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Mass screening-based case-control study of diet and prostate cancer in Changchun, China

Asian Journal of Andrology 2008年第4期10卷 551-560页

作者： Xiao-Meng Li Jiang Li ichiro Tsuji Naoki Nakaya Yoshikazu Nishino Xue-Jian Zhao School of Life Sciences Northeast Normal University Changchun 130024 China School of Basic Medical Sciences Changchun 130041 China Dental Hospital Jilin University Changchun 130041 China Department of Public Health Tohoku University Sendai 980-8576 Japan

Aim： To investigate possible correlation factors for prostate cancer by a population-based case-control study in China. Methods： We carded out a mass screening of prostate cancer in Changchun, China, using a prostate-specific antigen assisted by Japan International Cooperation Agency. From June 1998 to December 2000, 3 940 men over 50 years old were screened. Of these, 29 men were diagnosed with prostate cancer. We selected 28 cases and matched them with controls of low prostate-specific antigen value （〈 4.1 ng/mL） by 1：10 according to age and place of employment. A case-control study of diet and prostate cancer was then carded out. Results： After adjustment for education, body mass index （BMI）, smoking, alcohol consumption, marriage and diet, intake of soybean product was discovered to be inversely related to prostate cancer. Men who consumed soybean product more than twice per week on different days had a multivariate odds ratio （OR） of 0.38 （95% confidence interval [CI], 0.13-1.12）. In addition, men who consumed soybean products more than once per day had a multivariate OR of 0.29 （95% CI, 0.11-0.79） compared with men who consumed soybean products less than once per week. The P for trend was 0.02, which showed significant difference. There was no significant difference in P trend for any dairy food. Even when we matched the cases and controls by other criteria, we found that soybean food was the only preventive factor associated with prostate cancer. Conclusion： Our study suggests that consumption of soybeans, one of the most popular foods in Asia, would decrease the risk of prostate cancer.

关键词： soybean prostate cancer case-control study diet

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Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis

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World Journal of Gastroenterology 2009年第5期15卷 615-621页

作者： Motoko Sasaki ichiro Araki Toshiaki Yasui Masaru Kinoshita Keita Itatsu Takayuki Nojima Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine Kanazawa 920-8640 Japan Department of Internal Medicine Asanogawa General Hospital Kanazawa 920-8621 Japan Department of Surgery Asanogawa General Hospital Kanazawa 920-8621 Japan Hanazono Medical Office Kanazawa 920-0293 Japan Department of Pathology Kanazawa Medical University Ishikawa 920-0293 Japan

We report a case of primary localized malignant biphasic mesothelioma of the liver in a 66-year-old man associated with asbestosis. The tumor was detected as a hepatic nodule, 4 cm in diameter, in the right lobe (S8 segment) on CT scan. Histopathological examination demonstrated an intrahepatic tumor with central necrosis consisting of a papillary epithelioid pattern on the surface of the liver, microcystic (microglandular or adenomatoid) pattern mainly in the subcapsular area and sarcomatoid pattern intermingled with microcystic pattern in the major part of the hepatic nodular tumor. Tumor cells, especially of epithelioid type, showed distinct immunoreactivity for mesothelial markers (WT-1, calretinin, D2-40, CK5/6, mesothelin, thrombomodulin) and no immunoreactivity for epithelial (adenocarcinoma) markers (CEA, CD15, BerEP4, BG8, MOC31). P53 immunoreactivity was detected focally in papillary epithelioid tumor cells and extensively in microcystic and sarcomatoid components, suggesting that the papillary epithelioid mesothelioma arose on the surface of the liver, and tumor cells showing microcystic and sarcomatoid patterns invaded and grew into the liver. To date, this is the first case of primary localized malignant biphasic mesothelioma of the liver, since all three primary hepatic mesotheliomas reported so far were epithelioid type.

关键词： Malignant mesothelioma Pulmonaryasbestosis Liver Immunohistochemistry

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Numerical Analysis of Blast Furnace Performance Under Charging Iron-Bearing Burdens With High Reducibility

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Journal of Iron and Steel Research International 2007年第2期14卷 13-19页

作者： CHU Man-sheng GUO Xian-zhen SHEN Feng-man YAGI Jun-ichiro NOGAMI Hiroshi Institute of Ferrous Metallurgy Northeastern University Shenyang 110004 Liaoning China Ironmaking Plant Anyang Steel Company Limited Anyang 455004 Henan China Institute of Multidisciplinary Research for Advanced Materials Tohoku University Sendai 980-8577 Japan

The reducibility of iron-bearing burdens was emphasized for improving the operation efficiency of blast furnace. The blast furnace operation of charging the burdens with high reducibility has been numerically evaluated using a multi-fluid blast furnace model. The effects of reaction rate constants and diffusion coefficients were investigated separately or simultaneously for clarifying the variations of furnace state. According to the model simulation results, in the upper zone, the indirect reduction of the burdens proceeds at a faster rate and the shaft efficiency is enhanced with the improvement under the conditions of interface reaction and intra-particle diffusion. In the lower zone, direct reduction in molten slag is restrained. As a consequence, CO utilization of top gas is enhanced and the ratio of direct reduction is decreased. It is possible to achieve higher energy efficiency of the blast furnace, and this is represented by the improvement in productivity and the decrease in consumption of reducing agent. The use of high-reducibility burdens contributes to a better performance of blast furnace. More efforts are necessary to develop and apply highreducibility sinter and carbon composite agglomerates for practical application at a blast furnace.

关键词： blast furnace iron-bearing burden reducibility multi-fluid model 3-interface shrinking core model

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The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells

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Oncology Research 2023年第5期31卷 631-643页

作者： MASANORI KAWANO KAZUHIRO TANAKA ichiro ITONAGA TATSUYA IWASAKI YUTA KUBOTA HIROSHI TSUMURA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5593Japan

Heat shock protein(HSP)90 plays a crucial role in correcting the misfolded three-dimensional structure of proteins,assisting them in folding into proper ***90 is critical in maintaining the normal functions of various proteins within cells,as essential factors for cellular ***,HSP90 simultaneously supports the maturation of cancer-related proteins,including mesenchymal epithelial transition factor(MET)within tumor *** osteosarcoma cell lines had elevated MET expression in the cDNA array in our ***,a tyrosine kinase receptor,promotes proliferation and an anti-apoptotic state through the activation of the MET pathway constructed by *** this study,we treated osteosarcoma cells with an HSP90 inhibitor,17-demethoxygeldanamycin hydrochloride(17-DMAG),and assessed the changes in the MET signaling pathway and also the antitumor effect of the *** cell cycle in osteosarcoma cells administered 17-DMAG was found to be halted at the G2/M ***,treatment with 17-DMAG inhibited cell proliferation and induced *** of tumor cell proliferation was also observed in an in vivo model system,mice that were treated with *** on the results of this study,we were able to confirm that 17-DMAG promotes inhibition of osteosarcoma cell proliferation and induction of apoptosis by inhibition of MET,a protein highly expressed in osteosarcoma *** approach may be useful for the establishment of a new treatment strategy for patients resistant to the standard treatment for osteosarcoma.

关键词： Osteosarcoma MET HSP90 17-DMAG

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Legionella dumoffii Tex-KL Mutated in an Operon Homologous to traC-traD is Defective in Epithelial Cell Invasion

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Biomedical and Environmental Sciences 2016年第6期29卷 424-434页

作者： QIN Tian Iida Ken-ichiro REN Hong Yu ZHOU Hai Jian Shin-ichi Yoshida State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention beijing 102206 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003 Zhejiang China Departments of Bacteriology Faculty of Medical Sciences Kyushu University Higashi-ku Fukuoka 812-8582 Japan

Objective To understand the mechanism of invasion by Legionella dumoffii. Methods The L. dumoffii strain Tex-KL was mutated using the Tn903 derivative, Tn903 d IIlac Z. After screening 799 transposon insertion mutants, we isolated one defective mutant. We then constructed the gene-disrupted mutant, KL16, and studied its invasion of and intracellular growth in He La and A549 cells, and in A/J mice survival experiments. The structure of traC-traD operon was analyzed by RT-PCR. Results The transposon insertion was in a gene homologous to Salmonella typhi tra C, which is required for the assembly of F pilin into the mature F pilus structure and for conjugal DNA transmission. Results from RT-PCR suggested that the traC-traD region formed an operon. We found that when the tra C gene was disrupted, invasion and intracellular growth of L. dumoffii Tex-KL were impaired in human epithelial cells. When mice were infected by intranasal inoculation with a tra C deficient mutant, their survival significantly increased when compared to mice infected with the wild-type strain. Conclusion Our results indicated that the traC-traD operon is required for the invasion and intracellular growth abilities of L. dumoffii Tex-KL in epithelial cells.

关键词： L. dumoffii Tex-KL traC-traD operon Invasion ability Epithelial cells

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Big Data Analytics in E-commerce for the *** China Through Literature Reviewing

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Journal of Systems Science and Information 2021年第1期9卷 16-44页

作者： Weiqing ZHUANG Morgan C.WANG ichiro NA KAMOTO Ming JIANG School of Internet Economics and Business Fujian Universily of TechnologyFuzhou 350108China Research Center for“One Belt and Road"Economic and Policy Frujian University of TechnologyFiuzhou 350108China College of Science University of Central rloridaFlorida 32525USA School of Internet Econormics and Business Furjian Universily of TechnologyPuzhou 350108China School of Internet Econormics and Business Irujian University of TechnologyPuzhou 350108China

Big data analytics(BDA)in e-commerce,which is an emerging field that started in 2006,deeply affects the development of global e-commerce,especially its layout and performance in the *** *** paper seeks to examine the relative influence of theoretical research of BDA in e-commerce to explain the differences between the *** China by adopting a statistical analysis method on the basis of samples collected from two main literature databases,Web of Science and CNKI,aimed at the *** *** results of this study help clarify doubts regarding the development of China's e-commerce,which exceeds that of the ***,in view of the theoretical comparison of BDA in e-commerce between them.

关键词： big data analytics e-commerce U.S.and China literature review

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Machine learning modeling of superconducting critical temperature

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npj Computational Materials 2018年第1期3卷 405-418页

作者： Valentin Stanev Corey Oses A.Gilad Kusne Efrain Rodriguez Johnpierre Paglione Stefano Curtarolo ichiro Takeuchi Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742-4111USA Center for Nanophysics and Advanced Materials University of MarylandCollege ParkMD 20742USA Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Center for Materials Genomics Duke UniversityDurhamNC 27708USA National Institute of Standards and Technology GaithersburgMD 20899USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Department of Physics University of MarylandCollege ParkMD 20742USA Fritz-Haber-Institut der Max-Planck-Gesellschaft 14195 Berlin-DahlemGermany

Superconductivity has been the focus of enormous research effort since its discovery more than a century ***,some features of this unique phenomenon remain poorly understood;prime among these is the connection between superconductivity and chemical/structural properties of *** bridge the gap,several machine learning schemes are developed herein to model the critical temperatures(T_(c))of the 12,000+known superconductors available via the SuperCon *** are first divided into two classes based on their T_(c) values,above and below 10 K,and a classification model predicting this label is *** model uses coarse-grained features based only on the chemical *** shows strong predictive power,with out-of-sample accuracy of about 92%.Separate regression models are developed to predict the values of T_(c) for cuprate,iron-based,and low-T_(c) *** models also demonstrate good performance,with learned predictors offering potential insights into the mechanisms behind superconductivity in different families of *** improve the accuracy and interpretability of these models,new features are incorporated using materials data from the AFLOW Online ***,the classification and regression models are combined into a single-integrated pipeline and employed to search the entire Inorganic Crystallographic Structure Database(ICSD)for potential new *** identify>30 non-cuprate and non-iron-based oxides as candidate materials.

关键词： learning critical offering

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Electron Communication Between Electrode and Dye-Linked L-Proline Dehydrogenase in Organized Layer-by-Layer Multilayer Film

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Chemical Research in Chinese Universities 2009年第4期25卷 550-555页

作者： ZHENG Hai-tao DONG Li-ping LIU Hai-hui JIA Hai-lian SUYE Shin-ichiro School of Material Science and Chemical Engineering Tianjin Polytechnic University Tianjin 300160 P. R. China Department of Applied Chemistry and Biotechnology Graduate School of Engineering University of Fukui Fukui 910-8507 Japan

Multilayer film was fabricated on an electrode surface by alternate layer-by-layer（LBL） adsorption of polycationic redox polymer（PEI-Fc） and dye-linked L-proline dehydrogenase（L-proDH）.The electrochemistry of the PEI-Fc/L-proDH multilayer modified electrode was investigated by cyclic voltammetry,and the enzyme catalysis mediated by the redox polymer was studied in a solution containing *** was observed that electron communication between L-proDH and the electrode was achieved with the help of PEI-Fc.A mathematical expression for the current response was evaluated based on the Michaelis-Menten kinetics mode,and the calculated currents fitted well with the experimental *** kinetic analysis indicates that only a small fraction of the immobilized enzyme was efficiently electrically wired by the redox polymer.

关键词： Electron communication Dye-linked L-proline dehydrogenase Layer-by-layer adsorption Electrode kinetic

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Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets

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World Journal of Gastroenterology 2006年第33期12卷 5320-5325页

作者： Norihito Watanabe Tatehiro Kagawa Sei-ichiro Kojima Shinji Takashimizu Naruhiko Nagata Yasuhiro Nishizaki Tetsuya Mine Division of Gastroenterology Department of In-ternal Medicine Tokai University School of Medicine Japan

AIM: To investigate the effects of taurolithocholate (TLC)on the canalicular motility in isolated rat hepatocyte cou-plets (IRHC).METHODS: TLC was added to IRHC at concentrationsof 10 and 50 μmol/L, respectively. In each group, fi vetime-lapse movies containing 3 representative bile cana-liculi were taken under phase-contrast microscopy for12 h. The number of bile canalicular contractions andthe intervals between consecutive canalicular contrac-tions were calculated. Furthermore, the effects of TLC onIRHC were examined by transmission electron ***: The bile canalicular contractions were spon-taneous and forceful in the controls. Active vesicularmovement was observed in the pericanalicular *** after the addition of TLC, the bile canaliculiwere deformed, and canalicular bile was incorporatedinto the vacuoles. The canaliculi were gradually dilated,and canalicular contractions were markedly inhibited byTLC. The vesicular movements became extremely slowin the pericanalicular region. The number of canalicularcontractions significantly decreased in the TLC-treatedgroups, as compared with that in the controls. The timeintervals were prolonged, as the TLC dosage increased,indicating that bile secretion into the canaliculi wasimpaired with TLC. Transmission electron microscopyrevealed the lamellar transformation of the canalicularmembranes in IRHC treated with ***: TLC impairs both the bile canalicularcontractions and the canalicular bile secretion, possiblyby acting directly on the canalicular membranes in TLC-induced cholestasis.

关键词： Taurolithocholate Bile canaliculi Canalicularcontraction Bile secretion Isolated rat hepatocyte couplets Canalicular membrane Contractile protein

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A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings

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World Journal of Gastroenterology 2007年第19期13卷 2758-2760页

作者： Katsuyoshi Tamaki ichiro Shimizu Mari Urata Nao Kohno Hiroshi Fukuno Susumu Ito Nobuya Sano Department of Digestive and Cardiovascular Medicine Institute of Health Biosciences The University of Tokushima Graduate School Japan Division of Pathology Tokushima University Hospital Tokushima Japan

Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of the diseases and time. We report a patient with hepatocellular carcinoma (HCC) who was suspected of having spinal lesions based on neurological findings, and a metastatic spinal tumor was found by imaging examination. Assuming that metastasis had occurred at the time lumbar pain developed, the patient reached the level of gait disturbance within only 4 mo, showing a rapid advancement of symptoms. If early diagnosis had been possible, treatment could be performed before acute myelopathy progressed to complete paralysis. We speculate that the terminal stage of HCC is not only liver failure associated with intrahepatic lesions but also metastasis to other regions, treatment for individual pathologies therefore, will be needed, which constitutes an important issue.

关键词： Hepatocellular carcinoma Spinal cord metastasis Brain metastasis

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