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Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma

Chinese Journal of Cancer Research 2024年第2期36卷 195-214页

作者： Sana Rashid Yingchuan Sun Umair Ali Khan Saddozai Sikandar Hayyat Muhammad Usman Munir Muhammad Usman Akbar Muhammad Babar Khawar Zhiguang Ren Xinying Ji Malik ihsan ullah Khan Institute of Molecular Biology and Biotechnology University of LahoreLahore 54590Pakistan Department of Internal Oncology(Section Ⅰ) Xuchang Municipal Central HospitalXuchang 461000China Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225001China Australian Institute for Bioengineering&Nanotechnology the University of QueenslandBrisbane 4072Australia Gomal Center of Biochemistry and Biotechnology Gomal UniversityDera Ismail Khan 29111Pakistan Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowal Punjab 51600Pakistan Kaifeng Municipal Key Laboratory for Infection and Biosafety Henan International Joint Laboratory of Nuclear Protein RegulationSchool of Basic Medical SciencesHenan UniversityKaifeng 475004China Faculty of Basic Medical Subjects Shu-Qing Medical College of ZhengzhouZhengzhou 450064China Department of Medicine Huaxian County People's HospitalHuaxian 456400China

Hepatocellular carcinoma(HCC) is considered the fifth most prevalent cancer among all types of cancers and has the third most morbidity value. It has the most frequent duplication time and a high recurrence rate. Recently, the most unique technique used is liquid biopsies, which carry many markers;the most prominent is circulating tumor DNA(ctDNA). Varied methods are used to investigate ctDNA, including various forms of polymerase chain reaction(PCR) [emulsion PCR(ePCR), digital PCR(dPCR), and bead, emulsion, amplification, magnetic(BEAMing) PCR]. Hence ctDNA is being recognized as a potential biomarker that permits early cancer detection,treatment monitoring, and predictive data on tumor burden are subjective to therapy or surgery. Numerous ctDNA biomarkers have been investigated based on their alterations such as 1) single nucleotide variations(either insertion or deletion of a nucleotide) markers including TP53, KRAS, and CCND1;2) copy number variations which include markers such as CDK6, EFGR, MYC and BRAF;3) DNA methylation(RASSF1A, SEPT9, KMT2C and CCNA2);4) homozygous mutation includes ctDNA markers as CDKN2A, AXIN1;and 5) gain or loss of function of the genes, particularly for HCC. Various researchers have conducted many studies and gotten fruitful ***, there are some drawbacks to ctDNA namely low quantity, fragment heterogeneity, less stability, limited mutant copies and standards, and differential sensitivity. However, plenty of investigations demonstrate ctDNA's significance as a polyvalent biomarker for cancer and can be viewed as a future diagnostic, prognostic and therapeutic agent. This article overviews many conditions in genetic changes linked to the onset and development of HCC, such as dysregulated signaling pathways, somatic mutations, single-nucleotide polymorphisms, and genomic instability. Additionally, efforts are also made to develop treatments for HCC that are molecularly targeted and to unravel some of the genetic pathways that f

关键词： Hepatocellular carcinoma circulating tumor DNA biomarkers single nucleotide variations diagnosis prognosis

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Socio-Economic Drivers of Deforestation in Roghani Valley,Hindu-Raj Mountains,Northern Pakistan

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Journal of Mountain Science 2014年第1期11卷 167-179页

作者： Fazlur RAHMAN Fazlul HAQ Iffat TABASSUM ihsan ullah Institute of Geography Urban & Regional Planning University of Peshawar

Deforestation and associated ecological disturbances are the issues of global *** have investigated a number of driving forces which accelerate the rate of deforestation at local and regional *** include poverty,population growth,market demand and prices,political instability,agricultural expansion and changes in property right and ownership *** paper seeks to explore the impacts of population growth,changing tenure system and other socioeconomic factors on the forest cover of Roghani Valley,located in Hindu Raj Mountains,Northern *** present study is mainly based on information collected through participatory observation,selfadministered interviews and questionnaire *** Information System(GIS) database is also used for mapping and *** results reveal that in the past three to four decades the study area has been subjected to severe deforestation and about half of the forest area has been converted into barren ***,the area under natural forests decreased from 2099 to 1444 hectares in four *** large-scale deforestation is attributed to both proximate and under lying causes particularly traditional land tenure system and demographic ***,forest resources have been degraded and a number of plant species have disappeared from the forests of the study area while several others are in the process of disappearance.

关键词： Deforestation Natural Vegetation Cover Population Growth Traditional Tenure Systems Land Use and Land Cover Change Household Dynamics

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Preliminary study of adsorption behavior of bovine serum albumin(BSA) protein and its effect on antibacterial and corrosion property of Ti-3Cu alloy

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Journal of Materials Science & Technology 2021年第21期80卷 117-127页

作者： Muhammad Ali Siddiqui ihsan ullah Hui Liu Shuyuan Zhang Ling Ren Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China School of Materials Science and Engineering University of Science and Technology of China96 Jinzhai RoadHefei230026China Department of Metallurgical Engineering NED University of Engineering and TechnologyUniversity RoadKarachi75270Pakistan

The adsorption behavior, antibacterial, and corrosion properties of a Ti-3 Cu alloy were studied in a phosphate-buffered saline solution containing 0, 1, 3, and 6 gL^(-1) bovine serum albumin protein at 37℃ and pH = 7.4(±0.2). The protein adsorption behavior was examined via cyclic voltammetry, secondary ions mass spectroscopy(SIMS), and angle-resolved X-ray photoelectron spectroscopy(ARXPS). The corrosion property was analyzed by the open circuit potential(OCP), potentiodynamic polarization(PD),and electrochemical impedance spectroscopy(EIS) examinations. The antibacterial test was conducted according to the GB/T 21510 China Standard. It was observed that the surface charge density(QA DS) was directly proportional to the amount of the adsorbed BSA protein, signifying that the protein adsorption was accompanied by the charge transfer, pointing to chemisorptions phenomena. BSA amino groups and other organic species were observed in the surface analysis examinations. It was shown that the formation of barrier complexes between the TiO_(2) oxide-layer and PBS solution resulted in decreasing the release of Cu-ions, which consequently reduced the antibacterial activity. On the other hand, these barrier complexes improved the corrosion resistance by increasing the charge transfer resistance and double-layer capacitance of the Ti-3 Cu alloy.

关键词： Bovine serum albumin protein Ti-3Cu alloy Antibacterial Corrosion Adsorption behavior

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Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity

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Journal of Materials Science & Technology 2020年第13期47卷 130-139页

作者： Hui Liu Rui Liu ihsan ullah Shuyuan Zhang Ziqing Sun Ling Ren Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China School of Materials Science and Engineering University of Science and Technology of China96 Jinzhai RoadHefei230026China Institute of Molecular Medicine State Key Laboratory of Oncogenes and Related GenesRenji Hospital160 Pujian RoadShanghai220127China

Implant-related infection and early bone integration are the main risk factors of implants for long-term service,to overcome these difficulties,SLA-TiCu surface was prepared by sandblasting and large-grits etching(SLA)treatment on a novel antibacterial titanium-copper alloy(TiCu),which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based *** of SLA-TiCu surface on the adhesion,proliferation,apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen(Staphylococcus aureus)were *** to the following surfaces:sandblasting and large-grits etched pure titanium(SLATi),mechanically ground pure titanium and TiCu alloy(M-Ti and M-TiCu),these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions(alkaline phosphates(ALP),collagen typeⅠ(COLⅠ),Runt-related transcription factor 2(RUN x 2),and osteopontin(OPN)).Moreover,SLA-TiCu surface could maintain a sustainable release of Cu2+ions and effectively inhibited the viability of *** study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity,making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants.

关键词： Titanium Copper Roughness surface Osteogenesis Antibacterial

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Structural and optoelectronic properties of CsLnZnTe_(3)(Ln=La,Pr,Nd and Sm)

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Journal of Rare Earths 2023年第3期41卷 388-396,I0003页

作者： Imad Khan ihsan ullah Izaz Ul Haq Akbar Ali A.Dahshan Zahid Ali Iftikhar Ahmad Center for Computational Materials Science Department of PhysicsUniversity of MalakandChakdaraPakistan Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Department of Physics Faculty of SciencePort Said UniversityPort SaidEgypt Gomal University Dera Ismail KhanPakistan

Zinc telluride is a versatile wide band gap semiconductor used in many *** it has certain limitations like large dimensions and large band *** alkali metal to its bulk lattice(3D)can reduce its dimensions and lanthanide can produce a red shift in the energy gap by converting it into quaternary *** alkali and lanthanide incorporated quaternary zinc tellurides CsLnZnTe_(3)(Ln=La,Pr,Nd and Sm)form layered crystal structure in which_(∞)^(2)[LnZnTe_(3)]-layers are separated by Cs+*** famous lanthanide contraction is experimental both from lattice constants and bond *** calculated band gaps are 2.26,2.28,2.12,2.05 eV for CsLaZnTe_(3),CsPrZnTe_(3),CsNdZnTe_(3) and CsSmZnTe_(3),*** compounds show direct band gap *** energy band gaps of these compounds have not been evaluated yet both experimentally and *** loss functions,refractive index and dielectric functions were also calculated to explore the potential applications of CsLnZnTe_(3) in optoelectronic devices.

关键词： Chalcogenides Optical materials Electronic structure Dimensions reduction Ab-initio calculations Rare earths

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Machine Learning-based Stable P2P IPTV Overlay

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Computers, Materials & Continua 2022年第6期71卷 5381-5397页

作者： Muhammad Javid Iqbal ihsan ullah Muhammad Ali Atiq Ahmed Waheed Noor Abdul Basit Directorate of Information Technology Sardar Bahadur Khan Women’s UniversityQuettaPakistan Department of Computer Science and Information Technology University of BalochistanQuettaPakistan

Live video streaming is one of the newly emerged services over the Internet that has attracted immense interest of the service *** Internet was not designed for such services during its inception,such a service poses some serious challenges including cost and ***-to-Peer(P2P)Internet Protocol Television(IPTV)is an application-level distributed paradigm to offer live video *** terms of ease of deployment,it has emerged as a serious alternative to client server,Content Delivery Network(CDN)and IP multicast ***,P2P approach has struggled to provide the desired streaming quality due to a number of *** of peers in a network is one of themajor issues among *** of the existing approaches address this issue through older-stable *** paper first extensively investigates the older-stable principle to observe its validity in different *** is observed that the older-stable principle does not hold in several of ***,it utilizes machine learning approach to predict the stability of *** work evaluates the accuracy of severalmachine learning algorithms over the prediction of stability,where the Gradient Boosting Regressor(GBR)out-performs other ***,this work presents a proof-of-concept simulation to compare the effectiveness of older-stable rule and machine learning-based predictions for the stabilization of the *** results indicate that machine learning-based stability estimation significantly improves the system.

关键词： P2P IPTV live video streaming user behavior overlay networks stable peers machine learning

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Plasma spray of biofunctional(Mg, Sr)-substituted hydroxyapatite coatings for titanium alloy implants

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Journal of Materials Science & Technology 2019年第5期35卷 719-726页

作者： Lei Cao ihsan ullah Na Li Shiyu Niu Rujie Sun Dandan Xia Rui Yang Xing Zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China University of the Chinese Academy of Sciences Shijingshan District Beijing 100049 China School of Materials Science and Engineering University of Science and Technology of China. Hefei 239056 China Shenyang Pharmaceutical University Shenyang 110016 China University of Utah Salt Lake City UT 84112 USA

Plasma-sprayed hydroxyapatite (HA) coatings have been widely utilized in load-bearing titanium alloy implants. In this study, Mg, Sr co-substituted HA ((Mg,Sr)-HA) nano-scale powders have been synthesized, which are further used to prepare (Mg,Sr)-HA coatings on Ti-6A1-4V alloys in order to improve the biological functions. The average size of (Mg,Sr)-HA nano particles is ~75nm. The average bonding strength for (Mg,Sr)-HA coating and samples after heat treatment at 500℃ or 600℃ for 3h are 26.17±2.11 MPa, 36.07±4.48 MPa and 37.07 ±2.95 MPa, respectively. There is a significantly increase of bonding strength likely due to low residual stress after heated ***3T3-E1 cells show a high proliferation rate when cultured with (Mg,Sr)-HA coating extract compared to the normal culture medium, which also exhibit large extension and depositi on of extracellular matrices when adhered on the coating surfaces. Thus, these (Mg,Sr)-HA coatings show high bonding strength and improved biological functions, which offer promising future applications in the fields of orthopedics and dentistry.

关键词： Plasma spray Hydroxyapatite Titanium alloys Biological functions Bon ding strength

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Optimized Mechanical Properties,Corrosion Resistance and Bactericidal Ability of Ti-15Zr-xCu Biomedical Alloys During Aging Treatment

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Acta Metallurgica Sinica(English Letters) 2022年第2期35卷 304-316页

作者： Sharafadeen Kunle Kolawole Ling Ren Muhammad Ali Siddiqui ihsan ullah Hai Wang Shuyuan Zhang Ji Zhang Ke Yang School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Federal Polytechnic P.M.B.420OffaKwara StateNigeria

The effects of different aging conditions on the microstructure,strength,corrosion resistance,cytotoxicity and antibacterial ability of Ti-15Zr-xCu(3≤x≤7,wt%)(TZC)alloys were systematically *** evolution and behavior were analyzed by X-ray diffraction(XRD)patterns and scanning electron microscopy with energy-dispersive spectroscopy(SEM-EDS),while potentiodynamic polarization technique was employed to characterize the corrosion response of the alloys after solution-treatment and aging(STA).High-temperature aging at 660℃ for 4 h(660-4)gave the best combination of properties by enabling significant precipitation of the Cu-rich Ti_(2)Cu and Zr_(2)Cu compounds,and mild formation of the Zr_(7)Cu_(10) secondary *** high kinetics at this condition was beneficial to the complete precipitation and more homogeneous distribution of the intermetallic *** led to the inhibition of dislocation movements and allowed for significantly improved mechanical strengths with added ductility,availability of more Cu ions for the desired oligodynamic activity without evoking cytotoxicity,better corrosion resistance and very high antibacterial ability(over 99.5%),thus improving the overall properties of the TZC alloys for biomedical applications.

关键词： Ti-15Zr-xCu alloys Solution treatment and aging Cu-rich precipitates Improved strength Corrosion resistance Antibacterial ability

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Preliminary study of microstructure, mechanical properties and corrosion resistance of antibacterial Ti-15Zr-xCu alloy for dental application

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Journal of Materials Science & Technology 2020年第15期47卷 31-43页

作者： Sharafadeen Kunle Kolawole Wang Hai Shuyuan Zhang Ziqing Sun Muhammad Ali Siddiqui ihsan ullah Wei Song Frank Witte Ke Yang School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China Institute of Metal Research Chinese Academy of SciencesShenyang110016China Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersAssmannshauser Strane 4-614197BerlinGermany Federal Polytechnic OffaP.M.B.420OffaKwara StateNigeria

Ti-15 Zr-xCu(3≤x≤7,wt.%) novel antibacterial and antibiofilm alloys with competitive mechanical properties,biological responses and corrosion resistance were designed and *** heat treatment on Ti-15 Zr-7 Cu(TZC-7 A),after holding for 2 h at slightly above their beta transus temperature(BTT) ensured their tensile strength(UTS),yield strength(YS) and hardness(HRV) were improved by31.2%,20% and 12.3% respectively compared to the control without Cu,Ti-15 Zr(T-15 ZA).Although the3 wt.% Cu alloy displayed the highest elongation(26%),the TZC-7 A alloy also possessed a good *** of evenly dispersed Ti2 Cu and Zr2 Cu Cu-rich intermetallic phases formed as interwoven and alternating lamellae within the α+β matrix as a result of Cu addition,as revealed by X-ray diffraction(XRD),scanning electron microscopy(SEM) and transmission electron microscopy(TEM).These greatly contributed to their strengthening and bactericidal *** 98% antibacterial effect against *** and *** have been imparted,coupled with excellent biofilm *** polarization curves showed that the TZC-7 A alloy possessed higher corrosion resistance than commercially pure titanium,cp-Ti;contact angle test revealed enhanced hydrophilicity;while confocal laser scanning microscopy(CLSM) and cell counting kit(CCK-8) assays also displayed drastically lowered bacterial adhesion rate with comparatively no *** attachment on all alloys was similar but the best spread was obtained on TZC-7 A after 24 *** developed alloy has good potential as an antibacterial implant material with combination of optimized properties.

关键词： Ti-Zr alloy Cu addition Antibacterial Mechanical properties Intermetallic phases

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Machine Learning-Enabled Power Scheduling in IoT-Based Smart Cities

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Computers, Materials & Continua 2021年第5期67卷 2449-2462页

作者： Nabeela Awan Salman Khan Mohammad Khalid Imam Rahmani Muhammad Tahir Nur Alam MD Ryan Alturki ihsan ullah Department of Computer Science Government Girls Degree College MardanKPK23200Pakistan Department of Electrical Energy System UETPeshawar25000Pakistan Department of Computer Science College of Computing and InformaticsSaudi Electronic UniversityKSA Department of Smart Computing Kyungdong UniversityGlobal CampusGosung24764South Korea Department of Information Sciences College of Computer and Information SystemsUmm Al-Qura UniversityMakkahSaudi Arabia Robotics Engineering Daegu Gyeongbuk Institute of Science and TechnologySouth Korea

Recent advancements in hardware and communication technologies have enabled worldwide interconnection using the internet of things(IoT).The IoT is the backbone of smart city applications such as smart grids and green energy *** smart cities,the IoT devices are used for linking power,price,energy,and demand information for smart homes and home energy management(HEM)in the smart *** complex smart gridconnected systems,power scheduling and secure dispatch of information are the main research *** challenges can be resolved through various machine learning techniques and data *** this paper,we have proposed a particle swarm optimization based machine learning algorithm known as a collaborative execute-before-after dependency-based requirement,for the smart *** proposed collaborative execute-before-after dependencybased requirement algorithm works in two phases,analysis and assessment of the requirements of end-users and power distribution *** the rst phases,a xed load is adjusted over a period of 24 h,and in the second phase,a randomly produced population load for 90 days is evaluated using particle swarm *** simulation results demonstrate that the proposed algorithm performed better in terms of percentage cost reduction,peak to average ratio,and power variance mean ratio than particle swarm optimization and inclined block rate.

关键词： PSO IBR machine learning IoT smart cities CDBR

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