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Journey of a patient with scleroderma from renal failure up to kidney transplantation

World Journal of Transplantation 2021年第9期11卷 372-387页

作者： Fedaey Abbas Mohsen El Kossi ihab sakr shaheen Ajay Sharma Ahmed Halawa Department of Nephrology Faculty of Health and ScienceUniversity of LiverpoolInstitute of Learning and TeachingSchool of MedicineLiverpool L693GBUnited Kingdom Doncaster Renal Unit Doncaster Royal InfirmaryDoncaster DN25LTUnited Kingdom Department of Paediatric Nephrology St James’s University HospitalGlasgow G514TFUnited Kingdom Department of Transplant Surgery Royal Liverpool University HospitalLiverpool L78XPUnited Kingdom Department of Transplant Surgery Sheffield Teaching HospitalSheffield S57AUUnited Kingdom

The increased awareness of systemic sclerosis(SS)and its pathogenetic background made the management of this disease more amenable than previously ***,scleroderma renal crisis(SRC)is a rarely seen as an associated disorder that may involve 2%-15%of SS *** presented with earlier,rapidly progressing,diffuse cutaneous SS disease,mostly in the first 3-5 years after non-Raynaud clinical manifestations,are more vulnerable to develop *** comprises a collection of acute,mostly symptomatic rise in blood pressure,elevation in serum creatinine concentrations,oliguria and thrombotic microangiopathy in almost 50%of *** advent of the antihypertensive angiotensin converting enzyme inhibitors in 1980 was associated with significant improvement in SRC *** a scleroderma patient maintained on regular dialysis;every effort should be exerted to declare any possible evidence of renal recovery.A given period of almost two years has been suggested prior to proceeding in a kidney transplant(KTx).Of note,SS patients on dialysis have the highest opportunity of renal recovery and withdrawal from dialysis as compared to other causes of end-stage renal disease(ESRD).KTx that is the best well-known therapeutic option for ESRD patients can also be offered to SS *** to other primary renal diseases,SS-related ESRD was considered for a long period of poor patient and allograft *** involvement in an SS patient is considered a strong post-transplant independent risk factor of *** of SRC after transplantation has been observed in some ***,an excellent post-transplant patient and graft outcome have been recently ***,the absence of extrarenal manifestations in an SS-induced ESRD patient can be accepted as a robust indicator for a successful KTx.

关键词： Systemic sclerosis Scleroderma renal crisis Risk factors Renal failure Hemodialysis Kidney transplant

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Post-transplantation lymphoproliferative disorders:Current concepts and future therapeutic approaches

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World Journal of Transplantation 2020年第2期10卷 29-46页

作者： Fedaey Abbas Mohsen El Kossi ihab sakr shaheen Ajay Sharma Ahmed Halawa Nephrology Department Jaber El Ahmed Military HospitalSafat 13005Kuwait Faculty of Health and Science University of LiverpoolInstitute of Learning and TeachingSchool of MedicineLiverpool L693GBUnited Kingdom Doncaster Royal Infirmary Doncaster DN25LTUnited Kingdom Department of Paediatric Nephrology Royal Hospital for ChildrenGlasgow G514TFUnited Kingdom Department of Transplant Surgery Royal Liverpool University HospitalsLiverpool L78XPUnited Kingdom Department of Transplantation Sheffield Teaching HospitalsSheffield S57AUUnited Kingdom

Transplant recipients are vulnerable to a higher risk of malignancy after solid organ transplantation and allogeneic hematopoietic stem-cell *** lymphoproliferative disorders(PTLD)include a wide spectrum of diseases ranging from benign proliferation of lymphoid tissues to frank malignancy with aggressive *** main risk factors of PTLD are:Firstly,the cumulative immunosuppressive burden,and secondly,the oncogenic impact of the Epstein-Barr *** latter is a key pathognomonic driver of PTLD *** the last two decades,a considerable progress has been made in diagnosis and therapy of *** treatment of PTLD includes reduction of immunosuppression,rituximab therapy,either isolated or in combination with other chemotherapeutic agents,adoptive therapy,surgical intervention,antiviral therapy and *** this review we shall discuss the prevalence,clinical clues,prophylactic measures as well as the current and future therapeutic strategies of this devastating disorder.

关键词： Lymphoproliferative disorders Epstein-Barr virus Solid organ transplant Hematopoietic stem cell transplant Post-transplant lymphoproliferative disorder prevention Future therapies

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Complement-mediated renal diseases after kidney transplantation-current diagnostic and therapeutic options in de novo and recurrent diseases

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World Journal of Transplantation 2018年第6期8卷 203-219页

作者： Fedaey Abbas Mohsen El Kossi Jon Jin Kim ihab sakr shaheen Ajay Sharma Ahmed Halawa Nephrology Department Jaber El Ahmed Military Hospital Faculty of Health and Science University of Liverpool Institute of Learning and Teaching School of Medicine Doncaster Royal Infirmary Nottingham Children Hospital Royal Hospital for Children Glasgow G51 4TF United Kingdom Royal Liverpool University Hospitals Sheffield Teaching Hospitals

For decades, kidney diseases related to inappropriate complement activity, such as atypical hemolytic uremic syndrome and C3 glomerulopathy(a subtype of membranoproliferative glomerulonephritis), have mostly been complicated by worsened prognoses and rapid progression to end-stage renal failure. Alternative complement pathway dysregulation, whether congenital or acquired, is well-recognized as the main driver of the disease process in these patients. The list of triggers include: surgery, infection, immunologic factors, pregnancy and medications. The advent of complement activation blockade, however, revolutionized the clinical course and outcome of these diseases, rendering transplantation a viable option for patients who were previously considered as non-transplantable *** less-costly therapeutic lines and likely better efficacy and safety profiles are currently underway. In view of the challenging nature of diagnosing these diseases and the long-term cost implications, a multidisciplinary approach including the nephrologist, renal pathologist and the genetic laboratory is required to help improve overall care of these patients and draw the optimum therapeutic plan.

关键词： Complement-related diseases Kidney transplantation De novo Recurrent diseases

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Efficient Relational Techniques for Processing Graph Queries

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Journal of Computer Science & Technology 2010年第6期25卷 1237-1255页

作者： Sherif sakr Ghazi Al-Naymat School of Computer Science and Engineering University of New South Wales Managing Complexity Group National ICT Australia (NICTA)

Graphs are widely used for modeling complicated data such as social networks,chemical compounds,protein interactions and semantic *** effiectively understand and utilize any collection of graphs,a graph database that efficiently supports elementary querying mechanisms is crucially *** example,Subgraph and Supergraph queries are important types of graph queries which have many applications in practice.A primary challenge in computing the answers of graph queries is that pair-wise comparisons of graphs are usually hard *** database management systems（RDBMSs） have repeatedly been shown to be able to efficiently host different types of data such as complex objects and XML *** derive much of their performance from sophisticated optimizer components which make use of physical properties that are specific to the relational model such as sortedness,proper join ordering and powerful indexing *** this article,we study the problem of indexing and querying graph databases using the relational *** present a purely relational framework for processing graph *** framework relies on building a layer of graph features knowledge which capture metadata and summary features of the underlying graph *** describe different querying mechanisms which make use of the layer of graph features knowledge to achieve scalable performance for processing graph ***,we conduct an extensive set of experiments on real and synthetic datasets to demonstrate the efficiency and the scalability of our techniques.

关键词： graph database graph query subgraph query supergraph query

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Novel Framework for Generating Criminals Images Based on Textual Data Using Identity GANs

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Computers, Materials & Continua 2023年第7期76卷 383-396页

作者： Mohamed Fathallah Mohamed sakr Sherif Eletriby Department of Computer Science Faculty of Computers and InformationKafrelsheikh UniversityKafrelsheikhEgypt Department of Computer Science Faculty of Computers and InformationMenoufia UniversityMenoufiaEgypt

Text-to-image generation is a vital task in different fields,such as combating crime and terrorism and quickly arresting *** several years,due to a lack of deep learning and machine learning resources,police officials required artists to draw the face of a *** methods of identifying criminals are inefficient and *** paper presented a new proposed hybrid model for converting the text into the nearest images,then ranking the produced images according to the available *** framework contains two main steps:generation of the image using an Identity Generative Adversarial Network(IGAN)and ranking of the images according to the available data using multi-criteria decision-making based on neutrosophic *** IGAN has the same architecture as the classical Generative Adversarial Networks(GANs),but with different modifications,such as adding a non-linear identity block,smoothing the standard GAN loss function by using a modified loss function and label smoothing,and using mini-batch *** model achieves efficient results in Inception Distance(FID)and inception score(IS)when compared with other architectures of GANs for generating images from *** IGAN achieves 42.16 as FID and 14.96 as *** it comes to ranking the generated images using Neutrosophic,the framework also performs well in the case of missing information and missing data.

关键词： GAN deep learning text-to-image identity GAN

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A spatiotemporal algebra in Hadoop for moving objects

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Geo-Spatial Information Science 2018年第2期21卷 102-114页

作者： Mohamed S.Bakli Mahmoud A.sakr Taysir Hassan A.Soliman Faculty of Computers and Information Assiut UniversityAssiutEgypt Faculty of Computer and Information Sciences Ain Shams UniversityCairoEgypt Universitélibre de Bruxelles BruxellesBelgium

Spatiotemporal data represent the real-world objects that move in geographic space over *** enormous numbers of mobile sensors and location tracking devices continuously produce massive amounts of such *** leads to the need for scalable spatiotemporal data management *** systems shall be capable of representing spatiotemporal data in persistent storage and in *** shall also provide a range of query processing operators that may scale out in a cloud ***,very few researches have been conducted to meet this *** paper proposes a Hadoop extension with a spatiotemporal *** algebra consists of moving object types added as Hadoop native types,and operators on top of *** Hadoop file system has been extended to support parameter passing for files that contain spatiotemporal data,and for operators that can be unary or *** the types and operators are accessible for the MapReduce *** an extension allows users to write Hadoop programs that can perform spatiotemporal *** queries may call more than one operator for different jobs and keep these operators running in *** paper describes the design and implementation of this algebra,and evaluates it using a benchmark that is specific to moving object databases.

关键词： Spatiotemporal algebra Hadoop MapReduce moving objects

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A New Hybrid Model for Segmentation of the Skin Lesion Based on Residual Attention U-Net

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Computers, Materials & Continua 2023年第6期75卷 5177-5192页

作者： Saleh Naif Almuayqil Reham Arnous Noha sakr Magdy M.Fadel Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaSaudi Arabia Department of Communications and Electronics Delta Higher Institute for Engineering and Technology(DHIET)MansouraEgypt Computers Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansouraEgypt

Skin segmentation participates significantly in various biomedical applications,such as skin cancer identification and skin lesion *** paper presents a novel framework for segmenting the *** framework contains two main stages:The first stage is for removing different types of noises from the dermoscopic images,such as hair,speckle,and impulse noise,and the second stage is for segmentation of the dermoscopic images using an attention residual U-shaped Network(U-Net).The framework uses variational Autoencoders(VAEs)for removing the hair noises,the Generative Adversarial Denoising Network(DGAN-Net),the Denoising U-shaped U-Net(D-U-NET),and Batch Renormalization U-Net(Br-U-NET)for remov-ing the speckle noise,and the Laplacian Vector Median Filter(MLVMF)for removing the impulse *** the second main stage,the residual attention u-net was used for *** framework achieves(35.11,31.26,27.01,and 26.16),(36.34,33.23,31.32,and 28.65),and(36.33,32.21,28.54,and 27.11)for removing hair,speckle,and impulse noise,respectively,based on Peak Signal Noise Ratio(PSNR)at the level of(0.1,0.25,0.5,and 0.75)of *** framework also achieves an accuracy of nearly 94.26 in the dice score in the process of segmentation before removing noise and 95.22 after removing different types of *** experiments have shown the efficiency of the used model in removing noise according to the structural similarity index measure(SSIM)and PSNR and in the segmentation process as well.

关键词： Skin tumor speckle noise impulse noise hair noise deep learning segmentation

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Novel Framework of Segmentation 3D MRI of Brain Tumors

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Computers, Materials & Continua 2023年第2期74卷 3489-3502页

作者： Ibrahim Mahmoud El-Henawy Mostafa Elbaz Zainab H.Ali Noha sakr Department of Computer Science Faculty of Computers and InformaticsZagazig UniversityZagazigEgypt Department of Computer Science Faculty of Computers and InformaticsKafrelsheikh UniversityKafrelsheikhEgypt Department of Embedded Network Sys.and Tec. Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikhEgypt Computers Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansouraEgypt

Medical image segmentation is a crucial process for computer-aided diagnosis and *** image segmentation refers to portioning the images into small,disjointed parts for simplifying the processes of analysis and *** and speckle noise are different types of noise in magnetic resonance imaging(MRI)that affect the accuracy of the segmentation process ***,image enhancement has a significant role in MRI *** paper proposes a novel framework that uses 3D MRI images from Kaggle and applies different diverse models to remove Rician and speckle noise using the best possible noise-free *** proposed techniques consider the values of Peak Signal to Noise Ratio(PSNR)and the level of noise as inputs to the attention-U-Net model for segmentation of the *** framework has been divided into three stages:removing speckle and Rician noise,the segmentation stage,and the feature extraction *** framework presents solutions for each problem at a different stage of the *** the first stage,the framework uses Vibrational Mode Decomposition(VMD)along with Block-matching and 3D filtering(Bm3D)algorithms to remove the ***,the most significant Rician noise-free images are passed to the three different methods:Deep Residual Network(DeRNet),Dilated Convolution Auto-encoder Denoising Network(Di-Conv-AE-Net),andDenoising Generative Adversarial Network(DGAN-Net)for removing the speckle *** Bm3D have achieved PSNR values for levels of noise(0,0.25,0.5,0.75)for reducing the Rician noise by(35.243,32.135,28.214,24.124)and(36.11,31.212,26.215,24.123)*** framework also achieved PSNR values for removing the speckle noise process for each level as follows:(34.146,30.313,28.125,24.001),(33.112,29.103,27.110,24.194),and(32.113,28.017,26.193,23.121)forDeRNet,Di-Conv-AE-Net,and DGAN-Net,*** experiments that have been conducted have proved the efficiency of the proposed framework a

关键词： MRI Rician noise speckle noise segmentation deep learning

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Amino Acid Encryption Method Using Genetic Algorithm for Key Generation

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Computers, Materials & Continua 2022年第1期70卷 123-134页

作者： Ahmed S.sakr M.Y.Shams Amena Mahmoud Mohammed Zidan Department of Information System Faculty of Computers and InformationMenofia UniversityEgypt Department of Machine learning and Information Retrieval Faculty of Artificial IntelligenceKafrelsheikh UniversityEgypt Department of Computer Science Faculty of Computers and InformationKafrelshiekh UniversityEgypt Hurghada Faculty of Computers and Artificial Intelligence South Valley UniversityEgypt

In this new information era,the transfer of data and information has become a very important *** data must be kept secured from unauthorized persons using *** science of cryptography depends not only on complex mathematical models but also on encryption *** acid encryption is a promising model for data *** this paper,we propose an amino acid encryption model with two encryption *** first key is generated randomly using the genetic *** second key is called the protein key which is generated from converting DNA to a protein ***,the protein message and the first key are used in the modified Playfair matrix to generate the cypher *** experimental results show that the proposed model survives against known attacks such as the Brute-force attack and the Ciphertext-only *** addition,the proposed model has been tested over different types of characters including white spaces and special characters,as all the data is encoded to 8-bit *** performance of the proposed model is compared with other models using encryption time and decryption *** model also balances all three principles in the CIA triad.

关键词： Cryptography amino acid genetic algorithm playfair deep learning DNA computing

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Evaluation of the effect of neoadjuvant chemotherapy on tumor and axillary lymph nodes in locally advanced breast cancer: a study of 50 patients

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The Chinese-German Journal of Clinical Oncology 2014年第8期13卷 363-369页

作者： Ali H.Meebed ihab S.Fayek Amany Saber Reda H.Tabashy Mona A.sakr Department of Surgical Oncology National Cancer InstituteCairo Egypt Department of Medical Oncology Minia Cancer Center El Minia Egypt Department of Radiodiagnosis National Cancer Institute Cairo Egypt Department of Surgical Pathology National Cancer Institute Cairo Egypt

Objective： The purpose of the study was to correlate between effect of pre-neoadjuvant chemotherapy （NACT） and post-NACT clinical, sonographic and pathologic features of the tumor and axillary lymph nodes （ALNs） and to raise the possibility of applying the concept of sentinel lymph node biopsy （SLNB） in patients with initially positive ALNs before NACT. Methods： A prospective study of 50 female patients with locally advanced breast cancer （LABC） with clinically *** cytologically （under ultrasonographic guidance） positive ALNs. All patients received NACT and then referred for ultrasono- graphic assessment of the axilla regarding any detectable sonographic criteria of metastatic deposits in ALNs as well as the tumor size in relation to its prechemotherapy size, All patients were then subjected either to modified radical mastectomy or breast conserving surgery. The clinical, sonographic and pathological response of the tumor and the ALNs were documented, classified and correlated with each other. Results： Patients＇ mean age was 47.7±9.1 years. The mean clinical tumor size was 6.7 ± 1.4 cm; stage IliA that was presented in 32 patients （64%） and IIIB was presented in 18 patients （36%）. Chemotherapy was given for a median of 4 cycles, there was reduction of the mean clinical tumor size from 6.7 ± 1.4 cm to 4.3 ± 2.7 cm （P 〈 0.001）. Clinical response was complete in 5 （10%） tumors, complete pathological tumor response （post-neoadjuvant） was detected in 6 （16%） of patients. Complete clinical nodal response （post-neoadjuvant） in 23 （46%） axillae, on sonographic assessment of the axilla, response was complete in 17 （34%） axillae. Complete pathological nodal response occurred in 16 （32%） axillae. Out of 17 axillae that showed complete sonographic response 11 axillae showed complete pathological nodal response （P 〈 0.001）. Conclusion： Formal axillary lymph node dissection can be avoided and replaced by SLNB post NACT in patients with LABC with metastatic ALNs if there

关键词： locally advanced breast cancer (LABC) neoadjuvant chemotherapy (NACT) axUlary nodes

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