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neurocircuit regeneration by extracellular matrix reprogramming

neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su ian n.levasseur Kimberly M.Alonge Department of Medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

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Maternal anxiety associated with fetal echocardiography

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Open Journal of Pediatrics 2012年第2期2卷 143-149页

作者： Alexandra Channing Katherine Rosenberg Catherine Monk Charles S. Kleinman Julie S. Glickstein Stephanie M. levasseur Lynn L. Simpson Ismee A. Williams Department of Obstetrics & Gynecology Division of Maternal Fetal Medicine Columbia University College of Physicians & Surgeons Sloane Hospital for Women New York USA Department of Pediatrics Division of Pediatric Cardiology Columbia University College of Physicians & Surgeons Morgan Stanley Children’s Hospital of New York New York USA Department of Psychiatry Behavioral Medicine Columbia University Medical Center New York USA

Background: Women awaiting fetal echocardiography (fECHO) report high anxiety. It is unclear if anxiety decreases after performance of fECHO. Methods: At fECHO, subjects’ current (state) vs baseline (trait) anxiety was assessed using the Spielberger State-Trait Anxiety Inventory. Anxiety scores of the pre- and post-fECHO groups were compared. Results: From January 2007 to January 2009, we recruited 84 subjects: 40 pre-fECHO and 44 post-fECHO. Of the post-fECHO group, 30 had normal fetal cardiac structure and function confirmed, 12 were told of an abnormality, and 2 were told to follow up equivocal results. Anxiety scores were compared between the 40 pre-fECHO subjects and the 30 post-fECHO subjects with normal results. The mean state anxiety score of the pre-fECHO group was higher than that of the post-fECHO group (42.1 ± 15.1 vs 30.8 ± 8.5, p no difference in trait scores. neither state nor trait anxiety was associated with maternal age, parity, history of miscarriage or known fetal anomaly. Compared to those with a normal fECHO (n = 30), subjects with an abnormal fECHO result (n = 12) had higher state anxiety (46.8 ± 15.5 vs 30.8 ± 8.5, p = 0.005). There was no difference in anxiety scores between subjects awaiting fECHO and post-fECHO subjects who had an abnormal result. Conclusion: Immediately following normal fECHO, women report low anxiety compared with women awaiting fECHO. Women awaiting fECHO report anxiety levels that are as high as women who are told there is fetal cardiac anomaly.

关键词： Maternal Anxiety Prenatal Testing Birth Defects Fetal Echocardiography

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