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Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

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Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk Kim Hyun-Ju Park Hyo Won chang Ji Hyun Back Su Jin Lee Yae Eun Park Eun Hye Kim Yeonsun Hong Gijung Kwak ick chan kwon Ji Eun Lee Yoon Se Lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

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用于药物控释的多聚物凝胶

世界科学 1992年第8期 20-21页

作者： ick chan kwon 刘岳峰

人们正在开发新的受控制的药物释放体系以克服传统的剂量类型的不足。例如,受刺激的药物释放已被用来克服由于恒定的释放率所引起的耐药性问题,并模拟激素浓度的生理模型,在需要时供给药物。对刺激敏感的多聚物在药物的受激释放方面有... 详细信息

人们正在开发新的受控制的药物释放体系以克服传统的剂量类型的不足。例如,受刺激的药物释放已被用来克服由于恒定的释放率所引起的耐药性问题,并模拟激素浓度的生理模型,在需要时供给药物。对刺激敏感的多聚物在药物的受激释放方面有潜在的应用价值。它们能响应环境条件的变化而改变它们的结构或化学性质。来自环境的刺激包括温度、pH、光（紫外光或可见光）,电场或者某些化学物质。刺激敏感型的凝胶网络其体积变化对外部刺激尤为敏感,但膨胀却缓慢发生。这些体系不仅能用在药物的控释上,而且能帮助我们深入了解分子间的相互作用。在此我们报道一种新的多聚物体系,它能对微小的电流发生反应,通过将固态的多聚复合物分解为两个能溶于水的多聚物,很快地由固态变为溶液。我们证实用这种多聚物体系能实现胰岛素的调节释放,由此也能推广到其它的大分子物质。聚乙基恶唑啉（PEOx）与聚甲基丙烯酸（PMAA）

关键词：多聚物胰岛素多肽复合物

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急性化脓性髋关节炎的关节镜治疗

中国矫形外科杂志 2004年第Z1期 12-14页

作者： Young-Lae Moon,玄文虎,kwon ick HA 韩国光州广域市朝鲜大学附属医院矫形外科韩国光州广域市朝鲜大学附属医院矫形外科韩国光州广域市朝鲜大学附属医院矫形外科

目的 :对成人急性化脓性髋关节炎关节镜下施行引流术后评价其疗效。对象及方法 :9例成人急性化脓性髋关节炎 ,根据理学检查和关节穿刺确诊后关节镜下急诊行边缘切除术及冲洗术 ,术后监测ESR (血沉 )及CRP(C 反应蛋白 )值观察其疗效。结... 详细信息

目的 :对成人急性化脓性髋关节炎关节镜下施行引流术后评价其疗效。对象及方法 :9例成人急性化脓性髋关节炎 ,根据理学检查和关节穿刺确诊后关节镜下急诊行边缘切除术及冲洗术 ,术后监测ESR (血沉 )及CRP(C 反应蛋白 )值观察其疗效。结果 :ESR恢复正常需 11 9d ,CRP恢复正常需 8 9d。术后随访 1年全部病例关节功能恢复正常 ,化验检查未发现感染征象。结论 :成人急性化脓性髋关节炎在关节镜下行关节边缘切除术及冲洗、引流术比关节切开引流术能减少术后并发症 ,是能取得良好疗效的有效术式。

关键词：髋关节化脓性关节炎关节镜冲洗术边缘切除术

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急性化脓性髋关节炎的关节镜治疗

中国矫形外科杂志 2004年第1期12卷 13-15页

作者： Young-Lae Moon 玄文虎 kwon ick HA 韩国光州广域市朝鲜大学附属医院矫形外科

关键词：髋关节急性化脓性关节炎关节镜冲洗术边缘切除术

Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

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Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina Kim Joon-Tae Kim Ji Sung Lee Beom Joon Kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun kwon Wook-Joo Kim Dong-ick Shin Sung-Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-Joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone