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Ventilation practices in burn patients—an international prospective observational cohort study

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Burns & Trauma 2021年第1期9卷 47-57页

作者： Gerie J.Glas Janneke Horn Markus W.Hollmann Benedikt Preckel Kirsten Colpaert Manu Malbrain Ary Serpa Neto Karim Asehnoune Marcello Gamma de Abreu ignacio martin-Loeches Paolo Pelosi Folke Sjoerg Jan M.Binnekade Berry Cleffken Nicole P.Juffermans Paul Knape Bert G.Loef David P.Mackie Perenlei Enkhbaatar Nadia Depetris Anders Perner Eva Herrero Lucia Cachafeiro Marc Jeschke Jeffrey Lipman Matthieu Legrand Johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit Guttormsen Frederik Huss Mark Kol Helen Wong Therese Starr Luc De Crop Wilson de Oliveira Filho Joa Manoel Silva Junior Cintia M.C.Grion Marjorie Burnett Frederik Mondrup Francois Ravat Mathieu Fontaine Renan Le Floch Mathieu Jeanne Morgane Bacus Maite Chaussard Marcus Lehnhardt Bassem Daniel Mikhail Jochen Gille Aidan Sharkey Nicole Trommel Auke C.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim Maria Teresa Bouza Alexander Agrifoglio Filip Fredén Tina Palmieri Lynda E.Painting Marcus J.Schultz LAMiNAR investigators Academic Medical Center University of AmsterdamAmsterdamAZ 1105The Netherlands Department of Anaesthesia and Intensive Therapy Medical University of Lublin Aleje Racklawickie 1–20-059 Lublin–Poland AZ JAN PALFIJN GENT Watersportlaan 5–9000 Gent–Belgium ABC Medical School SaPauloBangúSP 5001Brazil Service d’Anesthésie Réanimation Chirurgicale Nantes 44093France University Hospital Carl Gustav Carus Dresden 01307Germany St James University Hospital Dublin D08 NHY1Ireland University of Genoa GenoaGE 16128Italy Linkoing University Hospital Linkoing 58185Sweden Maasstad Hospital RotterdamDZ 3079The Netherlands Red Cross Hospital BeverwijkLE 1942The Netherlands martini Hospital GroningenNT 9728The Netherlands University of Texas Medical Branch GalvestonTX 77555USA Turin CTO Burn Center TurinTO 10126Italy Rigshospitalet Copenhagen 2100Denmark La Paz University Hospital Madrid 28046Spain Ross Tilley Burn Centre Sunnybrook Health Sciences CentreToronto M4N 3M5Canada Royal Brisbane and Women’s Hospital Queensland UniversityHerstonQLD 4029Australia Australian and New Zealand Intensive Care Research Centre.Monash University MelbourneVIC 3004Australia GH St-Louis-Lariboisière APHPParis 75010France BG Klinik Ludwigshafen Ludwigshafen 67071Germany Papanikoalou Hospital Thessaloniki 54621Greece Middlemore Hospital OtahuhuAuckland 2025New Zealand Haukeland University Hospital Bergen 5021Norway Uppsala University Hospital Uppsala 75185Sweden Concord Repatriation General Hospital NSW University of SydneyConcord 2139Australia Ziekenhuis Netwerk Antwerpen-Stuivenberg Antwerpen 2060Belgium Universidade de Sao Paulo Sao Paulo 01246-903Brazil Universidade Estadual de Londrina Londrina 86057-970Brazil Sunnybrook Health Sciences Centre Toronto M4N 3M5Canada CHU Lyon St Luc Lyon 69007France CHU Nantes Service dánesthesie reanimation chirugicale Nantes 44093France Hopital Roger Salengro CHRU LilleLille 59037France Saint-Louis Hospital Paris 75010France BG University Hospital Bergmannsheil Bo

Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from *** study aimed to determine ventilation practices in burn intensive care units(ICUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).Methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical *** tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PEEP)and maximum airway pressures were *** association between V_(T) and VFD-28 was analyzed using a competing risk *** settings were presented for all patients,focusing on the first day of *** also compared ventilation settings between patients with and without inhalation ***:A total of 160 patients from 28 ICUs in 16 countries were *** V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).Median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PEEP levels≥5 cmH_(2)O;80%of patients had maximum airway pressures<30 cmH_(2)***:In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients,irrespective of the presence of inhalation *** of low V_(T) was not associated with a reduction in *** registration:*** *** of registration:9 December 2014.

关键词： Mechanical ventilation Inhalation trauma Lung-protective Critical care

Reference penile size measurement and correlation with other anthropometric dimensions:a prospective study in 800 men

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Asian Journal of Andrology 2022年第6期24卷 620-623页

作者： martina Sole ignacio Tobia Gonzalezi martin Compagnucci Guadalupe Colucci Marcos Dalvit Bernardo Chiconi Omar A Layus Guillermo Gueglio Gaston Rey-Valzacchi Department of Urology at Hospital Italiano Buenos Aires C1199ABBArgentina Department of Urology at Sanatorio Allende Cordoba 5000Argentina Department of Urology at Hospital Privado de la Comunidad Mar del Plata 7600Argentina Department of Urology at Hospital Central Mendoza 5500Argentina

Virility and sexual pleasure have long been associated with penile size and this,in turn,has typically been linked to some anthropometric measurements,such as foot size or height,leading to various misconceptions from both men and *** intention is to estimate penile size parameters in Argentina and evaluate the correlation between penile size and certain anthropometric *** is a cross-sectional,descriptive,multicenter,and observational *** patients who underwent a urological procedure were included in four hospitals located in different regions of the *** anthropometric measurements were obtained:height,weight,penile circumference,flaccid and stretched length,and foot length.A total of 8o0 patients were *** left foot was 26.4 *** flaccid penile length was 11.4(95%confidence interval[CI]:8-14)cm,and mean penile circumference was 10.1(95%CI:8-12)***,mean stretched penis was 15.2(95%CI:11-18.5)*** can confirm that estimates of the average penile measurements in Argentina are flaccid penis length of 11.4 cm,penile circumference of 10.1 cm,and stretching the penis to the maximum in flaccidity of 15.2 *** between flaccid penis length,stretched out,penile circumference,height,weight,and length of the left foot were evaluated,finding low or no correlation between those mentioned,exceptforflaccidand stretched length.

关键词： anthropometric measurements micropenis penile percentile

Myocarditis in athletes after COVID-19 infection:The heart is not the only place to screen

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Sports Medicine and Health Science 2020年第3期2卷 172-173页

作者： martin Ibarrola ignacio Davolos Centro Cardiovascular BV Bella VistaBuenos AiresArgentina Hospital de Clínicas Jose de San Martín Ciudad Autonoma de Buenos AiresArgentina

COVID-19 patients are susceptible to *** the safe return to sports after COVID-19,athletes or individuals wanting to resume physical activity should complete screening for myocardial injury and *** addition,patients with COVID-19 are reported at prevalence of 27%–31%for venous thromboembolic *** probability of deep vein thrombosis and pulmonary embolism prior to intensive exercise after COVID-19 infection should be *** prevalence of cardiac injury is reported at 19%,and the prevalence of deep vein thrombosis and pulmonary embolism is higher than that for ***,the heart is not the only system needing *** for myocardial injury and myocarditis are ***,deep vein thrombosis,and pulmonary thromboembolism must be considered,and when possible,blood troponin values,Ddimer prothrombin time,and activated partial thromboplastin time levels are determined for COVID-19 infection athletes or any individual before returning to sporting practice or intense physical activity or exercise.

关键词： Athletes Sports medicine Myocarditis Pulmonary embolism COVID-19 Screening Coronavirus Coagulopathy

The martin moving grate technology

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Waste Disposal and Sustainable Energy 2023年第3期5卷 283-293页

作者： Ralf Koralewska Ulrich martin Max Schönsteiner martin GmbH für Umwelt-und Energietechnik Leopoldstrasse 24680807MunichGermany

The thermal treatment of waste using grate-based systems has gained global acceptance as the preferred method for sustainable management of residual *** is because the energy content of the waste is utilized and quality products and residues are *** Waste-to-Energy(WtE)plants are extremely *** knowledge of“fuel”waste and its effects on the design and operation of WtE plants is crucial for the successful planning and operation of these *** respond to new challenges and/or priorities,developing and implementing innovative technologies is *** long-term global partnerships and innovative grate and combustion technologies,martin guarantees that in future,residual waste will be treated following ecological and economic constraints and in compliance with international legal requirements.

关键词： Waste-to-Energy Combustion Grate technologies Heating value Developing countries

Ultrasmall CoS nanoparticles embedded in heteroatom-doped carbon for sodium-ion batteries and mechanism explorations via synchrotron X-ray techniques

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Journal of Energy Chemistry 2023年第4期79卷 373-381页

作者： Congcong Liu Qiongqiong Lu Mikhail V.Gorbunov Ahmad Omar ignacio G.Gonzalez martinez Panpan Zhao martin Hantusch Antonius Dimas Chandra Permana Huanyu He Nikolai Gaponik Daria Mikhailova Leibniz Institute for Solid State and Materials Research(IFW)Dresden e.V. Helmholtzstraße 2001069 DresdenGermany Inorganic Chemistry II Technische Universität DresdenBergstraße 6601069 DresdenGermany Physical Chemistry Technische Universität DresdenZellescher Weg 1901069 DresdenGermany

Transition metal sulfides have been regarded as promising anode materials for sodium-ion batteries(SIB).However,they face the challenges of poor electronic conductivity and large volume change,which result in capacity fade and low rate *** this work,a composite containing ultrasmall CoS(~7 nm)nanoparticles embedded in heteroatom(N,S,and O)-doped carbon was synthesized by an efficient one-step sulfidation process using a Co(Salen)*** ultrasmall CoS nanoparticles are beneficial for mechanical stability and shortening Na-ions diffusion ***,the N,S,and O-doped defect-rich carbon provides a robust and highly conductive framework enriched with active sites for sodium storage as well as mitigates volume expansion and polysulfide *** anode for SIB,CoS@HDC exhibits a high initial capacity of 906 mA h g^(-1)at 100 mA g^(-1)and a stable long-term cycling life with over 1000 cycles at 500 mA g^(-1),showing a reversible capacity of 330 mA h g^(-1).Meanwhile,the CoS@HDC anode is proven to maintain its structural integrity and compositional reversibility during ***,Na-ion full batteries based on the CoS@HDC anode and Na_(3)V_(2)(PO_(4))_(3)cathode demonstrate a stable cycling behavior with a reversible specific capacity of~200 m A h g^(-1)at least for 100 ***,advanced synchrotron operando X-ray diffraction,ex-situ X-ray absorption spectroscopy,and comprehensive electrochemical tests reveal the structural transformation and the Co coordination chemistry evolution of the CoS@HDC during cycling,providing fundamental insights into the sodium storage mechanism.

关键词： Sodium-ion batteries Cobalt sulfide nanoparticles Heteroatom-doped porous carbon matrix Synchrotron X-ray techniques Reaction mechanisms

AMP-activated kinase in human spermatozoa： identification, intracellular localization, and key function in the reRulation of sperm motility

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Asian Journal of Andrology 2017年第6期19卷 707-714页

作者： Violeta Calle-Guisado Ana Hurtado de Llera David martin-Hidalgo Jose Mijares Maria C Gil ignacio S Alvarez Maria J Bragado Luis J Garcia-Marin Research Group of Intracellular Signalling and Technology of Reproduction (SINTREP) School of Veterinary Medicine University of Extremadura Caceres Spain Assisted Reproduction Unit at the-Minimally Invasive surgery Center Jesos Uson (CCMIJU) Caceres Spain Norba Clinic Caceres Spain Research Group of Reproduction and Embryo Development (REDES) University of Extremadura Badajoz Spain Extremadura Institute of Assisted Reproduction (IERA) Badajoz Spain.

AMP-activated kinase （AMPK）, a protein that regulates energy balance and metabolism, has recently been identified in boar spermatozoa where regulates key functional sperm processes essential for fertilization. This work＇s aims are AMPK identification, intracellular localization, and their role in human spermatozoa function. Semen was obtained from healthy human donors. Sperm AMPK and phospho-Thr172-AMPK were analyzed by Western blotting and indirect immunofluorescence. High- and low-quality sperm populations were separated by a 40%-80% density gradient. Human spermatozoa motility was evaluated by an Integrated Semen Analysis System （ISAS） in the presence or absence of the AMPK inhibitor compound C （CC）. AMPK is localized along the human spermatozoa, at the entire acrosome, midpiece and tail with variable intensity, whereas its active form, phospho-Thr172-AMPK, shows a prominent staining at the acrosome and sperm tail with a weaker staining in the midpiece and the postacrosomal region. Interestingly, spermatozoa bearing an excess residual cytoplasm show strong AMPK staining in this subcellular compartment. Both AMPK and phospho-Thr172-AMPK human spermatozoa contents exhibit important individual variations. Moreover, active AMPK is predominant in the high motility sperm population, where shows a stronger intensity compared with the low motility sperm population. Inhibition of AMPK activity in human spermatozoa by CC treatment leads to a significant reduction in any sperm motility parameter analyzed： percent of motile sperm, sperm velocities, progressivity, and other motility coefficients. This work identifies and points out AMPK as a new molecular mechanism involved in human spermatozoa motility. Further AMPK implications in the clinical efficiency of assisted reproduction and in other reproductive areas need to be studied.

关键词： AMP-activated kinase human spermatozoa immunolocalization sperm motility sperm quality

A Pilot Test for A One-year Cognitive Training Intervention in Elderly Adults with Mild Cognitive Impairment

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Biomedical and Environmental Sciences 2020年第10期33卷 796-802页

作者： MENDOZA-HOLGADO Cristina LOPEZ-ESPUELA Fidel MORAN Jose Maria RONCERO-martin Raul LAVADO-GARCIA Jesus ALIAGA ignacio PUERTO-PAREJO Luis Manuel LEAL-HERNANDEZ Olga VERA Vicente PEDRERA-CANAL Maria Nursing Department Metabolic Bone Disease Research GroupUniversity of ExtremaduraNursing and Occupational Therapy CollegueAvd.Universidad s/n10003-CaceresSpain Facultad de Odontologia Universidad ComplutenseMadridSpain

In Spain,the proportion of elderly individuals has increased to 19.1%.By 2068,the proportion of elderly individuals is estimated to increase to 29.4% given the largest birth cohorts in Spain’s history(Instituto Nacional de Estadistica,INE).This challenge needs a supportive plan,as economic and caring problems may occur because of age-related health problems,including cognitive decline and dementia[1].

关键词： elderly Pilot Training

Nodal, zonal, or uniform electricity pricing： how to deal withnetwork congestion

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Frontiers in Energy 2017年第2期11卷 210-232页

作者： martin WEIBELZAHI Friedrich-Alexander-University Erlangen-Nuremberg Discrete Optimi-zation Cauerstr. 11 91058 Erlangen Germany Energy CampusNuremberg Ffirther Str. 250 90429 Nuremberg Germany

In this paper, the main contributions to congestion management and electricity pricing, i.e., nodal, zonal, and uniform electricity pricing, are surveyed. The key electricity market concepts are structured and a formal model framework is proposed for electricity transportation, production, and consumption in the context of limited transmission networks and competitive, welfare maximizing electricity markets. In addition, the main results of existing short-run and long-run congestion management studies are explicitly summarized. In particular, the important interconnection between short-run network management approaches and optimal long-run investments in both generation facilities and network lines are highlighted.

关键词： nodal pricing zonal pricing uniform pricing competitive electricity markets welfare maximization redispatch optimization models

JET and the Physics Basis of ITER

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Plasma Science and Technology 2004年第1期6卷 2109-2122页

作者： martin Keilhacker Kapellengartenstr. 11 D-81247 Mimchen Germany Director of JET Joint Undertaking from 1992- 1999

JET has made unique contributions to the physics basis of ITER by virtue ofits ITER-like geometry, large plasma size and D-T capability. The paper discusses recent JET resultsand their implications for ITER in the areas of standard ELMy H-mode, D-T operation and advancedtokamak modes. In ELMy H-mode the separation of plasma energy into core and pedestal contributionsshows that core confinement scales like gyroBohm transport. High triangularity has a beneficialeffect on confinement and leads to an integrated plasma performance exceeding the ITER Q =10reference case. A revised type I ELM scaling predicts acceptable ELM energy losses for ITER, whileprogress in physics understanding of NTMs shows how to control them in ITER. The D-T experiments of1997 have validated ICRF scenarios for heating ITER/a reactor and identified ion minority schemes(e.g. (~3He)DT) with strong ion heating. They also show that the slowing down of alpha particles isclassical so that the self-heating by fusion alphas should cause no unexpected problems. With thePellet Enhanced Performance mode of 1988, JET has produced the first advanced tokamak mode, withpeaked pressure profiles sustained by reversed magnetic shear and strongly reduced transport. Morerecently, LHCD has provided easy tuning of reversed shear and reliable access to ITBs. Improvedphysics understanding shows that rational g-surfaces play a key role in the formation anddevelopment of ITBs. The demonstration of real time feedback control of plasma current and pressureprofiles opens the path towards fully controlled steady-state tokamak plasmas.

关键词： fusion experiment JET high confinement regime ELMy H-mode advanced tokamakscenario D-T experiments physics basis of ITER