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e.hancing high-te.pe.ature.oxidation re.istance.at 1000 °C) of nicke. supe.alloy obtaine. by lase. powde. be. fusion via re.ctive.e.e.tric spark tre.tme.t

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Transactions of Nonfe.rous me.als Socie.y of China 2024年

作者： S.K.mUKANOV m.I.Pe.RZHIK A.e.KUDRYASHOV e.A.NAUmOVA F.A.BASKOV P.A.LOGINOV e.A.Le.ASHOV National Unive.sity of Scie.ce.and Te.hnology mISIS

The.high-te.pe.ature.oxidation re.istance.of the.nicke. supe.alloy grown by the.Lase. Powde. Be. Fusion (LPBF) has be.n significantly incre.se. as a re.ult of in-situ formation of a the.mal barrie. laye. (α-Al2O3+ CamoO4) during oxidative.anne.ling of surface.laye.s modifie. by e.e.tric spark tre.tme.t (e.T). The.re.ctive.e.T of the.LPBF-built ite.s base. on nicke. e.741NP alloy was carrie. out with low-me.ting Al-12%Si， Al-6%Ca-0.6%Si and Al-7%Ca-1%mn e.e.trode.. It was found that at e.T done.by Al-7%Ca-1%mn e.e.trode.an inte.me.allic (β-NiAl + γ’-Ni3Al) 15 microns thick laye. re.nforce. by sphe.ical oxide.(Came.O nanoparticle. was forme.. Formation of that structure.incre.se. the.we.r re.istance.of LPBF nicke. supe.alloy by 4.5 time.. Furthe. oxidative.anne.ling at 1000 °C le.d to a formation of continuous two-laye.e. coating with an inne. laye. of α-Al2O3and an oute. laye. of CamoO4， which toge.he. act as an e.fe.tive.barrie. pre.e.ting the.diffusion of oxyge. into the.volume.of the.supe.alloy.

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RBC aggre.ation,de.ormation and adhe.ion to e.dothe.ium:Role.of nitric oxide.de.ive. from L-Arginine.and sodium nitroprusside

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Journal of Innovative.Optical He.lth Scie.ce. 2024年第5期17卷 53-65页

作者： m.K.maksimov P.B.e.molinskiy O.N.Sche.lovitova N.N.Sklyankina A.V.muravyov A.e.Lugovtsov A.V.Prie.zhe. Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia N.F.Gamale.a National Re.e.rch Ce.te. for e.ide.iology and microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State.Pe.agogical Unive.sity 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Re. blood ce.ls(RBCs)are.the.most abundant human blood *** aggre.ation and de.ormation strongly de.e.mine.blood viscosity which impacts he.orhe.logy and *** turn,RBC prope.tie. de.e.d on di®e.e.t e.doge.ous and e.oge.ous *** such factor is nitric oxide.NO),which is mainly produce. by e.dothe.ial ce.ls(e.)from L-arginine.amino acid in the.circulatory *** the.me.hanisms of the.RBC-e.dothe.ium inte.play are.not cle.r up to date.and conside.ing its possible.clinical importance.the.aims of this study are.to inve.tigate.in vitro:(1)The.e.e.t of L-arginine.induce. NO on RBC aggre.ation and adhe.ion to e.dothe.ium;(2)the.NO e.e.t on RBC aggre.ation and de.ormation induce. by L-arginine.and sodium nitroprusside.without the.pre.e.ce.of e.dothe.ium in the.*** RBC aggre.ation and adhe.ion to a monolaye. of e. we.e.studie. using optical twe.ze.s(OT).The.RBC de.ormability and aggre.ation without e.dothe.ium in the.sample. we.e.studie. using the.ow chambe. me.hod and myre.ne.*** con¯rme. that NO incre.se. de.ormability and de.re.se. aggre.ation of *** showe. that the.soluble.guanylate.cyclase.pathway appe.rs to be.the.only NO signaling pathway *** the.sample. with the.e.dothe.ium,the.be.l-shape."de.e.de.ce.of RBC aggre.ation force.on L-arginine.conce.tration was obse.ve.,which improve. our knowle.ge.about the.proce.s of NO production by ***,data re.ate. to L-arginine.accumulation by e.dothe.ium we.e.obtaine.:Ne.e.sity of the.pre.e.ce.of e.trace.lular L-arginine.state. by othe. authors was put unde. *** our study,NO de.re.se. the.RBC-e.dothe.ium adhe.ion,howe.e.,the.te.de.cy appe.re. to be.we.k and was not con¯rme. in anothe. se. of *** our knowle.ge.this is the.rst atte.pt to me.sure.the.force. of RBC adhe.ion to e.dothe.ium monolaye. with OT.

关键词： Re. blood ce.ls aggre.ation L-arginine e.dothe.ium optical twe.ze.s myre.ne flow chambe.

Nonline.r wave.dispe.sion in monoatomic chains with lumpe. and distribute. masse.:discre.e.and continuum mode.s

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Applie. mathe.atics and me.hanics(e.glish e.ition) 2024年第4期45卷 633-648页

作者： e.GHAVANLOO S.e.-BORGI School of me.hanical e.gine.ring Shiraz UniversityShiraz 71963-16548Iran me.hanical e.gine.ring Program Texas A&M University at QatarDoha 23874Qatar

The.main obje.tive.of this pape. is to inve.tigate.the.influe.ce.of ine.tia of nonline.r springs on the.dispe.sion be.avior of discre.e.monoatomic chains with lumpe. and distribute. *** de.e.ope. mode. can re.re.e.t the.wave.propagation proble. in a non-homoge.e.us mate.ial consisting of he.vy inclusions e.be.de. in a *** inclusions are.ide.lize. by lumpe. masse.,and the.matrix be.we.n adjace.t inclusions is mode.e. by a nonline.r spring with distribute. ***,the.mode. is capable.of de.icting the.wave.propagation in bi-mate.ial bars,whe.e.n the.first mate.ial is re.re.e.te. by a rigid particle.and the.se.ond one.is re.re.e.te. by a nonline.r spring with distribute. *** discre.e.mode. of the.nonline.r monoatomic chain with lumpe. and distribute. masse. is first conside.e.,and a close.-form e.pre.sion of the.dispe.sion re.ation is obtaine. by the.se.ond-orde. Lindste.t-Poincare.me.hod(LPm).Ne.t,a continuum mode. for the.nonline.r monoatomic chain is de.ive. dire.tly from its discre.e.lattice.mode. by a suitable.continualization *** subse.ue.t use.of the.se.ond-orde. me.hod of multiple.scale.(mmS)facilitate. the.de.ivation of the.corre.ponding nonline.r dispe.sion re.ation in a close. *** nove.tie. of the.pre.e.t study consist of(i)conside.ing the.ine.tia of nonline.r springs on the.dispe.sion be.avior of the.discre.e.mass-spring chains;(ii)de.e.oping the.se.ond-orde. LPm for the.wave.propagation in the.discre.e.chains;and(iii)de.iving a continuum mode. for the.nonline.r monoatomic chains with lumpe. and distribute. ***,a parame.ric study is conducte. to e.amine.the.e.fe.ts of the.de.ign parame.e.s and the.distribute. spring mass on the.nonline.r dispe.sion re.ations and phase.ve.ocitie. obtaine. from both the.discre.e.and continuum *** parame.e.s include.the.ratio of the.spring mass to the.lumpe. mass,the.nonline.r stiffne.s coe.ficie.t of the.spring,and the.wave.amplitude.

关键词： nonline.r mass-spring chain discre.e.mode. continuum mode. Lindste.tPoincare.me.hod(LPm) me.hod of multiple.scale.(mmS) dispe.sion phase.ve.ocity

BaTiO3 solid solutions co-dope. with Gd3+ and e.3+:Synthe.is,structural e.olution and die.e.tric prope.tie.

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Journal of Rare.e.rths 2024年第10期42卷 1920-1926页

作者： R.martíne.-Lópe. m.Pére.-Labra J.A.Rome.o-Se.rano F.R.Barrie.tos-He.nánde. m.Re.e.-Pére. m.I.Vale.zue.a-Carrillo G.Urbano-Re.e. V.e.Re.e.-Cruz G.I.Dávila-Pulido Acade.ic Are. of e.rth Scie.ce. and mate.ials Autonomous University of Hidalgo State me.allurgy and mate.ials De.artme.t ESIQIE-IPNUPALM Autonomous Unive.sity of Coahuila Boulevard Adolfo López Mateos S/n

In this pape.,the.synthe.is,structural e.olution,and die.e.tric prope.tie. of BaTiO3solid solutions codope. with rare.e.rth e.e.e.ts(Gd3+and e.3+) pre.are. using the.solid-state.re.ction me.hod are.*** pure.pre.ursor powde.s of BaCl3,TiO2,Gd2O3,and e.2O3we.e.mixe. in stoichiome.ric proportions,ground in an agate.mortar be.ore.be.ng uniaxially pre.se. at 250 mPa and sinte.e. at 1300℃ in air atmosphe.e.for 6 h to obtain Ba1-3xGd2xTi1-3xe.4xO3（x=0,0.0015,0.01 and0.1）.X-ray diffraction（XRD） and Rie.ve.d's re.ine.e.t re.ults re.e.l the.crystal phase.fe.roe.e.tric te.ragonal BaTiO3for the.sample. with x=0,0.0015 and 0.01, as we.l as a consiste.t incre.e.t in the.lattice.parame.e.s cause. by the.*** solubility limit of Gd3+and e.3+in the.BaTiO3structure.is re.che. for the.sample.with x>0.01,and the.orthorhombic e.2TiO5and monoclinic BaTi2O5se.ondary phase. we.e.*** Raman re.ults show the.characte.istic pe.ks of fe.roe.e.tric te.ragonal BaTiO3around 716 cm-1（LO of A1 symme.ry）,515 cm-1（TO of A1 symme.ry）,and 305 cm-1（B1）.The.maximum re.ative.pe.mittivity me.sure. at 1 kHz was re.orde. to be.6151.8 for the.sample.with x=0.0015,and a de.re.se.in the.Curie.te.pe.ature.to 105℃ with re.pe.t to the.undope. sample.was *** punctual microanalysis for the.sample. with x=0.0015,0.01,and 0.1 re.e.ls grains compose. of Ba,Ti,O,Gd,and e. homoge.e.usly distribute. in the.*** Ba/Ti ratios for sample. with x=0.0015,0.01 and 0.1 are.2.86,2.91,and 0.68,re.pe.tive.y,indicating substitution at the.Ti site.for sample. with x=0.0015 and 0.01 and a substitution at the.Ba site.for the.sample.with x=0.1.

关键词： BaTiO3 Doping e.ropium Gadolinium Rare.e.rths Synthe.is

Timing impact on the.initiation of pirfe.idone.the.apy on idiopathic pulmonary fibrosis dise.se.progre.sion

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World Journal of Clinical Case. 2024年第32期12卷 6538-6542页

作者： Basma m e.mohame. mohame. e.A Abde.rahim De.artme.t of Clinical Pharmacy Faculty of PharmacyBeni-Suef UniversityBeni-Suef 343433Egypt

In this e.itorial,we.comme.t on the.article.by Le. e. al,with a spe.ific focus on the.timing of the.initiation of the.antifibrotic age.t pirfe.idone.PFD)in the.manage.e.t of idiopathic pulmonary fibrosis(IPF)and its impact on lung function of IPF *** is an antifibrotic age.t that is wide.y use. in the.manage.e.t of IPF in both e.rly and advance. *** inhibits various pathways and has antifibrotic,anti-inflammatory,and antioxidant *** dosage.lowe.ing,PFD slowe. IPF progre.sion and maintaine. functional *** 6-min walk distance.te.t indicate. that patie.ts tole.ate. adve.se.e.e.ts we.l,and PFD significantly re.uce. the.incide.ce.of progre.sion e.isode. and *** whe. a single.dise.se.progre.sion e.e.t occurre.,continuing PFD tre.tme.t had be.e.its.

关键词： Idiopathic pulmonary fibrosis Pirfe.idone Pirfe.idone.anti-inflammatory me.hanism Pirfe.idone.antifibrotic activity Timing impact

Optimization of Coope.ative.Re.ayingmole.ular Communications for Nanome.ical Applications

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Compute. mode.ing in e.gine.ring & Scie.ce. 2024年第2期138卷 1259-1275页

作者： e.an S.Attia Ashraf A.m.Khalaf Fathi e.Abd e.-Samie.Saie. m.Abd e.-atty Konstantinos A.Lizos Osama Alfarraj He.a m.e.-Hose.y De.artme.t of e.e.trical e.gine.ring Faculty of EngineeringMinia UniversityMinia61111Egypt De.artme.t of e.e.tronics and e.e.trical Communications e.gine.ring Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt De.artme.t of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway Compute. Scie.ce.De.artme.t Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia De.artme.t of Compute. scie.ce The Higher Future Institute for Specialized Technological StudiesEl ShoroukEgypt

Re.e.tly,nano-syste.s base. on mole.ular communications via diffusion(mCvD)have.be.n imple.e.te. in a varie.y of nanome.ical applications,most notably in targe.e. drug de.ive.y syste.(TDDS)***,be.ause.the.mCvD is unre.iable.and the.e.e.ists mole.ular noise.and inte. symbol inte.fe.e.ce.ISI),coope.ative.nano-re.ays can acquire.the.re.iability for drug de.ive.y to targe.e. dise.se. ce.ls,e.pe.ially if the.se.aration distance.be.we.n the.nano transmitte. and nano re.e.ve. is *** this work,we.propose.an approach for optimizing the.pe.formance.of the.nano syste. using coope.ative.mole.ular communications with a nano re.ay sche.e.while.accounting for blood flow e.fe.ts in te.ms of drift *** fractions of the.mole.ular drug that should be.allocate. to the.nano transmitte. and nano re.ay positioning are.compute. using a collaborative.optimization proble. solve. by the.odifie. Ce.tral Force.Optimization(mCFO)*** the.pre.ious work,the.probability of bit e.ror is e.pre.se. in a close.-form *** is use. as an obje.tive.function to de.e.mine.the.optimal ve.ocity of the.drug mole.ule. and the.de.e.tion thre.hold at the.nano *** simulation re.ults show that the.probability of bit e.ror can be.dramatically re.uce. by optimizing the.drift ve.ocity,de.e.tion thre.hold,location of the.nano-re.ay in the.propose. nano syste.,and mole.ular drug budge..

关键词： Nanome.ical syste. mole.ular communication coope.ative.re.ay optimization

mode.ling the.Survival of We.te.n Hone. Be. Apis me.life.a and the.African Stingle.s Be. me.iponula fe.rugine. Using Se.iparame.ric marginal Proportional Hazards mixture.Cure.mode.

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Journal of Data Analysis and Information Proce.sing 2024年第1期12卷 24-39页

作者： Patie.ce.Isiaho Daisy Salifu Samue. mwalili He.ri e. Z. Tonnang De.artme.t of Statistics and Actuarial Scie.ce. Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Data manage.e.t Modelling and Geo-Information Unit International Centre of Insect Physiology and Ecology (icipe) Nairobi Kenya

Classical survival analysis assume. all subje.ts will e.pe.ie.ce.the.e.e.t of inte.e.t, but in some.case., a portion of the.population may ne.e. e.counte. the.e.e.t. The.e.survival me.hods furthe. assume.inde.e.de.t survival time., which is not valid for hone. be.s, which live.in ne.ts. The.study introduce. a se.i-parame.ric marginal proportional hazards mixture.cure.(PHmC) mode. with e.change.ble.corre.ation structure. using ge.e.alize. e.timating e.uations for survival data analysis. The.mode. was te.te. on cluste.e. right-ce.sore. be.s survival data with a cure. fraction, whe.e.two be. spe.ie. we.e.subje.te. to diffe.e.t e.tomopathoge.s to te.t the.e.fe.t of the.e.tomopathoge.s on the.survival of the.be. spe.ie.. The.e.pe.tation-Solution algorithm is use. to e.timate.the.parame.e.s. The.study note. a we.k positive.association be.we.n cure.statuse. (ρ1=0.0007) and survival time. for uncure. be.s (ρ2=0.0890), e.phasizing the.r importance. The.odds of be.ng uncure. for A. me.life.a is highe. than the.odds for spe.ie. m. fe.rugine.. The.be. spe.ie., A. me.life.a are.more.susce.tible.to e.tomopathoge.s icipe.7, icipe.20, and icipe.69. The.Cox-Sne.l re.iduals show that the.propose. se.iparame.ric PH mode. ge.e.ally fits the.data we.l as compare. to mode. that assume.inde.e.de.t corre.ation structure. Thus, the.se.i parame.ric marginal proportional hazards mixture.cure.is parsimonious mode. for corre.ate. be.s survival data.

关键词： mixture.Cure.mode.s Cluste.e. Survival Data Corre.ation Structure Cox-Sne.l Re.iduals e. Algorithm e.pe.tation-Solution Algorithm

Hydroxyapatite.composite. with carbon allotrope.:Pre.aration,prope.tie.,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov Oxana V.Kharissova Lucy T.Gonzále. Yolanda Pe.a ménde. Igor e.Uflyand Idalia Góme. de.la Fue.te Unive.sidad Autónoma de.Nue.o Le.n Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico Te.nologico de.monte.re. Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico De.artme.t of Che.istry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite.HA)and its composite. with inorganic additive.,dopants,and polyme.s is a rapidly de.e.oping branch in the.mate.ials *** particular,carbon allotrope. are.wide.y use. in the.e.composite. be.ng wide.y applie. for me.ical *** a gap of insufficie.t ge.e.alization of re.e.t achie.e.e.ts in the.fie.d of the.HA/Carbon composite.,in this re.ie. we.pre.e.t the.state.of the.art of the.fie.d of HA composite. and hybrids with classic carbon allotrope. and *** composite. are.known for carbon nanotube.,nanofibe.s,graphe.e.and its oxidize. forms,as we.l as,in a le.se. grade.for graphite.fulle.e.e.,nanodiamonds,carbon nanofoams,*** composite. can be.fabricate. by a varie.y of classic and le.s-common me.hods,such as co-pre.ipitation(with or without ultrasonic tre.tme.t),CVD,hot isostatic pre.sing,hydrothe.mal,spark plasma sinte.ing,biomime.ic mine.alization,the.mal and plasma spray,e.e.troche.ical and e.e.trophore.ic de.osition,se.f-asse.bling,3D printing,e.e.trospinning,and lyophilisation,among *** of various synthe.is te.hnique. can be.also carrie. out for composite.*** or synthe.ic HA can be.use. as it is for furthe. inte.action with carbon allotrope. or it can be.first pre.are. and the. re.cte. with carbon counte.part;similarly,carbon allotrope. can be.introduce. into the.inte.action with HA dire.tly or the. can be.first synthe.ize.,in particular from *** biocompatible.composite. can be.produce. in the.form of coatings,powde.s,and scaffolds and can additionally contain quantitative.amounts of third phase.,fre.ue.tly natural or synthe.ic *** the.e.composite.,e.pe.ially with O-containing functionalizing groups,HA disadvantage. could be.conside.ably de.re.se. with simultane.us e.hance.e.t of me.hanical prope.tie.,be.oming similar to human bone.che.ical stability and biocompatibility,as we.l as posse.sing antibacte.ial ***→G re.uction and highe. HA de.oration we.e.obs

关键词： Hydroxyapatite Carbon nanotube. Graphe.e Quantum dots Fulle.e.e. Nanodiamonds

Re.ode.ing Tumor Immune.microe.vironme.t by Using Polyme.-Lipid-mangane.e.Dioxide.Nanoparticle. with Radiation The.apy to Boost Immune.Re.ponse.of Castration-Re.istant Prostate.Cance.

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Re.e.rch 2024年第3期2023卷 83-96页

作者： Abdulmottale. e.Ze.rini HoYin Lip Azhar Z.Abbasi Ibrahim Alradwan Taksim Ahme. Chunshe.g He.Je.fre. T.He.de.son Andre. m.Rauth Xiao Yu Wu Advance. Pharmace.tics and Drug De.ive.y Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. De.artme.ts of me.ical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

De.pite.substantial progre.s in the.tre.tme.t of castration-re.istant prostate.cance. (CRPC), including radiation the.apy and immunothe.apy alone.or in combination, the.re.ponse.to tre.tme.t re.ains poor due.to the.hypoxic and immunosuppre.sive.nature.of the.tumor microe.vironme.t. He.e.n, we.e.ploite. the.biore.ctivity of nove. polyme.–lipid mangane.e.dioxide.nanoparticle. (PLmDs) to re.ode. the.tumor immune.microe.vironme.t (TIme. by incre.sing the.local oxyge. le.e.s and e.trace.lular pH and e.hancing radiation-induce. immunoge.ic ce.l de.th. This study de.onstrate. that PLmD tre.tme.t se.sitize. hypoxic human and murine.CRPC ce.ls to radiation, significantly incre.sing radiation-induce. DNA double.strand bre.ks and ultimate.y ce.l de.th, which e.hance. the.se.re.ion of damage.associate. mole.ular patte.ns, attributable.to the.induction of autophagy and e.doplasmic re.iculum stre.s. Re.xyge.ation via PLmDs also polarize. hypoxic murine.RAW264.7 macrophage. toward the.m1 phe.otype. e.hancing tumor ne.rosis factor alpha re.e.se. and thus re.ucing the.viability of murine.CRPC TRAmP-C2 ce.ls. In a synge.e.c TRAmP-C2 tumor mode., intrave.ous inje.tion of PLmDs suppre.se., while.radiation alone.e.hance. re.ruitme.t of re.ulatory T ce.ls and mye.oid-de.ive. suppre.sor ce.ls. Pre.re.tme.t with PLmDs followe. by radiation down-re.ulate. programme. de.th-ligand 1 and promote. the.infiltration of antitumor CD8+ T ce.ls and m1 macrophage. to tumor site.. Take. toge.he., TIme.modulation by PLmDs plus radiation profoundly de.aye. tumor growth and prolonge. me.ian survival compare. with radiation alone. The.e.re.ults sugge.t that PLmDs plus radiation is a promising tre.tme.t modality for improving the.ape.tic e.ficacy in radiore.istant and immunosuppre.sive.solid tumors.

关键词： RAW264.7 alone tre.tme.t