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DNA identification of compromised samples with massive parallel sequencing

Forensic Sciences Research 2019年第4期4卷 331-336页

作者： Andreas Tillmar ida grandell Kerstin Montelius Department of Forensic Genetics and Forensic Toxicology National Board of Forensic MedicineLinköpingSweden Department of Clinical and Experimental Medicine Faculty of Health SciencesLinköping UniversityLinköpingSweden

Genetic profiling is a standard procedure for human identification,*** criminal cases and mass disasters,and has been proven to be an important part in the process in the repatriation of victims to their *** the event of a catastrophe whether it be a natural disaster,terror attack or accident,fatalities of many nationalities may be a consequence and international collaboration becomes *** DNA techniques used on a routine basis at forensic laboratories world-wide are very useful,and results reported from different labs are compared,making it possible to be matched in order to declare the identification of a *** calculations of possibilities of a random match are achievable since population data from many parts of the world are ***,decomposition and degradation of the remains are not uncommon in the aftermath of a catastrophe and hence it may be difficult to retrieve detailed DNA profiles from such *** parallel sequencing(MPS)is a technique capable of producing a vast amount of DNA sequence data in a high-through put manner,and panels of single nucleotide polymorphism(SNP)markers allow the amplification of small DNA fragments,often seen in compromised ***,we report the results from a set of 10 samples from missing person identification cases,analyzed with an MPS based method comprising 131 SNP markers and compared with direct reference material or buccal swab samples collected from relatives of the *** assess the weight of evidence of a match by statistical ***,we compare results reported on different platforms using different SNP panels,and conclude that more work has to be done if results from missing person identification cases analyzed on MPS with SNP panels at different laboratories are to be fully reliable and thus comparable.

关键词： Forensic science forensic genetics disaster victim identification massive parallel sequencing SNP mass disaster

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