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Establishing delivery route-dependent safety and efficacy of living biodrug mesenchymal stem cells in heart failure patients

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World Journal of Cardiology 2024年第6期16卷 339-354页

作者： Muhammad Candragupta Jihwaprani idris Sula mohamed Ahmed Charbat Khawaja Husnain Haider Basic Sciences SRCAl Bukayriyah 52736AlQaseemSaudi Arabia

BACKGROUND Mesenchymal stem cells(MSCs)as living biopharmaceuticals with unique properties,i.e.,stemness,viability,phenotypes,paracrine activity,etc.,need to be administered such that they reach the target site,maintaining these properties unchanged and are retained at the injury site to participate in the repair *** of delivery(RoD)remains one of the critical determinants of safety and *** study elucidates the safety and effectiveness of different RoDs of MSC treatment in heart failure(HF)based on phase II randomized clinical trials(RCTs).We hypothesize that the RoD modulates the safety and efficacy of MSCbased therapy and determines the outcome of the *** To investigate the effect of RoD of MSCs on safety and efficacy in HF *** RCTs were retrieved from six *** endpoints included mortality and serious adverse events(SAEs),while efficacy outcomes encompassed changes in left ventricular ejection fraction(LVEF),6-minute walk distance(6MWD),and pro-B-type natriuretic peptide(pro-BNP).Subgroup analyses on RoD were performed for all study *** Twelve RCTs were ***,MSC therapy demonstrated a significant decrease in mortality[relative risk(RR):0.55,95%confidence interval(95%CI):0.33-0.92,P=0.02]compared to control,while SAE outcomes showed no significant difference(RR:0.84,95%CI:0.66-1.05,P=0.11).RoD subgroup analysis revealed a significant difference in SAE among the transendocardial(TESI)injection subgroup(RR=0.71,95%CI:0.54-0.95,P=0.04).The pooled weighted mean difference(WMD)demonstrated an overall significant improvement of LVEF by 2.44%(WMD:2.44%,95%CI:0.80-4.29,P value≤0.001),with only intracoronary(IC)subgroup showing significant improvement(WMD:7.26%,95%CI:5.61-8.92,P≤0.001).Furthermore,the IC delivery route significantly improved 6MWD by 115 m(WMD=114.99 m,95%CI:91.48-138.50),*** biochemical efficacy outcomes,only the IC subgroup showed a significant reduction in pro-

关键词： Clinical trial Heart failure Mesenchymal stem cells Living biodrug Meta-analysis Stem cells Systematic review

Mental Health Consequences among Sudanese Due to the Armed Conflicts and Civil Unrest of 2023: One Year Later

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Journal of Biosciences and Medicines 2024年第4期12卷 21-37页

作者： Sahar Moawia Balla Elnour Nahla Yousif Osman Mohammed saeed Awadia Babiker Mohammed Osman Abeer Alawad Hassan Eman mohamed Nour Hamad Alneel Mustafa Rowa Abdelmonem Sidig Hamato Malaz mohamed Khair Alsafi mohamed Amna Alnaim mohamed Ahmed Osman Awab Abdelbagi Mustafa Ahmed Jalal Abdelrasool Hassan Eltaib Department of Family Medicine Health Gates Riyadh Saudi Arabia Family Medicine Department Ultracare Home Health Care Riyadh Saudi Arabia Psychiatic Department Erada Hospital and Mental Health Alkharj Saudi Arabia Family Medicine Department Ahmed Gasim Diabetic Center Portsudan Sudan QCHP Qatar Qatar Primary Care Najran Health Cluster Najran Saudi Arabia Emergency Department Best Care Hospital Khartoum Sudan Family Medicine Department Mouwasat Hospital Khobar Saudi Arabia

Aim: To investigate depression, anxiety, PTSD, and insomnia levels among Sudanese citizens after a year has passed since the start of Armed Forces conflict in Sudan. Methods: An online survey was distributed. It is composed of five parts, covering the following areas: 1) sociodemographic data;2) depression assessment;3) generalized anxiety disorder assessment;4) post-traumatic stress disorder assessment;and 5) insomnia assessment. Statistical Package for Social Sciences version 27 was used for data analysis;frequency and percentage were used to describe the qualitative variables. Spearman’s correlation analysis and Chi-square test were used for correlation and association analysis;a P-value equal to or less than 0.05 was considered statistically significant. Results: The study included 283 participants, primarily female (76.0%), with a mean age of 35.26 ± 6.96 years. The majority of participants were married (50.5%) and had a university level of education (50.2%). At the start of the war, 70.3% of participants were inside the war zones, and at the time of data collection, 73.5% were outside Sudan. The length of stay in the war zone ranged from 1 to 300 days, with a mean of 48.59 ± 70.284 days. Additionally, 63.3% of participants stated that they did not receive any form of mental health intervention, and the remaining did not provide an answer. There was a high prevalence of moderate-severe depression (50.5%), moderate anxiety (35.3%), PTSD (56.5%), and sub-threshold insomnia (53.4%) among the participants. Correlation analyses revealed associations between demographic factors such as sex, age, marital status, and education and mental health issues. Notably, female participants showed a higher prevalence of PTSD (53.0%) compared to male participants (67.6%). Conclusions: There is a substantial impact of war-related trauma on mental health, revealing a high prevalence of moderate-severe depression, moderate anxiety, PTSD, and sub-threshold insomnia among the particip

关键词： Sudan War Conflict Mental Health

Gastrointestinal tolerability of organic infant formula compared to traditional infant formula: A systematic review

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World Journal of Clinical Pediatrics 2024年第1期13卷 125-140页

作者： Mohammed Al-Beltagi Nermin Kamal saeed Adel Salah Bediwy Reem Elbeltagi mohamed Basiony Hamza Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503MuharraqBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlgahrbiaEgypt

BACKGROUND Infants'nutrition significantly influences their growth,development,and overall *** the increasing demand for organic infant formula driven by the perception of health benefits and growing awareness of natural feeding options,it is crucial to conduct a comparative analysis of the gastrointestinal tolerability between organic and traditional infant *** To provide a concise and precise analysis of the gastrointestinal tolerability of organic infant formula compared to traditional infant *** to limited direct comparisons,the review synthesizes available literature on each formula type,presenting insights into their potential effects on infants'digestive *** An extensive literature search was conducted,compiling studies on organic and traditional infant formulas,their compositions,and reported effects on gastrointestinal *** searched academic databases such as PubMed and Google Scholar and specialized nutrition,paediatrics,and infant health journals using relevant keywords till October 1,*** Although specific comparative studies are scarce and formula heterogeneity is a significant limitation,this systematic review provides an in-depth understanding of organic infant formulas'composition and potential *** scientific evidence directly comparing gastrointestinal tolerability is limited,organic formulas strive to use carefully selected organic ingredients to imitate breast milk *** benefits include improved lipid profiles,higher methionine content,and decreased antibiotic-resistant bacteria *** the gastrointestinal tolerability of organic and traditional infant formulas is crucial for parents and healthcare providers to make informed *** Despite limitations in direct comparisons,this systematic review provides insights into the composition and potential benefits of organic infant *** emphasizes the need for further research to eluci

关键词： Organic infant formula Traditional infant formula Gastrointestinal tolerability Formula ingredients Digestive health Infant nutrition Organic farming

Nanoskin®-ACT—The Impact of Natural Membrane & Soft with Chronic and Untreated Wounds

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Journal of Biomaterials and Nanobiotechnology 2024年第3期15卷 39-50页

作者： Saqer Al Mualla Noura Salim Salman Salma saeed Ns. Nasreen Abdelatif mohamed Kanjou Gabriel Molina de Olyveira Pierre Basmaji Antônio Carlos Guastaldi Qassimi Hospital GEM International Sharjah United Arab Emirates Innovatecs-Biotechnology Research and Development So Carlos Brazil UNESP-IQ-Physical Chemistry Department Araraquara Brazil

Bacterial cellulose (BC) is a versatile biomaterial with unique properties that make it promising for various biomedical applications, including wound healing. The extracellular matrix (ECM) plays a crucial role in wound healing, providing a structural scaffold and signaling cues for cell migration and proliferation. This study investigates the potential of BC as a scaffold for ECM production and its effect on in vivo wound healing. In this work, the bacterial cellulose fermentation process is modified by the addition of Green Propolis and Usnic acid to the culture medium and natural materials before the bacteria are inoculated. In vivo behaviour using natural membranes for regenerative medicine is presented and it is in edit. Overall, our findings demonstrate the potential of BC as a scaffold for ECM production and its beneficial effects on in vivo wound healing. BC-based dressings may offer a novel approach to promoting wound healing and tissue regeneration in clinical settings. Further studies are warranted to optimize BC-based therapies and explore their full potential in regenerative medicine.

关键词： Bacterial Cellulose Biomaterials Nanomedicine Wound Healing Green Propolis and Usnic Acid

Effect of Diabetes Self-Management Education on Glycaemic Control in Sudanese Adults with Type 2 Diabetes

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Journal of Biosciences and Medicines 2024年第3期12卷 316-327页

作者： Sahar Moawia Balla Elnour Tayseer Abdelmotalib Ahmed Taha Haiam Abdalla Wadatalla Ziryab Zainelabdin mohamed Elmahdi Marwah Isam Abdulmajeed Mohammedahmed Rowa Abdelmonem Sidig Hamadto Nahla Yousif Osman Mohammed saeed Omnia Mubarak Saad Abdallah Sulafa Abdelbagi Mustafa Ahmed Hanady Abdelhameed Ahmed mohamed Sarah Khalil Fathi Khalil Family Medicine Health Gates Primary Care Riyadh SAU Family Medicine Dhaman Health Assurance Hospitals Company Kuwait KWT Family Medicine First Health Cluster Riyadh SAU Emergency Department Sheikh Khalifa Medical City Abudahbi ARE Family Medicine University of Medical Sciences and Technology Khartoum SDN Family Medicine Sudan Medical Specialization Board-Sudan Khartoum SDN Family Medicine Ultra Care Home Care Company Riyadh SAU Medicine Department Health Gates Primary Care Riyadh SAU Family Medicine Mouwasat Hospital Madinah SAU

Research Background: The high prevalence of diabetes in Sudan, estimated at 16%, highlights the importance of effective health education in diabetes management. Diabetes self-management education has been identified as a crucial tool in enhancing the knowledge, attitudes, and abilities necessary for self-management among individuals with diabetes. Aim: To assess the impact of diabetes self-management education on medication adherence and glycemic control in Sudanese adults with type 2 diabetes before and 3 months after the DSME intervention. Method: The study was conducted in Sudan between September 2022 and March 2023, it was an interventional, one-group, pre- and post-test study that aimed to assess the impact of diabetes self-management education (DSME) on medication adherence and diabetes control in Sudanese adults with type 2 diabetes. The research was conducted in primary health care centers in six cities in Sudan and involved 244 participants. The data entry and statistical analysis were conducted using the Statistical Package for Social Sciences version 27.0. A paired t test was used for analysis. Results: The study included 244 participants, 67% of whom were males. The age mean ± SD was 48.6 ± 9.3 years, and 85.3% of participants were married. Age at onset of diabetes mean ± SD was 40.60 ± 7.81 years;44.6% had diabetes for less than 5 years;and 84.1% had a positive family history of diabetes mellitus. The levels of poor, low, and partial adherence to medication decreased by 8.2%, 4%, and 20.6%, respectively, after the intervention. The levels of good and high medication regime adherence increased by 13% and 19.8%, respectively;BMI decreased by 1.1 ± 0.73 kg/m2 (p = 0.005). The fasting blood sugar decreased by 69 ± 32.9 mg/dl (p = 0.049), and the glycated hemoglobin decreased by 1.21 ± 0.28% (p = 0.001). Conclusions: The findings of this study reinforce the importance of patient education in improving glycemic control and enhancing self-management

关键词： Sudan Adherence Intervention Education Self-Management Diabetes

Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach

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World Journal of Gastroenterology 2022年第2期28卷 242-262页

作者： Abeer Babiker idris Alaa B idris Manal A Gumaa Mohammed Babiker idris Amanda Elgoraish mohamed Mansour Dalia Allam Bashir MO Arbab Nazar Beirag El-Amin M Ibrahim mohamed A Hassan Department of Agricultural Science and Technology Institute of Natural and Applied SciencesErciyes UniversityKayseri 38039Turkey Department of Medical Microbiology Faculty of Medical Laboratory SciencesUniversity of KhartoumKhartoum 11111Sudan Department of Neurosurgery Ribat University HospitalKhartoum 11111Sudan BioMérieux Clinical and Application Advisor Al-Jeel Medical Co.Riyadh 11422Saudi Arabia Department of Epidemiology Tropical Medicine Research InstituteKhartoum 11111Sudan Department of Gastroenterology Ibn Sina Specialized HospitalKhartoum 11111Sudan Department of Gastroenterology Modern Medical CentreKhartoum 11111Sudan Biosciences College of HealthMedicine and Life SciencesBrunel UniversityLondon UB83PHUxbridgeUnited Kingdom Department of Translation Bioinformatics Detavax BiotechKayseri 38350Turkey

BACKGROUND Helicobacter pylori(***)is a ubiquitous bacterium that affects nearly half of the world’s population with a high morbidity and mortality *** within the tumor necrosis factor-alpha(TNF-A)promoter region are considered a possible genetic basis for this *** To functionally characterize the genetic variations in the TNF-A 5’-region(-584 to+107)of Sudanese patients infected with *** using in silico *** An observational study was carried out in major public and private hospitals in Khartoum state.A total of 122 gastric biopsies were taken from patients who had been referred for *** DNA was *** of the TNF-A-1030 polymorphism was performed using PCR with confronting two-pair primer to investigate its association with the susceptibility to *** infection in the Sudanese ***,Sanger sequencing was applied to detect single nucleotide polymorphisms in the 5’-region(-584 to+107)of TNF-A in ***-infected *** analyses were used to predict whether these mutations would alter transcription factor binding sites or composite regulatory elements in this region.A comparative profiling analysis was conducted in 11 species using the ECR browser and multiple-sequence local alignment and visualization search engine to investigate the possible ***,a multivariate logistic regression model was constructed to estimate odds ratios and their 95%confidence intervals for the association between TNF-A-1030,sociodemographic characteristics and *** *** were statistically significant if PA,-76)was located at the in silico-predicted promoter region(-146 to+10),and it was predicted to alter transcription factor b

关键词： 5’-region Promoter TNF-A Helicobacter pylori In silico analysis Sudan

Analysis of photostimulable phosphor image plate artifacts and their prevalence

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World Journal of Clinical Cases 2022年第2期10卷 437-447页

作者： Sara mohamed Elkhateeb Ashwag Yagoub Aloyouny mohamed mohamed saeed Omer Soad Mahmoud Mansour Department of Basic Dental Science College of DentistryPrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia College of Dentistry Princess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia

BACKGROUND Digital radiography has recently been used in dentistry as a substitute for conventional film radiography *** imaging has many advantages and provides new possibilities for recording and interpreting radiographic *** system uses different types of digital *** To detect the frequency,type,and reasons behind the appearance of intraoral image artifacts acquired by photostimulable phosphor plates(PSP).METHODS This retrospective descriptive study was conducted in the oral and maxillofacial radiology unit of the dental clinics of the College of Dentistry,Princess Nourah University(PNU).All intraoral digital radiographs were acquired using(Gendex Expert DC.,United States)an intraoral X-ray machine with 7-mA,65-kVP using a PSP system(Soredex DIGORA Optime imaging plate)and laser scanners(Soredex DIGORA Optime),which can house all sizes of reusable intraoral PSP sensor plates with image acquisition software(MIPACS Dental Enterprise viewer 3.2.2).A total of 50000 intraoral radiographs were retrieved from the clinical database from April 2018 to April 2020 to evaluate the reason,type,and solutions to these image *** Overall,50000 intraoral digital radiographs were acquired in a two-year-period;that is,from April 2018 to April *** these,3550(7.1%)retakes were performed due to the presence of image *** radiographs were the most common image type of intraoral retakes(80.8%).Imaging artifacts were divided into three categories:operator,plate and scanning *** of 3550 retakes,5%,1.37%,and 0.73%were related to operator,plate,and scanning errors,*** cone cut was the most common operator error(988 images),Bite marks were the most common plate error(276 images),and delayed scanning artifacts were the most common scanning errors(145 images).The calculated kappa value for interobserver reliability was 0.99,indicating almost perfect interobserver *** Our study discussed intraora

关键词： Photostimulable phosphor image Artifacts Intraoral radiographs Errors Prevalence and types

Detection of Copy-Move Forgery in Digital Images Using Singular Value Decomposition

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Computers, Materials & Continua 2023年第2期74卷 4135-4147页

作者： Zaid Nidhal Khudhair Farhan mohamed Amjad Rehman Tanzila Saba saeed Ali bahaj Faculty of Engineering School of ComputingUniversity Technology of MalaysiaJohar BahruMalaysia UTM-IRDA MaGICX Institute of Human Centered EngineeringUniversiti Teknologi MalaysiaMalaysia Artificial Intelligence&Data Analytics Lab CCIS Prince Sultan University Riyadh Saudi Arabia Computer Techniques Engineering Department Faculty of Information TechnologyImam Ja’afar Al-Sadiq UniversityBaghdadIraq

This paper presents an improved approach for detecting copy-move forgery based on singular value decomposition(SVD).It is a block-based method where the image is scanned from left to right and top to down by a sliding window with a determined *** each step,the SVD is ***,the diagonal matrix’s maximum value(norm)is selected(representing the scaling factor for SVD and a fixed value for each set of matrix elements even when rotating thematrix or scaled).Then,the similar norms are grouped,and each leading group is separated into many subgroups(elements of each subgroup are neighbors)according to 8-adjacency(the subgroups for each leading group must be far from others by a specific distance).After that,a weight is assigned for each subgroup to classify the image as forgery or ***,the F1 score of the proposed system is measured,reaching 99.1%.This approach is robust against rotation,scaling,noisy images,and illumination *** is compared with other similarmethods and presents very promised results.

关键词： Forgery image forensic image processing region duplication SVD transformation technological development

Finger Vein Authentication Based on Wavelet Scattering Networks

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Computers, Materials & Continua 2022年第8期72卷 3369-3383页

作者： Amjad Rehman Majid Harouni Maedeh Omidiravesh Suliman mohamed Fati saeed Ali Bahaj Artificial Intelligence&Data Analytics Lab CCIS Prince Sultan UniversityRiyadh11586Saudi Arabia Department of Computer Engineering Dolatabad BranchIslamic Azad UniversityIsfahanIran Faculty of Computer Engineering Najafabad BranchIslamic Azad UniversityIsfahanIran MIS Department College of Business Administration Prince Sattam bin Abdulaziz UniversityAlkharj11942Saudi Arabia

Biometric-based authentication systems have attracted more attention than traditional authentication techniques such as passwords in the last two *** biometrics such as fingerprint,palm,iris,palm vein and finger vein and other biometrics have been *** of the challenges in biometrics is physical *** of finger vein is of the biometrics least exposed to physical *** methods have been proposed for authentication with the help of this biometric that suffer from weaknesses such as high computational complexity and low identification *** paper presents a novel method of scattering wavelet-based identity *** wavelet extracts image features from Gabor wavelet filters in a structure similar to convolutional neural *** distinguishes this algorithm from other popular feature extraction methods such as deep learning methods,filter-based methods,statistical methods,etc.,is that this algorithm has very high skill and accuracy in differentiating similar images but belongs to different classes,even when the image is subject to serious damage such as noise,angle changes or pixel location,this descriptor still generates feature vectors in away thatminimizes classifier *** improves classification and *** proposed method has been evaluated using two databases Finger Vein USM(FV-USM)and Homologous Multimodal biometrics Traits(SDUMLA-HMT).In addition to having reasonable computational complexity,it has recorded excellent identification rates in noise,rotation,and transmission *** best,it has a 98.2%identification rate for the SDUMLA-HMT database and a 96.1%identification rate for the FV-USM database.

关键词： Biometrics finger veins wavelet scattering vein authentication disaster risk reduction