji Takahashi Department of Gastroenterology Kouseikai Takeda Hospital Department of Pathology Shiga University of Medical Science Fujita Clinic

Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type II gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumorlike lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, wefinally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG.

关键词： Gastric adenocarcinoma of fundic gland type Heterotopic gastric glands Endoscopic submucosal dissection Paracancerous lesion Pepsinogen-I H/K-ATPase

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Effects of Facial Isometric Exercise on Antioxidant Capacity

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Health 2021年第11期13卷 1171-1180页

作者： Ikuyo Orita ikuhiro Morikita Mayumi Watanabe Zaigen Oh Shigeyuki Kanai Kansai University of Health Sciences Osaka Japan Osaka University of Health and Sport Sciences Osaka Japan Faculty of Science and Engineering Chuo University Tokyo Japan

Background: Facial isometric exercise is a static contraction of facial muscles without any visible movement in the angle of the joints. To examine the effects of facial isometric exercise on subjective stress and oxidative stress/antioxidant capacity. Methods: In this study, we included 13 participants (6 males, 7 females;average age, 44.8 ± 19.6 years;age range: 20 - 74 years) who were exposed to constant temperature and humidity in a room. Fifteen minutes after entering the room, the force was measured before and after facial isometric exercise of the target muscles: upper lip levator, small zygomatic, large zygomatic, levator animus, laughing, buccal, muzzle, mental, temporal, masseter, and cervical muscles), and further evaluated by comparing the facial isometric exercise group and control (non-facial isometric exercise) group (crossover test). Results: Subjective stress significantly improved by 8.7 ± 16.3 in the facial isometric exercise group, and no significant difference in oxidative stress level was observed in both the groups. However, the antioxidant capacity significantly increased by 126.8 ± 168.1 μmol/l in the facial isometric exercise group. Conclusion: The results of this study suggest that facial isometric exercise is an exercise therapy that can provide mental stability and antiaging effects due to improvement in subjective stress and biological antioxidant potential.

关键词： Facial Isometric Exercise Subjective Stress Oxidative Stress Levels Antioxidant Capacity

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连接器用钯金滑动接触体的特性

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机电元件 1984年第3期 38-43页

作者： ikuhiro Andoh ,刘立余

比较了常用镀金接触体和镀钯后再镀金的新型滑动接触体的特性,并对新型接触体做了评价。实验用的镍底层、钯镀层和金镀层是分别用镍、纯钯和纯金依次在瓦茨槽、碱槽和酸槽液中镀制而成。为了评价连接器的力学、电学和环境特性,进行了插... 详细信息

比较了常用镀金接触体和镀钯后再镀金的新型滑动接触体的特性,并对新型接触体做了评价。实验用的镍底层、钯镀层和金镀层是分别用镍、纯钯和纯金依次在瓦茨槽、碱槽和酸槽液中镀制而成。为了评价连接器的力学、电学和环境特性,进行了插拔、振动冲击、高温、湿度、热冲击、盐雾、H2S、SO2和高温电负荷试验。新型接触体的接触电阻、摩擦系数、耐磨和耐蚀等性能均比常用的镀金接触体高。

关键词：接触体镀钯连接器插头座接触电阻滑动接触

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减压条件下的氧气顶吹射流行为

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鞍钢技术 2008年第3期 55-58页

作者： ikuhiro SUMI 何立波

氧气顶吹射流应用在各种炼钢精炼过程中,是精炼过程的重要因素。人们对常压下的射流行为进行过大量的研究,但对真空精炼过程中减压条件下的射流行为了解不多。通过测量射流的动压研究减压条件下的射流行为,采用大量射流数值模型具体解... 详细信息

氧气顶吹射流应用在各种炼钢精炼过程中,是精炼过程的重要因素。人们对常压下的射流行为进行过大量的研究,但对真空精炼过程中减压条件下的射流行为了解不多。通过测量射流的动压研究减压条件下的射流行为,采用大量射流数值模型具体解释射流行为。对比模拟结果与实验数据得出结论,数值模拟方法有效。数学模型模拟了射流行为,详细说明了环境压力对射流行为的影响。当环境压力减小时,射流速度核心区延长,说明在减压条件下,射流衰减程度较常压下的小。采用该模型还可以解释喷口形状对RH实际顶吹过程中二次燃烧行为的影响。

关键词：炼钢 RH VOD 超音速射流模型

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Effects of Facial Isometric Exercise on Antioxidant Capacity

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Health（健康） 2021年第11期

作者： Ikuyo Orita ikuhiro Morikita Mayumi Watanabe Zaigen Oh Shigeyuki Kanai

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Skull metastasis from hepatocellular carcinoma with chronic hepatitis B

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World Journal of Gastrointestinal Oncology 2010年第3期2卷 165-168页

作者： Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi Department of Gastroenterology Akita University School of Medicine

A 56-year-old male visited our hospital for evaluation of an occipital *** computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the *** resonance imaging showed bone metastasis in the thoracic *** for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade *** diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis *** was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for *** he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and *** showed HCC with multiple bone *** liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular *** the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting *** necrosis was not *** fibrosis was *** 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial *** lesion was osteolytic and showed invasion into the dura *** the subdural cavity nor the brain showed involvement from the metastatic ***,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of ***,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC.

关键词： Hepatocellular carcinoma Skull metastasis Bone metastasis Osteolytic change Chronic hepatitis B

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