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Evaluation of Rational Use of Antiretrovirals before the Dolutegravir Transition in Kinshasa, Dem.cratic Republic of Congo

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World Journal of AIDS 2021年第2期11卷 41-49页

作者： Erick N. Kam.ngu Ben I. Bulanda idriss m. mwanaut Sim.lice K. m.koka Gauthier K. m.sia “Focus HIV/AIDS” Research Group Kinshasa Democratic Republic of Congo HIV/AIDS Unit Service of Molecular Biology Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Unit of Clinical Pharm.cology and Pharm.covigilance Department of Pharmacology and Therapeutics Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo

Background: The ultim.te goal of AntiRetroViral Treatm.nts (ART) is to achieve com.lete im.une restoration and lasting viral suppression in the infected patient. In order to ensure the efficacy, safety and accessibility of antiretroviral drugs (ARVs), it is recom.ended that they should be prescribed according to national guidelines;which are evolving with the various recom.endations of the World Health Organization (WHO) and the arrival of newer, m.re effective and safer m.lecules. Objective: The objective of this study was to assess the rational use of Antiretrovirals in patients treated in Kinshasa before the use of Dolutegravir within the national program.in order to assess the correct use of these m.lecules. m.thods: This work is a descriptive cross-sectional study to assess the rational use of first-line ARVs am.ng People Living with HIV (PLHIV) in different Centers of Treatm.nt (ATCs) in Kinshasa before the introduction of Dolutegravir. The records of patients on ARVs were random.y and rationally selected in 12 different ATCs for HIV in Kinshasa according to three centers per district in the period from.June to Septem.er 2018. Inform.tion on use and consum.tion of ARVs, com.liance with guidelines, change of therapeutic com.ination as well as their reasons were consulted for the present study. Results: 507 files of PLHIV were collected in the various ATCs. 274 (54.1%) were from.fem.le patients. The m.st represented age group was 26 to 35 years with 192 patients (37.9%). The m.an duration of first-line treatm.nt for all patients included was 16.30 ± 5.85 m.nths. The m.st widely used com.ination of ARVs overall was TDF + 3TC + EFV at 45.4%. 305 (60.2%) PLHIV kept the sam. first-line treatm.nt m.lecule throughout the treatm.nt period with an average treatm.nt duration of 12.9 ± 2.77 m.nths. The m.st com.on com.ination found in this population was TDF + 3TC + EFV (69.2%). 202 (39.8%) PLHIV changed

关键词： Rational Use ARVs Dolutegravir Kinshasa

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m.lecular Diversity of the Hum.n Im.unodeficiency Virus Type 1 in m.tropolitan Cities in Central Africa: An Update of Data

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World Journal of AIDS 2020年第2期10卷 80-93页

作者： Ben Ilunga Bulanda Berry Ikolango Bongenya Adawaye Chatte Elvis Tshunza Kateba Jean-Yves Debels Kabasele m.dard Okonda Om.koy Divine Chuga Christian Tshibum.u idriss mwanaut Erick Ntam.we Kam.ngu Research Group “Focus HIV/AIDS” Kinshasa Democratic Republic of Congo University Institute of Sciences and Technologies of Abéché Abéché Chad Service of m.lecular Biochem.stry Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

The Hum.n Im.unodeficiency Virus (HIV) has a diversity that is equal to the com.lexity of its m.nagem.nt. The group m.(m.jor) is the dom.nant group in Sub-Saharan Africa and its distribution is very heterogeneous;the diversity of the virus is m.re heterogeneous in this region than elsewhere in the world which follows a com.lex and specific algorithm.because of geographical positions and countries. This distribution is very dynam.c, evolving and unpredictable. This review aim.d to expose the specifics of the HIV Type 1 epidem.c in Central Africa, in term. of the different m.lecular variants of HIV published for the region com.ared to the geographic location. Both Type 1 and Type 2 of HIV are prevalent in sub-Saharan Africa due to distinct geographical contexts. HIV-2 is m.inly docum.nted in West and Central Africa, particularly in Cam.roon, Guinea-Bissau, Gam.ia, Senegal, Ivory Coast and Burkina-Faso however HIV-1 infection is widely distributed across the continent. The HIV-1 epidem.c in Sub-Saharan Africa is dom.nated by the Group m. The different subtypes respect a certain geographical distribution across the continent. West Africa is dom.nated by subtype A, East and South Africa are dom.nated by subtype C, while Central Africa is dom.nated by strains A, C, D, F, H, J, CRF01-AE and CRF02-AG. This review is the first to present de m.lecular diversity of HIV-1 in m.tropolitan cities in all central African countries. The Circulating Recom.inant Form.(CRF02_AG) and subtypes A and G are present in all Central African countries and are also the m.st com.only encountered;followed by the subtypes D, F, G, C, B, J, K and several Circulating Recom.inant Form. that are not represented in all Central African countries.

关键词： m.lecular Diversity HIV Sub-Saharan Countries m.tropolitan Cities

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